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5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil and zidovudine

5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil has been researched along with zidovudine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baba, M; De Clercq, E; Miyasaka, T; Nitta, I; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT1
Baba, M; Miyasaka, T; Nakashima, H; Nitta, I; Saito, S; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT1
Anné, J; de Clercq, E; de Vreese, K; Debyser, Z; Desmyter, J; Pauwels, R; Vandamme, AM1
Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R1
Baba, M; De Clercq, E; Ito, M; Miyasaka, T; Shigeta, S; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT1
Goudgaon, NM; McKenna, PM; Mellors, JW; Nguyen, MH; Schinazi, RF; Shi, C1
Baba, M; Fujiwara, M; Ijichi, K; Konno, K; Shigeta, S; Yokota, T1

Other Studies

7 other study(ies) available for 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil and zidovudine

ArticleYear
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
    Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25

    Topics: Antiviral Agents; Cells, Cultured; HIV-1; Structure-Activity Relationship; Thymine; Virus Replication

1992
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Thymine; Virus Replication

1991
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.
    Virology, 1992, Volume: 188, Issue:2

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Binding Sites; Deoxyguanine Nucleotides; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Uracil; Zidovudine

1992
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
    Molecular pharmacology, 1992, Volume: 41, Issue:5

    Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; HIV-1; Imidazoles; Kinetics; Molecular Structure; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Templates, Genetic; Thymidine; Thymine Nucleotides; Uracil; Zidovudine

1992
Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:7

    Topics: Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Synergism; HIV-1; Humans; Uracil; Virus Replication; Zidovudine

1991
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10

    Topics: Antiviral Agents; Drug Resistance; HIV-1; Humans; Mutation; Organoselenium Compounds; Structure-Activity Relationship; Uracil; Zidovudine

1994
Different properties of wild type and drug-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase in vitro.
    Microbiology and immunology, 1996, Volume: 40, Issue:5

    Topics: Antiviral Agents; Cells, Cultured; DNA, Viral; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Mutation; Proviruses; RNA-Directed DNA Polymerase; Uracil; Virus Replication; Zidovudine

1996