5'-methylthioadenosine has been researched along with adenosine in 168 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 134 (79.76) | 18.7374 |
1990's | 24 (14.29) | 18.2507 |
2000's | 4 (2.38) | 29.6817 |
2010's | 6 (3.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Daly, JW | 1 |
Almo, SC; Fedorov, AA; Fedorov, E; Hermann, JC; Marti-Arbona, R; Raushel, FM; Shoichet, BK | 1 |
Gäredal, M; Jacobsson, M; Karlén, A; Schultz, J | 1 |
Cummings, MR; Ferro, AJ; Law, RE; Sinibaldi, RM | 2 |
Ferro, AJ; Marchitto, K; Vandenbark, AA | 1 |
Murr, DP | 1 |
Edwards, CH; Edwards, GA; Freeburne, MM; Jones, EG; Seo, CW; Sherman, L; Stacey, RE; Wade, WD | 1 |
Hasegawa, S; Luo, JJ | 1 |
Daino, L; Feo, F; Lai, P; Pascale, R; Ruggiu, ME; Satta, G; Seddaiu, MA; Sequenza, MJ; Simile, MM; Vannini, MG | 1 |
Smalheiser, NR | 4 |
Carter, C; Clarke, S; Damore, MA; Law, RE; Stimmel, JB; Wall, R | 1 |
Inoue, H; Ishida, H; Kasahara, S; Nagata, T; Nishikawa, S; Ohishi, K; Wakano, Y; Yamauchi, N | 1 |
Haklai, R; Kloog, Y | 1 |
Gavagnin, M; La Colla, P; Marongiu, ME; Obino, P; Pani, A | 1 |
Akaoka, I; Fujimori, S; Kamatani, N; Kaneko, K; Kumakawa, T | 1 |
Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH | 1 |
Bernacki, RJ; Borchardt, RT; Kramer, DL; Lee, YH; Libby, PR; Miller, JT; Porter, CW; Spiess, AJ; Sufrin, JR | 1 |
Alecia, K; Bacchi, CJ; Garofalo, J; Hannan, T; Katz, L; Nathan, HC; Spiess, AJ; Sufrin, JR; Yarlett, N | 1 |
Jurewicz, TJ; Liteplo, RG | 1 |
Brackett, LE; Daly, JW | 2 |
Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J | 1 |
Liteplo, RG | 1 |
Akaoka, I; Fujii, H; Fujimori, S; Kamatani, N; Kanbayashi, T; Kaneko, K; Kumakawa, T; Miwa, S; Miyazawa, Y | 1 |
Altin, JG; Bradshaw, RA | 1 |
Dibner, JJ; Durley, RC; Ivey, FJ; Kostelc, JG | 1 |
Aswad, DW; Najbauer, J | 1 |
Kramer, DL; Libby, PR; Porter, CW; Spiess, AJ; Sufrin, JR | 1 |
Cacciapuoti, G; Cimino, G; Gavagnin, M; Porcelli, M; Sodano, G; Zappia, V | 2 |
Carson, DA; Kubota, M; Olavi, E; Wasson, DB; Willis, EH; Yamanaka, H | 1 |
Akedo, H; Horai, T; Inoue, H; Mukai, M; Nishikawa, S; Ohigashi, H; Shinkai, K; Takeda, Y | 1 |
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Puddu, M; Seddaiu, MA; Simile, MM | 1 |
Coward, JK; Pegg, AE; Poulin, R; Wechter, R; Woster, PM | 1 |
Chelsky, D; O'Neill, CL; Sobotka, C | 1 |
Heumann, R; Takahata, K; van Calker, D | 1 |
Alakuijala, L; Eloranta, TO; Lindqvist, L; Smith, TK | 1 |
Abeles, RH; Furfine, ES | 1 |
Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L | 1 |
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Ruggiu, ME; Vannini, MG | 1 |
Miyamoto, T; Nishida, Y; Suzuki, S | 3 |
Miyamoto, T; Nishida, Y; Takeuchi, A | 1 |
Carson, DA; Kajander, EO; Yamanaka, H | 1 |
Cartenì-Farina, M; Della Ragione, F; Gragnaniello, V; Schettino, MI; Zappia, V | 1 |
Koszalka, GW; Krenitsky, TA | 1 |
Carrera, CJ; Carson, DA; Chilcote, RR; Kubota, M; Willis, EH | 1 |
Emmerson, BT; Gordon, RB | 1 |
Blackwell, K; Emmerson, BT; Gordon, RB | 1 |
Carson, DA; Kubota, M; Yamanaka, H | 1 |
Krenitsky, TA; Miller, RL; Sabourin, CL | 1 |
Cannistra, AJ; Montgomery, JA; Parks, RE; Savarese, TM; Secrist, JA; Shortnacy, AT | 1 |
Bacchi, CJ; Ellenbogen, BB; Garofalo, J; Ghoda, LY; Katz, L; Northup, CH; Parks, RE; Savarese, TM | 1 |
Madhubala, R; Pegg, AE; Secrist, JA | 1 |
Chanarin, I; Deacon, R; Lumb, M; Perry, J | 4 |
Carrera, CJ; Carson, DA; Kajander, EO; Kubota, M; Nobori, T; Yamanaka, H | 1 |
Andreana, A; Della Ragione, F; Ruggiero, G; Russo, GL; Utili, R; Zappia, V | 1 |
Frost, P; Judde, JG | 1 |
Augé, J; Christa, L; Kersual, J; Pérignon, JL | 2 |
Baer, HP; Clanachan, AS; Munshi, R | 1 |
Della Ragione, F; Fioretti, A; Fioretti, M; Gragnaniello, V; Menna, LF; Oliva, A; Papparella, V; Zappia, V | 1 |
Ferro, AJ; Fitchen, JH; Olson, KD; Riscoe, MK; Schwamborn, J | 1 |
Li, SY; Stoeckler, JD | 1 |
Ehrenberg, L; Kláŝterská, I; Kolman, A; Näslund, M | 1 |
Schwartz, NB; Smalheiser, NR | 1 |
Cartier, PH; Christa, L; Kersual, J; Pérignon, JL | 1 |
Acheson, A; Huttner, WB; Thoenen, H; Vogl, W | 1 |
Kufe, DW; Shafman, TD; Sherman, ML; Spriggs, DR | 1 |
Goldblum, RM; Mills, GC; Schmalstieg, FC | 1 |
Ferro, AJ; Marchitto, KS | 1 |
Carson, DA; Iizasa, T | 1 |
Carson, DA; Kajander, EO; Kubota, M | 1 |
Mills, GC; Mills, JS | 1 |
Chan, VL; Ho, HJ | 1 |
Di Padova, C; Di Padova, F; Stramentinoli, G; Tritapepe, R | 1 |
Dainko, JL; Schlenk, F; Zydek-Cwick, CR | 1 |
Ferro, AJ; Riscoe, MK; Tower, PA | 1 |
Fredholm, BB; Jondal, M; Lanefelt, F; Ng, J | 1 |
Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM | 1 |
Law, RE; Miller, L | 2 |
Matsui, H; Yamamoto, C | 1 |
Ekström, P; Kanje, M | 1 |
Deeprose, RD; Duncan, GS; Schmitges, CJ; Wolberg, G; Zimmerman, TP | 1 |
Christa, L; Perignon, JL; Thuillier, L | 1 |
Arnaud, M; Dante, R; Niveleau, A | 1 |
Cooper, AJ | 1 |
Schlenk, F | 1 |
Ferro, AJ; Riscoe, MK; White, MW | 1 |
Boliska, SA; Bols, NC; Mosser, DD; Snyder, FF | 1 |
Della Ragione, F; Pegg, AE | 1 |
Dexter, DL; Parks, RE; Savarese, TM | 1 |
Dexter, DL; Ghoda, LY; Parks, RE; Savarese, TM | 1 |
Pajula, RL | 1 |
Christa, L; Munier, A; Perignon, JL; Thuillier, L | 1 |
Carrera, CJ; Carson, DA; Eddy, RL; Shows, TB | 1 |
Carson, DA; Frincke, LA; Kamatani, N; Kubota, M; Willis, EH | 1 |
Baglioni, C; de Ferra, F | 1 |
Carson, DA; Iizasa, T; Kubota, M | 1 |
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Geraci, G; Lancieri, M; Porcelli, M; Zappia, V | 1 |
Kufe, DW; Shafman, TD; Sherman, ML | 1 |
Akaoka, I; Fujimori, S; Kamatani, N; Kaneko, K | 1 |
Eloranta, TO; Kajander, EO | 1 |
Ferro, AJ; Fitchen, JH; Johnson, L; Riscoe, MK; Wolford, RW | 1 |
Carson, DA; Kamatani, N; Willis, EH | 1 |
Attadia, V; Cacciapuoti, G; Cartenì-Farina, M; Di Fiore, PP; Grieco, M; Pinto, A; Porcelli, M | 1 |
Pegg, AE | 1 |
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Galletti, P; Zappia, V | 1 |
Tisdale, MJ | 1 |
Helland, S; Schanche, JS; Schanche, T; Ueland, PM | 1 |
Abeles, RH; Dexter, DL; Ghoda, LY; Parks, RE; Savarese, TM; Trackman, PC | 1 |
Eloranta, T; Hyvönen, T; Raina, A; Samejima, K; Voutilainen, M; Yamanoha, B | 1 |
Seidenfeld, J; Williams-Ashman, HG; Wilson, J | 1 |
Carson, DA; Kamatani, N | 1 |
Chastain, B; Mahoney, L; Shugart, L | 1 |
Ferro, AJ; MacDonald, MR; Rogers, TJ; Wolford, RW; Zehfus, B | 1 |
Ferro, AJ; MacDonald, MR; Vandenbark, AA | 1 |
Barney, CL; Ferro, AJ; Vandenbark, AA; White, MW | 1 |
Galletti, P; Seidenfeld, J; Williams-Ashman, HG | 1 |
Fox, IH; Herring, C; Palella, TD; Thompson, D | 1 |
Cacciapuoti, G; Cartenì-Farina, M; della Ragione, F; Porcelli, M; Zappia, V | 3 |
Abeles, RH; Trackman, PC | 1 |
Toohey, JI | 2 |
Borchardt, RT; Huskey, WP; Schowen, RL; Wu, SE | 1 |
Chun, BG; Kim, S; Paik, WK | 1 |
Pajula, RL; Raina, A; Tuomi, K | 1 |
Eloranta, TO; Raina, AM; Tuomi, K | 1 |
Backlund, PS; Smith, RA | 2 |
Agarwal, KC; Parks, RE | 2 |
Schanche, JS; Schanche, T; Ueland, PM | 1 |
Agarwal, KC; Parks, RE; Russo, FX | 1 |
Hibasami, H; Ikeda, T | 1 |
Cone, MC; Ferro, AJ; Marchitto, K; Zehfus, B | 1 |
Guranowski, A; Paszewski, A | 1 |
Backlund, PS; Chang, CP; Smith, RA | 1 |
Schlenk, F; Shapiro, SK | 1 |
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Manna, C; Oliva, A | 1 |
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Giordano, F; Manna, C; Oliva, A | 1 |
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Porcelli, M | 1 |
Borchardt, RT; Coward, JK; Pegg, AE | 1 |
Barney, CL; Ferro, AJ; Vandenbark, AA | 1 |
Borchardt, RT; Chen, SY; Coward, JK; Hibasami, H; Pegg, AE | 1 |
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Porcelli, M; Ragosta, G | 1 |
Di Stefano, C; Liebich, HM; Schmid, HR; Wixforth, A | 1 |
Chen, ZH; Olopade, OI; Savarese, TM | 1 |
Bacchi, CJ; Goldberg, B; Gorrell, TE; Rattendi, D; Spiess, AJ; Sufrin, JR | 1 |
Clarke, S; Griffith, SC; Thapar, N; Yeates, TO | 1 |
Belardinelli, R; Dahlberg, AE; Demirci, H; Gregory, ST; Gualerzi, C; Jogl, G; Seri, E | 1 |
Basu, I; Belbin, TJ; Cassera, MB; Dong, X; Evans, GB; Guha, C; Hemeon, I; Locker, J; Merino, EF; Schramm, VL | 1 |
Liu, F; Ng, TB; Song, M; Zhang, YN; Zhao, L | 1 |
Bai, G; Liang, Q; Luo, G; Ma, J; Wang, Y; Ying, X | 1 |
Das, SR; Schneller, SW | 1 |
Namanja-Magliano, HA; Schramm, VL; Stratton, CF | 1 |
Abid, H; Barhoumi, M; Guizani, I; Harigua-Souiai, E; Mejri, T | 1 |
6 review(s) available for 5'-methylthioadenosine and adenosine
Article | Year |
---|---|
Adenosine receptors: targets for future drugs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1982 |
Methylthioadenosine (MeSAdo) phosphorylase deficiency in malignancy.
Topics: Adenosine; Animals; Deoxyadenosines; Humans; Neoplasms; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1988 |
Biochemistry of sulfur-containing amino acids.
Topics: Adenosine; Amino Acid Metabolism, Inborn Errors; Animals; Cysteine; Deoxyadenosines; Homocysteine; Humans; Methionine; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Structure-Activity Relationship; Sulfur; Sulfurtransferases; Thionucleosides; Thiosulfate Sulfurtransferase | 1983 |
Methylthioadenosine.
Topics: Adenosine; Animals; Biotin; Deoxyadenosines; Humans; Hydrolysis; Kinetics; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; T-Phages; Thionucleosides | 1983 |
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylase; Rats; Ribosemonophosphates; S-Adenosylmethionine; Spermidine; Spermine; Thioglycosides; Thionucleosides | 1982 |
[Inhibitors in polyamine biosynthesis (author's transl)].
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cattle; Deoxyadenosines; Mitoguazone; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides | 1981 |
162 other study(ies) available for 5'-methylthioadenosine and adenosine
Article | Year |
---|---|
Structure-based activity prediction for an enzyme of unknown function.
Topics: Adenine; Catalysis; Crystallography, X-Ray; Deamination; Deoxyadenosines; Enzymes; Homocysteine; Inosine; Models, Molecular; Nucleoside Deaminases; Protein Conformation; S-Adenosylhomocysteine; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; Thionucleosides | 2007 |
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.
Topics: Animals; Binding Sites; Databases, Factual; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 2-Ring; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium falciparum; Protein Binding; Quantitative Structure-Activity Relationship; Spermidine Synthase; Structure-Activity Relationship | 2008 |
Effect of 5'-methylthioadenosine on gene action during heat shock in Drosophila melanogaster.
Topics: Adenosine; Animals; Deoxyadenosines; Drosophila melanogaster; Hot Temperature; Kinetics; Salivary Glands; Thionucleosides; Transcription, Genetic; Uridine | 1979 |
The role of 5'-methylthioadenosine phosphorylase in 5'-methylthioadenosine-mediated inhibition of lymphocyte transformation.
Topics: Adenosine; Deoxyadenosines; Humans; Lymphocyte Activation; Pentosyltransferases; Phytohemagglutinins; Purine-Nucleoside Phosphorylase; Thionucleosides; Thymidine; Time Factors; Tubercidin | 1979 |
Methionine metabolism in apple tissue.
Topics: Adenosine; Deoxyadenosines; Ethylenes; Fruit; Methionine; Thionucleosides | 1977 |
Inhbition of RNA synthesis in salivary glands of Drosophila melanogaster by 5'-methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Dose-Response Relationship, Drug; Drosophila melanogaster; Kinetics; Larva; Salivary Glands; Thionucleosides; Transcription, Genetic; Uridine | 1976 |
Formation of methionine from alpha-amino-n-butyric acid and 5'-methylthioadenosine in the rat.
Topics: Adenosine; Aminobutyrates; Animals; Body Weight; Butyrates; Choline; Cysteine; Deoxyadenosines; Homoserine; Male; Methionine; Rats; S-Adenosylmethionine; Thionucleosides | 1977 |
Chick sympathetic neurons in culture respond differentially to nerve growth factor and conditioned medium from activated splenic lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Cell Survival; Cells, Cultured; Chickens; Culture Media; Deoxyadenosines; Ganglia, Sympathetic; Isoquinolines; Kinetics; Lymphocyte Activation; Lymphocytes; Nerve Growth Factors; Neurons; Piperazines; Proadifen; Protein Kinase Inhibitors; Spleen; Thioguanine; Thionucleosides | 1991 |
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1991 |
Cell attachment and neurite stability in NG108-15 cells: what is the role of microtubules?
Topics: Adenosine; Alkaloids; Axons; Cell Adhesion; Cell Line; Deoxyadenosines; Hybrid Cells; Immunohistochemistry; Microtubules; Nerve Tissue; Neurons; Nocodazole; Paclitaxel; Staining and Labeling; Thionucleosides; Trypsin; Tubulin | 1991 |
Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions.
Topics: Adenosine; B-Lymphocytes; Clone Cells; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunoglobulin kappa-Chains; Lipopolysaccharides; Lovastatin; Membrane Proteins; Methylation; NF-kappa B; Protein Biosynthesis; Signal Transduction; Thionucleosides; Transcriptional Activation | 1992 |
The role of 5'-methylthioadenosine on rat calvaria cell differentiation.
Topics: Adenine; Adenosine; Alkaline Phosphatase; Animals; Bone and Bones; Cell Differentiation; Cell Division; Cells, Cultured; Deoxyadenosines; Kinetics; Osteopontin; Purine-Nucleoside Phosphorylase; Rats; Sialoglycoproteins; Thionucleosides | 1992 |
Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.
Topics: Adenosine; Animals; Deoxyadenosines; Dimethyl Sulfoxide; GTP-Binding Proteins; Guanosine Triphosphate; Lovastatin; Membrane Proteins; Methylation; Mevalonic Acid; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Protein Processing, Post-Translational; Thionucleosides; Tumor Cells, Cultured | 1991 |
Antimicrobial and antiviral activity of xylosyl-methylthio-adenosine, a naturally occurring analogue of methylthio-adenosine from Doris verrucosa.
Topics: Adenosine; Animals; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Cell Survival; Cells, Cultured; Deoxyadenosines; Mollusca; Thionucleosides | 1991 |
Disturbance in the metabolism of 5'-methylthioadenosine and adenine in patients with neoplastic diseases, and in those with a deficiency in adenine phosphoribosyltransferase.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine; Adult; Aged; Deoxyadenosines; Female; Humans; Leukemia; Male; Middle Aged; Neoplasms; Osmolar Concentration; Thionucleosides | 1991 |
Role of 5'-deoxy-5'-methylthioadenosine in growth of several microbial B12 requirers.
Topics: Adenosine; Animals; Bacteria; Cell Division; Deoxyadenosines; Escherichia coli; Euglena gracilis; Eukaryota; Lactobacillus; Thionucleosides; Vitamin B 12 | 1991 |
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Humans; Hydrolases; Leukemia L1210; Leukemia, Experimental; Liver; Mice; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides; Tumor Cells, Cultured | 1991 |
5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides.
Topics: Adenosine; Animals; Deoxyadenosines; Methionine; Mice; Purine-Nucleoside Phosphorylase; Rats; Thionucleosides; Trypanocidal Agents; Trypanosoma brucei brucei | 1991 |
Serum has a differential effect on DNA replication in a human melanoma cell line cultured in methionine or 5'-deoxy-5'-methylthioadenosine.
Topics: Adenosine; Blood; Culture Media; Deoxyadenosines; DNA Replication; Humans; Melanoma; Methionine; Thionucleosides; Transferrin; Tumor Cells, Cultured | 1991 |
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms.
Topics: Adenosine; Animals; Carbachol; Deoxyadenosines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Receptors, Purinergic; Theophylline; Thionucleosides; Trachea; Xanthine; Xanthines | 1991 |
Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Bone Marrow; Carbon; Deoxyadenosines; Folic Acid; Formates; Glycine; Guanine; Male; Methionine; Methionine Adenosyltransferase; Oxidation-Reduction; Rats; Rats, Inbred Strains; Serine; Thionucleosides | 1990 |
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured | 1990 |
Measurement of 5'-methylthioadenosine in patients with neoplasms.
Topics: Adenosine; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Humans; Male; Middle Aged; Neoplasms; Remission Induction; Thionucleosides | 1990 |
Cell attachment and neurite stability in NG108-15 cells: effects of 5'-deoxy, 5'-methyl thioadenosine (MTA) compared with laminin, kinase inhibitor H-7, and Mn2+ ions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Cell Adhesion; Cells, Cultured; Dendrites; Deoxyadenosines; Isoquinolines; Laminin; Manganese; Nerve Growth Factors; Neurons; Piperazines; Thionucleosides | 1990 |
Production of 1,2-diacylglycerol in PC12 cells by nerve growth factor and basic fibroblast growth factor.
Topics: Acids; Adenosine; Adrenal Gland Neoplasms; Animals; Arsenicals; Calcium; Carbachol; Culture Media; Deoxyadenosines; Diglycerides; Extracellular Space; Fibroblast Growth Factors; Glycerides; Inositol Phosphates; Nerve Growth Factors; Pheochromocytoma; Potassium; Thionucleosides; Tumor Cells, Cultured | 1990 |
2-Hydroxy-4-(methylthio) butanoic acid is a naturally occurring methionine precursor in the chick.
Topics: Adenosine; Animals; Chickens; Deoxyadenosines; Gas Chromatography-Mass Spectrometry; Kinetics; Liver; Male; Methionine; Thionucleosides | 1990 |
Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Deoxyadenosines; Electrophoresis, Gel, Two-Dimensional; Methylation; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Pheochromocytoma; Rats; S-Adenosylmethionine; Thionucleosides; Tubercidin; Tumor Cells, Cultured | 1990 |
Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine.
Topics: Adenosine; Animals; Biogenic Polyamines; Cell Division; Deoxyadenosines; Leukemia, Experimental; Mice; Purine-Nucleoside Phosphorylase; Thionucleosides; Tumor Cells, Cultured | 1989 |
Biosynthesis and metabolism of 9-[5'-deoxy-5'-(methylthio)-beta-D-xylofuranosyl]adenine, a novel natural analogue of methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Mollusca; Polyamines; Purine-Nucleoside Phosphorylase; Thionucleosides | 1989 |
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells.
Topics: Adenosine; Animals; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Mice, Mutant Strains; Pentosyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured | 1989 |
Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Deoxyadenosines; Fibrosarcoma; Humans; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Melanoma, Experimental; Methylation; Neoplasm Invasiveness; Rats; Rats, Inbred Strains; Thionucleosides; Tumor Cells, Cultured | 1989 |
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Phagocytosis; Phenobarbital; Phenotype; Precancerous Conditions; Proto-Oncogenes; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1989 |
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line, Transformed; Deoxyadenosines; Dose-Response Relationship, Drug; Fibroblasts; Leukemia L1210; Mice; Polyamines; S-Adenosylmethionine; Spermine Synthase; Thionucleosides; Transferases; Tumor Cells, Cultured | 1989 |
Lamin B methylation and assembly into the nuclear envelope.
Topics: Adenosine; Animals; Benzimidazoles; Cell Cycle; Cell Line; Chromatin; Cricetinae; Deoxyadenosines; Isoelectric Point; Lamin Type B; Lamins; Methylation; Morphogenesis; Nocodazole; Nuclear Envelope; Nuclear Proteins; Phosphorylation; Thionucleosides | 1989 |
Nerve growth factor potentiates the hormone-stimulated intracellular accumulation of inositol phosphates and Ca2+ in rat PC12 pheochromocytoma cells: comparison with the effect of epidermal growth factor.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Bradykinin; Calcium; Cell Line; Deoxyadenosines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Inositol Phosphates; Male; Mice; Nerve Growth Factors; Pheochromocytoma; Sugar Phosphates; Thionucleosides | 1989 |
Effects of dietary polyamine precursors on the metabolism and tissue concentrations of amino acids in the rat.
Topics: Adenosine; Amino Acids; Animals; Arginine; Biogenic Polyamines; Deoxyadenosines; Diet; Liver; Male; Methionine; Muscles; Ornithine; Rats; Rats, Inbred Strains; RNA, Transfer, Amino Acid-Specific; S-Adenosylmethionine; Thionucleosides | 1989 |
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae.
Topics: Adenosine; Aldose-Ketose Isomerases; Animals; Carbohydrate Epimerases; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Formates; Klebsiella pneumoniae; Liver; Magnetic Resonance Spectroscopy; Methionine; Organophosphorus Compounds; Oxidation-Reduction; Periodic Acid; Rats; Ribosemonophosphates; Thioglycosides; Thionucleosides | 1988 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1987 |
Morphologic plasticity of rapid-onset neurites in NG108-15 cells stimulated by substratum-bound laminin.
Topics: Adenosine; Animals; Cell Differentiation; Cells, Cultured; Cytochalasin B; Dendrites; Deoxyadenosines; Glioma; Laminin; Neuroblastoma; Thionucleosides; Time Factors; Tumor Cells, Cultured | 1989 |
Altered cell shapes in fibroblasts treated with 5'-deoxy-5'-methylthioadenosine: relation to morphogenesis of neural cells.
Topics: Adenosine; Animals; Cell Differentiation; Cells, Cultured; Deoxyadenosines; Fibroblasts; Humans; Mice; Thionucleosides | 1989 |
Pharmacological action of 5'-methylthioadenosine on isolated rabbit aorta strips.
Topics: Adenosine; Animals; Aorta, Thoracic; Deoxyadenosines; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Receptors, Cell Surface; Receptors, Purinergic; Thionucleosides | 1985 |
Modulation of polymorphonuclear leukocyte function by adenosine analogues.
Topics: Adenosine; Chemotaxis, Leukocyte; Deoxyadenosines; Dideoxyadenosine; Humans; Kinetics; Neutrophils; Phagocytosis; Phenylisopropyladenosine; Reference Values; Superoxides; Thionucleosides | 1986 |
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
Topics: Adenosine; Adenosine Diphosphate Ribose; Animals; Cell Line; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides | 1986 |
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta.
Topics: Adenosine; Deoxyadenosines; Hot Temperature; Humans; Isoelectric Point; Kinetics; Macromolecular Substances; Molecular Weight; Pentosyltransferases; Phosphates; Placenta; Purine-Nucleoside Phosphorylase; Thionucleosides | 1986 |
5'-Methylthioadenosine (MTA) phosphorylase from promastigotes of Leishmania donovani.
Topics: Adenosine; Animals; Deoxyadenosines; Kinetics; Leishmania donovani; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thermodynamics; Thionucleosides | 1986 |
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects.
Topics: Adenosine; Animals; Chromosome Mapping; Deoxyadenosines; Humans; Leukemia, Lymphoid; Mice; Neoplasm Transplantation; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1986 |
Inhibition of de novo purine synthesis by methylthioadenosine.
Topics: Adenosine; Cell Line; Deoxyadenosines; Humans; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; Thionucleosides | 1986 |
Synthesis of purines in human lymphoblast cells deficient in methylthioadenosine phosphorylase activity.
Topics: Adenine; Adenosine; B-Lymphocytes; Cell Line; Deoxyadenosines; Humans; Kinetics; Leukemia, Lymphoid; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; T-Lymphocytes; Thionucleosides | 1987 |
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Synergism; Eflornithine; Kinetics; Lymphoma; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides | 1987 |
Trypanosoma cruzi adenine nucleoside phosphorylase. Purification and substrate specificity.
Topics: Adenine; Adenosine; Animals; Deoxyadenosines; Kinetics; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thionucleosides; Trypanosoma cruzi | 1987 |
5'-deoxy-5'-methylthioadenosine phosphorylase--IV. Biological activity of 2-fluoroadenine-substituted 5'-deoxy-5'-methylthioadenosine analogs.
Topics: Adenine Phosphoribosyltransferase; Adenosine; Cell Line; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Humans; Leukemia, Myeloid, Acute; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides | 1987 |
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells.
Topics: Adenosine; Animals; Deoxyadenosines; Mice; N-Glycosyl Hydrolases; Neoplasm Proteins; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; Sarcoma 180; Species Specificity; Substrate Specificity; Thionucleosides; Trypanosoma brucei brucei | 1988 |
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Drug Resistance; Eflornithine; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured | 1988 |
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
Topics: Adenosine; Animals; Betaine; Carbon Dioxide; Deoxyadenosines; Formyltetrahydrofolates; Glycine; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thionucleosides; Time Factors | 1988 |
Studies on human serum 5'-deoxy-5'-methylthioadenosine phosphorylase: molecular properties and clinical perspectives.
Topics: Adenosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chromatography, Ion Exchange; Deoxyadenosines; Dialysis; Dithiothreitol; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Rats; Rats, Inbred Strains; Thionucleosides | 1988 |
Patterns of methionine auxotrophy in normal and neoplastic cells: the methionine independence of lymphocyte mitogenesis and low frequency of the methionine-dependent phenotype in human tumors.
Topics: Adenosine; Animals; Culture Media; Deoxyadenosines; Humans; Lymphocyte Activation; Methionine; Mice; Neoplasms; Phenotype; Thionucleosides; Tumor Cells, Cultured | 1988 |
Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.
Topics: Adenosine; Cell Division; Cell Line; Deoxyadenosines; Humans; Intracellular Fluid; Methionine; Methionine Adenosyltransferase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured | 1988 |
Characterization and biogenesis of 5'-methylthioxylofuranosyl adenine, a new natural analog of 5'-methylthioadenosine.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Mollusca; Thionucleosides | 1988 |
5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Cerebellum; Deoxyadenosines; In Vitro Techniques; Jejunum; Mice; Muscle Contraction; Neuroblastoma; Rabbits; Rats; Receptors, Purinergic; Thioinosine; Thionucleosides | 1988 |
Chromatographic and radioimmunological methods for the determination of 5'-deoxy-5'-methylthioadenosine in biological fluids.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Hemocyanins; Humans; Male; Rabbits; Radioimmunoassay; Thionucleosides | 1988 |
Inhibition of growth but not differentiation of normal and leukemic myeloid cells by methylthioadenosine.
Topics: Adenosine; Cell Differentiation; Cell Division; Cell Line; Colony-Forming Units Assay; Deoxyadenosines; Granulocytes; Humans; Leukemia, Myeloid, Acute; Macrophages; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Thionucleosides | 1987 |
Influx of 5'-deoxy-5'-methylthioadenosine into HL-60 human leukemia cells and erythrocytes.
Topics: Adenosine; Biological Transport; Cell Line; Deoxyadenosines; Erythrocytes; Humans; Kinetics; Leukemia, Myeloid, Acute; Thionucleosides; Vasodilator Agents | 1987 |
Mutagenic and comutagenic action of 5'-deoxy-5'-(methylthio)adenosine.
Topics: Adenosine; Animals; Cell Line; Cricetinae; Cricetulus; Deoxyadenosines; Escherichia coli; Female; Hypoxanthine Phosphoribosyltransferase; Kidney; Mutagenicity Tests; Mutagens; Mutation; Ovary; Sister Chromatid Exchange; Thionucleosides | 1986 |
Kinetic analysis of 'rapid onset' neurite formation in NG108-15 cells reveals a dual role for substratum-bound laminin.
Topics: Adenosine; Cell Differentiation; Cell Line; Colforsin; Cycloheximide; Deoxyadenosines; Laminin; Neurons; Tetradecanoylphorbol Acetate; Thionucleosides | 1987 |
Actions of 5'-methylthioadenosine in isolated guinea pig tracheal rings.
Topics: Adenosine; Animals; Deoxyadenosines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, Purinergic; SRS-A; Thionucleosides; Trachea | 1986 |
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Propranolol; Receptors, Purinergic; SRS-A; Tetrodotoxin; Theophylline; Thionucleosides | 1986 |
Metabolism of 5'-methylthioadenosine in methionine-dependent and methionine-independent cells.
Topics: Adenosine; Cell Cycle; Cell Line; Deoxyadenosines; Humans; Methionine; Tetrahydrofolates; Thionucleosides | 1986 |
Methyltransferase inhibitors block NGF-regulated survival and protein phosphorylation in sympathetic neurons.
Topics: Adenosine; Animals; Cell Survival; Chick Embryo; Deoxyadenosines; Ganglia, Sympathetic; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phosphorylation; Potassium; Protein Methyltransferases; Thionucleosides | 1986 |
Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Differentiation; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; DNA; Leukemia, Erythroblastic, Acute; Methylation; Mice; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin | 1985 |
Urinary purines and nucleosides in immune deficiencies.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adult; Child; Deoxyadenosines; Female; Humans; Immunologic Deficiency Syndromes; Inosine; Purine Nucleosides; Purines; Pyrimidine Nucleosides; Pyrimidines; S-Adenosylhomocysteine; Thionucleosides | 1985 |
The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae.
Topics: Adenosine; Chromatography, Paper; Deoxyadenosines; Methionine; Ribosemonophosphates; Saccharomyces cerevisiae; Thioglycosides; Thionucleosides | 1985 |
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; Homocysteine; Humans; Kinetics; Methylation; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides | 1985 |
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Deoxyadenosines; Eflornithine; Lymphoma; Mice; Ornithine; Ornithine Decarboxylase; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Thionucleosides | 1985 |
Salvage of 5'-deoxy-5'-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium: a study of "methionine-dependence".
Topics: Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Homocysteine; Humans; Methionine; Thionucleosides | 1986 |
Urinary excretion of methylthioadenosine in immunodeficient children.
Topics: Adenosine; Adult; Child; Chromatography, Ion Exchange; Creatinine; Deoxyadenosines; Humans; Immunologic Deficiency Syndromes; Spectrometry, Fluorescence; Thionucleosides | 1985 |
Multiple mechanisms of adenosine toxicity in an adenosine sensitive mutant of baby hamster kidney (BHK) cells.
Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cytidine Triphosphate; Deoxyadenosines; Drug Resistance; Guanosine Triphosphate; Kidney; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Uridine Triphosphate; Vidarabine | 1985 |
Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.
Topics: Acyltransferases; Adenosine; Animals; Deoxyadenosines; Hydroxymethyl and Formyl Transferases; In Vitro Techniques; Liver; Male; Methionine; Nitrous Oxide; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Purines; Rats; Rats, Inbred Strains; Thionucleosides; Vitamin B 12 | 1985 |
Inhibition of lymphocyte function by a naturally occurring nucleoside: 5'-methylthioadenosine (MTA).
Topics: Adenosine; Antibody Formation; Cell Differentiation; Cells, Cultured; Deoxyadenosines; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Thionucleosides | 1985 |
Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.
Topics: Acyltransferases; Adenosine; Anemia, Megaloblastic; Animals; Bone Marrow; Deoxyadenosines; Humans; Hydroxymethyl and Formyl Transferases; Liver; Male; Methionine; Nitrous Oxide; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Purines; Rats; Rats, Inbred Strains; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
5'-Methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast.
Topics: Adenine; Adenosine; Aerobiosis; Candida; Carbon Radioisotopes; Deoxyadenosines; Methionine; Optical Rotation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Sulfides; Sulfur Radioisotopes; Thionucleosides; Time Factors | 1973 |
Mechanism of action of 5'-methylthioadenosine in S49 cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Deoxyadenosines; Lymphoma; Mice; Mutation; Protein Kinases; Thionucleosides | 1984 |
Effect of 5'-methylthioadenosine, 3-deazaadenosine, and related compounds on human natural killer cell activity. Relation to cyclic AMP and methylation potential.
Topics: Adenosine; Cyclic AMP; Cytotoxicity, Immunologic; Deoxyadenosines; Humans; Killer Cells, Natural; Lymphocytes; Methylation; Ribonucleosides; Thionucleosides; Tubercidin | 1984 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin | 1983 |
Effect of 5'-methylthioadenosine on RNA and DNA synthesis in cultured Xenopus laevis cells.
Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Deoxyadenosines; DNA; Poly A; RNA; RNA Polymerase I; RNA Polymerase II; RNA, Messenger; Thionucleosides; Transcription, Genetic; Xenopus laevis | 1983 |
The possible involvement of adenylate cyclase inhibition in the field potential suppression through alpha-2 adrenergic receptors in the bed nucleus of the stria terminalis.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Bucladesine; Deoxyadenosines; Diencephalon; Drug Interactions; Electrophysiology; Guinea Pigs; Norepinephrine; Receptors, Adrenergic, alpha; Thionucleosides | 1984 |
Inhibition of fast axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Axonal Transport; Cycloleucine; Deoxyadenosines; Rana esculenta; Rana temporaria; Sciatic Nerve; Thionucleosides | 1984 |
Inhibition of lymphocyte cyclic AMP phosphodiesterase and lymphocyte function by 5'-methylthioadenosine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Deoxyadenosines; In Vitro Techniques; Lymphocytes; Mice; Spleen; Thionucleosides | 1982 |
5'-Deoxy-5'-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase: correlation with inhibition of Con A induced proliferation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cell Division; Concanavalin A; Cyclic AMP; Deoxyadenosines; Dose-Response Relationship, Drug; In Vitro Techniques; Phosphodiesterase Inhibitors; Rats; T-Lymphocytes; Thionucleosides | 1983 |
Effects of 5'deoxy-5'-methylthioadenosine on the metabolism of S-adenosyl methionine.
Topics: Adenosine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferases; Kidney; Kinetics; Rats; S-Adenosylmethionine; Sulfur Radioisotopes; Thionucleosides | 1983 |
The comparative effects of 5'-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5'-methylthioadenosine phosphorylase.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Leukemia L1210; Mice; Mice, Inbred AKR; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1983 |
The transfer of 5'-methylthioadenosine from B82 cells through the medium to CHW-1102 cells.
Topics: Adenine; Adenosine; Animals; Cell Communication; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Mitoguazone; Purine-Nucleoside Phosphorylase; Thionucleosides | 1983 |
Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Deoxyadenosines; Formycins; Homocysteine; Hydrolases; Purine-Nucleoside Phosphorylase; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides | 1983 |
5'-deoxy-5'-methylthioadenosine phosphorylase--II. Role of the enzyme in the metabolism and antineoplastic action of adenine-substituted analogs of 5'-deoxy-5'-methylthioadenosine.
Topics: Adenosine; Antineoplastic Agents; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Colonic Neoplasms; Deoxyadenosines; Humans; Leukemia; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thionucleosides | 1983 |
Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
Topics: Adenosine; Cells, Cultured; Deoxyadenosines; Humans; Inosine; Leukemia; Leukemia, Myeloid, Acute; Methionine; Methylthioinosine; Purine-Nucleoside Phosphorylase; T-Lymphocytes; Thionucleosides | 1983 |
Kinetic properties of spermine synthase from bovine brain.
Topics: Adenosine; Animals; Brain; Cattle; Deoxyadenosines; Kinetics; Placenta; Purine-Nucleoside Phosphorylase; Serum Albumin, Bovine; Spermidine; Spermine; Spermine Synthase; Thionucleosides; Transferases | 1983 |
Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation.
Topics: Adenosine; Azaserine; Cell Cycle; Cell Line; Concanavalin A; Deoxyadenosines; Humans; Lymphocytes; Methionine; Purine-Nucleoside Phosphorylase; Purines; Thionucleosides | 1984 |
Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization.
Topics: Adenosine; Animals; Chromosome Mapping; Chromosomes, Human, 6-12 and X; Deoxyadenosines; Humans; Hybrid Cells; Isoelectric Point; Isoenzymes; Mice; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1984 |
5'-Methylthioadenosine is the major source of adenine in human cells.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine; Cell Line; Cells, Cultured; Deoxyadenosines; Humans; Leukemia, Lymphoid; Purine-Nucleoside Phosphorylase; Thionucleosides | 1984 |
Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon.
Topics: Adenosine; Adenosylhomocysteinase; Burkitt Lymphoma; Cell Division; Cell Line; Deoxyadenosines; HeLa Cells; Humans; Hydrolases; Interferon Type I; Kinetics; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1984 |
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Biological Transport; Cell Division; Cell Line; Deoxyadenosines; Dipyridamole; Humans; Lymphocytes; Lymphoma; Nucleoside Deaminases; Purine-Nucleoside Phosphorylase; Thioinosine; Thionucleosides | 1984 |
Studies on the metabolic effects of methylthioformycin.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Brain; Cell Division; Cell Membrane Permeability; Deoxyadenosines; Erythrocytes; Formycins; Friend murine leukemia virus; Humans; Hydrolases; Leukemia, Erythroblastic, Acute; Liver; Purine-Nucleoside Phosphorylase; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides | 1984 |
Effect of 5'-methylthioadenosine on induction of murine erythroleukemia cell differentiation.
Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; Kinetics; Leukemia, Experimental; Mice; Putrescine; Spermidine; Spermine; Thionucleosides | 1984 |
5'-Methylthioadenosine in urine from normal subjects and cancer patients.
Topics: Adenosine; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Neoplasms; Thionucleosides | 1984 |
Catabolism and lability of S-adenosyl-L-methionine in rat liver extracts.
Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Female; In Vitro Techniques; Liver; Proteins; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides | 1984 |
Effect of 5'-methylthioadenosine (a naturally occurring nucleoside) on murine hematopoiesis.
Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Deoxyadenosines; Female; Hematopoiesis; Hematopoietic Stem Cells; Kinetics; Mice; Mice, Inbred BALB C; Thionucleosides | 1984 |
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Humans; Inosine; Leukemia L1210; Methionine; Methylthioinosine; Mice; Thionucleosides | 1983 |
Inhibition of dimethyl sulfoxide-induced differentiation of Friend erythroleukemic cells by 5'-methylthioadenosine.
Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Clone Cells; Deoxyadenosines; Dimethyl Sulfoxide; Globins; Heme; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myeloid, Acute; Mice; RNA, Messenger; Thionucleosides | 1984 |
Inhibition of aminopropyltransferases.
Topics: Adenosine; Animals; Cattle; Deoxyadenosines; In Vitro Techniques; Male; Polyamines; Rats; S-Adenosylmethionine; Spermidine Synthase; Thionucleosides; Transferases | 1983 |
High-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1983 |
Methionine synthesis from 5'-methylthioadenosine by tumour cells.
Topics: Adenosine; Animals; Carbon Radioisotopes; Cell Line; Cells, Cultured; Deoxyadenosines; Humans; Kinetics; Leukemia; Methionine; Mice; Neoplasms; Thionucleosides; Urinary Bladder Neoplasms | 1983 |
A simple and sensitive liquid chromatographic method for the determination of 5'-methylthioadenosine in tissues.
Topics: 2-Chloroadenosine; Adenosine; Animals; Chromatography, Ion Exchange; Chromatography, Liquid; Deoxyadenosines; Rats; Thionucleosides; Tissue Distribution | 1983 |
Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma.
Topics: Adenosine; Animals; Cell Line; Colonic Neoplasms; Deoxyadenosines; Humans; Liver; Methionine; Rats; Ribosemonophosphates; Ribulosephosphates; Thioglycosides; Thionucleosides | 1984 |
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain.
Topics: Adenosine; Animals; Brain; Cattle; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Putrescine; S-Adenosylmethionine; Spermidine; Spermidine Synthase; Thionucleosides; Transferases | 1984 |
Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate.
Topics: Adenosine; Androgens; Animals; Castration; Deoxyadenosines; Male; Ornithine Decarboxylase; Pentosyltransferases; Polyamines; Prostate; Purine-Nucleoside Phosphorylase; Rats; Testosterone; Thionucleosides | 1980 |
Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines.
Topics: Adenosine; Cell Line; Deoxyadenosines; Humans; Leukemia; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides | 1980 |
Kinetic studies of Drosophila melanogaster methylthioadenosine nucleoside phosphorylase.
Topics: Adenosine; Animals; Deoxyadenosines; Drosophila melanogaster; Kinetics; Pentosyltransferases; Phosphates; Purine-Nucleoside Phosphorylase; Ribosemonophosphates; Thioglycosides; Thionucleosides | 1981 |
Effect of 5''-methylthioadenosine and its analogs on murine lymphoid cell proliferation.
Topics: Adenosine; Animals; Cell Division; Cell Line; Cell Survival; Deoxyadenosines; Dose-Response Relationship, Drug; Lymphocytes; Mice; Purine-Nucleoside Phosphorylase; Thionucleosides; Tubercidin | 1981 |
Inactivation of S-adenosylhomocysteine hydrolase by 5'-deoxy-5'-methylthioadenosine.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Deoxyadenosines; Erythrocytes; Humans; Hydrolases; In Vitro Techniques; Ribose; Thioglycosides; Thionucleosides | 1981 |
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation.
Topics: Adenosine; Deoxyadenosines; Humans; In Vitro Techniques; Lymphocyte Activation; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Substrate Specificity; Thionucleosides | 1982 |
Adenosine metabolism: modification by S-adenosylhomocysteine and 5'-methylthioadenosine.
Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; B-Lymphocytes; Cells, Cultured; Deoxyadenosines; Erythrocytes; Homocysteine; Humans; Hydrolases; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides | 1982 |
Transport and metabolism of 5'-methylthioadenosine in human erythrocytes.
Topics: Adenosine; Biological Transport; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Ribonucleosides; Thionucleosides | 1983 |
Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose.
Topics: Adenosine; Animals; Chromatography, Thin Layer; Deoxyadenosines; Liver; Male; Methionine; Oxygen Consumption; Pentosephosphates; Phosphorylation; Rats; Rats, Inbred Strains; Ribosemonophosphates; Ribulosephosphates; Thioglycosides; Thionucleosides | 1983 |
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Topics: Adenosine; Animals; Deoxyadenosines; Folic Acid; Formyltetrahydrofolates; Liver; Male; Methionine; Nitrous Oxide; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency | 1983 |
Ketomethylthiobutyric acid formation from methylthioadenosine: a diffusion assay.
Topics: Adenosine; Animals; Cell Line; Cells, Cultured; Cysteine; Deoxyadenosines; Diffusion; Methionine; Mice; Neoplasms, Experimental; Sulfhydryl Compounds; Thionucleosides | 1983 |
Chiral instability at sulfur of S-adenosylmethionine.
Topics: Adenosine; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Homoserine; Kinetics; Molecular Conformation; S-Adenosylmethionine; Sulfur; Thionucleosides | 1983 |
Simple separation of adenine and adenosyl-sulfur compounds by high-performance liquid chromatography.
Topics: Adenine; Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1983 |
Inhibition of the synthesis of polyamines and macromolecules by 5'-methylthioadenosine and 5'-alkylthiotubercidins in BHK21 cells.
Topics: Adenosine; Animals; Cell Line; Cricetinae; Deoxyadenosines; Depression, Chemical; Kidney; Polyamines; Protein Biosynthesis; Ribonucleosides; Spermidine Synthase; Thionucleosides; Tubercidin | 1982 |
Uptake and utilization of 5'-methylthioadenosine by cultured baby-hamster kidney cells.
Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Deoxyadenosines; Kidney; Thionucleosides; Tubercidin | 1982 |
5'-Methylthioadenosine metabolism and methionine synthesis in mammalian cells grown in culture.
Topics: Adenosine; Animals; Breast; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; HeLa Cells; Humans; Leukemia L1210; Leukemia, Myeloid; Methionine; Mice; Spleen; Thionucleosides | 1982 |
5'-Methylthioadenosine and 2',5'-dideoxyadenosine blockade of the inhibitory effects of adenosine on ADP-induced platelet aggregation by different mechanisms.
Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclases; Blood Platelets; Deoxyadenosines; Dideoxyadenosine; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Thionucleosides | 1980 |
Effect of 5'-deoxy-5'-S-isobutyl-thioadenosine (SIBA) on the disposition of 5'-methylthioadenosine by isolated rat hepatocytes.
Topics: Adenosine; Animals; Antineoplastic Agents; Biological Transport; Chromatography, High Pressure Liquid; Deoxyadenosines; In Vitro Techniques; Kinetics; Liver; Rats; Thionucleosides | 1982 |
Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).
Topics: Adenosine; Adenosine Diphosphate; Animals; Deoxyadenosines; Depression, Chemical; Dideoxyadenosine; Fungi; Humans; Plant Extracts; Platelet Aggregation; Rats; Rats, Inbred Strains; Thionucleosides | 1982 |
Synergistic inhibition of platelet aggregation by forskolin plus PGE1 or 2-fluoroadenosine: effects of 2',5'-dideoxyadenosine and 5'-methylthioadenosine.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Alprostadil; Colforsin; Deoxyadenosines; Dideoxyadenosine; Diterpenes; Drug Synergism; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Thionucleosides | 1982 |
Methionine synthesis from 5'-methylthioadenosine in rat liver.
Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Female; Kinetics; Liver; Methionine; Radioisotope Dilution Technique; Rats; Sulfur Radioisotopes; Thionucleosides; Tritium | 1981 |
High-performance liquid chromatographic analysis of 5'-methylthioadenosine in rat tissues.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Thionucleosides; Tissue Distribution | 1981 |
Utilization by Saccharomyces cerevisiae of 5'-methylthioadenosine as a source of both purine and methionine.
Topics: Adenosine; Deoxyadenosines; Genotype; Methionine; Mutation; Purine Nucleosides; Saccharomyces cerevisiae; Species Specificity; Thionucleosides | 1982 |
Metabolism of 5'-methylthioadenosine in Aspergillus nidulans. An alternative pathway for methionine synthesis via utilization of the nucleoside methylthio group.
Topics: Adenosine; Aspergillus nidulans; Deoxyadenosines; Methionine; Mutation; Species Specificity; Thionucleosides | 1982 |
Identification of 2-keto-4-methylthiobutyrate as an intermediate compound in methionine synthesis from 5'-methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Kinetics; Liver; Magnesium; Methionine; Rats; Thionucleosides | 1982 |
Methylthioadenosine metabolism in malignant murine cells.
Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Leukemia L5178; Leukemia, Experimental; Mass Spectrometry; Mice; Mice, Inbred DBA; Sulfur Radioisotopes; Thionucleosides | 1982 |
Conversion of 5'-methylthioadenosine into S-adenosylmethionine by yeast cells.
Topics: Adenosine; Amino Acids; Candida; Cells, Cultured; Culture Media; Deoxyadenosines; S-Adenosylmethionine; Thionucleosides | 1980 |
Effect of 5'-methylthioadenosine on in vivo methyl esterification of human erythrocyte membrane proteins.
Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein Methyltransferases; Protein O-Methyltransferase; Thionucleosides | 1981 |
[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].
Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein O-Methyltransferase; S-Adenosylmethionine; Thionucleosides | 1981 |
[New method of synthesis of structural analogs of 5'-methylthioadenosine].
Topics: Adenosine; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Thionucleosides | 1981 |
Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Transformation, Viral; Cells, Cultured; Deoxyadenosines; Fibroblasts; Mice; Ornithine Decarboxylase Inhibitors; Polyamines; S-Adenosylhomocysteine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases | 1981 |
Effect of 5'-methylthioadenosine on nucleolar morphology and RNA metabolism in cultured Xenopus laevis cells.
Topics: Adenosine; Animals; Cell Line; Cell Nucleolus; Deoxyadenosines; Larva; RNA, Ribosomal; Skin; Thionucleosides; Xenopus | 1981 |
Studies on 5'-methylthioadenosine uptake by human erythrocytes.
Topics: Adenosine; Biological Transport, Active; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Phosphates; Thionucleosides | 1981 |
Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5'-methylthioadenosine.
Topics: Adenosine; Cell Count; Cell Survival; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Immunologic; Humans; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thionucleosides; Tuberculin | 1980 |
Studies of inhibition of rat spermidine synthase and spermine synthase.
Topics: Adenosine; Animals; Deoxyadenosines; Male; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases | 1980 |
[A new method of measuring 5'-methylthioadenosine with high pressure liquid chromatography].
Topics: Adenosine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Thionucleosides | 1980 |
Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; Deoxyadenosines; Mice; PC12 Cells; Pheochromocytoma; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Thionucleosides; Xanthines | 1994 |
Quantitation of urinary nucleosides by high-performance liquid chromatography.
Topics: Adenosine; Breast Neoplasms; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Guanosine; Humans; Male; Mouth Neoplasms; Nucleosides; Pseudouridine; Ribonucleosides; Thionucleosides | 1997 |
Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.
Topics: Adenosine; Antimalarials; Antimetabolites, Antineoplastic; Azaserine; Biomarkers, Tumor; Cell Count; Deoxyadenosines; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Methionine; Methotrexate; Pancreatic Neoplasms; Purine-Nucleoside Phosphorylase; Purines; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured | 1997 |
Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes.
Topics: Adenosine; Animals; Biological Transport; Deoxyadenosines; Methionine; Models, Chemical; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; S-Adenosylmethionine; Spermidine; Structure-Activity Relationship; Substrate Specificity; Thionucleosides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 1999 |
Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.
Topics: Adenosine; Alanine; Archaeal Proteins; Deoxyadenosines; Enzyme Stability; Ethionine; Humans; Hydrogen-Ion Concentration; Methylation; Molecular Structure; Oligopeptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Pyrococcus furiosus; Recombinant Proteins; S-Adenosylhomocysteine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Temperature; Thionucleosides | 2002 |
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.
Topics: Adenosine; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyadenosines; Methyltransferases; Protein Binding; Protein Conformation; Thermus thermophilus; Thionucleosides | 2009 |
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
Topics: Adenine; Adenosine; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyadenosines; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Purine-Nucleoside Phosphorylase; Pyrrolidines; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2011 |
Purification and characterization of antioxidant components from the fruiting bodies of Pleurotus abalonus including 9-beta-d-ribofuranosidoadenine, 5'-deoxy-5'-(methylthio)adenosine, and a triterpenoid.
Topics: Adenosine; Animals; Antioxidants; Blood Glucose; Brain; Deoxyadenosines; DNA Damage; Fruiting Bodies, Fungal; Hemolysis; Hydroxyl Radical; Kidney; Lipid Peroxidation; Male; Mice; Pleurotus; Thionucleosides; Time Factors; Triterpenes | 2013 |
Identification and analysis of the constituents in an aqueous extract of Tricholoma matsutake by HPLC coupled with diode array detection/electrospray ionization mass spectrometry.
Topics: Adenine; Adenosine; Chromatography, High Pressure Liquid; Cytidine; Deoxyadenosines; Guanosine; Inosine; Phenylalanine; Riboflavin; Spectrometry, Mass, Electrospray Ionization; Thionucleosides; Tricholoma; Tryptophan; Tyrosine; Uridine; Water | 2013 |
The 5'-nor aristeromycin analogues of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-thiophenyladenosine.
Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Deoxyadenosines; Drug Design; Structure-Activity Relationship; Thionucleosides; Viruses | 2014 |
Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
Topics: Adenosine; Deoxyadenosines; Imino Furanoses; Mycobacterium tuberculosis; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrrolidines; Quantum Theory; S-Adenosylhomocysteine; Thionucleosides | 2016 |
Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
Topics: Adenosine; Amino Acid Motifs; Amino Acid Sequence; Antibodies; Binding Sites, Antibody; Catalytic Domain; Deoxyadenosines; Humans; Leishmania infantum; Molecular Docking Simulation; Peptide Fragments; Protein Binding; Protein Conformation; Purine-Nucleoside Phosphorylase; Sequence Analysis, DNA; Sequence Homology; Static Electricity; Substrate Specificity; Thionucleosides; Trypanosoma brucei brucei | 2017 |