5'-methylthioadenosine and adenosine

5'-methylthioadenosine has been researched along with adenosine in 168 studies

Research

Studies (168)

TimeframeStudies, this research(%)All Research%
pre-1990134 (79.76)18.7374
1990's24 (14.29)18.2507
2000's4 (2.38)29.6817
2010's6 (3.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Daly, JW1
Almo, SC; Fedorov, AA; Fedorov, E; Hermann, JC; Marti-Arbona, R; Raushel, FM; Shoichet, BK1
Gäredal, M; Jacobsson, M; Karlén, A; Schultz, J1
Cummings, MR; Ferro, AJ; Law, RE; Sinibaldi, RM2
Ferro, AJ; Marchitto, K; Vandenbark, AA1
Murr, DP1
Edwards, CH; Edwards, GA; Freeburne, MM; Jones, EG; Seo, CW; Sherman, L; Stacey, RE; Wade, WD1
Hasegawa, S; Luo, JJ1
Daino, L; Feo, F; Lai, P; Pascale, R; Ruggiu, ME; Satta, G; Seddaiu, MA; Sequenza, MJ; Simile, MM; Vannini, MG1
Smalheiser, NR4
Carter, C; Clarke, S; Damore, MA; Law, RE; Stimmel, JB; Wall, R1
Inoue, H; Ishida, H; Kasahara, S; Nagata, T; Nishikawa, S; Ohishi, K; Wakano, Y; Yamauchi, N1
Haklai, R; Kloog, Y1
Gavagnin, M; La Colla, P; Marongiu, ME; Obino, P; Pani, A1
Akaoka, I; Fujimori, S; Kamatani, N; Kaneko, K; Kumakawa, T1
Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH1
Bernacki, RJ; Borchardt, RT; Kramer, DL; Lee, YH; Libby, PR; Miller, JT; Porter, CW; Spiess, AJ; Sufrin, JR1
Alecia, K; Bacchi, CJ; Garofalo, J; Hannan, T; Katz, L; Nathan, HC; Spiess, AJ; Sufrin, JR; Yarlett, N1
Jurewicz, TJ; Liteplo, RG1
Brackett, LE; Daly, JW2
Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J1
Liteplo, RG1
Akaoka, I; Fujii, H; Fujimori, S; Kamatani, N; Kanbayashi, T; Kaneko, K; Kumakawa, T; Miwa, S; Miyazawa, Y1
Altin, JG; Bradshaw, RA1
Dibner, JJ; Durley, RC; Ivey, FJ; Kostelc, JG1
Aswad, DW; Najbauer, J1
Kramer, DL; Libby, PR; Porter, CW; Spiess, AJ; Sufrin, JR1
Cacciapuoti, G; Cimino, G; Gavagnin, M; Porcelli, M; Sodano, G; Zappia, V2
Carson, DA; Kubota, M; Olavi, E; Wasson, DB; Willis, EH; Yamanaka, H1
Akedo, H; Horai, T; Inoue, H; Mukai, M; Nishikawa, S; Ohigashi, H; Shinkai, K; Takeda, Y1
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Puddu, M; Seddaiu, MA; Simile, MM1
Coward, JK; Pegg, AE; Poulin, R; Wechter, R; Woster, PM1
Chelsky, D; O'Neill, CL; Sobotka, C1
Heumann, R; Takahata, K; van Calker, D1
Alakuijala, L; Eloranta, TO; Lindqvist, L; Smith, TK1
Abeles, RH; Furfine, ES1
Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L1
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Gaspa, L; Pascale, R; Ruggiu, ME; Vannini, MG1
Miyamoto, T; Nishida, Y; Suzuki, S3
Miyamoto, T; Nishida, Y; Takeuchi, A1
Carson, DA; Kajander, EO; Yamanaka, H1
Cartenì-Farina, M; Della Ragione, F; Gragnaniello, V; Schettino, MI; Zappia, V1
Koszalka, GW; Krenitsky, TA1
Carrera, CJ; Carson, DA; Chilcote, RR; Kubota, M; Willis, EH1
Emmerson, BT; Gordon, RB1
Blackwell, K; Emmerson, BT; Gordon, RB1
Carson, DA; Kubota, M; Yamanaka, H1
Krenitsky, TA; Miller, RL; Sabourin, CL1
Cannistra, AJ; Montgomery, JA; Parks, RE; Savarese, TM; Secrist, JA; Shortnacy, AT1
Bacchi, CJ; Ellenbogen, BB; Garofalo, J; Ghoda, LY; Katz, L; Northup, CH; Parks, RE; Savarese, TM1
Madhubala, R; Pegg, AE; Secrist, JA1
Chanarin, I; Deacon, R; Lumb, M; Perry, J4
Carrera, CJ; Carson, DA; Kajander, EO; Kubota, M; Nobori, T; Yamanaka, H1
Andreana, A; Della Ragione, F; Ruggiero, G; Russo, GL; Utili, R; Zappia, V1
Frost, P; Judde, JG1
Augé, J; Christa, L; Kersual, J; Pérignon, JL2
Baer, HP; Clanachan, AS; Munshi, R1
Della Ragione, F; Fioretti, A; Fioretti, M; Gragnaniello, V; Menna, LF; Oliva, A; Papparella, V; Zappia, V1
Ferro, AJ; Fitchen, JH; Olson, KD; Riscoe, MK; Schwamborn, J1
Li, SY; Stoeckler, JD1
Ehrenberg, L; Kláŝterská, I; Kolman, A; Näslund, M1
Schwartz, NB; Smalheiser, NR1
Cartier, PH; Christa, L; Kersual, J; Pérignon, JL1
Acheson, A; Huttner, WB; Thoenen, H; Vogl, W1
Kufe, DW; Shafman, TD; Sherman, ML; Spriggs, DR1
Goldblum, RM; Mills, GC; Schmalstieg, FC1
Ferro, AJ; Marchitto, KS1
Carson, DA; Iizasa, T1
Carson, DA; Kajander, EO; Kubota, M1
Mills, GC; Mills, JS1
Chan, VL; Ho, HJ1
Di Padova, C; Di Padova, F; Stramentinoli, G; Tritapepe, R1
Dainko, JL; Schlenk, F; Zydek-Cwick, CR1
Ferro, AJ; Riscoe, MK; Tower, PA1
Fredholm, BB; Jondal, M; Lanefelt, F; Ng, J1
Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM1
Law, RE; Miller, L2
Matsui, H; Yamamoto, C1
Ekström, P; Kanje, M1
Deeprose, RD; Duncan, GS; Schmitges, CJ; Wolberg, G; Zimmerman, TP1
Christa, L; Perignon, JL; Thuillier, L1
Arnaud, M; Dante, R; Niveleau, A1
Cooper, AJ1
Schlenk, F1
Ferro, AJ; Riscoe, MK; White, MW1
Boliska, SA; Bols, NC; Mosser, DD; Snyder, FF1
Della Ragione, F; Pegg, AE1
Dexter, DL; Parks, RE; Savarese, TM1
Dexter, DL; Ghoda, LY; Parks, RE; Savarese, TM1
Pajula, RL1
Christa, L; Munier, A; Perignon, JL; Thuillier, L1
Carrera, CJ; Carson, DA; Eddy, RL; Shows, TB1
Carson, DA; Frincke, LA; Kamatani, N; Kubota, M; Willis, EH1
Baglioni, C; de Ferra, F1
Carson, DA; Iizasa, T; Kubota, M1
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Geraci, G; Lancieri, M; Porcelli, M; Zappia, V1
Kufe, DW; Shafman, TD; Sherman, ML1
Akaoka, I; Fujimori, S; Kamatani, N; Kaneko, K1
Eloranta, TO; Kajander, EO1
Ferro, AJ; Fitchen, JH; Johnson, L; Riscoe, MK; Wolford, RW1
Carson, DA; Kamatani, N; Willis, EH1
Attadia, V; Cacciapuoti, G; Cartenì-Farina, M; Di Fiore, PP; Grieco, M; Pinto, A; Porcelli, M1
Pegg, AE1
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Galletti, P; Zappia, V1
Tisdale, MJ1
Helland, S; Schanche, JS; Schanche, T; Ueland, PM1
Abeles, RH; Dexter, DL; Ghoda, LY; Parks, RE; Savarese, TM; Trackman, PC1
Eloranta, T; Hyvönen, T; Raina, A; Samejima, K; Voutilainen, M; Yamanoha, B1
Seidenfeld, J; Williams-Ashman, HG; Wilson, J1
Carson, DA; Kamatani, N1
Chastain, B; Mahoney, L; Shugart, L1
Ferro, AJ; MacDonald, MR; Rogers, TJ; Wolford, RW; Zehfus, B1
Ferro, AJ; MacDonald, MR; Vandenbark, AA1
Barney, CL; Ferro, AJ; Vandenbark, AA; White, MW1
Galletti, P; Seidenfeld, J; Williams-Ashman, HG1
Fox, IH; Herring, C; Palella, TD; Thompson, D1
Cacciapuoti, G; Cartenì-Farina, M; della Ragione, F; Porcelli, M; Zappia, V3
Abeles, RH; Trackman, PC1
Toohey, JI2
Borchardt, RT; Huskey, WP; Schowen, RL; Wu, SE1
Chun, BG; Kim, S; Paik, WK1
Pajula, RL; Raina, A; Tuomi, K1
Eloranta, TO; Raina, AM; Tuomi, K1
Backlund, PS; Smith, RA2
Agarwal, KC; Parks, RE2
Schanche, JS; Schanche, T; Ueland, PM1
Agarwal, KC; Parks, RE; Russo, FX1
Hibasami, H; Ikeda, T1
Cone, MC; Ferro, AJ; Marchitto, K; Zehfus, B1
Guranowski, A; Paszewski, A1
Backlund, PS; Chang, CP; Smith, RA1
Schlenk, F; Shapiro, SK1
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Manna, C; Oliva, A1
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Giordano, F; Manna, C; Oliva, A1
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Porcelli, M1
Borchardt, RT; Coward, JK; Pegg, AE1
Barney, CL; Ferro, AJ; Vandenbark, AA1
Borchardt, RT; Chen, SY; Coward, JK; Hibasami, H; Pegg, AE1
Cacciapuoti, G; Cartenì-Farina, M; Della Ragione, F; Porcelli, M; Ragosta, G1
Di Stefano, C; Liebich, HM; Schmid, HR; Wixforth, A1
Chen, ZH; Olopade, OI; Savarese, TM1
Bacchi, CJ; Goldberg, B; Gorrell, TE; Rattendi, D; Spiess, AJ; Sufrin, JR1
Clarke, S; Griffith, SC; Thapar, N; Yeates, TO1
Belardinelli, R; Dahlberg, AE; Demirci, H; Gregory, ST; Gualerzi, C; Jogl, G; Seri, E1
Basu, I; Belbin, TJ; Cassera, MB; Dong, X; Evans, GB; Guha, C; Hemeon, I; Locker, J; Merino, EF; Schramm, VL1
Liu, F; Ng, TB; Song, M; Zhang, YN; Zhao, L1
Bai, G; Liang, Q; Luo, G; Ma, J; Wang, Y; Ying, X1
Das, SR; Schneller, SW1
Namanja-Magliano, HA; Schramm, VL; Stratton, CF1
Abid, H; Barhoumi, M; Guizani, I; Harigua-Souiai, E; Mejri, T1

Reviews

6 review(s) available for 5'-methylthioadenosine and adenosine

ArticleYear
Adenosine receptors: targets for future drugs.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1982
Methylthioadenosine (MeSAdo) phosphorylase deficiency in malignancy.
    Advances in experimental medicine and biology, 1988, Volume: 250

    Topics: Adenosine; Animals; Deoxyadenosines; Humans; Neoplasms; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides

1988
Biochemistry of sulfur-containing amino acids.
    Annual review of biochemistry, 1983, Volume: 52

    Topics: Adenosine; Amino Acid Metabolism, Inborn Errors; Animals; Cysteine; Deoxyadenosines; Homocysteine; Humans; Methionine; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Structure-Activity Relationship; Sulfur; Sulfurtransferases; Thionucleosides; Thiosulfate Sulfurtransferase

1983
Methylthioadenosine.
    Advances in enzymology and related areas of molecular biology, 1983, Volume: 54

    Topics: Adenosine; Animals; Biotin; Deoxyadenosines; Humans; Hydrolysis; Kinetics; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; T-Phages; Thionucleosides

1983
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
    Biochemical pharmacology, 1982, Feb-01, Volume: 31, Issue:3

    Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylase; Rats; Ribosemonophosphates; S-Adenosylmethionine; Spermidine; Spermine; Thioglycosides; Thionucleosides

1982
[Inhibitors in polyamine biosynthesis (author's transl)].
    Seikagaku. The Journal of Japanese Biochemical Society, 1981, Volume: 53, Issue:4

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cattle; Deoxyadenosines; Mitoguazone; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides

1981

Other Studies

162 other study(ies) available for 5'-methylthioadenosine and adenosine

ArticleYear
Structure-based activity prediction for an enzyme of unknown function.
    Nature, 2007, Aug-16, Volume: 448, Issue:7155

    Topics: Adenine; Catalysis; Crystallography, X-Ray; Deamination; Deoxyadenosines; Enzymes; Homocysteine; Inosine; Models, Molecular; Nucleoside Deaminases; Protein Conformation; S-Adenosylhomocysteine; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; Thionucleosides

2007
Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening.
    Journal of medicinal chemistry, 2008, May-08, Volume: 51, Issue:9

    Topics: Animals; Binding Sites; Databases, Factual; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 2-Ring; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium falciparum; Protein Binding; Quantitative Structure-Activity Relationship; Spermidine Synthase; Structure-Activity Relationship

2008
Effect of 5'-methylthioadenosine on gene action during heat shock in Drosophila melanogaster.
    FEBS letters, 1979, Mar-15, Volume: 99, Issue:2

    Topics: Adenosine; Animals; Deoxyadenosines; Drosophila melanogaster; Hot Temperature; Kinetics; Salivary Glands; Thionucleosides; Transcription, Genetic; Uridine

1979
The role of 5'-methylthioadenosine phosphorylase in 5'-methylthioadenosine-mediated inhibition of lymphocyte transformation.
    Biochimica et biophysica acta, 1979, Dec-11, Volume: 588, Issue:3

    Topics: Adenosine; Deoxyadenosines; Humans; Lymphocyte Activation; Pentosyltransferases; Phytohemagglutinins; Purine-Nucleoside Phosphorylase; Thionucleosides; Thymidine; Time Factors; Tubercidin

1979
Methionine metabolism in apple tissue.
    Experientia, 1977, Dec-15, Volume: 33, Issue:12

    Topics: Adenosine; Deoxyadenosines; Ethylenes; Fruit; Methionine; Thionucleosides

1977
Inhbition of RNA synthesis in salivary glands of Drosophila melanogaster by 5'-methylthioadenosine.
    Biochemical and biophysical research communications, 1976, Dec-06, Volume: 73, Issue:3

    Topics: Adenosine; Animals; Deoxyadenosines; Dose-Response Relationship, Drug; Drosophila melanogaster; Kinetics; Larva; Salivary Glands; Thionucleosides; Transcription, Genetic; Uridine

1976
Formation of methionine from alpha-amino-n-butyric acid and 5'-methylthioadenosine in the rat.
    The Journal of nutrition, 1977, Volume: 107, Issue:10

    Topics: Adenosine; Aminobutyrates; Animals; Body Weight; Butyrates; Choline; Cysteine; Deoxyadenosines; Homoserine; Male; Methionine; Rats; S-Adenosylmethionine; Thionucleosides

1977
Chick sympathetic neurons in culture respond differentially to nerve growth factor and conditioned medium from activated splenic lymphocytes.
    Neuroscience research, 1991, Volume: 10, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Cell Survival; Cells, Cultured; Chickens; Culture Media; Deoxyadenosines; Ganglia, Sympathetic; Isoquinolines; Kinetics; Lymphocyte Activation; Lymphocytes; Nerve Growth Factors; Neurons; Piperazines; Proadifen; Protein Kinase Inhibitors; Spleen; Thioguanine; Thionucleosides

1991
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
    Cancer letters, 1991, Volume: 56, Issue:3

    Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1991
Cell attachment and neurite stability in NG108-15 cells: what is the role of microtubules?
    Brain research. Developmental brain research, 1991, Feb-22, Volume: 58, Issue:2

    Topics: Adenosine; Alkaloids; Axons; Cell Adhesion; Cell Line; Deoxyadenosines; Hybrid Cells; Immunohistochemistry; Microtubules; Nerve Tissue; Neurons; Nocodazole; Paclitaxel; Staining and Labeling; Thionucleosides; Trypsin; Tubulin

1991
Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions.
    Molecular and cellular biology, 1992, Volume: 12, Issue:1

    Topics: Adenosine; B-Lymphocytes; Clone Cells; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunoglobulin kappa-Chains; Lipopolysaccharides; Lovastatin; Membrane Proteins; Methylation; NF-kappa B; Protein Biosynthesis; Signal Transduction; Thionucleosides; Transcriptional Activation

1992
The role of 5'-methylthioadenosine on rat calvaria cell differentiation.
    Biochemical and biophysical research communications, 1992, Jan-31, Volume: 182, Issue:2

    Topics: Adenine; Adenosine; Alkaline Phosphatase; Animals; Bone and Bones; Cell Differentiation; Cell Division; Cells, Cultured; Deoxyadenosines; Kinetics; Osteopontin; Purine-Nucleoside Phosphorylase; Rats; Sialoglycoproteins; Thionucleosides

1992
Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.
    Cellular and molecular neurobiology, 1991, Volume: 11, Issue:4

    Topics: Adenosine; Animals; Deoxyadenosines; Dimethyl Sulfoxide; GTP-Binding Proteins; Guanosine Triphosphate; Lovastatin; Membrane Proteins; Methylation; Mevalonic Acid; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Protein Processing, Post-Translational; Thionucleosides; Tumor Cells, Cultured

1991
Antimicrobial and antiviral activity of xylosyl-methylthio-adenosine, a naturally occurring analogue of methylthio-adenosine from Doris verrucosa.
    Experientia, 1991, Dec-01, Volume: 47, Issue:11-12

    Topics: Adenosine; Animals; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Cell Survival; Cells, Cultured; Deoxyadenosines; Mollusca; Thionucleosides

1991
Disturbance in the metabolism of 5'-methylthioadenosine and adenine in patients with neoplastic diseases, and in those with a deficiency in adenine phosphoribosyltransferase.
    Metabolism: clinical and experimental, 1991, Volume: 40, Issue:9

    Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine; Adult; Aged; Deoxyadenosines; Female; Humans; Leukemia; Male; Middle Aged; Neoplasms; Osmolar Concentration; Thionucleosides

1991
Role of 5'-deoxy-5'-methylthioadenosine in growth of several microbial B12 requirers.
    Life sciences, 1991, Volume: 48, Issue:2

    Topics: Adenosine; Animals; Bacteria; Cell Division; Deoxyadenosines; Escherichia coli; Euglena gracilis; Eukaryota; Lactobacillus; Thionucleosides; Vitamin B 12

1991
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Humans; Hydrolases; Leukemia L1210; Leukemia, Experimental; Liver; Mice; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides; Tumor Cells, Cultured

1991
5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:7

    Topics: Adenosine; Animals; Deoxyadenosines; Methionine; Mice; Purine-Nucleoside Phosphorylase; Rats; Thionucleosides; Trypanocidal Agents; Trypanosoma brucei brucei

1991
Serum has a differential effect on DNA replication in a human melanoma cell line cultured in methionine or 5'-deoxy-5'-methylthioadenosine.
    Biochimica et biophysica acta, 1991, Mar-26, Volume: 1088, Issue:3

    Topics: Adenosine; Blood; Culture Media; Deoxyadenosines; DNA Replication; Humans; Melanoma; Methionine; Thionucleosides; Transferrin; Tumor Cells, Cultured

1991
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Adenosine; Animals; Carbachol; Deoxyadenosines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Receptors, Purinergic; Theophylline; Thionucleosides; Trachea; Xanthine; Xanthines

1991
Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells.
    Biochimica et biophysica acta, 1990, Jun-20, Volume: 1034, Issue:3

    Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Bone Marrow; Carbon; Deoxyadenosines; Folic Acid; Formates; Glycine; Guanine; Male; Methionine; Methionine Adenosyltransferase; Oxidation-Reduction; Rats; Rats, Inbred Strains; Serine; Thionucleosides

1990
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
    Experimental cell research, 1990, Volume: 186, Issue:2

    Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured

1990
Measurement of 5'-methylthioadenosine in patients with neoplasms.
    International journal of cancer, 1990, Jan-15, Volume: 45, Issue:1

    Topics: Adenosine; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Humans; Male; Middle Aged; Neoplasms; Remission Induction; Thionucleosides

1990
Cell attachment and neurite stability in NG108-15 cells: effects of 5'-deoxy, 5'-methyl thioadenosine (MTA) compared with laminin, kinase inhibitor H-7, and Mn2+ ions.
    Brain research. Developmental brain research, 1990, Feb-01, Volume: 51, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Cell Adhesion; Cells, Cultured; Dendrites; Deoxyadenosines; Isoquinolines; Laminin; Manganese; Nerve Growth Factors; Neurons; Piperazines; Thionucleosides

1990
Production of 1,2-diacylglycerol in PC12 cells by nerve growth factor and basic fibroblast growth factor.
    Journal of neurochemistry, 1990, Volume: 54, Issue:5

    Topics: Acids; Adenosine; Adrenal Gland Neoplasms; Animals; Arsenicals; Calcium; Carbachol; Culture Media; Deoxyadenosines; Diglycerides; Extracellular Space; Fibroblast Growth Factors; Glycerides; Inositol Phosphates; Nerve Growth Factors; Pheochromocytoma; Potassium; Thionucleosides; Tumor Cells, Cultured

1990
2-Hydroxy-4-(methylthio) butanoic acid is a naturally occurring methionine precursor in the chick.
    The Journal of nutrition, 1990, Volume: 120, Issue:6

    Topics: Adenosine; Animals; Chickens; Deoxyadenosines; Gas Chromatography-Mass Spectrometry; Kinetics; Liver; Male; Methionine; Thionucleosides

1990
Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde.
    The Journal of biological chemistry, 1990, Jul-25, Volume: 265, Issue:21

    Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Deoxyadenosines; Electrophoresis, Gel, Two-Dimensional; Methylation; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Pheochromocytoma; Rats; S-Adenosylmethionine; Thionucleosides; Tubercidin; Tumor Cells, Cultured

1990
Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:5

    Topics: Adenosine; Animals; Biogenic Polyamines; Cell Division; Deoxyadenosines; Leukemia, Experimental; Mice; Purine-Nucleoside Phosphorylase; Thionucleosides; Tumor Cells, Cultured

1989
Biosynthesis and metabolism of 9-[5'-deoxy-5'-(methylthio)-beta-D-xylofuranosyl]adenine, a novel natural analogue of methylthioadenosine.
    The Biochemical journal, 1989, Nov-01, Volume: 263, Issue:3

    Topics: Adenosine; Animals; Deoxyadenosines; Mollusca; Polyamines; Purine-Nucleoside Phosphorylase; Thionucleosides

1989
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Adenosine; Animals; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Mice, Mutant Strains; Pentosyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured

1989
Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.
    Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:8

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Deoxyadenosines; Fibrosarcoma; Humans; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Melanoma, Experimental; Methylation; Neoplasm Invasiveness; Rats; Rats, Inbred Strains; Thionucleosides; Tumor Cells, Cultured

1989
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Phagocytosis; Phenobarbital; Phenotype; Precancerous Conditions; Proto-Oncogenes; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1989
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
    Biochemistry, 1989, Oct-17, Volume: 28, Issue:21

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line, Transformed; Deoxyadenosines; Dose-Response Relationship, Drug; Fibroblasts; Leukemia L1210; Mice; Polyamines; S-Adenosylmethionine; Spermine Synthase; Thionucleosides; Transferases; Tumor Cells, Cultured

1989
Lamin B methylation and assembly into the nuclear envelope.
    The Journal of biological chemistry, 1989, May-05, Volume: 264, Issue:13

    Topics: Adenosine; Animals; Benzimidazoles; Cell Cycle; Cell Line; Chromatin; Cricetinae; Deoxyadenosines; Isoelectric Point; Lamin Type B; Lamins; Methylation; Morphogenesis; Nocodazole; Nuclear Envelope; Nuclear Proteins; Phosphorylation; Thionucleosides

1989
Nerve growth factor potentiates the hormone-stimulated intracellular accumulation of inositol phosphates and Ca2+ in rat PC12 pheochromocytoma cells: comparison with the effect of epidermal growth factor.
    Journal of neurochemistry, 1989, Volume: 52, Issue:1

    Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Bradykinin; Calcium; Cell Line; Deoxyadenosines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Inositol Phosphates; Male; Mice; Nerve Growth Factors; Pheochromocytoma; Sugar Phosphates; Thionucleosides

1989
Effects of dietary polyamine precursors on the metabolism and tissue concentrations of amino acids in the rat.
    Annals of nutrition & metabolism, 1989, Volume: 33, Issue:3

    Topics: Adenosine; Amino Acids; Animals; Arginine; Biogenic Polyamines; Deoxyadenosines; Diet; Liver; Male; Methionine; Muscles; Ornithine; Rats; Rats, Inbred Strains; RNA, Transfer, Amino Acid-Specific; S-Adenosylmethionine; Thionucleosides

1989
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae.
    The Journal of biological chemistry, 1988, Jul-15, Volume: 263, Issue:20

    Topics: Adenosine; Aldose-Ketose Isomerases; Animals; Carbohydrate Epimerases; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Formates; Klebsiella pneumoniae; Liver; Magnetic Resonance Spectroscopy; Methionine; Organophosphorus Compounds; Oxidation-Reduction; Periodic Acid; Rats; Ribosemonophosphates; Thioglycosides; Thionucleosides

1988
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
    Toxicologic pathology, 1987, Volume: 15, Issue:1

    Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1987
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
    Carcinogenesis, 1987, Volume: 8, Issue:5

    Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1987
Morphologic plasticity of rapid-onset neurites in NG108-15 cells stimulated by substratum-bound laminin.
    Brain research. Developmental brain research, 1989, Jan-01, Volume: 45, Issue:1

    Topics: Adenosine; Animals; Cell Differentiation; Cells, Cultured; Cytochalasin B; Dendrites; Deoxyadenosines; Glioma; Laminin; Neuroblastoma; Thionucleosides; Time Factors; Tumor Cells, Cultured

1989
Altered cell shapes in fibroblasts treated with 5'-deoxy-5'-methylthioadenosine: relation to morphogenesis of neural cells.
    Brain research. Developmental brain research, 1989, Jan-01, Volume: 45, Issue:1

    Topics: Adenosine; Animals; Cell Differentiation; Cells, Cultured; Deoxyadenosines; Fibroblasts; Humans; Mice; Thionucleosides

1989
Pharmacological action of 5'-methylthioadenosine on isolated rabbit aorta strips.
    Blood vessels, 1985, Volume: 22, Issue:5

    Topics: Adenosine; Animals; Aorta, Thoracic; Deoxyadenosines; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Receptors, Cell Surface; Receptors, Purinergic; Thionucleosides

1985
Modulation of polymorphonuclear leukocyte function by adenosine analogues.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt A

    Topics: Adenosine; Chemotaxis, Leukocyte; Deoxyadenosines; Dideoxyadenosine; Humans; Kinetics; Neutrophils; Phagocytosis; Phenylisopropyladenosine; Reference Values; Superoxides; Thionucleosides

1986
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
    Biochimica et biophysica acta, 1986, Sep-19, Volume: 888, Issue:2

    Topics: Adenosine; Adenosine Diphosphate Ribose; Animals; Cell Line; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides

1986
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta.
    The Journal of biological chemistry, 1986, Sep-15, Volume: 261, Issue:26

    Topics: Adenosine; Deoxyadenosines; Hot Temperature; Humans; Isoelectric Point; Kinetics; Macromolecular Substances; Molecular Weight; Pentosyltransferases; Phosphates; Placenta; Purine-Nucleoside Phosphorylase; Thionucleosides

1986
5'-Methylthioadenosine (MTA) phosphorylase from promastigotes of Leishmania donovani.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Animals; Deoxyadenosines; Kinetics; Leishmania donovani; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thermodynamics; Thionucleosides

1986
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Animals; Chromosome Mapping; Deoxyadenosines; Humans; Leukemia, Lymphoid; Mice; Neoplasm Transplantation; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides

1986
Inhibition of de novo purine synthesis by methylthioadenosine.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Cell Line; Deoxyadenosines; Humans; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; Thionucleosides

1986
Synthesis of purines in human lymphoblast cells deficient in methylthioadenosine phosphorylase activity.
    Biochimica et biophysica acta, 1987, Jan-19, Volume: 927, Issue:1

    Topics: Adenine; Adenosine; B-Lymphocytes; Cell Line; Deoxyadenosines; Humans; Kinetics; Leukemia, Lymphoid; Lymphocytes; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; T-Lymphocytes; Thionucleosides

1987
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
    Cancer research, 1987, Apr-01, Volume: 47, Issue:7

    Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Synergism; Eflornithine; Kinetics; Lymphoma; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides

1987
Trypanosoma cruzi adenine nucleoside phosphorylase. Purification and substrate specificity.
    Biochemical pharmacology, 1987, Feb-15, Volume: 36, Issue:4

    Topics: Adenine; Adenosine; Animals; Deoxyadenosines; Kinetics; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thionucleosides; Trypanosoma cruzi

1987
5'-deoxy-5'-methylthioadenosine phosphorylase--IV. Biological activity of 2-fluoroadenine-substituted 5'-deoxy-5'-methylthioadenosine analogs.
    Biochemical pharmacology, 1987, Jun-15, Volume: 36, Issue:12

    Topics: Adenine Phosphoribosyltransferase; Adenosine; Cell Line; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Humans; Leukemia, Myeloid, Acute; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Thionucleosides

1987
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells.
    Molecular and biochemical parasitology, 1988, Jan-15, Volume: 27, Issue:2-3

    Topics: Adenosine; Animals; Deoxyadenosines; Mice; N-Glycosyl Hydrolases; Neoplasm Proteins; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; Sarcoma 180; Species Specificity; Substrate Specificity; Thionucleosides; Trypanosoma brucei brucei

1988
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
    Cancer research, 1988, May-15, Volume: 48, Issue:10

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Drug Resistance; Eflornithine; Leukemia L1210; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured

1988
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
    Journal of clinical pathology, 1988, Volume: 41, Issue:11

    Topics: Adenosine; Animals; Betaine; Carbon Dioxide; Deoxyadenosines; Formyltetrahydrofolates; Glycine; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thionucleosides; Time Factors

1988
Studies on human serum 5'-deoxy-5'-methylthioadenosine phosphorylase: molecular properties and clinical perspectives.
    Advances in experimental medicine and biology, 1988, Volume: 250

    Topics: Adenosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chromatography, Ion Exchange; Deoxyadenosines; Dialysis; Dithiothreitol; Molecular Weight; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Rats; Rats, Inbred Strains; Thionucleosides

1988
Patterns of methionine auxotrophy in normal and neoplastic cells: the methionine independence of lymphocyte mitogenesis and low frequency of the methionine-dependent phenotype in human tumors.
    Cancer research, 1988, Dec-01, Volume: 48, Issue:23

    Topics: Adenosine; Animals; Culture Media; Deoxyadenosines; Humans; Lymphocyte Activation; Methionine; Mice; Neoplasms; Phenotype; Thionucleosides; Tumor Cells, Cultured

1988
Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.
    The Biochemical journal, 1988, Oct-01, Volume: 255, Issue:1

    Topics: Adenosine; Cell Division; Cell Line; Deoxyadenosines; Humans; Intracellular Fluid; Methionine; Methionine Adenosyltransferase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured

1988
Characterization and biogenesis of 5'-methylthioxylofuranosyl adenine, a new natural analog of 5'-methylthioadenosine.
    Advances in experimental medicine and biology, 1988, Volume: 250

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Mollusca; Thionucleosides

1988
5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types.
    Biochemical pharmacology, 1988, May-15, Volume: 37, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Cerebellum; Deoxyadenosines; In Vitro Techniques; Jejunum; Mice; Muscle Contraction; Neuroblastoma; Rabbits; Rats; Receptors, Purinergic; Thioinosine; Thionucleosides

1988
Chromatographic and radioimmunological methods for the determination of 5'-deoxy-5'-methylthioadenosine in biological fluids.
    Journal of chromatography, 1988, May-25, Volume: 440

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Hemocyanins; Humans; Male; Rabbits; Radioimmunoassay; Thionucleosides

1988
Inhibition of growth but not differentiation of normal and leukemic myeloid cells by methylthioadenosine.
    Cancer research, 1987, Jul-15, Volume: 47, Issue:14

    Topics: Adenosine; Cell Differentiation; Cell Division; Cell Line; Colony-Forming Units Assay; Deoxyadenosines; Granulocytes; Humans; Leukemia, Myeloid, Acute; Macrophages; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Thionucleosides

1987
Influx of 5'-deoxy-5'-methylthioadenosine into HL-60 human leukemia cells and erythrocytes.
    The Journal of biological chemistry, 1987, Jul-15, Volume: 262, Issue:20

    Topics: Adenosine; Biological Transport; Cell Line; Deoxyadenosines; Erythrocytes; Humans; Kinetics; Leukemia, Myeloid, Acute; Thionucleosides; Vasodilator Agents

1987
Mutagenic and comutagenic action of 5'-deoxy-5'-(methylthio)adenosine.
    Mutation research, 1986, Volume: 161, Issue:1

    Topics: Adenosine; Animals; Cell Line; Cricetinae; Cricetulus; Deoxyadenosines; Escherichia coli; Female; Hypoxanthine Phosphoribosyltransferase; Kidney; Mutagenicity Tests; Mutagens; Mutation; Ovary; Sister Chromatid Exchange; Thionucleosides

1986
Kinetic analysis of 'rapid onset' neurite formation in NG108-15 cells reveals a dual role for substratum-bound laminin.
    Brain research, 1987, Volume: 431, Issue:1

    Topics: Adenosine; Cell Differentiation; Cell Line; Colforsin; Cycloheximide; Deoxyadenosines; Laminin; Neurons; Tetradecanoylphorbol Acetate; Thionucleosides

1987
Actions of 5'-methylthioadenosine in isolated guinea pig tracheal rings.
    General pharmacology, 1986, Volume: 17, Issue:4

    Topics: Adenosine; Animals; Deoxyadenosines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Receptors, Purinergic; SRS-A; Thionucleosides; Trachea

1986
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Propranolol; Receptors, Purinergic; SRS-A; Tetrodotoxin; Theophylline; Thionucleosides

1986
Metabolism of 5'-methylthioadenosine in methionine-dependent and methionine-independent cells.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Cell Cycle; Cell Line; Deoxyadenosines; Humans; Methionine; Tetrahydrofolates; Thionucleosides

1986
Methyltransferase inhibitors block NGF-regulated survival and protein phosphorylation in sympathetic neurons.
    The EMBO journal, 1986, Volume: 5, Issue:11

    Topics: Adenosine; Animals; Cell Survival; Chick Embryo; Deoxyadenosines; Ganglia, Sympathetic; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phosphorylation; Potassium; Protein Methyltransferases; Thionucleosides

1986
Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 2

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Differentiation; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; DNA; Leukemia, Erythroblastic, Acute; Methylation; Mice; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin

1985
Urinary purines and nucleosides in immune deficiencies.
    Annals of the New York Academy of Sciences, 1985, Volume: 451

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adult; Child; Deoxyadenosines; Female; Humans; Immunologic Deficiency Syndromes; Inosine; Purine Nucleosides; Purines; Pyrimidine Nucleosides; Pyrimidines; S-Adenosylhomocysteine; Thionucleosides

1985
The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae.
    Journal of general microbiology, 1985, Volume: 131, Issue:9

    Topics: Adenosine; Chromatography, Paper; Deoxyadenosines; Methionine; Ribosemonophosphates; Saccharomyces cerevisiae; Thioglycosides; Thionucleosides

1985
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells.
    Biochimica et biophysica acta, 1985, Mar-21, Volume: 844, Issue:3

    Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; Homocysteine; Humans; Kinetics; Methylation; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides

1985
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.
    Cancer research, 1985, Volume: 45, Issue:8

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Deoxyadenosines; Eflornithine; Lymphoma; Mice; Ornithine; Ornithine Decarboxylase; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Thionucleosides

1985
Salvage of 5'-deoxy-5'-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium: a study of "methionine-dependence".
    Biochemical and biophysical research communications, 1986, Feb-26, Volume: 135, Issue:1

    Topics: Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Homocysteine; Humans; Methionine; Thionucleosides

1986
Urinary excretion of methylthioadenosine in immunodeficient children.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Mar-30, Volume: 147, Issue:1

    Topics: Adenosine; Adult; Child; Chromatography, Ion Exchange; Creatinine; Deoxyadenosines; Humans; Immunologic Deficiency Syndromes; Spectrometry, Fluorescence; Thionucleosides

1985
Multiple mechanisms of adenosine toxicity in an adenosine sensitive mutant of baby hamster kidney (BHK) cells.
    Basic life sciences, 1985, Volume: 31

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cytidine Triphosphate; Deoxyadenosines; Drug Resistance; Guanosine Triphosphate; Kidney; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Uridine Triphosphate; Vidarabine

1985
Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.
    The Biochemical journal, 1985, Apr-01, Volume: 227, Issue:1

    Topics: Acyltransferases; Adenosine; Animals; Deoxyadenosines; Hydroxymethyl and Formyl Transferases; In Vitro Techniques; Liver; Male; Methionine; Nitrous Oxide; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Purines; Rats; Rats, Inbred Strains; Thionucleosides; Vitamin B 12

1985
Inhibition of lymphocyte function by a naturally occurring nucleoside: 5'-methylthioadenosine (MTA).
    International journal of immunopharmacology, 1985, Volume: 7, Issue:2

    Topics: Adenosine; Antibody Formation; Cell Differentiation; Cells, Cultured; Deoxyadenosines; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Thionucleosides

1985
Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.
    Journal of clinical pathology, 1985, Volume: 38, Issue:12

    Topics: Acyltransferases; Adenosine; Anemia, Megaloblastic; Animals; Bone Marrow; Deoxyadenosines; Humans; Hydroxymethyl and Formyl Transferases; Liver; Male; Methionine; Nitrous Oxide; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Purines; Rats; Rats, Inbred Strains; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency

1985
5'-Methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast.
    Biochimica et biophysica acta, 1973, Sep-14, Volume: 320, Issue:2

    Topics: Adenine; Adenosine; Aerobiosis; Candida; Carbon Radioisotopes; Deoxyadenosines; Methionine; Optical Rotation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Sulfides; Sulfur Radioisotopes; Thionucleosides; Time Factors

1973
Mechanism of action of 5'-methylthioadenosine in S49 cells.
    Biochemical pharmacology, 1984, Nov-15, Volume: 33, Issue:22

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Deoxyadenosines; Lymphoma; Mice; Mutation; Protein Kinases; Thionucleosides

1984
Effect of 5'-methylthioadenosine, 3-deazaadenosine, and related compounds on human natural killer cell activity. Relation to cyclic AMP and methylation potential.
    Scandinavian journal of immunology, 1984, Volume: 20, Issue:6

    Topics: Adenosine; Cyclic AMP; Cytotoxicity, Immunologic; Deoxyadenosines; Humans; Killer Cells, Natural; Lymphocytes; Methylation; Ribonucleosides; Thionucleosides; Tubercidin

1984
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
    Nucleic acids research, 1983, Jan-25, Volume: 11, Issue:2

    Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin

1983
Effect of 5'-methylthioadenosine on RNA and DNA synthesis in cultured Xenopus laevis cells.
    Experimental cell research, 1983, Volume: 147, Issue:2

    Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Deoxyadenosines; DNA; Poly A; RNA; RNA Polymerase I; RNA Polymerase II; RNA, Messenger; Thionucleosides; Transcription, Genetic; Xenopus laevis

1983
The possible involvement of adenylate cyclase inhibition in the field potential suppression through alpha-2 adrenergic receptors in the bed nucleus of the stria terminalis.
    Brain research, 1984, Feb-13, Volume: 293, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Bucladesine; Deoxyadenosines; Diencephalon; Drug Interactions; Electrophysiology; Guinea Pigs; Norepinephrine; Receptors, Adrenergic, alpha; Thionucleosides

1984
Inhibition of fast axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine.
    Journal of neurochemistry, 1984, Volume: 43, Issue:5

    Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Axonal Transport; Cycloleucine; Deoxyadenosines; Rana esculenta; Rana temporaria; Sciatic Nerve; Thionucleosides

1984
Inhibition of lymphocyte cyclic AMP phosphodiesterase and lymphocyte function by 5'-methylthioadenosine.
    Biochemical pharmacology, 1982, Jun-15, Volume: 31, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenylyl Cyclases; Animals; Deoxyadenosines; In Vitro Techniques; Lymphocytes; Mice; Spleen; Thionucleosides

1982
5'-Deoxy-5'-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase: correlation with inhibition of Con A induced proliferation.
    Biochemical and biophysical research communications, 1983, Jun-15, Volume: 113, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cell Division; Concanavalin A; Cyclic AMP; Deoxyadenosines; Dose-Response Relationship, Drug; In Vitro Techniques; Phosphodiesterase Inhibitors; Rats; T-Lymphocytes; Thionucleosides

1983
Effects of 5'deoxy-5'-methylthioadenosine on the metabolism of S-adenosyl methionine.
    Biochemical and biophysical research communications, 1983, Jul-18, Volume: 114, Issue:1

    Topics: Adenosine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferases; Kidney; Kinetics; Rats; S-Adenosylmethionine; Sulfur Radioisotopes; Thionucleosides

1983
The comparative effects of 5'-methylthioadenosine and some of its analogs on cells containing, and deficient in, 5'-methylthioadenosine phosphorylase.
    Biochimica et biophysica acta, 1983, Jun-02, Volume: 762, Issue:3

    Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Leukemia L1210; Mice; Mice, Inbred AKR; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides

1983
The transfer of 5'-methylthioadenosine from B82 cells through the medium to CHW-1102 cells.
    Experimental cell research, 1983, Apr-15, Volume: 145, Issue:1

    Topics: Adenine; Adenosine; Animals; Cell Communication; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Mitoguazone; Purine-Nucleoside Phosphorylase; Thionucleosides

1983
Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.
    The Biochemical journal, 1983, Feb-15, Volume: 210, Issue:2

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Deoxyadenosines; Formycins; Homocysteine; Hydrolases; Purine-Nucleoside Phosphorylase; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides

1983
5'-deoxy-5'-methylthioadenosine phosphorylase--II. Role of the enzyme in the metabolism and antineoplastic action of adenine-substituted analogs of 5'-deoxy-5'-methylthioadenosine.
    Biochemical pharmacology, 1983, Jun-15, Volume: 32, Issue:12

    Topics: Adenosine; Antineoplastic Agents; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Colonic Neoplasms; Deoxyadenosines; Humans; Leukemia; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Substrate Specificity; Thionucleosides

1983
Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
    Cancer research, 1983, Volume: 43, Issue:10

    Topics: Adenosine; Cells, Cultured; Deoxyadenosines; Humans; Inosine; Leukemia; Leukemia, Myeloid, Acute; Methionine; Methylthioinosine; Purine-Nucleoside Phosphorylase; T-Lymphocytes; Thionucleosides

1983
Kinetic properties of spermine synthase from bovine brain.
    The Biochemical journal, 1983, Dec-01, Volume: 215, Issue:3

    Topics: Adenosine; Animals; Brain; Cattle; Deoxyadenosines; Kinetics; Placenta; Purine-Nucleoside Phosphorylase; Serum Albumin, Bovine; Spermidine; Spermine; Spermine Synthase; Thionucleosides; Transferases

1983
Salvage of 5'-deoxy-methylthioadenosine into purines and methionine by lymphoid cells and inhibition of cell proliferation.
    Biochimica et biophysica acta, 1984, Feb-17, Volume: 803, Issue:1-2

    Topics: Adenosine; Azaserine; Cell Cycle; Cell Line; Concanavalin A; Deoxyadenosines; Humans; Lymphocytes; Methionine; Purine-Nucleoside Phosphorylase; Purines; Thionucleosides

1984
Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:9

    Topics: Adenosine; Animals; Chromosome Mapping; Chromosomes, Human, 6-12 and X; Deoxyadenosines; Humans; Hybrid Cells; Isoelectric Point; Isoenzymes; Mice; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides

1984
5'-Methylthioadenosine is the major source of adenine in human cells.
    Advances in experimental medicine and biology, 1984, Volume: 165 Pt B

    Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine; Cell Line; Cells, Cultured; Deoxyadenosines; Humans; Leukemia, Lymphoid; Purine-Nucleoside Phosphorylase; Thionucleosides

1984
Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Adenosine; Adenosylhomocysteinase; Burkitt Lymphoma; Cell Division; Cell Line; Deoxyadenosines; HeLa Cells; Humans; Hydrolases; Interferon Type I; Kinetics; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1984
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells.
    Biochemical and biophysical research communications, 1984, Jun-15, Volume: 121, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Biological Transport; Cell Division; Cell Line; Deoxyadenosines; Dipyridamole; Humans; Lymphocytes; Lymphoma; Nucleoside Deaminases; Purine-Nucleoside Phosphorylase; Thioinosine; Thionucleosides

1984
Studies on the metabolic effects of methylthioformycin.
    Biochimica et biophysica acta, 1984, Oct-12, Volume: 805, Issue:2

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Brain; Cell Division; Cell Membrane Permeability; Deoxyadenosines; Erythrocytes; Formycins; Friend murine leukemia virus; Humans; Hydrolases; Leukemia, Erythroblastic, Acute; Liver; Purine-Nucleoside Phosphorylase; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides

1984
Effect of 5'-methylthioadenosine on induction of murine erythroleukemia cell differentiation.
    Biochemical and biophysical research communications, 1984, Oct-15, Volume: 124, Issue:1

    Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; Kinetics; Leukemia, Experimental; Mice; Putrescine; Spermidine; Spermine; Thionucleosides

1984
5'-Methylthioadenosine in urine from normal subjects and cancer patients.
    Biochimica et biophysica acta, 1984, Nov-28, Volume: 802, Issue:2

    Topics: Adenosine; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Neoplasms; Thionucleosides

1984
Catabolism and lability of S-adenosyl-L-methionine in rat liver extracts.
    The Biochemical journal, 1984, Nov-15, Volume: 224, Issue:1

    Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Female; In Vitro Techniques; Liver; Proteins; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides

1984
Effect of 5'-methylthioadenosine (a naturally occurring nucleoside) on murine hematopoiesis.
    Experimental hematology, 1984, Volume: 12, Issue:11

    Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Deoxyadenosines; Female; Hematopoiesis; Hematopoietic Stem Cells; Kinetics; Mice; Mice, Inbred BALB C; Thionucleosides

1984
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells.
    Biochemical and biophysical research communications, 1983, Apr-29, Volume: 112, Issue:2

    Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Humans; Inosine; Leukemia L1210; Methionine; Methylthioinosine; Mice; Thionucleosides

1983
Inhibition of dimethyl sulfoxide-induced differentiation of Friend erythroleukemic cells by 5'-methylthioadenosine.
    Cancer research, 1984, Volume: 44, Issue:9

    Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Clone Cells; Deoxyadenosines; Dimethyl Sulfoxide; Globins; Heme; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myeloid, Acute; Mice; RNA, Messenger; Thionucleosides

1984
Inhibition of aminopropyltransferases.
    Methods in enzymology, 1983, Volume: 94

    Topics: Adenosine; Animals; Cattle; Deoxyadenosines; In Vitro Techniques; Male; Polyamines; Rats; S-Adenosylmethionine; Spermidine Synthase; Thionucleosides; Transferases

1983
High-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis.
    Methods in enzymology, 1983, Volume: 94

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1983
Methionine synthesis from 5'-methylthioadenosine by tumour cells.
    Biochemical pharmacology, 1983, Oct-01, Volume: 32, Issue:19

    Topics: Adenosine; Animals; Carbon Radioisotopes; Cell Line; Cells, Cultured; Deoxyadenosines; Humans; Kinetics; Leukemia; Methionine; Mice; Neoplasms; Thionucleosides; Urinary Bladder Neoplasms

1983
A simple and sensitive liquid chromatographic method for the determination of 5'-methylthioadenosine in tissues.
    Journal of chromatography, 1983, Nov-11, Volume: 278, Issue:1

    Topics: 2-Chloroadenosine; Adenosine; Animals; Chromatography, Ion Exchange; Chromatography, Liquid; Deoxyadenosines; Rats; Thionucleosides; Tissue Distribution

1983
Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma.
    The Journal of biological chemistry, 1984, Jun-10, Volume: 259, Issue:11

    Topics: Adenosine; Animals; Cell Line; Colonic Neoplasms; Deoxyadenosines; Humans; Liver; Methionine; Rats; Ribosemonophosphates; Ribulosephosphates; Thioglycosides; Thionucleosides

1984
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain.
    The Biochemical journal, 1984, May-01, Volume: 219, Issue:3

    Topics: Adenosine; Animals; Brain; Cattle; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Putrescine; S-Adenosylmethionine; Spermidine; Spermidine Synthase; Thionucleosides; Transferases

1984
Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate.
    Biochemical and biophysical research communications, 1980, Aug-29, Volume: 95, Issue:4

    Topics: Adenosine; Androgens; Animals; Castration; Deoxyadenosines; Male; Ornithine Decarboxylase; Pentosyltransferases; Polyamines; Prostate; Purine-Nucleoside Phosphorylase; Rats; Testosterone; Thionucleosides

1980
Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines.
    Cancer research, 1980, Volume: 40, Issue:11

    Topics: Adenosine; Cell Line; Deoxyadenosines; Humans; Leukemia; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides

1980
Kinetic studies of Drosophila melanogaster methylthioadenosine nucleoside phosphorylase.
    The International journal of biochemistry, 1981, Volume: 13, Issue:5

    Topics: Adenosine; Animals; Deoxyadenosines; Drosophila melanogaster; Kinetics; Pentosyltransferases; Phosphates; Purine-Nucleoside Phosphorylase; Ribosemonophosphates; Thioglycosides; Thionucleosides

1981
Effect of 5''-methylthioadenosine and its analogs on murine lymphoid cell proliferation.
    Cancer research, 1981, Volume: 41, Issue:8

    Topics: Adenosine; Animals; Cell Division; Cell Line; Cell Survival; Deoxyadenosines; Dose-Response Relationship, Drug; Lymphocytes; Mice; Purine-Nucleoside Phosphorylase; Thionucleosides; Tubercidin

1981
Inactivation of S-adenosylhomocysteine hydrolase by 5'-deoxy-5'-methylthioadenosine.
    Biochemical and biophysical research communications, 1981, May-29, Volume: 100, Issue:2

    Topics: Adenine; Adenosine; Adenosylhomocysteinase; Deoxyadenosines; Erythrocytes; Humans; Hydrolases; In Vitro Techniques; Ribose; Thioglycosides; Thionucleosides

1981
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation.
    Biochemical pharmacology, 1982, Feb-15, Volume: 31, Issue:4

    Topics: Adenosine; Deoxyadenosines; Humans; In Vitro Techniques; Lymphocyte Activation; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Substrate Specificity; Thionucleosides

1982
Adenosine metabolism: modification by S-adenosylhomocysteine and 5'-methylthioadenosine.
    Archives of biochemistry and biophysics, 1982, Apr-15, Volume: 215, Issue:1

    Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; B-Lymphocytes; Cells, Cultured; Deoxyadenosines; Erythrocytes; Homocysteine; Humans; Hydrolases; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides

1982
Transport and metabolism of 5'-methylthioadenosine in human erythrocytes.
    Biochimica et biophysica acta, 1983, Jan-19, Volume: 727, Issue:2

    Topics: Adenosine; Biological Transport; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; Kinetics; Ribonucleosides; Thionucleosides

1983
Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose.
    The Journal of biological chemistry, 1983, Jun-10, Volume: 258, Issue:11

    Topics: Adenosine; Animals; Chromatography, Thin Layer; Deoxyadenosines; Liver; Male; Methionine; Oxygen Consumption; Pentosephosphates; Phosphorylation; Rats; Rats, Inbred Strains; Ribosemonophosphates; Ribulosephosphates; Thioglycosides; Thionucleosides

1983
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
    The Journal of clinical investigation, 1983, Volume: 71, Issue:5

    Topics: Adenosine; Animals; Deoxyadenosines; Folic Acid; Formyltetrahydrofolates; Liver; Male; Methionine; Nitrous Oxide; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Vitamin B 12; Vitamin B 12 Deficiency

1983
Ketomethylthiobutyric acid formation from methylthioadenosine: a diffusion assay.
    Archives of biochemistry and biophysics, 1983, Volume: 223, Issue:2

    Topics: Adenosine; Animals; Cell Line; Cells, Cultured; Cysteine; Deoxyadenosines; Diffusion; Methionine; Mice; Neoplasms, Experimental; Sulfhydryl Compounds; Thionucleosides

1983
Chiral instability at sulfur of S-adenosylmethionine.
    Biochemistry, 1983, Jun-07, Volume: 22, Issue:12

    Topics: Adenosine; Chemical Phenomena; Chemistry; Deoxyadenosines; Drug Stability; Homoserine; Kinetics; Molecular Conformation; S-Adenosylmethionine; Sulfur; Thionucleosides

1983
Simple separation of adenine and adenosyl-sulfur compounds by high-performance liquid chromatography.
    Journal of chromatography, 1983, Jul-15, Volume: 264, Issue:2

    Topics: Adenine; Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1983
Inhibition of the synthesis of polyamines and macromolecules by 5'-methylthioadenosine and 5'-alkylthiotubercidins in BHK21 cells.
    The Biochemical journal, 1982, Jun-15, Volume: 204, Issue:3

    Topics: Adenosine; Animals; Cell Line; Cricetinae; Deoxyadenosines; Depression, Chemical; Kidney; Polyamines; Protein Biosynthesis; Ribonucleosides; Spermidine Synthase; Thionucleosides; Tubercidin

1982
Uptake and utilization of 5'-methylthioadenosine by cultured baby-hamster kidney cells.
    The Biochemical journal, 1982, Jun-15, Volume: 204, Issue:3

    Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Deoxyadenosines; Kidney; Thionucleosides; Tubercidin

1982
5'-Methylthioadenosine metabolism and methionine synthesis in mammalian cells grown in culture.
    Biochemical and biophysical research communications, 1982, Sep-30, Volume: 108, Issue:2

    Topics: Adenosine; Animals; Breast; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; HeLa Cells; Humans; Leukemia L1210; Leukemia, Myeloid; Methionine; Mice; Spleen; Thionucleosides

1982
5'-Methylthioadenosine and 2',5'-dideoxyadenosine blockade of the inhibitory effects of adenosine on ADP-induced platelet aggregation by different mechanisms.
    Biochemical pharmacology, 1980, Sep-15, Volume: 29, Issue:18

    Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclases; Blood Platelets; Deoxyadenosines; Dideoxyadenosine; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Thionucleosides

1980
Effect of 5'-deoxy-5'-S-isobutyl-thioadenosine (SIBA) on the disposition of 5'-methylthioadenosine by isolated rat hepatocytes.
    FEBS letters, 1982, Jan-25, Volume: 137, Issue:2

    Topics: Adenosine; Animals; Antineoplastic Agents; Biological Transport; Chromatography, High Pressure Liquid; Deoxyadenosines; In Vitro Techniques; Kinetics; Liver; Rats; Thionucleosides

1982
Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).
    Thrombosis and haemostasis, 1982, Oct-29, Volume: 48, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Animals; Deoxyadenosines; Depression, Chemical; Dideoxyadenosine; Fungi; Humans; Plant Extracts; Platelet Aggregation; Rats; Rats, Inbred Strains; Thionucleosides

1982
Synergistic inhibition of platelet aggregation by forskolin plus PGE1 or 2-fluoroadenosine: effects of 2',5'-dideoxyadenosine and 5'-methylthioadenosine.
    Biochemical pharmacology, 1982, Nov-15, Volume: 31, Issue:22

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Alprostadil; Colforsin; Deoxyadenosines; Dideoxyadenosine; Diterpenes; Drug Synergism; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Thionucleosides

1982
Methionine synthesis from 5'-methylthioadenosine in rat liver.
    The Journal of biological chemistry, 1981, Feb-25, Volume: 256, Issue:4

    Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Female; Kinetics; Liver; Methionine; Radioisotope Dilution Technique; Rats; Sulfur Radioisotopes; Thionucleosides; Tritium

1981
High-performance liquid chromatographic analysis of 5'-methylthioadenosine in rat tissues.
    Journal of chromatography, 1981, Nov-13, Volume: 226, Issue:1

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Thionucleosides; Tissue Distribution

1981
Utilization by Saccharomyces cerevisiae of 5'-methylthioadenosine as a source of both purine and methionine.
    Journal of bacteriology, 1982, Volume: 151, Issue:1

    Topics: Adenosine; Deoxyadenosines; Genotype; Methionine; Mutation; Purine Nucleosides; Saccharomyces cerevisiae; Species Specificity; Thionucleosides

1982
Metabolism of 5'-methylthioadenosine in Aspergillus nidulans. An alternative pathway for methionine synthesis via utilization of the nucleoside methylthio group.
    Biochimica et biophysica acta, 1982, Aug-06, Volume: 717, Issue:2

    Topics: Adenosine; Aspergillus nidulans; Deoxyadenosines; Methionine; Mutation; Species Specificity; Thionucleosides

1982
Identification of 2-keto-4-methylthiobutyrate as an intermediate compound in methionine synthesis from 5'-methylthioadenosine.
    The Journal of biological chemistry, 1982, Apr-25, Volume: 257, Issue:8

    Topics: Adenosine; Animals; Deoxyadenosines; Kinetics; Liver; Magnesium; Methionine; Rats; Thionucleosides

1982
Methylthioadenosine metabolism in malignant murine cells.
    Biochemical and biophysical research communications, 1982, Nov-30, Volume: 109, Issue:2

    Topics: Adenosine; Animals; Carbon Radioisotopes; Deoxyadenosines; Leukemia L5178; Leukemia, Experimental; Mass Spectrometry; Mice; Mice, Inbred DBA; Sulfur Radioisotopes; Thionucleosides

1982
Conversion of 5'-methylthioadenosine into S-adenosylmethionine by yeast cells.
    Biochimica et biophysica acta, 1980, Dec-01, Volume: 633, Issue:2

    Topics: Adenosine; Amino Acids; Candida; Cells, Cultured; Culture Media; Deoxyadenosines; S-Adenosylmethionine; Thionucleosides

1980
Effect of 5'-methylthioadenosine on in vivo methyl esterification of human erythrocyte membrane proteins.
    FEBS letters, 1981, Apr-20, Volume: 126, Issue:2

    Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein Methyltransferases; Protein O-Methyltransferase; Thionucleosides

1981
[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Jun-15, Volume: 57, Issue:11

    Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein O-Methyltransferase; S-Adenosylmethionine; Thionucleosides

1981
[New method of synthesis of structural analogs of 5'-methylthioadenosine].
    Bollettino della Societa italiana di biologia sperimentale, 1981, May-30, Volume: 57, Issue:10

    Topics: Adenosine; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Thionucleosides

1981
Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.
    The Biochemical journal, 1981, Jan-15, Volume: 194, Issue:1

    Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Transformation, Viral; Cells, Cultured; Deoxyadenosines; Fibroblasts; Mice; Ornithine Decarboxylase Inhibitors; Polyamines; S-Adenosylhomocysteine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases

1981
Effect of 5'-methylthioadenosine on nucleolar morphology and RNA metabolism in cultured Xenopus laevis cells.
    Experimental cell research, 1981, Volume: 135, Issue:2

    Topics: Adenosine; Animals; Cell Line; Cell Nucleolus; Deoxyadenosines; Larva; RNA, Ribosomal; Skin; Thionucleosides; Xenopus

1981
Studies on 5'-methylthioadenosine uptake by human erythrocytes.
    Medical biology, 1981, Volume: 59, Issue:5-6

    Topics: Adenosine; Biological Transport, Active; Chromatography, High Pressure Liquid; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Phosphates; Thionucleosides

1981
Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5'-methylthioadenosine.
    Cellular immunology, 1980, Volume: 49, Issue:1

    Topics: Adenosine; Cell Count; Cell Survival; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Immunologic; Humans; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thionucleosides; Tuberculin

1980
Studies of inhibition of rat spermidine synthase and spermine synthase.
    The Biochemical journal, 1980, May-01, Volume: 187, Issue:2

    Topics: Adenosine; Animals; Deoxyadenosines; Male; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases

1980
[A new method of measuring 5'-methylthioadenosine with high pressure liquid chromatography].
    Bollettino della Societa italiana di biologia sperimentale, 1980, Oct-15, Volume: 56, Issue:19

    Topics: Adenosine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyadenosines; Thionucleosides

1980
Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts.
    Biochemical pharmacology, 1994, Mar-02, Volume: 47, Issue:5

    Topics: 3T3 Cells; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; Deoxyadenosines; Mice; PC12 Cells; Pheochromocytoma; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Thionucleosides; Xanthines

1994
Quantitation of urinary nucleosides by high-performance liquid chromatography.
    Journal of chromatography. A, 1997, Feb-28, Volume: 763, Issue:1-2

    Topics: Adenosine; Breast Neoplasms; Chromatography, High Pressure Liquid; Deoxyadenosines; Female; Guanosine; Humans; Male; Mouth Neoplasms; Nucleosides; Pseudouridine; Ribonucleosides; Thionucleosides

1997
Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.
    Molecular pharmacology, 1997, Volume: 52, Issue:5

    Topics: Adenosine; Antimalarials; Antimetabolites, Antineoplastic; Azaserine; Biomarkers, Tumor; Cell Count; Deoxyadenosines; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Methionine; Methotrexate; Pancreatic Neoplasms; Purine-Nucleoside Phosphorylase; Purines; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured

1997
Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes.
    Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1

    Topics: Adenosine; Animals; Biological Transport; Deoxyadenosines; Methionine; Models, Chemical; Molecular Structure; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; S-Adenosylmethionine; Spermidine; Structure-Activity Relationship; Substrate Specificity; Thionucleosides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense

1999
Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.
    The Journal of biological chemistry, 2002, Jan-11, Volume: 277, Issue:2

    Topics: Adenosine; Alanine; Archaeal Proteins; Deoxyadenosines; Enzyme Stability; Ethionine; Humans; Hydrogen-Ion Concentration; Methylation; Molecular Structure; Oligopeptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Pyrococcus furiosus; Recombinant Proteins; S-Adenosylhomocysteine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Temperature; Thionucleosides

2002
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.
    Journal of molecular biology, 2009, May-01, Volume: 388, Issue:2

    Topics: Adenosine; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyadenosines; Methyltransferases; Protein Binding; Protein Conformation; Thermus thermophilus; Thionucleosides

2009
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
    The Journal of biological chemistry, 2011, Feb-11, Volume: 286, Issue:6

    Topics: Adenine; Adenosine; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyadenosines; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Purine-Nucleoside Phosphorylase; Pyrrolidines; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2011
Purification and characterization of antioxidant components from the fruiting bodies of Pleurotus abalonus including 9-beta-d-ribofuranosidoadenine, 5'-deoxy-5'-(methylthio)adenosine, and a triterpenoid.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2

    Topics: Adenosine; Animals; Antioxidants; Blood Glucose; Brain; Deoxyadenosines; DNA Damage; Fruiting Bodies, Fungal; Hemolysis; Hydroxyl Radical; Kidney; Lipid Peroxidation; Male; Mice; Pleurotus; Thionucleosides; Time Factors; Triterpenes

2013
Identification and analysis of the constituents in an aqueous extract of Tricholoma matsutake by HPLC coupled with diode array detection/electrospray ionization mass spectrometry.
    Journal of food science, 2013, Volume: 78, Issue:8

    Topics: Adenine; Adenosine; Chromatography, High Pressure Liquid; Cytidine; Deoxyadenosines; Guanosine; Inosine; Phenylalanine; Riboflavin; Spectrometry, Mass, Electrospray Ionization; Thionucleosides; Tricholoma; Tryptophan; Tyrosine; Uridine; Water

2013
The 5'-nor aristeromycin analogues of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-thiophenyladenosine.
    Nucleosides, nucleotides & nucleic acids, 2014, Volume: 33, Issue:10

    Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Deoxyadenosines; Drug Design; Structure-Activity Relationship; Thionucleosides; Viruses

2014
Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
    ACS chemical biology, 2016, 06-17, Volume: 11, Issue:6

    Topics: Adenosine; Deoxyadenosines; Imino Furanoses; Mycobacterium tuberculosis; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrrolidines; Quantum Theory; S-Adenosylhomocysteine; Thionucleosides

2016
Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
    BMC structural biology, 2017, Dec-19, Volume: 17, Issue:1

    Topics: Adenosine; Amino Acid Motifs; Amino Acid Sequence; Antibodies; Binding Sites, Antibody; Catalytic Domain; Deoxyadenosines; Humans; Leishmania infantum; Molecular Docking Simulation; Peptide Fragments; Protein Binding; Protein Conformation; Purine-Nucleoside Phosphorylase; Sequence Analysis, DNA; Sequence Homology; Static Electricity; Substrate Specificity; Thionucleosides; Trypanosoma brucei brucei

2017