5-deazaaminopterin has been researched along with methotrexate in 4 studies
*Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [MeSH]
*Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montgomery, JA; Otter, GM; Piper, JR; Schmid, FA; Sirotnak, FM | 1 |
| Chou, TC; Huang, JT; Otter, GM; Sirotnak, FM; Su, TL; Watanabe, KA | 1 |
| Montgomery, JA; Morrison, JF; Stone, SR | 1 |
| Colwell, WT; DeGraw, JI; Johnson, CA; Piper, JR; Sirotnak, FM; Smith, RL; Waud, WR | 1 |
4 other study(ies) available for 5-deazaaminopterin and methotrexate
| Article | Year |
|---|---|
Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
Topics: Adenocarcinoma; Alkylation; Aminopterin; Animals; Drug Compounding; Epithelium; Intestine, Small; Kinetics; Mammary Neoplasms, Experimental; Methotrexate; Mice; Sarcoma 180; Structure-Activity Relationship | 1988 |
Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).
Topics: Aminopterin; Antineoplastic Agents; Humans; Methotrexate; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues.
Topics: Aminopterin; Animals; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; Protein Binding; Structure-Activity Relationship | 1984 |
Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Survival; Collagen; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Mice, Inbred DBA; Molecular Structure; Tumor Cells, Cultured | 1997 |