Page last updated: 2024-08-22

5-azacytosine and cytosine

5-azacytosine has been researched along with cytosine in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199010 (27.03)18.7374
1990's4 (10.81)18.2507
2000's12 (32.43)29.6817
2010's11 (29.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Friedman, S; Huang, YC1
Friedman, S; Som, S; Yang, LF1
Cihák, A; Cízková, J; Korbová, L; Kucerová, V; Pískala, A1
Fujii, N; Oguma, K1
Frahm, J; Hoshino, J; Kröger, H1
Jones, PA; Michalowsky, LA1
Acs, G; Christman, JK; Schneiderman, N2
Friedman, S1
Jehn, U; Knüppel, W; Wilmanns, W1
Kaczmarek, L; Surmacz, E1
Faraggi, M; Riesz, P; Rosenthal, I1
Friedman, S; Som, S1
Bhagwat, AS; Gabbara, S; Sheluho, D1
Cheng, YC; Dutschman, GE; Gullen, EA; Lin, TS; Liu, MC; Luo, MZ; Mozdziesz, DE; Sartorelli, AC1
Forood, B; Hebert, N; Katritzky, AR; Rogovoy, BV; Vvedensky, VY1
Brank, AS; Christman, JK; Eritja, R; Güimil García, R; Marquez, VE1
Pakneshan, P; Rabbani, SA; Xing, RH1
Cappellacci, L; Montgomery, JA; Secrist, JA; Tiwari, KN1
Hoffman, AR; Hu, JF; Li, T; Sun, Z; Ulaner, GA; Vu, TH; Yang, Y; Yao, X1
Colleoni, S; Donofrio, G; Duchi, R; Galli, C; Lagutina, I; Lazzari, G1
Bailey, KA; Baylin, S; Carraway, H; Fandy, TE; Gore, SD; Herman, JG; Jiemjit, A1
Dracínský, M; Holý, A; Krecmerová, M1
Andrei, G; De Clercq, E; Holý, A; Krecmerová, M; Naesens, L; Neyts, J; Snoeck, R; Votruba, I1
Brank, AS; Christman, JK; Eritja, R; Marquez, VE; van Bemmel, DM1
Huang, X; Wang, X; Yin, J; Zhong, J1
Harada, Y; Ichimura, T; Kobayashi, T; Kuramochi, H; Suzuki, T1
Holý, A; Krecmerová, M; Masojídková, M1
Craddock, C1
Gutierrez, JA; Hemeon, I; Ho, MC; Schramm, VL1
Bhatnagar, D; Ehrlich, KC; Kale, SP; Wilkinson, JR; Yu, J1
Krečmerová, M; Otmar, M1
Bai, C; Geng, J; Li, B; Li, S; Liu, J; Ma, L; Song, Q; Wang, H; Wang, L1
Andrei, G; Coen, N; Duraffour, S; Krecmerová, M; Naesens, L; Snoeck, R; Van den Oord, J1
Ali, ST; Geffertová, D; Havlas, Z; Holý, A; Kašička, V; Krečmerová, M; Šolínová, V1
Carlos Borin, A; González, L; Mai, S; Marquetand, P1
Deng, P; Jiang, JH1

Reviews

2 review(s) available for 5-azacytosine and cytosine

ArticleYear
[Effect of 5-methylcytosine in DNA and 5-azacytosine on the expression of various genes in vertebrates].
    Postepy biochemii, 1985, Volume: 31, Issue:1

    Topics: 5-Methylcytosine; Animals; Chickens; Cytosine; Gene Expression Regulation; Genes, Regulator; Humans; In Vitro Techniques; Methylation; Methyltransferases; Mice; Oncogenes

1985
5-azacytosine compounds in medicinal chemistry: current stage and future perspectives.
    Future medicinal chemistry, 2012, Volume: 4, Issue:8

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Azacitidine; Cytosine; DNA Methylation; Drug Discovery; HIV; HIV Infections; Humans; Neoplasms

2012

Trials

1 trial(s) available for 5-azacytosine and cytosine

ArticleYear
Intensive maintenance treatment in acute myelogenous leukemia (AML): single institution experience of a multicenter randomized trial.
    Onkologie, 1988, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Cytosine; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leukemia, Myeloid, Acute; Middle Aged; Random Allocation; Vincristine

1988

Other Studies

34 other study(ies) available for 5-azacytosine and cytosine

ArticleYear
Inhibition of recA-mediated strand exchange by adducts of azacytosine-containing DNA and the EcoRII methylase.
    The Journal of biological chemistry, 1991, Sep-15, Volume: 266, Issue:26

    Topics: Cytosine; DNA; DNA-Cytosine Methylases; Guanidine; Guanidines; Kinetics; Rec A Recombinases; Recombination, Genetic

1991
The core element of the EcoRII methylase as defined by protease digestion and deletion analysis.
    Nucleic acids research, 1991, Oct-11, Volume: 19, Issue:19

    Topics: Amino Acid Sequence; Base Sequence; Chromosome Deletion; Cytosine; DNA Mutational Analysis; DNA-Cytosine Methylases; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Escherichia coli; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutation; Protein Conformation; Restriction Mapping; S-Adenosylmethionine

1991
Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives.
    Experientia, 1986, Jan-15, Volume: 42, Issue:1

    Topics: Animals; Azacitidine; Cytosine; Gastric Acid; Gastric Juice; Gastric Mucosa; Male; Pancreatitis; Rats; Rats, Inbred Strains; Stomach Ulcer

1986
Induction of oligo-2',5'-adenylate synthetase in human lymphoid cells treated with 5-azacytosine and 5-iododeoxyuridine.
    The Journal of general virology, 1986, Volume: 67 ( Pt 11)

    Topics: 2',5'-Oligoadenylate Synthetase; Azacitidine; B-Lymphocytes; Cell Line; Cell Transformation, Viral; Cytosine; Enzyme Induction; Herpesvirus 4, Human; Humans; Idoxuridine; Interferon Type I

1986
Suppression of nuclear ADP-ribosyltransferase activity in Ehrlich ascites tumor cells by 5-azacytidine and its analogs.
    Biochemical and biophysical research communications, 1987, Jan-30, Volume: 142, Issue:2

    Topics: Animals; Azacitidine; Carcinoma, Ehrlich Tumor; Cell Nucleus; Cytosine; DNA; Female; Hydroxyurea; Methylation; Mice; Mice, Inbred Strains; Poly(ADP-ribose) Polymerase Inhibitors

1987
Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.
    Molecular and cellular biology, 1987, Volume: 7, Issue:9

    Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cell Nucleus; Cytarabine; Cytosine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Drug Resistance; Methylation; Mice

1987
Formation of highly stable complexes between 5-azacytosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression.
    The Journal of biological chemistry, 1985, Apr-10, Volume: 260, Issue:7

    Topics: Animals; Chromosomal Proteins, Non-Histone; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Endonucleases; Gene Expression Regulation; Sarcosine; Single-Strand Specific DNA and RNA Endonucleases; Sodium Chloride

1985
The irreversible binding of azacytosine-containing DNA fragments to bacterial DNA(cytosine-5)methyltransferases.
    The Journal of biological chemistry, 1985, May-10, Volume: 260, Issue:9

    Topics: Cytosine; Deoxyribonuclease HpaII; DNA Restriction Enzymes; DNA-Cytosine Methylases; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Methyltransferases; Molecular Weight; Potassium Chloride; Pronase; S-Adenosylmethionine

1985
Interaction of DNA methyltransferase and other non-histone proteins isolated from Friend erythroleukemia cell nuclei with 5-azacytosine residues in DNA.
    Progress in clinical and biological research, 1985, Volume: 198

    Topics: Animals; Cell Line; Cell Nucleus; Chromosomal Proteins, Non-Histone; Cytosine; Deoxyribonucleoproteins; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Histones; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Molecular Weight; Protein Binding

1985
Pulse radiolysis studies of some aza analogues of nucleic acid components.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 44, Issue:5

    Topics: Aza Compounds; Azacitidine; Azauridine; Cytosine; Pulse Radiolysis; Thymine; Uracil

1983
Inhibition of transcription in vitro by binding of DNA (cytosine-5)-methylases to DNA templates containing cytosine analogs.
    The Journal of biological chemistry, 1994, Oct-21, Volume: 269, Issue:42

    Topics: Base Sequence; Cytosine; DNA; DNA-Cytosine Methylases; Exodeoxyribonucleases; Flucytosine; Molecular Sequence Data; RNA; Transcription, Genetic

1994
Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially active.
    Biochemistry, 1995, Jul-11, Volume: 34, Issue:27

    Topics: Base Sequence; Binding Sites; Catalysis; Cysteine; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA, Recombinant; Escherichia coli; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Serine

1995
Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.
    Bioorganic & medicinal chemistry letters, 2000, Sep-18, Volume: 10, Issue:18

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Division; Cytosine; Dioxolanes; Hepatitis B virus; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV-1; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Nucleosides; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured

2000
Synthesis of substituted 4(6)-amino-1,3,5-triazin-2-ones and -1,3,5-triazin-2-thiones.
    The Journal of organic chemistry, 2001, Oct-05, Volume: 66, Issue:20

    Topics: Antineoplastic Agents; Cytosine; Thiones; Triazines

2001
Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites.
    Antisense & nucleic acid drug development, 2001, Volume: 11, Issue:6

    Topics: Base Sequence; Cytosine; DNA (Cytosine-5-)-Methyltransferases; Indicators and Reagents; Oligodeoxyribonucleotides, Antisense

2001
Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:9

    Topics: Animals; Base Sequence; Blotting, Southern; Cell Division; Cytosine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Invasiveness; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; RNA, Messenger; Sequence Analysis, DNA; Sulfites; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator

2003
Synthesis and anti-cancer activity of some novel 5-azacytosine nucleosides.
    Nucleosides, nucleotides & nucleic acids, 2003, Volume: 22, Issue:12

    Topics: Antineoplastic Agents; Azacitidine; Carbohydrate Conformation; Cell Line, Tumor; Cell Survival; Cytidine; Cytosine; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pentoses; Pyrimidine Nucleosides; Sulfur Compounds

2003
Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.
    Cancer genetics and cytogenetics, 2004, Volume: 151, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Base Sequence; Cell Line, Tumor; Cytosine; DNA Methylation; DNA Primers; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Neoplasm Proteins; Paclitaxel; Promoter Regions, Genetic; RNA, Messenger

2004
Establishment, differentiation, electroporation, viral transduction, and nuclear transfer of bovine and porcine mesenchymal stem cells.
    Cloning and stem cells, 2005, Volume: 7, Issue:3

    Topics: Animals; Blastocyst; Cattle; Cell Differentiation; Cell Division; Cell Lineage; Cell Nucleus; Cells, Cultured; Cloning, Organism; Cytosine; Electroporation; Mesenchymal Stem Cells; Nuclear Transfer Techniques; Osteogenesis; Swine; Transduction, Genetic

2005
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.
    Oncogene, 2008, Jun-05, Volume: 27, Issue:25

    Topics: Caffeine; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cytosine; DNA Damage; DNA Repair; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Humans; Leukemia; Models, Biological; Models, Genetic; Transcriptional Activation

2008
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Antiviral Agents; Cytosine; Drug Stability; Guanidines; Hydrolysis; Magnetic Resonance Spectroscopy; Nucleosides; Organophosphonates

2008
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
    Biochemical pharmacology, 2008, Oct-15, Volume: 76, Issue:8

    Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytosine; DNA Replication; DNA Viruses; DNA, Neoplasm; Drug Stability; Female; Herpesvirus 1, Human; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred Strains; Organophosphonates

2008
DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site.
    Biochemical pharmacology, 2009, Sep-15, Volume: 78, Issue:6

    Topics: Binding Sites; Cytidine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Conformation; Structure-Activity Relationship

2009
DNA methyltransferase inhibitors increase baculovirus-mediated gene expression in mammalian cells when applied before infection.
    Analytical biochemistry, 2010, Jan-15, Volume: 396, Issue:2

    Topics: Animals; Azacitidine; Baculoviridae; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Gene Expression Regulation; Genetic Vectors; Humans

2010
Intersystem crossing to excited triplet state of aza analogues of nucleic acid bases in acetonitrile.
    The journal of physical chemistry. A, 2009, Nov-05, Volume: 113, Issue:44

    Topics: Absorption; Acetonitriles; Adenine; Aza Compounds; Azaguanine; Cytosine; Nucleic Acids; Quantum Theory; Singlet Oxygen; Solvents; Spectrum Analysis; Uracil

2009
Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cytosine; Humans; Nucleosides; Organophosphonates; Vero Cells; Virus Diseases; Viruses

2010
Epigenetic manipulation of the immune response: a novel treatment strategy in hematologic malignancies.
    Cytotherapy, 2011, Volume: 13, Issue:5

    Topics: Antigens, Neoplasm; Chromatin; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Hematologic Neoplasms; Histone Deacetylase Inhibitors; Humans; Immunity, Cellular; Leukemia, Myeloid, Acute; Methyltransferases; Myelodysplastic Syndromes; Neoplasm Proteins; Promoter Regions, Genetic

2011
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
    Analytical chemistry, 2011, Jun-15, Volume: 83, Issue:12

    Topics: Azacitidine; Bacteria; Cytosine; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Assays; Humans; Kinetics; Light; Luciferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

2011
Expression profiling of non-aflatoxigenic Aspergillus parasiticus mutants obtained by 5-azacytosine treatment or serial mycelial transfer.
    Toxins, 2011, Volume: 3, Issue:8

    Topics: Aflatoxins; Aspergillus; Cloning, Molecular; Cytosine; Down-Regulation; Expressed Sequence Tags; Gene Expression Profiling; Gene Expression Regulation, Fungal; Multigene Family; Oligonucleotide Array Sequence Analysis; Phenotype; Transcription, Genetic

2011
Preparation and adsorption performance of 5-azacytosine-functionalized hydrothermal carbon for selective solid-phase extraction of uranium.
    Journal of colloid and interface science, 2012, Nov-15, Volume: 386, Issue:1

    Topics: Adsorption; Carbon; Cytosine; Hot Temperature; Microspheres; Molecular Structure; Solid Phase Extraction; Uranium

2012
Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells.
    Journal of virology, 2013, Volume: 87, Issue:22

    Topics: Animals; Antiviral Agents; Apoptosis; Blotting, Western; Cells, Cultured; Cidofovir; Cyclic AMP; Cytosine; Gammaherpesvirinae; Herpesviridae Infections; Humans; Kidney; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; NIH 3T3 Cells; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tumor Virus Infections; Virus Activation; Virus Replication

2013
Investigation of the acid-base and electromigration properties of 5-azacytosine derivatives using capillary electrophoresis and density functional theory calculations.
    Journal of chromatography. A, 2017, Jan-06, Volume: 1479

    Topics: Acids; Cytosine; Electrolytes; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Osmolar Concentration; Quantum Theory; Thermodynamics

2017
Ab initio molecular dynamics relaxation and intersystem crossing mechanisms of 5-azacytosine.
    Physical chemistry chemical physics : PCCP, 2017, Feb-22, Volume: 19, Issue:8

    Topics: Cytosine; Electronics; Molecular Dynamics Simulation

2017
Discovery of New Inhibitors of Transforming Growth Factor-Beta Type 1 Receptor by Utilizing Docking and Structure-Activity Relationship Analysis.
    International journal of molecular sciences, 2019, Aug-21, Volume: 20, Issue:17

    Topics: Cytosine; Fluorouracil; Humans; Mercaptopurine; Molecular Docking Simulation; Receptor, Transforming Growth Factor-beta Type I; Structure-Activity Relationship

2019