Page last updated: 2024-09-02

5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid and ochratoxin a

5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid has been researched along with ochratoxin a in 24 studies

Compound Research Comparison

Studies
(5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid)
Trials
(5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid)
Recent Studies (post-2010)
(5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid)
Studies
(ochratoxin a)
Trials
(ochratoxin a)
Recent Studies (post-2010) (ochratoxin a)
260163,170181,600

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's6 (25.00)18.2507
2000's1 (4.17)29.6817
2010's12 (50.00)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
Appelgren, LE; Breitholtz-Emanuelsson, A; Fuchs, R; Hult, K1
Galtier, P1
Creppy, EE; Dirheimer, G; Röschenthaler, R; Størmer, FC1
Bolt, HM; Creppy, EE; Föllmann, W; Hillebrand, IE1
Barriault, C; Bouchard, G; Frohlich, AA; Kerkadi, A; Marquardt, RR; Tuchweber, B; Yousef, IM1
Bruinink, A; Rasonyi, T; Sidler, C1
Eggert, W; Lerch, C; Müller, HM; Müller, K1
Müller, HM; Müller, K; Steingass, H1
Ahn, J; Jahng, KY; Kim, D; Kim, H1
Cano-Sancho, G; Coronel, MB; Marin, S; Ramos, AJ; Sanchis, V; Tarragó, M1
Banjari, I; Klapec, T; Sarkanj, B; Strelec, I1
Bouisseau, A; Cavelier, F; Reillon, F; Roland, A; Schneider, R1
Al Nahid, A; Ali, N; Blaszkewicz, M; Degen, GH; Hossain, K; Mahmood, S; Manirujjaman, M; Perveen, R; Rahman, M1
Cramer, B; Gerding, J; Humpf, HU1
Li, XT; Sun, BG; Wang, XL; Xiong, K; Zhi, HW1
Cheng, Z; Li, J; Ma, L; Zhang, X; Zhou, Z1
Fernandes, E; Freitas, M; Furlong, EB; Kupski, L; Ribeiro, D1
Ali, N; Degen, GH; Muñoz, K1
Bibi, R; Paoloni, A; Pecorelli, I; Solfrizzo, M1
Chen, D; Fan, S; Li, B; Liu, P; Wang, Z; Xin, S; Zhao, R1
Behrens, M; Galla, HJ; Humpf, HU; Hüwel, S1
Aguilar-Zuniga, K; Carrasco-Sánchez, V; Lobos, O; Ortiz-Villeda, B1
Aurora Elizabeth, RG; Briscia Socorro, BV; Cyndia Azucena, GA; Irma Martha, MD; José Francisco, HM; Miguel Alfonso, RA; Monserrat, S; Yael Yvette, BH1
Czabany, T; Marchetti-Deschmann, M; Prasad, S; Streit, B; Weingart, G1

Reviews

2 review(s) available for 5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid and ochratoxin a

ArticleYear
Pharmacokinetics of ochratoxin A in animals.
    IARC scientific publications, 1991, Issue:115

    Topics: Albumins; Animals; Animals, Domestic; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Eggs; Female; Fishes; Haplorhini; Humans; Inactivation, Metabolic; Intestinal Absorption; Kidney; Liver; Male; Maternal-Fetal Exchange; Milk; Mixed Function Oxygenases; Ochratoxins; Poultry; Pregnancy; Protein Binding; Rats; Rodentia; Swine; Tissue Distribution

1991
Ochratoxins in Wines: A Review of Their Occurrence in the Last Decade, Toxicity, and Exposure Risk in Humans.
    Toxins, 2021, 07-10, Volume: 13, Issue:7

    Topics: Chromatography, High Pressure Liquid; Environmental Exposure; Food Contamination; Humans; Mycotoxins; Ochratoxins; Wine

2021

Other Studies

22 other study(ies) available for 5-chloro-8-hydroxy-3,4-dihydro-3-methylisocoumarin-7-carboxylic acid and ochratoxin a

ArticleYear
Synthesis of 14C-ochratoxin A and 14C-ochratoxin B and a comparative study of their distribution in rats using whole body autoradiography.
    Pharmacology & toxicology, 1992, Volume: 70, Issue:4

    Topics: Animals; Autoradiography; Carbon Radioisotopes; Chromatography, Thin Layer; Ochratoxins; Organ Specificity; Rats; Rats, Inbred Strains; Whole-Body Counting

1992
Effects of two metabolites of ochratoxin A, (4R)-4-hydroxyochratoxin A and ochratoxin alpha, on immune response in mice.
    Infection and immunity, 1983, Volume: 39, Issue:3

    Topics: Animals; Antibody-Producing Cells; Hemolytic Plaque Technique; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Ochratoxins; Structure-Activity Relationship

1983
Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha.
    Archives of toxicology, 1995, Volume: 69, Issue:4

    Topics: Animals; Cells, Cultured; Epithelium; Mutagenicity Tests; Mutagens; Ochratoxins; Sister Chromatid Exchange; Swine; Urinary Bladder

1995
Dietary cholestyramine reduces ochratoxin A-induced nephrotoxicity in the rat by decreasing plasma levels and enhancing fecal excretion of the toxin.
    Journal of toxicology and environmental health. Part A, 1998, Feb-06, Volume: 53, Issue:3

    Topics: Acetylglucosaminidase; Animal Feed; Animals; Anion Exchange Resins; Bile; Bile Acids and Salts; Cholestyramine Resin; Dose-Response Relationship, Drug; Feces; Food Contamination; Glutathione Transferase; Kidney; Kidney Diseases; Male; Mycotoxins; Ochratoxins; Rats; Rats, Sprague-Dawley

1998
Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-alpha in vitro.
    Natural toxins, 1998, Volume: 6, Issue:5

    Topics: Animals; Cells, Cultured; Chick Embryo; Coloring Agents; Isocoumarins; Mycotoxins; Neurons; Neurotoxins; Ochratoxins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles

1998
Kinetic profiles of ochratoxin A and ochratoxin alpha during in vitro incubation in buffered forestomach and abomasal contents from cows.
    Natural toxins, 1998, Volume: 6, Issue:6

    Topics: Abomasum; Animals; Buffers; Cattle; Diet; Female; Gastrointestinal Contents; Half-Life; Mycotoxins; Ochratoxins; Rumen

1998
Effect of feeding regime on the metabolism of ochratoxin A during the in vitro incubation in buffered rumen fluid from cows.
    Archiv fur Tierernahrung, 2001, Volume: 54, Issue:4

    Topics: Animal Feed; Animals; Cattle; Diet; Fistula; Half-Life; In Vitro Techniques; Mycotoxins; Ochratoxins; Poaceae; Rumen

2001
Quantitative determination of mycotoxins in urine by LC-MS/MS.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2010, Volume: 27, Issue:12

    Topics: Adult; Aflatoxin M1; Analytic Sample Preparation Methods; Biomarkers; Carcinogens; Child; Chromatography, High Pressure Liquid; Female; Fumonisins; Glucuronides; Humans; Limit of Detection; Male; Microchemistry; Mycotoxins; Ochratoxins; Pilot Projects; Republic of Korea; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2010
Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of the exposure of inhabitants of Lleida, Spain.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Carcinogens; Environmental Exposure; Environmental Monitoring; Female; Food Contamination; Humans; Male; Middle Aged; Mycotoxins; Ochratoxins; Spain; Young Adult

2011
Urinary ochratoxin A and ochratoxin alpha in pregnant women.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12

    Topics: Adult; Animals; Beverages; Cacao; Chromatography, High Pressure Liquid; Coffee; Creatinine; Diet; Edible Grain; Female; Food Contamination; Food Handling; Food Microbiology; Fruit; Humans; Meat Products; Ochratoxins; Pregnancy; Surveys and Questionnaires; Swine; Vitis; Wine

2012
First synthesis of a stable isotope of Ochratoxin A metabolite for a reliable detoxification monitoring.
    Organic letters, 2013, Aug-02, Volume: 15, Issue:15

    Topics: Food Contamination; Inactivation, Metabolic; Isocoumarins; Mycotoxins; Ochratoxins

2013
Biomonitoring of ochratoxin A in blood plasma and exposure assessment of adult students in Bangladesh.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:11

    Topics: Adolescent; Bangladesh; Body Mass Index; Environmental Monitoring; Female; Food Analysis; Food Contamination; Healthy Volunteers; Humans; Male; Ochratoxins; Reproducibility of Results; Students; Young Adult

2014
Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:12

    Topics: Adult; Aflatoxins; Chromatography, High Pressure Liquid; Chromatography, Liquid; Feeding Behavior; Female; Food Contamination; Food Microbiology; Fumonisins; Germany; Glucuronides; Humans; Male; Mycotoxins; Ochratoxins; Reproducibility of Results; Surveys and Questionnaires; T-2 Toxin; Tandem Mass Spectrometry; Trichothecenes; Young Adult; Zearalenone; Zeranol

2014
Identification and safety evaluation of a product from the biodegradation of ochratoxin A by an Aspergillus strain.
    Journal of the science of food and agriculture, 2017, Volume: 97, Issue:2

    Topics: Agriculture; Aspergillus niger; Biodegradation, Environmental; Decontamination; DNA Damage; Food Contamination; Food Microbiology; Humans; Lipid Peroxidation; Ochratoxins; Solubility; Superoxide Dismutase

2017
High-performance liquid chromatography-tandem mass spectrometry method for simultaneous detection of ochratoxin A and relative metabolites in Aspergillus species and dried vine fruits.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2016, Volume: 33, Issue:8

    Topics: Aspergillus; Chromatography, High Pressure Liquid; Fruit; Ochratoxins; Tandem Mass Spectrometry; Vitis

2016
Ochratoxin A activates neutrophils and kills these cells through necrosis, an effect eliminated through its conversion into ochratoxin α.
    Toxicology, 2016, Aug-10, Volume: 368-369

    Topics: Carcinogens; Cell Survival; Food Contamination; Food Microbiology; Humans; Membrane Potential, Mitochondrial; Necrosis; Neutrophils; Ochratoxins; Teratogens

2016
Ochratoxin A and its metabolites in urines of German adults-An assessment of variables in biomarker analysis.
    Toxicology letters, 2017, Jun-05, Volume: 275

    Topics: Adult; Biomarkers; Cohort Studies; Environmental Monitoring; Environmental Pollutants; Female; Food Contamination; Germany; Humans; Limit of Detection; Male; Ochratoxins; Young Adult

2017
Development and validation of LC-MS/MS method for the determination of Ochratoxin A and its metabolite Ochratoxin α in poultry tissues and eggs.
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 2018, May-04, Volume: 53, Issue:5

    Topics: Animals; Chromatography, Liquid; Eggs; Food Analysis; Food Contamination; Limit of Detection; Ochratoxins; Poultry Products; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry

2018
[Determination of ochratoxin A and ochratoxin alpha in wine by ultra-performance liquid chromatography tandem mass spectrometry].
    Wei sheng yan jiu = Journal of hygiene research, 2019, Volume: 48, Issue:4

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Ochratoxins; Tandem Mass Spectrometry; Wine

2019
Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.
    Toxins, 2021, 04-30, Volume: 13, Issue:5

    Topics: Animals; Blood-Brain Barrier; Brain; Citrinin; Ochratoxins; Swine

2021
Genotoxic effects of the ochratoxin A (OTA), its main metabolite (OTα) per se and in combination with fumonisin B1 in HepG2 cells and human lymphocytes.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2022, Volume: 878

    Topics: Animals; Cytostatic Agents; DNA Damage; Fumonisins; Hep G2 Cells; Humans; Lymphocytes; Ochratoxins

2022
Toolbox for the Extraction and Quantification of Ochratoxin A and Ochratoxin Alpha Applicable for Different Pig and Poultry Matrices.
    Toxins, 2022, 06-24, Volume: 14, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Mycotoxins; Ochratoxins; Poultry; Swine; Tandem Mass Spectrometry

2022