5-4--dihydroxy-7-3--dimethoxyflavone and moronic-acid

Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 microg/mL.

Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Flowers; Humans; Inhibitory Concentration 50; Madagascar; Malpighiaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Triterpenes; Tumor Cells, Cultured