Page last updated: 2024-08-26

5,6-dihydrouridine and uridine

5,6-dihydrouridine has been researched along with uridine in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199010 (28.57)18.7374
1990's11 (31.43)18.2507
2000's8 (22.86)29.6817
2010's6 (17.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amano, M; Kawakami, M1
Gornicki, P; Podkowinski, J1
Okimoto, R; Wolstenholme, DR1
McClure, TD; Nakano, K; Nakao, T; Reimer, ML; Schram, KH; Yamamoto, H; Yasaka, T1
Chaix, C; Duplaa, AM; Gasparutto, D; Molko, D; Téoule, R1
Frick, L; Marquez, VE; Wolfenden, R; Yang, C1
Nakano, K; Reimer, ML; Schram, KH; Yasaka, T1
Davis, DR; Griffey, RH; Nishimura, S; Poulter, CD; Yamaizumi, Z1
Kawai, H; Moriguchi, M; Tochikura, T; Yamamoto, K1
Armstrong, PW; Barrell, BG; Chen, EY; de Bruijn, MH; Eperon, IC; Roe, BA; Schreier, PH; Wong, JF1
Buckingham, RH; Ramstein, J1
Puzo, G; Wiebers, JL1
Bell, JB; Lo, RY; Roy, KL1
Anukanth, A; Ponnuswamy, PK1
Duden, R; Schöch, G; Topp, H1
House, CH; Miller, SL1
Dalluge, JJ; Davis, DR; Hashizume, T; McCloskey, JA; Sopchik, AE1
Dalluge, JJ; Hashizume, T; McCloskey, JA1
Dalluge, JJ; Hamamoto, T; Horikoshi, K; McCloskey, JA; Morita, RY; Stetter, KO1
Bolt, H; Dörrenhaus, A; Föllmann, W; Schöch, G; Topp, H1
Beagley, CT; Okimoto, R; Wolstenholme, DR1
Mirzabekov, AD; Prokopenko, DV; Vasiliskov, VA1
Snider, MJ; Wolfenden, R1
Clivio, P; Fourrey, JL; Peyrane, F1
Cavicchioli, R; Crain, PF; Guymon, R; Lim, J; McCloskey, JA; Noon, KR; Thomm, M1
Kulik, W; van Cruchten, A; van Kuilenburg, AB; van Lenthe, H1
Cardaioli, E; Da Pozzo, P; Dotti, MT; Federico, A; Radi, E1
Bishop, AC; de Crécy-Lagard, V; Savage, DF1
Nawrot, B; Sochacka, E1
Fedorova, OS; Ishchenko, AA; Koval, VV; Saparbaev, MK; Timofeyeva, NA1
Battastini, AM; Figueiró, F; Hoppe, JB; Jandrey, EH; Montes D'Oca, Cda R; Montes D'Oca, MG; Piovesan, LA; Rosa, SB; Russowsky, D; Salbego, CG; Taborda, PS; Treptow, TG1
Awai, T; Hirata, A; Hori, H; Iwasaki, E; Kazayama, A; Kusuba, H; Tomikawa, C; Yamagami, R; Yoshida, T1
Bou-Nader, C; Brégeon, D; Guérineau, V; Hamdane, D; Jean-Jean, O; Montémont, H1
Dzuba, SA; Fedorova, OS; Kuznetsov, NA; Kuznetsova, AA; Matveeva, AG; Milov, AD; Vorobjev, YN1
Liu, KF; Yanas, A1

Reviews

1 review(s) available for 5,6-dihydrouridine and uridine

ArticleYear
RNA modifications and the link to human disease.
    Methods in enzymology, 2019, Volume: 626

    Topics: 5-Methylcytosine; Adenosine; Animals; Guanosine; Humans; Methylation; Nucleic Acid Conformation; Pseudouridine; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Uridine

2019

Other Studies

34 other study(ies) available for 5,6-dihydrouridine and uridine

ArticleYear
Assignment of the magnetic resonances of the imino protons and methyl protons of Bombyx mori tRNA(GlyGCC) and the effect of ion binding on its structure.
    European journal of biochemistry, 1992, Dec-15, Volume: 210, Issue:3

    Topics: Animals; Anticodon; Base Composition; Base Sequence; Bombyx; Codon; Hydrogen Bonding; Magnesium; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Transfer, Gly; RNA, Transfer, Phe; Saccharomyces cerevisiae; Spermine; Uridine

1992
Neighbourhood of the central fold of the tRNA molecule bound to the E. coli ribosome--affinity labeling studies with modified tRNAs carrying photoreactive probes attached to the dihydrouridine loop.
    Nucleic acids research, 1991, Feb-25, Volume: 19, Issue:4

    Topics: Affinity Labels; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genes, Bacterial; Nucleic Acid Conformation; Ribosomal Proteins; Ribosomes; RNA Probes; RNA, Bacterial; RNA, Transfer, Met; Uridine

1991
A set of tRNAs that lack either the T psi C arm or the dihydrouridine arm: towards a minimal tRNA adaptor.
    The EMBO journal, 1990, Volume: 9, Issue:10

    Topics: Animals; Ascaris; Base Sequence; Blotting, Northern; Caenorhabditis; DNA, Circular; DNA, Mitochondrial; Genes; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Hybridization; Oligonucleotide Probes; RNA, Transfer; RNA, Transfer, Arg; RNA, Transfer, Ser; Sequence Homology, Nucleic Acid; Uridine

1990
Isolation and identification of urinary nucleosides. Applications of high-performance liquid chromatographic methods to the synthesis of 5'-deoxyxanthosine and the simultaneous determination of 5,6-dihydrouridine and pseudouridine.
    Journal of chromatography, 1990, Aug-31, Volume: 515

    Topics: Chromatography, High Pressure Liquid; Creatine; Deoxyribonucleosides; Female; Gas Chromatography-Mass Spectrometry; Gastrointestinal Neoplasms; Humans; Male; Nucleosides; Pseudouridine; Ribonucleosides; Uridine

1990
Labile protecting groups in tRNA synthesis.
    Nucleic acids symposium series, 1989, Issue:21

    Topics: Bacillus subtilis; Base Sequence; Molecular Sequence Data; Pseudouridine; RNA, Bacterial; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Met; Uridine

1989
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.
    Biochemistry, 1989, Nov-28, Volume: 28, Issue:24

    Topics: Cytidine; Cytidine Deaminase; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Molecular Structure; Nucleoside Deaminases; Pyrimidine Nucleosides; Pyrimidinones; Ribonucleosides; Spectrophotometry, Ultraviolet; Thermodynamics; Uridine

1989
The identification of 5,6-dihydrouridine in normal human urine by combined gas chromatography/mass spectrometry.
    Analytical biochemistry, 1989, Volume: 181, Issue:2

    Topics: Chromatography, Affinity; Chromatography, High Pressure Liquid; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Male; Molecular Weight; Trimethylsilyl Compounds; Uridine

1989
15N-labeled tRNA. Identification of dihydrouridine in Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR.
    The Journal of biological chemistry, 1986, Mar-15, Volume: 261, Issue:8

    Topics: Escherichia coli; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; RNA, Transfer, Amino Acyl; Uridine

1986
Inhibition of UDP-N-acetylglucosamine pyrophosphorylase by uridine.
    Biochimica et biophysica acta, 1980, Aug-07, Volume: 614, Issue:2

    Topics: Kinetics; Neurospora crassa; Nucleotidyltransferases; Pseudouridine; Saccharomyces cerevisiae; Uridine; Uridine Diphosphate N-Acetylglucosamine

1980
A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem.
    Nucleic acids research, 1980, Nov-25, Volume: 8, Issue:22

    Topics: Animals; Anticodon; Base Sequence; Cattle; Cloning, Molecular; DNA, Recombinant; Humans; Mitochondria, Liver; Nucleic Acid Conformation; Plasmids; RNA, Transfer, Amino Acyl; Species Specificity; Uridine

1980
Tritium exchange on transfer RNA: slowly exchanging protons sensitive to a change in the dihydrouridine stem.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:3

    Topics: Escherichia coli; Kinetics; Models, Molecular; Nucleic Acid Conformation; Osmolar Concentration; Radioisotope Dilution Technique; RNA, Transfer; Spermine; Tritium; Uridine

1981
Identification of modified nucleosides in intact transfer ribonucleic acid by pyrolysis-electron impact-collisional activation mass spectrometry.
    Nucleic acids research, 1981, Sep-25, Volume: 9, Issue:18

    Topics: Escherichia coli; Guanosine; Mass Spectrometry; Nucleosides; RNA, Transfer; Thiouridine; Uridine

1981
Dihydrouridine-deficient tRNAs in Saccharomyces cerevisiae.
    Nucleic acids research, 1982, Feb-11, Volume: 10, Issue:3

    Topics: Base Composition; Kinetics; Mutation; Protein Biosynthesis; Ribonucleosides; RNA, Transfer; Saccharomyces cerevisiae; Uridine

1982
Modified nucleotides: their conformational characteristics.
    Journal of theoretical biology, 1982, May-21, Volume: 96, Issue:2

    Topics: Adenosine; Guanosine; Molecular Conformation; Nucleotides; Pseudouridine; Uridine

1982
5,6-Dihydrouridine: a marker ribonucleoside for determining whole body degradation rates of transfer RNA in man and rats.
    Clinica chimica acta; international journal of clinical chemistry, 1993, Sep-17, Volume: 218, Issue:1

    Topics: Adenosine; Adult; Animals; Biomarkers; Cytoplasm; Female; Free Radicals; Humans; Infant, Newborn; Male; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Transfer; Species Specificity; Uridine

1993
Hydrolysis of dihydrouridine and related compounds.
    Biochemistry, 1996, Jan-09, Volume: 35, Issue:1

    Topics: Archaea; Bacteria; Eukaryotic Cells; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mathematics; RNA, Transfer; Structure-Activity Relationship; Thermodynamics; Uridine

1996
Conformational flexibility in RNA: the role of dihydrouridine.
    Nucleic acids research, 1996, Mar-15, Volume: 24, Issue:6

    Topics: Drug Stability; Escherichia coli; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Oligoribonucleotides; RNA; RNA Processing, Post-Transcriptional; RNA, Bacterial; Solutions; Thermodynamics; Uridine

1996
Quantitative measurement of dihydrouridine in RNA using isotope dilution liquid chromatography-mass spectrometry (LC/MS).
    Nucleic acids research, 1996, Aug-15, Volume: 24, Issue:16

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Mass Spectrometry; Nitrogen Isotopes; Reproducibility of Results; RNA; Sensitivity and Specificity; Uridine

1996
Posttranscriptional modification of tRNA in psychrophilic bacteria.
    Journal of bacteriology, 1997, Volume: 179, Issue:6

    Topics: Base Composition; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cold Temperature; Gram-Negative Bacteria; Lactobacillus; Mass Spectrometry; Nucleosides; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Transfer; Uridine; Vibrio

1997
Determination of degradation rates of transfer and ribosomal ribonucleic acids in cultured rat hepatocytes by measuring N6-threoninocarbonyladenosine, dihydrouridine, and pseudouridine in medium using high-performance liquid chromatography.
    Analytical biochemistry, 1997, Dec-15, Volume: 254, Issue:2

    Topics: Adenosine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Liver; Male; Pseudouridine; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA; RNA, Ribosomal; RNA, Transfer; Uridine

1997
Mytilus mitochondrial DNA contains a functional gene for a tRNASer(UCN) with a dihydrouridine arm-replacement loop and a pseudo-tRNASer(UCN) gene.
    Genetics, 1999, Volume: 152, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Bivalvia; DNA, Mitochondrial; Electron Transport Complex I; Electron Transport Complex IV; Molecular Sequence Data; NADH Dehydrogenase; Nucleic Acid Conformation; Proteins; Pseudogenes; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Ser; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Transcription, Genetic; Uridine

1999
Parallel multiplex thermodynamic analysis of coaxial base stacking in DNA duplexes by oligodeoxyribonucleotide microchips.
    Nucleic acids research, 2001, Jun-01, Volume: 29, Issue:11

    Topics: Acridines; Acrylic Resins; Base Pair Mismatch; DNA; Fluorescein-5-isothiocyanate; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Sodium Chloride; Solutions; Thermodynamics; Uridine

2001
Site-bound water and the shortcomings of a less than perfect transition state analogue.
    Biochemistry, 2001, Sep-25, Volume: 40, Issue:38

    Topics: Ammonia; Calorimetry; Cytidine Deaminase; Escherichia coli; Kinetics; Models, Molecular; Plasmids; Protein Conformation; Protein Subunits; Thermodynamics; Uridine; Water

2001
Thiation of 2'-deoxy-5,6-dihydropyrimidine nucleosides with Lawesson's reagent: characterisation of oxathiaphosphepane intermediates.
    Chemical communications (Cambridge, England), 2003, Mar-21, Issue:6

    Topics: Deoxyribose; Hot Temperature; Organothiophosphorus Compounds; Pyrimidine Nucleosides; Stereoisomerism; Thiouridine; Uridine

2003
Influence of temperature on tRNA modification in archaea: Methanococcoides burtonii (optimum growth temperature [Topt], 23 degrees C) and Stetteria hydrogenophila (Topt, 95 degrees C).
    Journal of bacteriology, 2003, Volume: 185, Issue:18

    Topics: Cell Division; Chromatography, Liquid; Desulfurococcaceae; Guanosine; Mass Spectrometry; Methanosarcinaceae; Nucleosides; Ribose; RNA Processing, Post-Transcriptional; RNA, Transfer; Species Specificity; Temperature; Uridine

2003
Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometry.
    Clinical chemistry, 2004, Volume: 50, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Spectrometry, Mass, Electrospray Ionization; Uracil; Uridine

2004
A novel heteroplasmic tRNA(Leu(CUN)) mtDNA point mutation associated with chronic progressive external ophthalmoplegia.
    Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3

    Topics: Animals; Base Sequence; DNA, Mitochondrial; Fibroblasts; Humans; Lymphocytes; Mitochondrial Myopathies; Muscle Fibers, Skeletal; Ophthalmoplegia, Chronic Progressive External; Point Mutation; Polymorphism, Restriction Fragment Length; RNA, Transfer, Leu; Uridine

2005
Molecular determinants of dihydrouridine synthase activity.
    FEBS letters, 2006, Oct-02, Volume: 580, Issue:22

    Topics: Amino Acid Sequence; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Models, Molecular; Molecular Sequence Data; Oxidoreductases; Protein Structure, Tertiary; Uridine

2006
Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine.
    Current protocols in nucleic acid chemistry, 2009, Volume: Chapter 16

    Topics: Chemistry, Organic; Oligonucleotides; Pseudouridine; RNA, Small Interfering; Thiouridine; Uridine

2009
Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Amino Acid Substitution; Base Sequence; Buffers; Catalytic Domain; DNA; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Humans; Hydrolysis; Kinetics; Ligands; Lysine; Mutation; Spectrometry, Fluorescence; Uridine

2011
Novel hybrid DHPM-fatty acids: synthesis and activity against glioma cell growth in vitro.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Fatty Acids; Glioma; Humans; Male; Rats; Rats, Wistar; Uridine

2015
In vitro dihydrouridine formation by tRNA dihydrouridine synthase from Thermus thermophilus, an extreme-thermophilic eubacterium.
    Journal of biochemistry, 2015, Volume: 158, Issue:6

    Topics: Bacterial Proteins; Enzyme Assays; Oxidation-Reduction; Oxidoreductases; Recombinant Proteins; RNA, Transfer; Temperature; Thermus thermophilus; Uridine

2015
Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario.
    Nucleic acids research, 2018, 02-16, Volume: 46, Issue:3

    Topics: Base Pairing; Base Sequence; Binding Sites; Crystallography, X-Ray; Escherichia coli; Evolution, Molecular; Isoenzymes; Kinetics; Models, Molecular; Nucleic Acid Conformation; Oxidation-Reduction; Oxidoreductases; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; RNA, Transfer; Substrate Specificity; Thermodynamics; Uridine

2018
Substrate specificity of human apurinic/apyrimidinic endonuclease APE1 in the nucleotide incision repair pathway.
    Nucleic acids research, 2018, 11-30, Volume: 46, Issue:21

    Topics: Adenosine; Catalytic Domain; Cloning, Molecular; DNA; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Electron Spin Resonance Spectroscopy; Escherichia coli; Fluorescence Resonance Energy Transfer; Gene Expression; Humans; Kinetics; Molecular Dynamics Simulation; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity; Uridine

2018