5-fluoro-2-indolyldeschlorohalopemide and halopemide

5-fluoro-2-indolyldeschlorohalopemide has been researched along with halopemide* in 1 studies

Other Studies

1 other study(ies) available for 5-fluoro-2-indolyldeschlorohalopemide and halopemide

Article	Year
Optimization of halopemide for phospholipase D2 inhibition. Bioorganic & medicinal chemistry letters, 2007, Apr-15, Volume: 17, Issue:8 Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2. Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Domperidone; Enzyme Inhibitors; Inhibitory Concentration 50; Pharmacokinetics; Phospholipase D; Rats; Structure-Activity Relationship	2007

Article

Year

Optimization of halopemide for phospholipase D2 inhibition.

Bioorganic & medicinal chemistry letters, 2007, Apr-15, Volume: 17, Issue:8

Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2.

Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Domperidone; Enzyme Inhibitors; Inhibitory Concentration 50; Pharmacokinetics; Phospholipase D; Rats; Structure-Activity Relationship

2007