Compounds > 5-alpha-dihydroprogesterone
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5-alpha-dihydroprogesterone and 20-alpha-dihydroprogesterone

5-alpha-dihydroprogesterone has been researched along with 20-alpha-dihydroprogesterone in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kollman, PA; Lee, DL; Marsh, FJ; Wolff, ME1
Barfield, RJ; Etgen, AM; Glaser, JH1
Weiler, PJ; Wiebe, JP1
Pawlak, KJ; Wiebe, JP; Zhang, G1
Beausoleil, M; Cialacu, V; Wiebe, JP; Zhang, G1
Blair, IA; Byrns, MC; Duan, L; Lee, SH; Penning, TM1
Frye, CA; Llaneza, DC; Paris, JJ; Walf, AA1
Cadieux-Pitre, HA; Welch, I; Wiebe, JP; Zhang, G1
Balthazart, J; Cornil, CA; de Bournonville, MP; Keller, M; Liere, P; Pianos, A; Schumacher, M1

Other Studies

9 other study(ies) available for 5-alpha-dihydroprogesterone and 20-alpha-dihydroprogesterone

ArticleYear
Quantitative relationships between steroid structure and binding to putative progesterone receptors.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:9

    Topics: Androstenes; Animals; Guinea Pigs; Humans; Hydroxyprogesterones; Protein Binding; Rabbits; Receptors, Progesterone; Sheep; Steroids; Structure-Activity Relationship

1977
Intrahypothalamic effects of progestin agonists on estrous behavior and progestin receptor binding.
    Physiology & behavior, 1985, Volume: 34, Issue:6

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Animals; Brain Mapping; Desoxycorticosterone; Estrus; Female; Hypothalamus, Middle; Pregnanediones; Progesterone; Rats; Receptors, Progesterone

1985
Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells.
    Biochemical and biophysical research communications, 2000, Jun-16, Volume: 272, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Binding Sites; Breast Neoplasms; Cell Fractionation; Cell Membrane; Cell Nucleus; Cytosol; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pregnanediones; Progesterone; Receptors, Cell Surface; Substrate Specificity; Thermodynamics; Tumor Cells, Cultured

2000
Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 97, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Fractionation; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cycloheximide; Dactinomycin; Down-Regulation; Estradiol; Female; Humans; Progesterone; Receptors, Estradiol; Receptors, Progesterone; Up-Regulation

2005
Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 118, Issue:1-2

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; Mitosis; Progesterone; Proto-Oncogene Proteins c-bcl-2

2010
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.
    The Journal of steroid biochemistry and molecular biology, 2010, Feb-15, Volume: 118, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Aldo-Keto Reductase Family 1 Member C3; Androstenedione; Androsterone; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dinoprost; Estradiol; Estrone; Etiocholanolone; Female; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Hydroxyprostaglandin Dehydrogenases; Ketosteroids; Kinetics; Progesterone; Prostaglandin D2; Prostaglandins; Recombinant Proteins; Testosterone; Transfection; Up-Regulation

2010
I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female rats.
    Brain research, 2011, Mar-16, Volume: 1379

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Age Factors; Animals; Female; Male; Mesencephalon; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior

2011
Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.
    Breast cancer research : BCR, 2013, May-11, Volume: 15, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice, Inbred NOD; Mice, SCID; Receptors, Estrogen; Receptors, Progesterone; Tissue Distribution; Tumor Burden; Xenograft Model Antitumor Assays

2013
Steroid profiles in quail brain and serum: Sex and regional differences and effects of castration with steroid replacement.
    Journal of neuroendocrinology, 2019, Volume: 31, Issue:2

    Topics: 20-alpha-Dihydroprogesterone; 5-alpha-Dihydroprogesterone; Animals; Brain; Castration; Corticosterone; Estrogens; Female; Hypothalamus; Male; Pregnenolone; Preoptic Area; Quail; Sex Characteristics; Steroids; Testosterone

2019