Compounds > 5,6-dihydroorotate

5,6-dihydroorotate and brequinar

5,6-dihydroorotate has been researched along with brequinar in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cleaveland, ES; Cooney, DA; Ford, H; Kelley, JA; Paull, K; Zaharevitz, DW1
Carrey, EA; Fairbanks, LD; Kirschbaum, B; Rückemann, K; Simmonds, HA; Swaminathan, R1
Antal, T; Hansen, M; Johansson, E; Larsen, S; Le Nours, J; Löffler, M; Ullrich, A1
Al-Karadaghi, S; Dahlberg, L; Dufe, VT; Fritzson, I; Khairoullina, A; Svensson, B; Walse, B; Wellmar, U1

Other Studies

4 other study(ies) available for 5,6-dihydroorotate and brequinar

ArticleYear
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
    Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3

    Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; Humans; Kidney Neoplasms; Kinetics; Leukemia; Lung Neoplasms; Male; Melanoma; Mitochondria; Orotic Acid; Ovarian Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Prostatic Neoplasms; Ribonucleotides; Sodium Bicarbonate; Software; Tumor Cells, Cultured

1996
Simultaneous separation by high-performance liquid chromatography of carbamoyl aspartate, carbamoyl phosphate and dihydroorotic acid.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Sep-24, Volume: 732, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Biphenyl Compounds; Carbamyl Phosphate; Chromatography, High Pressure Liquid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Orotic Acid; T-Lymphocytes

1999
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.
    Protein science : a publication of the Protein Society, 2004, Volume: 13, Issue:4

    Topics: Amino Acid Sequence; Aniline Compounds; Animals; Atovaquone; Biphenyl Compounds; Catalysis; Crotonates; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hydrogen Bonding; Hydroxybutyrates; Immunosuppressive Agents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Naphthoquinones; Nitriles; Orotic Acid; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Alignment; Substrate Specificity; Toluidines

2004
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
    Biochemistry, 2008, Aug-26, Volume: 47, Issue:34

    Topics: Binding Sites; Biphenyl Compounds; Carboxylic Acids; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Flavin Mononucleotide; Humans; Naphthalenes; Orotic Acid; ortho-Aminobenzoates; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Ubiquinone

2008