5-benzylacyclouridine has been researched along with uracil in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 12 (44.44) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calabresi, P; Darnowski, JW; Goulette, FA; Handschumacher, RE; Wiegand, RA | 1 |
| Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC | 1 |
| Brunetti, I; Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; Ruprecht, RM | 1 |
| Boothman, DA; Briggle, TV; Greer, SB; Perez, LM; Santos, O | 1 |
| Cha, SM | 1 |
| Martin, DS; Sawyer, RC; Stolfi, RL | 1 |
| Cha, S; el Kouni, MH; Iltzsch, MH; Naguib, FN; Niedzwicki, JG | 1 |
| Darnowski, JW; Handschumacher, RE | 2 |
| Cha, S; el Kouni, MH | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Cha, S; el Kouni, MH; Messier, NJ | 1 |
| Lin, TS; Siegel, SA | 1 |
| Calabresi, P; Cha, S; Chu, MY; Chu, SH; el Kouni, MH; Iltzsch, MH; Naguib, FN | 1 |
| Cha, S; Chu, HS; el Kouni, MH; Lee, KH | 1 |
| Ayers, O; Cysyk, RL; Monks, A | 1 |
| Cha, S; Chu, SH; el Kouni, MH; Niedzwicki, JG; Rowe, EC | 1 |
| Anderson, DC; Cretton, EM; el Kouni, MH; Kidd, LB; McClure, HM; Sommadossi, JP | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| el Kouni, MH; Levesque, DL; Naguib, FN; Panzica, RP; Wang, EC | 1 |
| Baccanari, DP; Chandrasurin, P; Davis, ST; Joyner, SS | 1 |
| Adams, ER; Bergman, AM; Holland, SK; Pizzorno, G; Zhao, Y | 1 |
| Calabresi, P; Chen, TM; Chu, E; Chu, MY; Chu, SH; Lipsky, MH; Pan, BC; Yee, LK | 1 |
| Burtness, BA; Calabresi, P; Chu, E; Chu, MY; Chu, SH; Darnowski, JW; Handschumacher, RE; Leffert, JJ; Marsh, JC; Pizzorno, G; Yee, L | 1 |
| Cao, D; Handschumacher, RE; Liu, M; Pizzorno, G; Russell, R | 1 |
| Castronovo, S; Fabbiani, M; Pizzorno, G; Roosild, TP | 1 |
| Castronovo, S; Pizzorno, G; Roosild, TP; Villoso, A; Ziemba, A | 1 |
2 review(s) available for 5-benzylacyclouridine and uracil
| Article | Year |
|---|---|
Development of inhibitors of pyrimidine metabolism.
Topics: Humans; Neoplasms; Pentosyltransferases; Pyrimidines; Structure-Activity Relationship; Thymidine Phosphorylase; Uracil; Uridine Phosphorylase | 1989 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
1 trial(s) available for 5-benzylacyclouridine and uracil
| Article | Year |
|---|---|
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.
Topics: Aged; Aged, 80 and over; Animals; Biological Availability; Dogs; Enzyme Inhibitors; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Swine; Tissue Distribution; Uracil; Uridine Phosphorylase | 1998 |
24 other study(ies) available for 5-benzylacyclouridine and uracil
| Article | Year |
|---|---|
Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine.
Topics: Administration, Oral; Animals; Dipyridamole; Drug Synergism; Female; Injections, Intravenous; Mice; Mice, Inbred Strains; Time Factors; Tissue Distribution; Uracil; Uridine; Uridine Phosphorylase | 1991 |
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbred BALB C; Uracil; Uridine; Zidovudine | 1990 |
Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice.
Topics: Acquired Immunodeficiency Syndrome; Anemia; Animals; Dose-Response Relationship, Drug; Female; Kinetics; Leukemia, Experimental; Leukopenia; Mice; Mice, Inbred BALB C; Rauscher Virus; Uracil; Uridine; Zidovudine | 1990 |
Radiation, pool size and incorporation studies in mice with 5-chloro-2'-deoxycytidine.
Topics: Animals; Aspartic Acid; Combined Modality Therapy; Cytidine Deaminase; Deoxycytidine; DNA, Neoplasm; Drug Therapy, Combination; Mice; Mice, Inbred C3H; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tetrahydrouridine; Uracil; Uridine Phosphorylase | 1990 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disease Models, Animal; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Uracil; Uridine; Uridine Phosphorylase | 1989 |
Uridine phosphorylase from Schistosoma mansoni.
Topics: Animals; Kinetics; Molecular Weight; Pentosyltransferases; Schistosoma mansoni; Structure-Activity Relationship; Uracil; Uridine Phosphorylase | 1988 |
Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Injections, Intravenous; Metabolic Clearance Rate; Mice; Tissue Distribution; Uracil; Uridine; Uridine Phosphorylase | 1988 |
Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors.
Topics: Adenosine; Animals; Biological Transport; Dilazep; Dipyridamole; Kinetics; Nucleosides; Schistosoma mansoni; Structure-Activity Relationship; Thioinosine; Thionucleotides; Uracil | 1987 |
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Topics: Animals; Body Temperature; Brain; Colonic Neoplasms; Cytidine; Cytidine Deaminase; Dose-Response Relationship, Drug; Female; Hypothermia; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Tetrahydrouridine; Thymidine; Uracil; Uridine; Uridine Phosphorylase | 1987 |
Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.
Topics: Adenosine; Animals; Biological Transport; Dilazep; Dipyridamole; Drug Therapy, Combination; Female; Mice; Purine Nucleosides; Ribonucleosides; Schistosoma mansoni; Schistosomiasis; Thioinosine; Thionucleotides; Toyocamycin; Tubercidin; Uracil | 1987 |
Biological activity of two novel inhibitors of uridine phosphorylase.
Topics: Antineoplastic Agents; Pentosyltransferases; Solubility; Structure-Activity Relationship; Uracil; Uridine Phosphorylase | 1985 |
Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Female; Fluorouracil; Lethal Dose 50; Mice; Mice, Inbred C57BL; Uracil; Uridine | 1985 |
Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine.
Topics: Animals; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Drug Synergism; Female; Floxuridine; Humans; Kinetics; Lung Neoplasms; Mice; Mice, Inbred Strains; Pancreatic Neoplasms; Pentosyltransferases; Uracil; Uridine Phosphorylase | 1984 |
Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Erythrocytes; Kinetics; Leukemia L5178; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Pentosyltransferases; Uracil; Uridine; Uridine Phosphorylase | 1984 |
Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver.
Topics: Animals; Kinetics; Liver; Pentosyltransferases; Perfusion; Rats; Rats, Inbred Strains; Uracil; Uridine; Uridine Phosphorylase | 1983 |
5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cytosol; In Vitro Techniques; Liver; Male; Mice; Neoplasms, Experimental; Pentosyltransferases; Structure-Activity Relationship; Uracil; Uridine Phosphorylase | 1982 |
Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Macaca mulatta; Uracil; Uridine; Uridine Phosphorylase | 1995 |
5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase.
Topics: Animals; Barbiturates; Humans; Liver; Mice; Uracil; Uridine; Uridine Phosphorylase | 1993 |
Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine.
Topics: Animals; Female; Half-Life; Kinetics; Liver; Macaca fascicularis; Male; Mice; Rats; Species Specificity; Tissue Extracts; Uracil; Uridine; Uridine Phosphorylase | 1993 |
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Uracil; Uridine Phosphorylase | 1997 |
Benzylacyclouridine enhances 5-fluorouracil cytotoxicity against human prostate cancer cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorouracil; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured; Uracil; Uridine Phosphorylase | 1998 |
Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Cloning, Molecular; DNA, Complementary; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Kinetics; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasms; Rabbits; Sequence Homology, Amino Acid; Uracil; Uridine; Uridine Phosphorylase | 1998 |
Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.
Topics: Bacterial Proteins; Catalytic Domain; Crystallization; Dimerization; Drug Design; Enzyme Inhibitors; Escherichia coli; Humans; Protein Binding; Protein Conformation; Recombinant Proteins; Structural Homology, Protein; Uracil; Uridine Phosphorylase | 2009 |
A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Crystallography, X-Ray; Cystine; Enzyme Assays; Humans; Hydrogen Bonding; Mice; Models, Molecular; Oxidation-Reduction; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Uracil; Uridine Phosphorylase | 2011 |