5-6-dihydroxy-8-aminoquinoline and daphnetin

To investigate the anti-hemolytic and anti-membranous lipid peroxidation effects of daphnetin.. The inhibition rates of daphnetin on AQD-induced hemolysis and erythrocytic membranous lipid peroxidation were determined by routine in vitro assay for detecting hemolytic toxicity and by HPLC for detecting membranous lipid peroxidation products.. Daphnetin at a range of 10-80 mumol/L inhibited dose-dependently AQD-induced hemolysis and lipid peroxidation by 33.0%-69.2% and 11.9%-58.2%, respectively.. Daphnetin has anti-hemolytic and anti-erythrocytic membranous lipid peroxidation effects.

Topics: Aminoquinolines; Animals; Antioxidants; Dose-Response Relationship, Drug; Erythrocyte Membrane; Hemolysis; In Vitro Techniques; Lipid Peroxidation; Rabbits; Umbelliferones