5-carboxy-8-hydroxyquinoline has been researched along with daphnetin* in 1 studies
1 other study(ies) available for 5-carboxy-8-hydroxyquinoline and daphnetin
| Article | Year |
|---|---|
Screening for Active Compounds Targeting Human Natural Killer Cell Activation Identifying Daphnetin as an Enhancer for IFN-γ Production and Direct Cytotoxicity.
Natural killer (NK) cells are a potent weapon against tumor and viral infection. Finding active compounds with the capacity of enhancing NK cell effector functions will be effective to develop new anti-cancer drugs. In this study, we initially screened 287 commercially available active compounds by co-culturing with peripheral blood mononuclear cells (PBMCs). We found that five compounds, namely, Daphnetin, MK-8617, LW6, JIB-04, and IOX1, increased the IFN-γ Topics: Acetanilides; Adamantane; Adolescent; Adult; Aminopyridines; Cytotoxicity, Immunologic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Humans; Hydrazones; Hydroxyquinolines; Interferon-gamma; Interleukin-12; K562 Cells; Killer Cells, Natural; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrimidines; Signal Transduction; TOR Serine-Threonine Kinases; Umbelliferones; Young Adult | 2021 |