5,7-dichlorokynurenic acid has been researched along with glycine in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (68.75) | 18.2507 |
| 2000's | 17 (26.56) | 29.6817 |
| 2010's | 3 (4.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ae, N; Antoku, F; Kato, T; Kodo, T; Nagata, R; Nishimura, T; Tanaka, Y; Tanno, N; Tatsuno, T; Yamaguchi, H | 1 |
| Iversen, LL; Leeson, PD | 1 |
| Floersheim, P; Koller, M; Roy, BL; Urwyler, S | 1 |
| Blanchard, JC; Canton, T; Doble, A; Jimonet, P; Miquet, JM | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Baron, BM; Harrison, BL; Hurt, SD; Palfreyman, MG; Siegel, BW; Slone, AL | 1 |
| Baron, BM; Hurt, SD | 1 |
| Calligaro, DO; Dingledine, R; McNamara, D; McQuaid, LA; O'Malley, PJ; Smith, EC | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Anegawa, NJ; Lynch, DR; Pritchett, DB; Verdoorn, T | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Guastella, J; Huettner, JE; Keana, JF; Weber, E; Woodward, RM | 1 |
| Lukasiewicz, PD; Roeder, RC | 1 |
| McNamara, M; Nowak, G; Paul, IA; Redmond, A | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Ary, T; Faull, RL; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Ary, T; Faull, RL; Gan, XD; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P; Trullas, R | 1 |
| Corbett, R; Dunn, RW | 1 |
| Layer, RT; Nowak, G; Paul, IA; Popik, P; Skolnick, P | 1 |
| Challiss, RA; Nahorski, SR; Simpson, PB | 1 |
| Nowak, G; Paul, IA; Popik, P; Skolnick, P; Young, A | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Cappendijk, SL; de Vries, R; Dzoljic, MR | 1 |
| Han, D; Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Layer, RT; Olds, T; Popik, P; Skolnick, P | 1 |
| Cai, SX; Egbuwoku, ZO; Hawkinson, JE; Huang, JC; Keana, JF; Lü, Y; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Gunasekar, PG; Kanthasamy, AG; Matsumoto, RR; Trunong, DD | 1 |
| Franklin, PH; Ishmael, JE; Leid, M; Murray, TF | 1 |
| Baron, BM; Gross, RS; Harrison, BL; Hawes, C; Siegel, BW; Towers, P | 1 |
| Erdõ, SL; Molnár, P | 1 |
| Gondo, M; Goodman, JC; Robertson, CS; Simpson, RK | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Ilyin, V; Keana, JF; Kher, SM; Tran, M; Weber, E; Woodward, RM; Zhou, ZL | 1 |
| Han, Y; Slaughter, MM; Zhang, J | 1 |
| Matoba, M; Nishikawa, T; Tomita, U | 1 |
| Leslie, SW; Randall, PK; Robichon, R | 1 |
| Fontana, G; Raiteri, M; Valenti, L | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Han, Y; Slaughter, MM | 1 |
| Faull, RL; Layer, RT; Leiner, KA; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Reynolds, IJ; Sharma, TA | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| VanDongen, AM; VanDongen, HM; Wood, MW | 1 |
| Harkin, A; Nowak, G; Paul, IA | 1 |
| Li, Y; Nowak, G; Paul, IA | 1 |
| Nowak, G; Popik, P; Wróbel, M | 1 |
| Dannhardt, G; Kohl, BK; Parsons, CG; von Gruchalla, M | 1 |
| Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Mirshahi, T; Ronald, KM; Woodward, JJ | 1 |
| Blantz, RC; Deng, A; Munger, KA; Thomson, SC; Valdivielso, JM | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Keana, JF; Kher, SM; Tran, M; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Furukawa, H; Gouaux, E | 1 |
| Han, Y; Li, P; Slaughter, MM | 1 |
| Johnson, MS; Moretti, L; Pentikäinen, OT; Settimo, L | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y | 1 |
| Chen, PE; Erreger, K; Geballe, MT; Katz, E; Le, P; Lee, CJ; Livesey, MR; O'Toole, KK; Snyder, JP; Traynelis, SF; Wyllie, DJ | 1 |
| Cousins, SL; Kenny, AV; Pinho, L; Stephenson, FA | 1 |
| Kussius, CL; Popescu, GK | 1 |
| Borker, P; Prodromou, ML; Salussolia, CL; Wollmuth, LP | 1 |
| Milanese, M; Oliveri, M; Raiteri, L; Romei, C; Usai, C | 1 |
| Acton, D; Miles, GB | 1 |
1 review(s) available for 5,7-dichlorokynurenic acid and glycine
| Article | Year |
|---|---|
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Binding Sites; Cognition; Glycine; Humans; Kynurenic Acid; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
63 other study(ies) available for 5,7-dichlorokynurenic acid and glycine
| Article | Year |
|---|---|
Tricyclic quinoxalinediones: 5,6-dihydro-1H-pyrrolo[1,2,3-de] quinoxaline-2,3-diones and 6,7-dihydro-1H,5H-pyrido[1,2,3-de] quinoxaline-2,3-diones as potent antagonists for the glycine binding site of the NMDA receptor.
Topics: Animals; Binding Sites; Glycine; Mice; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1994 |
Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.
Topics: Alanine; Animals; Binding Sites; Cerebral Cortex; Drug Design; Drug Partial Agonism; Glycine; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Models, Molecular; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 2009 |
A rapid filtration assay for the glycine binding site on the NMDA receptor in rat cortical membranes using [3H]dichlorokynurenic acid.
Topics: Animals; Binding Sites; Cerebral Cortex; Filtration; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
[3H]5,7-dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Glycine; In Vitro Techniques; Kynurenic Acid; Ligands; Male; Polyamines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine; Synaptosomes | 1991 |
[3H] 5,7-dichlorokynurenic acid, a high affinity ligand for the NMDA receptor glycine regulatory site.
Topics: Animals; Glycine; Kynurenic Acid; Ligands; Molecular Structure; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.
Topics: Animals; Binding, Competitive; Brain; Evoked Potentials; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Xenopus | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents.
Topics: Binding Sites; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Kynurenic Acid; Receptors, N-Methyl-D-Aspartate; Transfection | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.
Topics: Animals; Binding Sites; Brain; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Electrophysiology; Female; Glycine; Kynurenic Acid; Neurons; Oocytes; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1995 |
Evidence for glycine modulation of excitatory synaptic inputs to retinal ganglion cells.
Topics: Ambystoma; Animals; Biological Transport; Dendrites; Dose-Response Relationship, Drug; Evoked Potentials; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Light; Patch-Clamp Techniques; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Serine; Stereoisomerism; Synapses; Synaptic Transmission; Time Factors | 1995 |
Swim stress increases the potency of glycine at the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding, Competitive; Frontal Lobe; Glycine; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Swimming | 1995 |
Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Electroshock; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Interaction of felbamate with [3H]DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain.
Topics: Adult; Aged; Anticonvulsants; Autopsy; Autoradiography; Binding, Competitive; Brain; Felbamate; Female; Glycine; Hippocampus; Humans; Kinetics; Kynurenic Acid; Male; Mesencephalon; Middle Aged; Neurons; Organ Specificity; Phenylcarbamates; Propylene Glycols; Radioligand Assay; Receptors, Glycine; Strychnine; Tritium | 1994 |
Felbamate: interaction with glycine receptors in human cerebral cortex.
Topics: Adult; Aged; Anticonvulsants; Autoradiography; Cerebral Cortex; Felbamate; Glycine; Humans; Kynurenic Acid; Male; Middle Aged; Phenylcarbamates; Propylene Glycols; Receptors, Glycine; Strychnine | 1994 |
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Brain; Dizocilpine Maleate; Drug Administration Schedule; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1993 |
Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Discrimination Learning; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Social Behavior | 1993 |
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, Drug; Electroshock; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Strychnine; Time Factors; Tritium | 1994 |
Potentiation of N-methyl-D-aspartate-evoked elevation of intracellular Ca2+ concentrations by exogenous glycine in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channel Agonists; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Glycine; Kynurenic Acid; Nicotinic Acids; Oxadiazoles; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex.
Topics: Animals; Antidepressive Agents; Binding Sites; Calcium Channel Blockers; Cerebral Cortex; Depression; Diltiazem; Glycine; Kynurenic Acid; Male; Mice; Nimodipine; Receptors, N-Methyl-D-Aspartate | 1993 |
Differential profiles of binding of a radiolabeled agonist and antagonist at a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1994 |
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Dependence; Naloxone; Quinoxalines; Receptors, Amino Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance Withdrawal Syndrome | 1993 |
Support for radiolabeling of a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex by 5,7-[3H]dichlorokynurenate in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substrate Specificity; Synaptic Membranes; Tritium | 1993 |
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715).
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Polyamines; Brain Chemistry; Down-Regulation; Excitatory Amino Acid Antagonists; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Glycine | 1995 |
Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.
Topics: Animals; Brain; Cell Membrane; Cerebral Cortex; Cloning, Molecular; Excitatory Amino Acid Antagonists; Female; Glycine; Kinetics; Kynurenic Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Oocytes; Oximes; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1996 |
Excitoprotective effect of felbamate in cultured cortical neurons.
Topics: Animals; Anticonvulsants; Binding Sites; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
High level expression of the NMDAR1 glutamate receptor subunit in electroporated COS cells.
Topics: Animals; beta-Galactosidase; Binding, Competitive; Calcium; Cell Line; Chlorocebus aethiops; COS Cells; Electroporation; Excitatory Amino Acid Antagonists; Glycine; Humans; Kidney; Kinetics; Kynurenic Acid; Macromolecular Substances; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Stereoisomerism; Transfection | 1996 |
[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site.
Topics: Animals; Binding Sites; Glycine; Hydrogen-Ion Concentration; Indoles; Kynurenic Acid; Ligands; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds.
Topics: Animals; Cerebrospinal Fluid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Injections, Spinal; Kynurenic Acid; Male; Mechanoreceptors; Neuralgia; Nociceptors; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine; Transcutaneous Electric Nerve Stimulation | 1996 |
Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Oocytes; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1997 |
Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
Topics: Alanine; Ambystoma; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Kynurenic Acid; Receptors, Glycine; Retinal Ganglion Cells; Serine; Strychnine; Synaptic Transmission; Taurine | 1997 |
Characterization of 5,7-dichlorokynurenate-insensitive D-[3H]serine binding to synaptosomal fraction isolated from rat brain tissues.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cations; Cerebellum; Cerebral Cortex; Detergents; Excitatory Amino Acid Antagonists; Glycine; Kidney; Kynurenic Acid; Liver; Male; Octoxynol; Rats; Rats, Wistar; Serine; Subcellular Fractions; Synaptosomes; Tritium | 1997 |
A partial agonist model used in the allosteric modulation of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Models, Biological; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.
Topics: Animals; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; HIV-1; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Protein kinases modulate two glycine currents in salamander retinal ganglion cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Ambystoma; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Isoquinolines; Kinetics; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Retinal Ganglion Cells; Strychnine; Sulfonamides | 1998 |
Felbamate increases [3H]glycine binding in rat brain and sections of human postmortem brain.
Topics: Animals; Anticonvulsants; Autoradiography; Brain Chemistry; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Humans; Kynurenic Acid; Male; Phenylcarbamates; Postmortem Changes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site.
Topics: Aminoquinolines; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Indoles; Kynurenic Acid; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1998 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Topics: Animals; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Mice; Mutation; Oocytes; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1999 |
Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents, Tricyclic; Benzylamines; Cerebral Cortex; Desipramine; Fluoxetine; Glycine; Kynurenic Acid; Male; Mice; Norepinephrine; Receptors, N-Methyl-D-Aspartate | 2000 |
Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Behavior, Animal; Binding Sites; Cerebral Cortex; Glycine; Hippocampus; Kynurenic Acid; Male; Mice; Psychomotor Performance; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium | 2000 |
Chronic treatment with antidepressants affects glycine/NMDA receptor function: behavioral evidence.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Mice; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2000 |
A novel series of 2-carboxytetrahydroquinolines provides new insights into the eastern region of glycine site NMDA antagonists.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Patch-Clamp Techniques; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Urea | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Motor Activity; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2001 |
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2001 |
Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; DNA, Complementary; Glomerular Filtration Rate; Glycine; Hemodynamics; Immunohistochemistry; Kidney Cortex; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2003 |
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Disulfides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Binding; Protein Conformation; Protein Subunits; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sequence Alignment; Serine | 2003 |
Selective antagonism of rat inhibitory glycine receptor subunits.
Topics: Animals; Arginine; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Humans; Kynurenic Acid; Mutation; Osmolar Concentration; Rats; Receptors, Glycine; Strychnine | 2004 |
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cycloserine; Databases as Topic; Escherichia coli; Excitatory Amino Acid Antagonists; Glycine; Humans; Hydrogen Bonding; Indoles; Kynurenic Acid; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Potassium Channels; Proline; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Serine; Threonine; Tryptophan; Water | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
Topics: Amino Acid Sequence; Animals; Chimera; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; Xenopus laevis | 2008 |
The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
Topics: Amino Acid Motifs; Binding Sites; Cell Line; Cell Membrane; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glycine; Humans; Kynurenic Acid; Point Mutation; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Protein Transport; Receptors, N-Methyl-D-Aspartate | 2009 |
Kinetic basis of partial agonism at NMDA receptors.
Topics: Action Potentials; Alanine; Amino Acids, Cyclic; Animals; Binding Sites; Cell Line; Cell Membrane; Cycloserine; Excitatory Amino Acid Agents; Glutamates; Glutamic Acid; Glycine; Humans; Kinetics; Kynurenic Acid; Models, Molecular; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Arrangement of subunits in functional NMDA receptors.
Topics: 4-Aminopyridine; Amino Acid Motifs; Analysis of Variance; Animals; Cell Line, Transformed; Copper Sulfate; Cysteine; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Membrane Potentials; Microinjections; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Protein Subunits; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Statistics, Nonparametric; Transfection; Xenopus | 2011 |
A new function for glycine GlyT2 transporters: Stimulation of γ-aminobutyric acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca(2+)-dependent anion channels.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Kynurenic Acid; Male; Mice; Nerve Tissue Proteins; Nipecotic Acids; Synaptosomes; Tritium | 2014 |
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Efferent Pathways; Glycine; Interneurons; Kynurenic Acid; Mice; Mice, Inbred C57BL; Motor Activity; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Spinal Nerve Roots; Synapses | 2017 |