5'-methylthioadenosine and s-adenosylmethionine

5'-methylthioadenosine has been researched along with s-adenosylmethionine in 62 studies

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-199029 (46.77)18.7374
1990's6 (9.68)18.2507
2000's11 (17.74)29.6817
2010's11 (17.74)24.3611
2020's5 (8.06)2.80

Authors

AuthorsStudies
Almo, SC; Fedorov, AA; Fedorov, E; Hermann, JC; Marti-Arbona, R; Raushel, FM; Shoichet, BK1
Aranda, R; Bobinski, TP; Briere, DM; Burns, AC; Christensen, JG; Clarine, J; Engstrom, LD; Gunn, RJ; Ivetac, A; Jean-Baptiste, R; Ketcham, JM; Kobayashi, M; Kuehler, J; Kulyk, S; Lawson, JD; Marx, MA; Moya, K; Olson, P; Rahbaek, L; Smith, CR; Thomas, NC; Wang, X; Waters, LM1
Edwards, CH; Edwards, GA; Freeburne, MM; Jones, EG; Seo, CW; Sherman, L; Stacey, RE; Wade, WD1
Daino, L; Feo, F; Lai, P; Pascale, R; Ruggiu, ME; Satta, G; Seddaiu, MA; Sequenza, MJ; Simile, MM; Vannini, MG1
Liteplo, RG1
Aswad, DW; Najbauer, J1
Carson, DA; Kubota, M; Olavi, E; Wasson, DB; Willis, EH; Yamanaka, H1
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Puddu, M; Seddaiu, MA; Simile, MM1
Coward, JK; Pegg, AE; Poulin, R; Wechter, R; Woster, PM1
Alakuijala, L; Eloranta, TO; Lindqvist, L; Smith, TK1
Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L1
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Ruggiu, ME; Vannini, MG1
Carson, DA; Kajander, EO; Yamanaka, H1
Chanarin, I; Deacon, R; Lumb, M; Perry, J2
Augé, J; Christa, L; Kersual, J; Pérignon, JL1
Kufe, DW; Shafman, TD; Sherman, ML; Spriggs, DR1
Chan, VL; Ho, HJ1
Dainko, JL; Schlenk, F; Zydek-Cwick, CR1
Arnaud, M; Dante, R; Niveleau, A1
Cooper, AJ1
Schlenk, F1
Baglioni, C; de Ferra, F1
Eloranta, TO; Kajander, EO1
Pegg, AE1
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Galletti, P; Zappia, V1
Eloranta, T; Hyvönen, T; Raina, A; Samejima, K; Voutilainen, M; Yamanoha, B1
Galletti, P; Seidenfeld, J; Williams-Ashman, HG1
Borchardt, RT; Huskey, WP; Schowen, RL; Wu, SE1
Chun, BG; Kim, S; Paik, WK1
Schlenk, F; Shapiro, SK1
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Giordano, F; Manna, C; Oliva, A1
Borchardt, RT; Chen, SY; Coward, JK; Hibasami, H; Pegg, AE1
Hamasaki-Katagiri, N; Tabor, CW; Tabor, H1
Barrett, J; Walker, J1
Bacchi, CJ; Goldberg, B; Gorrell, TE; Rattendi, D; Spiess, AJ; Sufrin, JR1
Becker, A; Surdin-Kerjan, Y; Thomas, D1
Angioni, E; Banni, S; Calvisi, DF; Carru, A; Carta, G; De Miglio, MR; Feo, F; Muroni, MR; Pascale, RM; Simile, MM1
Ansorena, E; Avila, MA; Chen, L; García-Trevijano, ER; Huang, ZZ; Iraburu, M; Lu, SC; Martínez-Chantar, ML; Mato, JM1
Bock, CW; Markham, GD; Norrby, PO1
GAWEL, LJ; PARKS, LW; TURNER, JR1
Avila, MA; Berasain, C; Corrales, FJ; García-Trevijano, ER; Hevia, H; Latasa, MU; Lu, SC; Martínez-Chantar, ML; Mato, JM; Varela-Rey, M1
Hsieh, CL; Lu, S; Mato, JM; Tsukamoto, H; Veal, N; Xiong, S1
Diegelman, P; Kee, K; Kisiel, N; Kramer, DL; Merali, S; Porter, CW; Powell, CT; Vujcic, S1
Bae, W; Chen, L; Li, M; Lu, SC; Mato, JM; Ou, X; Runnegar, MT; Sadda, MR; Yang, H; Zeng, Y1
Ansorena, E; Avila, MA; Berasain, C; García-Trevijano, ER; Iraburu, MJ; López Zabalza, MJ1
Aw, TY; Bemanian, S; Chen, H; Circ, M; Lastra, N; Li, TW; Lu, SC; Mato, JM; Moyer, MP; Oh, P; Xia, M; Zhang, Q1
Farrar, CE; Howell, PL; Jarrett, JT; Siu, KK1
Droggiti, A; Lu, SC; Martinez-Chantar, ML; Varela-Rey, M; Warner, A; Yamaji, S1
Basu, I; Belbin, TJ; Cassera, MB; Dong, X; Evans, GB; Guha, C; Hemeon, I; Locker, J; Merino, EF; Schramm, VL1
Demick, JM; Lanzilotta, WN1
Feussner, I; Feussner, K; Klebl, F; Pommerrenig, B; Rabinovych, V; Sauer, N; Zierer, W1
Gutierrez, JA; Hemeon, I; Ho, MC; Schramm, VL1
Anderson, PS; Hong-Geller, E; Martí-Arbona, R; Nowak-Lovato, KL; Teshima, M; Unkefer, CJ; Unkefer, PJ1
Cho, K; Erb, TJ; Evans, BS; Gerlt, JA; Imker, HJ; Sriram, J; Sweedler, JV; Tabita, FR; Warlick, BP; Wood, BM1
Kurniawidjaja, S; Li, TW; Lu, SC; Mato, JM; Panthaki, P; Peng, H; Yang, H; Zheng, Y1
Deng, X; Pang, P; Wang, Z; Xie, W1
Chu, YD; Huang, YH; Lai, HY; Liang, KH; Lin, YH; Pai, LM; Yeh, CT1
Byerly, KM; Erb, TJ; Evans, BS; Gerlt, JA; North, JA; Tabita, FR; Wildenthal, JA1
Chang, CF; Dontsova, OA; Efimov, SV; Kechko, OI; Klochkov, VV; Mariasina, SS; Mitkevich, VA; Petrova, OA; Polshakov, VI; Sergiev, PV1
Heinrich, C; Schilling, M; Takors, R; Teleki, A; Unsöld, A; Verhagen, N1
Evans, GB; Hofferek, V; Jackson, M; Munkacsi, AB; Reid, GE; Rustam, YH; Salita, T; Schramm, VL; Sheridan, JP; Tollestrup, I1

Reviews

4 review(s) available for 5'-methylthioadenosine and s-adenosylmethionine

ArticleYear
Biochemistry of sulfur-containing amino acids.
    Annual review of biochemistry, 1983, Volume: 52

    Topics: Adenosine; Amino Acid Metabolism, Inborn Errors; Animals; Cysteine; Deoxyadenosines; Homocysteine; Humans; Methionine; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Structure-Activity Relationship; Sulfur; Sulfurtransferases; Thionucleosides; Thiosulfate Sulfurtransferase

1983
Methylthioadenosine.
    Advances in enzymology and related areas of molecular biology, 1983, Volume: 54

    Topics: Adenosine; Animals; Biotin; Deoxyadenosines; Humans; Hydrolysis; Kinetics; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; T-Phages; Thionucleosides

1983
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
    Biochemical pharmacology, 1982, Feb-01, Volume: 31, Issue:3

    Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylase; Rats; Ribosemonophosphates; S-Adenosylmethionine; Spermidine; Spermine; Thioglycosides; Thionucleosides

1982
Parasite sulphur amino acid metabolism.
    International journal for parasitology, 1997, Volume: 27, Issue:8

    Topics: Amino Acids, Sulfur; Animals; Cystathionine; Cysteine; Deoxyadenosines; Eukaryota; Helminthiasis; Helminths; Humans; Methionine; Protozoan Infections; S-Adenosylmethionine; Thionucleosides

1997

Other Studies

58 other study(ies) available for 5'-methylthioadenosine and s-adenosylmethionine

ArticleYear
Structure-based activity prediction for an enzyme of unknown function.
    Nature, 2007, Aug-16, Volume: 448, Issue:7155

    Topics: Adenine; Catalysis; Crystallography, X-Ray; Deamination; Deoxyadenosines; Enzymes; Homocysteine; Inosine; Models, Molecular; Nucleoside Deaminases; Protein Conformation; S-Adenosylhomocysteine; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; Thionucleosides

2007
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of
    Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxyadenosines; Female; Gene Deletion; Humans; Mice, Nude; Neoplasms; Phthalazines; Protein Binding; Protein-Arginine N-Methyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides; Xenograft Model Antitumor Assays

2022
Formation of methionine from alpha-amino-n-butyric acid and 5'-methylthioadenosine in the rat.
    The Journal of nutrition, 1977, Volume: 107, Issue:10

    Topics: Adenosine; Aminobutyrates; Animals; Body Weight; Butyrates; Choline; Cysteine; Deoxyadenosines; Homoserine; Male; Methionine; Rats; S-Adenosylmethionine; Thionucleosides

1977
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
    Cancer letters, 1991, Volume: 56, Issue:3

    Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1991
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
    Experimental cell research, 1990, Volume: 186, Issue:2

    Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured

1990
Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde.
    The Journal of biological chemistry, 1990, Jul-25, Volume: 265, Issue:21

    Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Deoxyadenosines; Electrophoresis, Gel, Two-Dimensional; Methylation; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Pheochromocytoma; Rats; S-Adenosylmethionine; Thionucleosides; Tubercidin; Tumor Cells, Cultured

1990
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Adenosine; Animals; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Mice, Mutant Strains; Pentosyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured

1989
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Phagocytosis; Phenobarbital; Phenotype; Precancerous Conditions; Proto-Oncogenes; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1989
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
    Biochemistry, 1989, Oct-17, Volume: 28, Issue:21

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line, Transformed; Deoxyadenosines; Dose-Response Relationship, Drug; Fibroblasts; Leukemia L1210; Mice; Polyamines; S-Adenosylmethionine; Spermine Synthase; Thionucleosides; Transferases; Tumor Cells, Cultured

1989
Effects of dietary polyamine precursors on the metabolism and tissue concentrations of amino acids in the rat.
    Annals of nutrition & metabolism, 1989, Volume: 33, Issue:3

    Topics: Adenosine; Amino Acids; Animals; Arginine; Biogenic Polyamines; Deoxyadenosines; Diet; Liver; Male; Methionine; Muscles; Ornithine; Rats; Rats, Inbred Strains; RNA, Transfer, Amino Acid-Specific; S-Adenosylmethionine; Thionucleosides

1989
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
    Toxicologic pathology, 1987, Volume: 15, Issue:1

    Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1987
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
    Carcinogenesis, 1987, Volume: 8, Issue:5

    Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1987
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
    Biochimica et biophysica acta, 1986, Sep-19, Volume: 888, Issue:2

    Topics: Adenosine; Adenosine Diphosphate Ribose; Animals; Cell Line; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides

1986
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
    Journal of clinical pathology, 1988, Volume: 41, Issue:11

    Topics: Adenosine; Animals; Betaine; Carbon Dioxide; Deoxyadenosines; Formyltetrahydrofolates; Glycine; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thionucleosides; Time Factors

1988
Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.
    The Biochemical journal, 1988, Oct-01, Volume: 255, Issue:1

    Topics: Adenosine; Cell Division; Cell Line; Deoxyadenosines; Humans; Intracellular Fluid; Methionine; Methionine Adenosyltransferase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured

1988
Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 2

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Differentiation; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; DNA; Leukemia, Erythroblastic, Acute; Methylation; Mice; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin

1985
Multiple mechanisms of adenosine toxicity in an adenosine sensitive mutant of baby hamster kidney (BHK) cells.
    Basic life sciences, 1985, Volume: 31

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cytidine Triphosphate; Deoxyadenosines; Drug Resistance; Guanosine Triphosphate; Kidney; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Uridine Triphosphate; Vidarabine

1985
5'-Methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast.
    Biochimica et biophysica acta, 1973, Sep-14, Volume: 320, Issue:2

    Topics: Adenine; Adenosine; Aerobiosis; Candida; Carbon Radioisotopes; Deoxyadenosines; Methionine; Optical Rotation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Sulfides; Sulfur Radioisotopes; Thionucleosides; Time Factors

1973
Effects of 5'deoxy-5'-methylthioadenosine on the metabolism of S-adenosyl methionine.
    Biochemical and biophysical research communications, 1983, Jul-18, Volume: 114, Issue:1

    Topics: Adenosine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferases; Kidney; Kinetics; Rats; S-Adenosylmethionine; Sulfur Radioisotopes; Thionucleosides

1983
Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Adenosine; Adenosylhomocysteinase; Burkitt Lymphoma; Cell Division; Cell Line; Deoxyadenosines; HeLa Cells; Humans; Hydrolases; Interferon Type I; Kinetics; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1984
Catabolism and lability of S-adenosyl-L-methionine in rat liver extracts.
    The Biochemical journal, 1984, Nov-15, Volume: 224, Issue:1

    Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Female; In Vitro Techniques; Liver; Proteins; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1984
Inhibition of aminopropyltransferases.
    Methods in enzymology, 1983, Volume: 94

    Topics: Adenosine; Animals; Cattle; Deoxyadenosines; In Vitro Techniques; Male; Polyamines; Rats; S-Adenosylmethionine; Spermidine Synthase; Thionucleosides; Transferases

1983
High-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis.
    Methods in enzymology, 1983, Volume: 94

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1983
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain.
    The Biochemical journal, 1984, May-01, Volume: 219, Issue:3

    Topics: Adenosine; Animals; Brain; Cattle; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Putrescine; S-Adenosylmethionine; Spermidine; Spermidine Synthase; Thionucleosides; Transferases

1984
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
    The Journal of clinical investigation, 1983, Volume: 71, Issue:5

    Topics: Adenosine; Animals; Deoxyadenosines; Folic Acid; Formyltetrahydrofolates; Liver; Male; Methionine; Nitrous Oxide; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency

1983
Chiral instability at sulfur of S-adenosylmethionine.
    Biochemistry, 1983, Jun-07, Volume: 22, Issue:12

    Topics: Adenosine; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Homoserine; Kinetics; Molecular Conformation; S-Adenosylmethionine; Sulfur; Thionucleosides

1983
Simple separation of adenine and adenosyl-sulfur compounds by high-performance liquid chromatography.
    Journal of chromatography, 1983, Jul-15, Volume: 264, Issue:2

    Topics: Adenine; Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1983
Conversion of 5'-methylthioadenosine into S-adenosylmethionine by yeast cells.
    Biochimica et biophysica acta, 1980, Dec-01, Volume: 633, Issue:2

    Topics: Adenosine; Amino Acids; Candida; Cells, Cultured; Culture Media; Deoxyadenosines; S-Adenosylmethionine; Thionucleosides

1980
[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Jun-15, Volume: 57, Issue:11

    Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein O-Methyltransferase; S-Adenosylmethionine; Thionucleosides

1981
Studies of inhibition of rat spermidine synthase and spermine synthase.
    The Biochemical journal, 1980, May-01, Volume: 187, Issue:2

    Topics: Adenosine; Animals; Deoxyadenosines; Male; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases

1980
Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase).
    Gene, 1997, Mar-10, Volume: 187, Issue:1

    Topics: Amino Acid Sequence; Chromosome Mapping; Cloning, Molecular; Conserved Sequence; Deoxyadenosines; Genes, Fungal; Molecular Sequence Data; Mutation; S-Adenosylmethionine; Saccharomyces cerevisiae; Sequence Analysis; Sequence Homology, Amino Acid; Spermidine; Spermidine Synthase; Thionucleosides

1997
Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes.
    Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1

    Topics: Adenosine; Animals; Biological Transport; Deoxyadenosines; Methionine; Models, Chemical; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; S-Adenosylmethionine; Spermidine; Structure-Activity Relationship; Substrate Specificity; Thionucleosides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense

1999
Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells.
    The Journal of biological chemistry, 2000, Dec-29, Volume: 275, Issue:52

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Deoxyadenosines; Fungal Proteins; Gene Expression Regulation; Homocysteine S-Methyltransferase; Membrane Proteins; Methionine; Molecular Sequence Data; S-Adenosylmethionine; Saccharomyces cerevisiae Proteins; Thionucleosides; Vitamin B 12; Vitamin U; Yeasts

2000
5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.
    Journal of hepatology, 2001, Volume: 34, Issue:3

    Topics: Acute Disease; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Cell Division; Deoxyadenosines; Enzyme Inhibitors; Fibrosis; Gene Expression; Lipid Peroxides; Liver; Procollagen-Proline Dioxygenase; Rats; Rats, Wistar; S-Adenosylmethionine; Thionucleosides

2001
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.
    Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:2

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cells, Cultured; Cytochrome c Group; Deoxyadenosines; Enzyme Activation; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Okadaic Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; S-Adenosylmethionine; Species Specificity; Thionucleosides

2002
S-adenosylmethionine conformations in solution and in protein complexes: conformational influences of the sulfonium group.
    Biochemistry, 2002, Jun-18, Volume: 41, Issue:24

    Topics: Adenosine Triphosphate; Crystallography, X-Ray; Deoxyadenosines; Macromolecular Substances; Mathematical Computing; Molecular Conformation; Monte Carlo Method; Nuclear Magnetic Resonance, Biomolecular; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Software; Solutions; Sulfonium Compounds; Sulfur; Thionucleosides; Vitamin U

2002
Accumulation of S-adenosylmethionine by microorganisms.
    Journal of bacteriology, 1962, Volume: 83

    Topics: Deoxyadenosines; Escherichia coli; Methionine; Oregon; Pseudomonas; S-Adenosylmethionine; Saccharomyces cerevisiae; Thionucleosides; Yeasts

1962
5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.
    Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Deoxyadenosines; Enzyme Inhibitors; Hepatocytes; Humans; Kupffer Cells; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Rats; S-Adenosylmethionine; Shock, Septic; Thionucleosides

2004
Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:2

    Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Deoxyadenosines; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; E1A-Associated p300 Protein; Kupffer Cells; Lipopolysaccharides; Methionine; NF-kappa B; Nuclear Proteins; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylmethionine; Thionucleosides; Time Factors; Trans-Activators; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2004
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Humans; Male; Methionine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; RNA, Messenger; S-Adenosylmethionine; Tetracyclines; Thionucleosides; Tumor Cells, Cultured

2004
S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
    Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:1

    Topics: Acetylation; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Histones; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Protein Isoforms; Protein Phosphatase 1; Proto-Oncogene Proteins c-bcl-2; S-Adenosylmethionine; Sarcoplasmic Reticulum; Thionucleosides; Tubercidin

2004
Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:6

    Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Deoxyadenosines; Gene Expression Regulation; Hepatocytes; Humans; Male; MAP Kinase Kinase 4; Rats; Rats, Wistar; S-Adenosylmethionine; Signal Transduction; Thionucleosides; Transcription Factor AP-1

2006
S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.
    Molecular pharmacology, 2009, Volume: 76, Issue:1

    Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cycloheximide; Cytochromes c; Deoxyadenosines; HT29 Cells; Humans; S-Adenosylmethionine; Thionucleosides; TNF-Related Apoptosis-Inducing Ligand

2009
Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules.
    Biochemistry, 2010, Nov-23, Volume: 49, Issue:46

    Topics: Binding Sites; Catalysis; Catalytic Domain; Deoxyadenosines; Kinetics; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Sulfurtransferases; Thionucleosides

2010
S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes.
    European journal of cell biology, 2011, Volume: 90, Issue:4

    Topics: Animals; beta Catenin; Cell Differentiation; Cells, Cultured; Connexins; Deoxyadenosines; Gap Junctions; Gene Expression Regulation; Hepatocytes; Mice; Mice, Knockout; S-Adenosylmethionine; Thionucleosides

2011
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
    The Journal of biological chemistry, 2011, Feb-11, Volume: 286, Issue:6

    Topics: Adenine; Adenosine; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyadenosines; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Purine-Nucleoside Phosphorylase; Pyrrolidines; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2011
Radical SAM activation of the B12-independent glycerol dehydratase results in formation of 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine.
    Biochemistry, 2011, Feb-01, Volume: 50, Issue:4

    Topics: Catalysis; Deoxyadenosines; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Glycine; Hydro-Lyases; Methionine; Oxidation-Reduction; S-Adenosylmethionine; Thionucleosides; Vitamin B 12

2011
Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis.
    The Plant cell, 2011, Volume: 23, Issue:5

    Topics: Aldose-Ketose Isomerases; Alkenes; Arabidopsis; Arabidopsis Proteins; Azetidinecarboxylic Acid; Deoxyadenosines; Ethylenes; Gene Expression Regulation, Plant; Genes, Reporter; Methionine; Phloem; Phosphotransferases (Alcohol Group Acceptor); Phylogeny; Plant Growth Regulators; Plant Leaves; Plant Proteins; Plant Vascular Bundle; Plantago; Polyamines; RNA, Messenger; RNA, Plant; S-Adenosylmethionine; Thionucleosides; Transcriptome; Yeasts

2011
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
    Analytical chemistry, 2011, Jun-15, Volume: 83, Issue:12

    Topics: Azacitidine; Bacteria; Cytosine; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Assays; Humans; Kinetics; Light; Luciferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

2011
Identification of new ligands for the methionine biosynthesis transcriptional regulator (MetJ) by FAC-MS.
    Journal of molecular microbiology and biotechnology, 2012, Volume: 22, Issue:4

    Topics: Adenine; Bacterial Proteins; Binding Sites; Chromatography, Affinity; Cloning, Molecular; Deoxyadenosines; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Vectors; High-Throughput Screening Assays; Ligands; Methionine; Protein Binding; Repressor Proteins; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Thionucleosides; Time Factors; Transcription, Genetic

2012
A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
    Nature chemical biology, 2012, Volume: 8, Issue:11

    Topics: Deoxyadenosines; Magnetic Resonance Spectroscopy; Molecular Structure; Polyamines; Proteomics; Rhodospirillum rubrum; Ribulose-Bisphosphate Carboxylase; S-Adenosylmethionine; Terpenes; Thionucleosides; Transcriptome

2012
S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer.
    Molecular pharmacology, 2015, Volume: 87, Issue:1

    Topics: Animals; beta Catenin; Cell Line, Tumor; Colonic Neoplasms; Deoxyadenosines; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Neoplasms, Experimental; S-Adenosylmethionine; Signal Transduction; Thionucleosides

2015
Structural and biochemical insights into the 2'-O-methylation of pyrimidines 34 in tRNA.
    The FEBS journal, 2017, Volume: 284, Issue:14

    Topics: Amino Acid Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; Deoxyadenosines; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; Models, Molecular; Protein Conformation; Pyrimidines; RNA, Transfer, Leu; S-Adenosylmethionine; Substrate Specificity; Thermus thermophilus; Thionucleosides; tRNA Methyltransferases

2017
The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine.
    Cell death & disease, 2019, 03-11, Volume: 10, Issue:3

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caveolin 1; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Deoxyadenosines; Dioxygenases; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Prognosis; Promoter Regions, Genetic; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous

2019
A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products that is widespread in bacteria, including pathogenic Escherichia coli.
    Molecular microbiology, 2020, Volume: 113, Issue:5

    Topics: Bacterial Proteins; Carbon; Deoxyadenosines; Dihydroxyacetone Phosphate; Escherichia coli; Fructose-Bisphosphate Aldolase; Isomerases; Metabolic Networks and Pathways; Methionine; N-Glycosyl Hydrolases; Oxygen; Phosphorylases; Phosphotransferases; Rhodospirillum rubrum; S-Adenosylmethionine; Thionucleosides

2020
Williams-Beuren syndrome-related methyltransferase WBSCR27: cofactor binding and cleavage.
    The FEBS journal, 2020, Volume: 287, Issue:24

    Topics: Animals; Apoenzymes; Deoxyadenosines; Methyltransferases; Mice; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

2020
S-adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ovary cells.
    Biotechnology and bioengineering, 2020, Volume: 117, Issue:11

    Topics: Animals; Antibodies; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; Culture Media; Deoxyadenosines; Recombinant Proteins; S-Adenosylmethionine; Thionucleosides

2020
Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023, Volume: 1868, Issue:9

    Topics: Animals; Mammals; Oxidation-Reduction; Phosphatidylinositols; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine

2023