Compounds > 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide
Page last updated: 2024-09-03

5-ethynyl-1-ribofuranosylimidazole-4-carboxamide and guanosine triphosphate

5-ethynyl-1-ribofuranosylimidazole-4-carboxamide has been researched along with guanosine triphosphate in 5 studies

Compound Research Comparison

Studies
(5-ethynyl-1-ribofuranosylimidazole-4-carboxamide)		Trials
(5-ethynyl-1-ribofuranosylimidazole-4-carboxamide)		Recent Studies (post-2010)
(5-ethynyl-1-ribofuranosylimidazole-4-carboxamide)		Studies
(guanosine triphosphate)		Trials
(guanosine triphosphate)		Recent Studies (post-2010) (guanosine triphosphate)
210214,728252,115

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balzarini, J; De Clercq, E1
Balzarini, J; De Clercq, E; Lee, CK; Schols, D1
Balzarini, J; Bohman, C; De Clercq, E; Fridland, A; Herdewijn, P; Horská, K; Karlsson, A; Van Aerschot, A; Votruba, I; Wang, L1
Balzarini, J; De Clercq, E; Leyssen, P; Neyts, J1
Günther, S; Neyts, J; Ölschläger, S1

Other Studies

5 other study(ies) available for 5-ethynyl-1-ribofuranosylimidazole-4-carboxamide and guanosine triphosphate

ArticleYear
Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytes.
    The Biochemical journal, 1992, Nov-01, Volume: 287 ( Pt 3)

    Topics: Adenosine Triphosphate; Antimetabolites; Cell Line; Guanosine Triphosphate; Humans; Hypoxanthine; Hypoxanthines; IMP Dehydrogenase; Inosine; Inosine Monophosphate; Kinetics; Lymphocytes; Ribonucleosides

1992
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymph
    Biochemical and biophysical research communications, 1991, Jul-31, Volume: 178, Issue:2

    Topics: Antiviral Agents; Cells, Cultured; Didanosine; Drug Synergism; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; HIV-1; Humans; Inosine Monophosphate; Kinetics; Lymphocytes; Ribavirin; Ribonucleosides

1991
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.
    The Journal of biological chemistry, 1993, Nov-25, Volume: 268, Issue:33

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Division; Deoxyguanine Nucleotides; Guanine; Guanosine; Guanosine Triphosphate; Humans; IMP Dehydrogenase; Leukemia L1210; Lymphocytes; Mice; Mycophenolic Acid; Purine Nucleotides; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured

1993
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.
    Journal of virology, 2005, Volume: 79, Issue:3

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Guanosine Triphosphate; IMP Dehydrogenase; Microbial Sensitivity Tests; Mycophenolic Acid; Parainfluenza Virus 3, Human; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication; Yellow fever virus

2005
Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus.
    Antiviral research, 2011, Volume: 91, Issue:2

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Ebolavirus; Guanosine; Guanosine Triphosphate; IMP Dehydrogenase; Lassa virus; Mycophenolic Acid; Ribavirin; Ribonucleosides; Vero Cells; Virus Replication

2011