5-fluoromethylornithine has been researched along with ornithine in 22 studies
| Studies (5-fluoromethylornithine) | Trials (5-fluoromethylornithine) | Recent Studies (post-2010) (5-fluoromethylornithine) | Studies (ornithine) | Trials (ornithine) | Recent Studies (post-2010) (ornithine) |
|---|---|---|---|---|---|
| 22 | 0 | 2 | 5,192 | 100 | 827 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 14 (63.64) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knödgen, B; Sarhan, S; Seiler, N | 1 |
| Edström, S; Gustafsson, B; Hellander, K; Lundholm, K; Reinholdtsen, L; Tibell, L; Westin, T | 1 |
| Bolkenius, FN; Knödgen, B; Seiler, N | 1 |
| Bolkenius, FN; Daune, G; Knödgen, B; Seiler, N | 1 |
| Daune, G; Gerhart, F; Seiler, N | 1 |
| Daune-Anglard, G; Grauffel, C; Knödgen, B; Sarhan, S; Seiler, N | 1 |
| Butterworth, RF; Knödgen, B; Sarhan, S; Seiler, N; Therrien, G | 1 |
| Knoedgen, B; Sarhan, S; Seiler, N | 1 |
| Hornsperger, JM; Knoedgen, B; Sablone, M; Sarhan, S; Seiler, N | 1 |
| Bonaventure, N; Daune-Anglard, G; Seiler, N | 1 |
| Alakuijala, L; Alhonen, L; Halmekytö, M; Halonen, T; Jänne, J; Kauppinen, R; MacDonald, E; Miettinen, R; Sinervirta, R; Sivenius, J | 1 |
| Grauffel, C; Knödgen, B; Sarhan, S; Seiler, N | 1 |
| Alakuijala, L; Alhonen, L; Halmekytö, M; Jänne, J | 1 |
| Ando, A; Del Monte, MA; Ito, S; Maeda, H; Masu, Y; Ueda, M; Uyama, M | 1 |
| Capitani, G; Jansonius, JN; Müller, R; Schirmer, T; Storici, P | 1 |
| Fukushige, T; Kobayashi, K; Li, MX; Nakajima, T; Saheki, T; Seiler, N | 1 |
| Ando, A; Ito, S; Masu, Y; Okumura, T; Ueda, M; Uyama, M | 1 |
| Seiler, N | 1 |
| Ando, A; Ito, S; Matsumura, M; Nakauchi, T; Ueda-Yamada, M; Uyama, M; Yamazaki, Y | 1 |
| Ando, A; Furuta, K; Igarashi, K; Ito, S; Kaneko, S; Maeda, M; Matsumura, M; Nishimura, K; Okuda-Ashitaka, E; Suzuki, M | 1 |
| Ando, A; Furuta, K; Ito, S; Kaneko, S; Maeda, M; Ohnaka, M; Okuda-Ashitaka, E; Suzuki, M; Takahashi, K | 1 |
| Breuer, M; Carl, M; Hoffmann, GF; Kölker, S; Okun, JG; Zielonka, M | 1 |
1 review(s) available for 5-fluoromethylornithine and ornithine
| Article | Year |
|---|---|
Ornithine aminotransferase, a potential target for the treatment of hyperammonemias.
Topics: Ammonia; Animals; Biogenic Polyamines; Brain; Chorioretinitis; Enzyme Inhibitors; Humans; Hyperammonemia; Kidney; Liver; Mice; Ornithine; Ornithine-Oxo-Acid Transaminase; Thioacetamide; Urea | 2000 |
21 other study(ies) available for 5-fluoromethylornithine and ornithine
| Article | Year |
|---|---|
Inhibition of ornithine aminotransferase by 5-fluoromethylornithine: protection against acute thioacetamide intoxication by elevated tissue ornithine levels.
Topics: Amino Acids; Ammonia; Animals; Biogenic Polyamines; Chemical and Drug Induced Liver Injury; Hemorrhage; Liver Diseases; Male; Mice; Ornithine; Ornithine-Oxo-Acid Transaminase; Pilot Projects; Poisoning; Thioacetamide | 1992 |
Tumor cytokinetic effects of acute starvation versus polyamine depletion in tumor-bearing mice.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Female; Flow Cytometry; Food Deprivation; Male; Mice; Mice, Inbred C57BL; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Sarcoma, Experimental | 1991 |
DL-canaline and 5-fluoromethylornithine. Comparison of two inactivators of ornithine aminotransferase.
Topics: Aminobutyrates; Animals; Brain; Enzyme Activation; Kidney; Kinetics; Liver; Mice; Mice, Inbred Strains; Ornithine; Ornithine-Oxo-Acid Transaminase; Rats; Rats, Inbred Strains; Stereoisomerism; Transaminases | 1990 |
Ornithine aminotransferase activity, tissue ornithine concentrations and polyamine metabolism.
Topics: Animals; Brain; Eflornithine; Female; Male; Mice; Mice, Hairless; Ornithine; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Polyamines; Rats; Rats, Inbred Strains; Transaminases | 1989 |
5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase.
Topics: Animals; Brain; Female; In Vitro Techniques; Liver; Male; Mice; Ornithine; Ornithine-Oxo-Acid Transaminase; Putrescine; Rats; Rats, Inbred Strains; Time Factors; Transaminases | 1988 |
Decreased hyperammonaemia and orotic aciduria due to inactivation of ornithine aminotransferase in mice with a hereditary abnormal ornithine carbamoyltransferase.
Topics: Amino Acids; Ammonia; Animals; Behavior, Animal; Female; Male; Metabolism, Inborn Errors; Mice; Mice, Mutant Strains; Mutation; Ornithine; Ornithine Carbamoyltransferase; Ornithine-Oxo-Acid Transaminase; Orotic Acid | 1994 |
Effects of ornithine aminotransferase inactivation by 5-fluoromethylornithine in rats following portacaval anastomosis.
Topics: Amino Acids; Ammonia; Animals; Body Weight; Brain; Liver; Male; Ornithine; Ornithine-Oxo-Acid Transaminase; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley | 1994 |
Protection against lethal ammonia intoxication: synergism between endogenous ornithine and L-carnitine.
Topics: Acetates; Amino Acids; Ammonia; Animals; Brain; Carnitine; Drug Synergism; Drug Therapy, Combination; Female; Mice; Ornithine; Poisoning | 1994 |
Enhanced endogenous ornithine concentrations protect against tonic seizures and coma in acute ammonia intoxication.
Topics: 3-Mercaptopropionic Acid; Ammonia; Animals; Brain Chemistry; Coma; Dialysis; Dizocilpine Maleate; Electroshock; Epilepsy, Generalized; Female; Glutamate-Ammonia Ligase; Methionine Sulfoximine; Mice; N-Methylaspartate; Ornithine; Ornithine-Oxo-Acid Transaminase; Pentylenetetrazole; Postural Balance; Putrescine; Strychnine | 1993 |
Some biochemical and pathophysiological aspects of long-term elevation of brain ornithine concentrations.
Topics: Animals; Brain; Carnosine; Chickens; Disease Models, Animal; Electroretinography; Eye; Female; gamma-Aminobutyric Acid; Gyrate Atrophy; Longitudinal Studies; Mice; Mice, Inbred C57BL; Ornithine; Ornithine-Oxo-Acid Transaminase | 1993 |
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
Topics: Animals; Brain; Differential Threshold; Electroshock; Escape Reaction; Immunohistochemistry; Learning; Mice; Mice, Transgenic; Motor Activity; Ornithine; Ornithine Decarboxylase Inhibitors; Pentylenetetrazole; Polyamines; Putrescine; Reference Values; Seizures; Space Perception; Swimming | 1993 |
Effects of inhibition of ornithine aminotransferase on thioacetamide-induced hepatogenic encephalopathy.
Topics: Amino Acids; Animals; Behavior, Animal; Brain; Citrulline; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Liver; Male; Mice; Motor Activity; Ornithine; Ornithine-Oxo-Acid Transaminase; Thioacetamide; Urea | 1993 |
Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines.
Topics: Animals; Brain; Diamines; Gene Expression; Male; Mice; Mice, Transgenic; Ornithine; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Polyamines; Putrescine; Spermidine; Spermine; Testis | 1993 |
Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells.
Topics: Arginine; Carcinoma, Hepatocellular; Cell Death; Cell Division; Cell Line; Cell Survival; DNA; DNA Replication; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fluorescent Antibody Technique, Indirect; Humans; Keratins; Liver Neoplasms; Ornithine; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proline | 1998 |
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Humans; Microspectrophotometry; Models, Molecular; Molecular Sequence Data; Molecular Structure; Ornithine; Ornithine-Oxo-Acid Transaminase; Protein Conformation; Solutions; Substrate Specificity | 1999 |
Aberrations of ammonia metabolism in ornithine carbamoyltransferase-deficient spf-ash mice and their prevention by treatment with urea cycle intermediate amino acids and an ornithine aminotransferase inactivator.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Ammonium Chloride; Animals; Arginine; Citrulline; Enzyme Inhibitors; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Transgenic; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease; Perfusion; Urea | 1999 |
Heterogeneity in ornithine cytotoxicity of bovine retinal pigment epithelial cells in primary culture.
Topics: Animals; Cattle; Cell Death; Cells, Cultured; DNA; Drug Synergism; Enzyme Inhibitors; Gyrate Atrophy; Ornithine; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proline | 2000 |
Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells.
Topics: Amino Acid Transport System y+; Amino Acids; Amino Acids, Cyclic; Cell Survival; Cells, Cultured; Colorimetry; Cytoprotection; Fusion Regulatory Protein 1, Heavy Chain; Fusion Regulatory Protein 1, Light Chains; Gyrate Atrophy; Humans; Large Neutral Amino Acid-Transporter 1; Ornithine; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2003 |
Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Topics: Animals; Cationic Amino Acid Transporter 1; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proto-Oncogene Proteins c-myc; Putrescine; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermidine; Spermine; Swine; Telomerase; Time Factors; Transfection; Up-Regulation | 2007 |
Induction of arginase II mRNA by nitric oxide using an in vitro model of gyrate atrophy of choroid and retina.
Topics: Animals; Arginase; Boronic Acids; Cell Line; Enzyme Inhibitors; Gyrate Atrophy; Humans; Models, Biological; Nitric Oxide; Ornithine; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Swine; Tetrazolium Salts; Thiazoles; Up-Regulation | 2011 |
Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase.
Topics: Acetates; Animals; Hyperammonemia; Ornithine; Ornithine-Oxo-Acid Transaminase; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Zebrafish | 2018 |