5-fluorodihydrouracil has been researched along with fluorouracil in 44 studies
| Studies (5-fluorodihydrouracil) | Trials (5-fluorodihydrouracil) | Recent Studies (post-2010) (5-fluorodihydrouracil) | Studies (fluorouracil) | Trials (fluorouracil) | Recent Studies (post-2010) (fluorouracil) |
|---|---|---|---|---|---|
| 44 | 3 | 6 | 45,562 | 9,307 | 14,663 |
| Protein | Taxonomy | 5-fluorodihydrouracil (IC50) | fluorouracil (IC50) |
|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | 0.32 | |
| Thymidylate synthase | Mus musculus (house mouse) | 1.58 | |
| Aromatase | Homo sapiens (human) | 0.63 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (31.82) | 18.7374 |
| 1990's | 7 (15.91) | 18.2507 |
| 2000's | 16 (36.36) | 29.6817 |
| 2010's | 6 (13.64) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| McDermott, BJ; Murphy, RF; Van den Berg, HW | 1 |
| Lee, KR; Sheu, SY | 1 |
| de Bruijn, EA; Pinedo, HM; Reeuwijk, HJ; Tjaden, UR; van Oosterom, AT | 1 |
| Fosså, SD; Heier, MS; Heintz, R | 1 |
| Driessen, O; Erkelens, C; van den Bosch, N; van der Velde, EA | 1 |
| de Brauw, LM; de Bruijn, EA; Erkelens, C; Remeyer, L; Tjaden, UR; van de Velde, CJ | 1 |
| Cross, DS; Diasio, RB; Heggie, GD; Huster, WJ; Sommadossi, JP | 1 |
| Armand, JP; Bernadou, J; Lopez, A; Malet-Martino, MC; Martino, R | 1 |
| Diasio, RB; Schuetz, JD; Sommadossi, JP; Wallace, HJ | 1 |
| Cotten, ML; Gollnick, P; Hardin, CC; Horowitz, J | 1 |
| De Bruijn, EA; Driessen, O; Slee, PH; Tjaden, UR; van den Bosch, N; van Oosterom, AT; van Strijen, E | 1 |
| Hoshi, A; Iigo, M; Kuretani, K; Nakamura, A | 1 |
| Aubert, C; Cano, JP; Carcassonne, Y; Rigault, JP; Seitz, JF | 1 |
| Aubert, C; Cano, JP; Carcassone, Y; Coassolo, P; Gilli, R; Monjanel, S; Rigault, JP; Seitz, JF | 1 |
| Almond, MR; Chestnut, WG; Harrington, JA; Porter, DJ; Spector, T; Tanoury, G | 1 |
| Cao, S; Harrington, JA; Porter, DJ; Rustum, YM; Spector, T | 1 |
| Almond, MR; Harrington, JA; Lowen, GT; Porter, DJ; Spector, T | 1 |
| Ackland, SP; Dunstan, RH; Garg, MB | 1 |
| Kobayashi, S; Kumai, T; Nakura, H; Tanaka, M; Tateishi, T; Watanabe, M | 1 |
| Bachert, P; Becker, M; Dietz, A; Knopp, MV; Rudat, V; Schlemmer, HP; van Kaick, G; Vanselow, B; Wannenmacher, M; Weidauer, H; Wollensack, P; Zuna, I | 1 |
| Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL | 1 |
| Allegrini, G; Barsanti, G; Battistoni, M; Bocci, G; Conte, PF; Danesi, R; Del Tacca, M; Di Paolo, AD; Falcone, A; Innocenti, F; Melosi, A | 1 |
| Amiand, M; Campion, L; Déporte-Féty, R; Lanoë, D; Milano, G; Moreau, A; Picot, M; Renée, N | 1 |
| Amadori, D; Danesi, R; Del Tacca, M; Di Paolo, A; Flamini, E; Ibrahim, T; Maltoni, M; Vannozzi, F; Zoli, W | 1 |
| Amadori, D; Cionini, L; Danesi, R; Del Tacca, M; Di Paolo, A; Falcone, A; Ibrahim, T; Mini, E; Vannozzi, F | 1 |
| Allegrini, G; Bocci, G; Conte, PF; Danesi, R; Del Tacca, M; Di Paolo, A; Falcone, A; Innocenti, F | 1 |
| De Vries, EG; Groen, HJ; Maring, JG; Piersma, H; Uges, DR; van Dalen, A | 1 |
| Kikuchi, K; Masuike, T; Nakamura, A; Ohishi, T | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Ciccolini, J; Etienne-Grimaldi, MC; Fischel, JL; Formento, P; Milano, G | 1 |
| de Vries, EG; Greijdanus, B; Maring, JG; Schouten, L; Uges, DR | 1 |
| Bocci, G; Danesi, R; Del Tacca, M; Innocenti, F; Natale, G | 1 |
| Boisdron-Celle, M; Gamelin, A; Morel, A; Remaud, G | 1 |
| Hirakawa, K; Kim, WY; Nakata, B | 1 |
| Katzenellenbogen, JA; LaFrate, AL | 1 |
| Amatori, F; Bocci, G; Danesi, R; Del Tacca, M; Di Donato, S; Di Paolo, A; Falcone, A; Federici, F; Iannopollo, M; Lastella, M; Lencioni, M; Orlandini, C; Ricci, S | 1 |
| Hanauske, A; Hilger, RA; Krauss, J; Kredtke, S; Makris, L; Mende, B; Scheulen, ME; Scigalla, P; Strumberg, D; Thyssen, D; Urrea, PD | 1 |
| Beijnen, JH; Rosing, H; Schellens, JH; Vainchtein, LD | 1 |
| Akın, O; Cihan, M; Serdar, MA; Sertoğlu, E; Tapan, S; Uyanık, M | 1 |
| Amadori, D; Amatori, F; Danesi, R; Del Tacca, M; Di Paolo, A; Flamini, E; Ibrahim, T; Mercatali, L; Ravaioli, E; Sacanna, E | 1 |
| Amstutz, U; Büchel, B; Bühr, C; Largiadèr, CR; Rhyn, P; Schürch, S | 1 |
| Bocci, G; Ciccolini, J; Danesi, R; Di Paolo, A; Iliadis, A; Lacarelle, B; Marouani, H; Woloch, C | 1 |
| Cheng, YY; Hsieh, CH; Liu, JH; Tsai, TH | 1 |
| Aruldhas, BW; Chacko, RT; Jacob, J; Mathew, BS; Mathew, SK; Prabha, R; Singh, A | 1 |
3 trial(s) available for 5-fluorodihydrouracil and fluorouracil
| Article | Year |
|---|---|
Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidoreductases | 2000 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged | 2012 |
41 other study(ies) available for 5-fluorodihydrouracil and fluorouracil
| Article | Year |
|---|---|
Gas-liquid-chromatographic analysis of 5-fluorouracil and its metabolite 5-fluorodihydrouracil in plasma [proceedings].
Topics: Chromatography, Gas; Fluorouracil; Humans | 1979 |
Evidence of a new metabolic pathway of 5-fluorouracil in Escherichia coli from in vivo 19F-NMR spectroscopy.
Topics: Escherichia coli; Fluorouracil; Hydroxylation; Kinetics; Magnetic Resonance Spectroscopy | 1989 |
Pharmacology of 5'-deoxy-5-fluorouridine in patients with resistant ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Middle Aged; Ovarian Neoplasms | 1985 |
Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical phase 1 study.
Topics: Adult; Aged; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged | 1986 |
The stability of 5,6-dihydrofluorouracil in plasma and the consequences for its analysis.
Topics: Drug Stability; Fluorouracil; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Specimen Handling; Temperature | 1987 |
Non-linear pharmacokinetics of 5-fluorouracil as described by in vivo behaviour of 5,6 dihydro-5-fluorouracil.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fluorouracil; Half-Life; Kinetics; Rats | 1986 |
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.
Topics: Adult; Bile; Chromatography, High Pressure Liquid; Female; Fluorouracil; Humans; Kinetics; Male; Middle Aged | 1987 |
Complete urinary excretion profile of 5-fluorouracil during a six-day chemotherapeutic schedule, as resolved by 19F nuclear magnetic resonance.
Topics: beta-Alanine; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Radioisotopes; Urea | 1985 |
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Female; Fluorouracil; Humans; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase | 1985 |
Characterization of the fluorodihydrouracil substituent in 5-fluorouracil-containing Escherichia coli transfer RNA.
Topics: Escherichia coli; Fluorouracil; Kinetics; Magnetic Resonance Spectroscopy; RNA, Transfer; RNA, Transfer, Amino Acyl; RNA, Transfer, Met; Spectrophotometry, Ultraviolet | 1983 |
A gas chromatographic assay for the determination of 5,6-dihydrofluorouracil and 5-fluorouracil in human plasma.
Topics: Aged; Chromatography, Gas; Female; Fluorouracil; Humans; Kinetics; Middle Aged | 1983 |
Excretion of 1-hexylcarbamoyl-5-fluorouracil in urine of mice.
Topics: Animals; beta-Alanine; Female; Fluorouracil; Mice; Mice, Inbred Strains | 1981 |
Pharmacokinetics of 5-fluorouracil : impact of the measurement of the 5,6-dihydrofluorouracil.
Topics: Fluorouracil; Humans; Kinetics; Neoplasms | 1981 |
Advantages and limitations of pharmacokinetic studies in the rationalization of anticancer therapy: methotrexate and 5-FU.
Topics: Drug Administration Schedule; Fluorouracil; Humans; Kinetics; Methotrexate; Models, Biological | 1981 |
Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine.
Topics: Alanine; Alanine Transaminase; Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; beta-Alanine; Catalysis; Chemical Phenomena; Chemistry, Physical; Enzyme Activation; Enzyme Inhibitors; Fluorides; Fluorouracil; Glyoxylates; Kinetics; Liver; Malondialdehyde; Molecular Sequence Data; Rats; Stereoisomerism; Substrate Specificity; Transaminases | 1995 |
Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil.
Topics: Animals; Drug Interactions; Female; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1995 |
(R)-5-fluoro-5,6-dihydrouracil: kinetics of oxidation by dihydropyrimidine dehydrogenase and hydrolysis by dihydropyrimidine aminohydrolase.
Topics: Amidohydrolases; Animals; Cattle; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Hydrolysis; Kinetics; Liver; Oxidation-Reduction; Oxidoreductases; Rats; Stereoisomerism | 1994 |
Simultaneous determination of dihydrofluorouracil and 5-fluorouracil in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Esophageal Neoplasms; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans | 1997 |
Sex- or age-related differences were not detected in the activity of dihydropyrimidine dehydrogenase from rat liver.
Topics: Aging; Animals; Body Weight; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Liver; Male; Organ Size; Oxidoreductases; Rats; Rats, Sprague-Dawley; Sex Factors; Urea | 1997 |
Alterations of intratumoral pharmacokinetics of 5-fluorouracil in head and neck carcinoma during simultaneous radiochemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Biotransformation; Carboplatin; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorine; Fluorouracil; Head and Neck Neoplasms; Humans; Isotopes; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged | 1999 |
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine | 1999 |
High-performance liquid chromatographic assay with ultraviolet detection for quantification of dihydrofluorouracil in human lymphocytes: application to measurement of dihydropyrimidine dehydrogenase activity.
Topics: Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Lymphocytes; Oxidoreductases; Radiometry; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2001 |
Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients.
Topics: Aged; Analysis of Variance; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Oxidoreductases; Patients | 2002 |
Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Administration Schedule; Drug Monitoring; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Predictive Value of Tests; Regression Analysis | 2002 |
Severe 5-fluorouracil toxicity associated with a marked alteration of pharmacokinetics of 5-fluorouracil and its catabolite 5-fluoro-5,6-dihydrouracil: a case report.
Topics: Alopecia; Antimetabolites, Antineoplastic; Area Under Curve; Diarrhea; Drug Eruptions; Female; Fever; Fluorouracil; Humans; Middle Aged; Neutropenia; Stomatitis; Vomiting | 2002 |
Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics.
Topics: Aged; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver; Liver Neoplasms; Male; Middle Aged | 2003 |
[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Liver; Male; Rats; Uracil | 2004 |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Topics: Antineoplastic Agents; beta-Alanine; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Inhibitory Concentration 50; Keratinocytes; Syndrome; Thymidine Phosphorylase | 2004 |
A simple and sensitive fully validated HPLC-UV method for the determination of 5-fluorouracil and its metabolite 5,6-dihydrofluorouracil in plasma.
Topics: Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Monitoring; Fluorouracil; Humans; Spectrophotometry, Ultraviolet | 2005 |
5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Tetrachloride; Female; Fluorouracil; Liver Diseases; Mice; Mice, Inbred ICR | 2005 |
Sensitive MS/MS-liquid chromatography assay for simultaneous determination of tegafur, 5-fluorouracil and 5-fluorodihydrouracil in plasma.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Mass Spectrometry; Reproducibility of Results; Tegafur; Time Factors | 2005 |
Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; beta-Alanine; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur | 2007 |
Improved chemical syntheses of 5,6-dihydro-5-fluorouracil.
Topics: Fluorouracil; Molecular Structure; Stereoisomerism | 2007 |
5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancer.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Multivariate Analysis; Retrospective Studies | 2008 |
Pharmacokinetic study of S-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil | 2009 |
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine | 2010 |
Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography-tandem mass spectrometry method for evaluation of dihydropyrimidine dehydrogenase enzyme activity.
Topics: Antimetabolites, Antineoplastic; Biotransformation; Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Monitoring; Enzyme Assays; Fluorouracil; Humans; Kinetics; Leukocytes, Mononuclear; Limit of Detection; Neoplasms; Precision Medicine; Reproducibility of Results; Severity of Illness Index; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, Liquid; Colorectal Neoplasms; Drug Monitoring; Drug Stability; Female; Fluorouracil; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Uracil | 2013 |
Population pharmacokinetic analysis of 5-FU and 5-FDHU in colorectal cancer patients: search for biomarkers associated with gastro-intestinal toxicity.
Topics: Aged; Biomarkers; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Female; Fluorouracil; Humans; Logistic Models; Male; Middle Aged; Models, Biological; Nausea; Retrospective Studies; Vomiting | 2012 |
The Herb-Drug Pharmacokinetic Interaction of 5-Fluorouracil and Its Metabolite 5-Fluoro-5,6-Dihydrouracil with a Traditional Chinese Medicine in Rats.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fluorouracil; Herb-Drug Interactions; Limit of Detection; Male; Medicine, Chinese Traditional; Rats, Sprague-Dawley; Reproducibility of Results | 2017 |
Systemic exposure to 5-fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-fluorouracil in patients with gastrointestinal malignancy.
Topics: Fluorouracil; Gastrointestinal Neoplasms; Humans; Pharmaceutical Preparations; Prospective Studies | 2021 |