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5,6-dihydro-5-azacytidine and azacitidine

5,6-dihydro-5-azacytidine has been researched along with azacitidine in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (67.86)	18.7374
1990's	6 (21.43)	18.2507
2000's	2 (7.14)	29.6817
2010's	1 (3.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abbasi, MM; Beisler, JA; Driscoll, JS; Kelley, JA	1
Abbasi, MM; Beisler, JA; Driscoll, JS	1
Abbasi, MM; Beisler, JA; Voytek, P; Wolpert-DeFilippes, MK	1
Dhingra, HM; Hong, WK; Murphy, WK; Raber, MN; Winn, RJ	1
Batist, G; Collins, JM; Curt, GA; Fine, RL; Huguenin, PN; Jenkins, J; Kelley, JA; Roth, JS	1
Veselý, J	1
Covey, JM; D'Incalci, M; Kohn, KW; Tilchen, EJ; Zaharko, DS	1
Antonsson, BE; Avramis, VI; Holcenberg, JS; Nyce, J	1
Asmeron, Y; Blayney, D; Carr, BI; Doroshow, JH; Goldberg, D; Leong, L; Rahbar, S	1
Carr, DT; Dhingra, HM; Holoye, PY; Lee, JS; Murphy, WK; Umsawasdi, T	1
Avramis, VI; Powell, WC	1
Albury, D; Johnson-Thompson, M	1
Avramis, VI; Mecum, RA; Powell, WC	1
Abbasi, MM; Beisler, JA; Glazer, RI; Peale, AL	1
Abbasi, MM; Beisler, JA; Kelley, JA	1
Glazer, RI; Hartman, KD	1
Coulter, D; Presant, CA; Valeriote, F; Vietti, TJ	1
Darzynkiewicz, Z; Melamed, MR; Staiano-Coico, L; Traganos, F; Xue, S	1
Glazer, RI; Lin, HL	1
Cheng, H; Malspeis, L; Staubus, AE	1
Avramis, VI; Kees, UR	1
Caspary, WJ; Gibis, P; Körber, C; Spencer, DL; Stopper, H	1
Creagan, ET; Hartmann, LC; Loprinzi, CL; Schaid, DJ	1
Antman, KH; Cirrincione, C; Citron, ML; Corson, JM; Green, MR; Harmon, DC; Herndon, JE; Suzuki, Y; Yogelzang, NJ	1
Aisner, J; Carey, R; Corson, JM; Green, MR; Harmon, DC; Herndon, JE; Samuels, BL; Suzuki, Y; Vogelzang, NJ	1
Brabant, W; Daifuku, R; Gall, A; Harris, KS; Styrchak, S	1
Green, MR; Kern, JA; Kindler, HL; Kratzke, MG; Kratzke, RA; Vogelzang, NJ; Vokes, EE; Wang, X; Wong, L	1
Krečmerová, M; Otmar, M	1

Reviews

2 review(s) available for 5,6-dihydro-5-azacytidine and azacitidine

Article	Year
Mode of action and effects of 5-azacytidine and of its derivatives in eukaryotic cells. Pharmacology & therapeutics, 1985, Volume: 28, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cells; Cytidine; Drug Resistance; Enzyme Activation; Eukaryotic Cells; Humans; Leukemia, Experimental; Liver Regeneration; Uridine Kinase	1985
5-azacytosine compounds in medicinal chemistry: current stage and future perspectives. Future medicinal chemistry, 2012, Volume: 4, Issue:8 Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Azacitidine; Cytosine; DNA Methylation; Drug Discovery; HIV; HIV Infections; Humans; Neoplasms	2012

Trials

4 trial(s) available for 5,6-dihydro-5-azacytidine and azacitidine

Article	Year
Phase II trial of 5,6-dihydro-5-azacytidine in pleural malignant mesothelioma. Investigational new drugs, 1991, Volume: 9, Issue:1 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Drug Evaluation; Female; Humans; Male; Mesothelioma; Middle Aged; Pleural Neoplasms	1991
A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma. American journal of clinical oncology, 1993, Volume: 16, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biopsy; Chest Pain; Female; Humans; Immunologic Factors; Infusions, Intravenous; Male; Melanoma; Middle Aged; Nausea; Remission Induction; Risk Factors; Severity of Illness Index; Survival Rate; Vomiting	1993
Dihydro-5-azacytidine in malignant mesothelioma. A phase II trial demonstrating activity accompanied by cardiac toxicity. Cancer and Leukemia Group B. Cancer, 1997, Jun-01, Volume: 79, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arrhythmias, Cardiac; Azacitidine; Chest Pain; Female; Humans; Male; Mesothelioma; Middle Aged; Pleural Neoplasms	1997
Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma: a phase II study by the Cancer and Leukemia Group B. Cancer, 1998, Apr-15, Volume: 82, Issue:8 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chest Pain; Cisplatin; Female; Humans; Leukopenia; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Prognosis; Survival Analysis	1998

Other Studies

22 other study(ies) available for 5,6-dihydro-5-azacytidine and azacitidine

Article	Year
Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine. Journal of medicinal chemistry, 1977, Volume: 20, Issue:6 Topics: Animals; Antineoplastic Agents; Azacitidine; Hydrolysis; Leukemia L1210; Leukemia, Experimental; Melanoma; Mice; Neoplasms, Experimental	1977
Dihydro-5-azacytidine hydrochloride, a biologically active and chemically stable analog of 5-azacytidine. Cancer treatment reports, 1976, Volume: 60, Issue:11 Topics: Animals; Azacitidine; Leukemia L1210; Mice	1976
Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine. Cancer research, 1977, Volume: 37, Issue:7 Pt 1 Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Cytidine; Cytidine Deaminase; Deoxycytidine; Drug Synergism; Kinetics; Leukemia L1210; Oxidative Phosphorylation; Tetrahydrouridine; Thymidine; Uridine	1977
A phase I and pharmacokinetic study of dihydro-5-azacytidine (NSC 264880). Cancer research, 1985, Volume: 45, Issue:7 Topics: Adult; Aged; Azacitidine; Drug Evaluation; Drug Stability; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms	1985
Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells. Cancer research, 1986, Volume: 46, Issue:11 Topics: Animals; Azacitidine; Cell Cycle; Cell Line; Decitabine; DNA; DNA Damage; DNA Replication; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Lymphocytes; Mice	1986
Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/0 and CCRF/CEM/dCk-1. Cancer research, 1987, Jul-15, Volume: 47, Issue:14 Topics: Azacitidine; Cell Line; Cytarabine; Decitabine; Deoxycytidine Kinase; DNA; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance; Humans; Lymphoid Tissue; Methylation; Phosphotransferases	1987
Fetal hemoglobin gene activation in a phase II study of 5,6-dihydro-5-azacytidine for bronchogenic carcinoma. Cancer research, 1987, Aug-01, Volume: 47, Issue:15 Topics: Adult; Antibodies, Antinuclear; Azacitidine; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fetal Hemoglobin; Gene Expression Regulation; Globins; Heart Diseases; Humans; Lung Neoplasms; Neoplasm Proteins; Pain; Transcriptional Activation	1987
Phase II study of 5,6-dihydro-5-azacytidine in extensive, untreated non-small cell lung cancer. Cancer treatment reports, 1987, Volume: 71, Issue:9 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged	1987
Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:2 Topics: Animals; Azacitidine; Bone Marrow; Brain; Chromatography, High Pressure Liquid; DNA, Neoplasm; Erythrocytes; Intestinal Mucosa; Kidney; Leukemia L1210; Liver; Lung; Male; Methylation; Mice; Muscles; Myocardium; Spleen; Testis; Tissue Distribution; Tumor Cells, Cultured	1988
Azapyrimidine analogues: inhibition of viral DNA synthesis and protein synthesis in SV40 infected BSC-1 cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1988, Volume: 24, Issue:11 Topics: Animals; Azacitidine; Cell Line; Chlorocebus aethiops; DNA, Viral; Dose-Response Relationship, Drug; Methylation; Protein Biosynthesis; Simian virus 40; Structure-Activity Relationship; Virus Replication	1988
Cellular metabolism of 5,6-dihydro-5-azacytidine and its incorporation into DNA and RNA of human lymphoid cells CEM/O and CEM/dCk(-). Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:3 Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line; DNA, Neoplasm; Humans; Leukemia; Lymphocytes; Methylation; Mutation; RNA, Neoplasm; Time Factors; Tritium; Tumor Cells, Cultured	1989
The effect of 5-azacytidine and dihydro-5-azacytidine on nuclear ribosomal RNA and poly(A) RNA synthesis in L1210 cells in vitro. Molecular pharmacology, 1980, Volume: 17, Issue:1 Topics: Adenosine; Animals; Azacitidine; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Leukemia L1210; Methionine; Methylation; Mice; Poly A; RNA; RNA, Heterogeneous Nuclear; RNA, Messenger; RNA, Ribosomal; Uridine	1980
Silylation-mediated oxidation of dihydropyrimidine bases and nucleosides. Analytical biochemistry, 1980, Volume: 103, Issue:2 Topics: Azacitidine; Chemical Phenomena; Chemistry; Deuterium; Gas Chromatography-Mass Spectrometry; Kinetics; Methods; Oxidation-Reduction; Pyrimidine Nucleosides; Pyrimidines; Silicon; Triazines; Trimethylsilyl Compounds	1980
The comparative effects of 5-azacytidine and dihydro-5-azacytidine on 4 S and 5 S nuclear RNA. Molecular pharmacology, 1980, Volume: 17, Issue:2 Topics: Animals; Azacitidine; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Leukemia L1210; Methylation; Mice; Molecular Weight; RNA, Neoplasm	1980
Contrasting cytotoxicity kinetics of 5-azacytidine and dihydro-5-azacytidine hydrochloride in L1210 leukemia in mice. Journal of the National Cancer Institute, 1981, Volume: 66, Issue:6 Topics: Animals; Azacitidine; Bone Marrow; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Kinetics; Lethal Dose 50; Leukemia L1210; Male; Mice; Spleen	1981
Rapid analysis of drug effects on the cell cycle. Cytometry, 1981, Volume: 1, Issue:4 Topics: Animals; Anthraquinones; Azacitidine; Butyrates; Cell Line; Chromatin; Cytological Techniques; DNA; Interphase; Kinetics; Mice; Mitosis	1981
The comparative effects of 5-azacytidine and dihydro-5-azacytidine on polysomal RNA in Ehrlich ascites cells in vitro. Molecular pharmacology, 1981, Volume: 20, Issue:3 Topics: Adenosine; Animals; Azacitidine; Carcinoma, Ehrlich Tumor; Mice; Polyribosomes; Protein Biosynthesis; Reticulocytes; RNA, Neoplasm; RNA, Ribosomal	1981
Pharmacokinetics of 5,6-dihydro-5-azacytidine (NSC-264880) in the foxhound. Investigational new drugs, 1983, Volume: 1, Issue:1 Topics: Animals; Azacitidine; Chromatography, High Pressure Liquid; Dogs; Half-Life; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Models, Biological	1983
Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163. Anti-cancer drugs, 1995, Volume: 6, Issue:2 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; DNA; Humans; Leukemia; Methylation; Tumor Cells, Cultured	1995
Micronuclei induced by modulators of methylation: analogs of 5-azacytidine. Carcinogenesis, 1995, Volume: 16, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Deoxycytidine; Leukemia L5178; Methylation; Mice; Mice, Inbred C3H; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutation	1995
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral research, 2005, Volume: 67, Issue:1 Topics: Animals; Anti-HIV Agents; Azacitidine; Cell Line; Cricetinae; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Nucleosides; Reverse Transcriptase Inhibitors; Zidovudine	2005
Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2008, Volume: 3, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mesothelioma; Middle Aged; Polymerase Chain Reaction; Prognosis; Survival Rate	2008