Compounds > 5'-iodoindirubin
Page last updated: 2024-09-03

5'-iodoindirubin and indirubin-3'-monoxime

5'-iodoindirubin has been researched along with indirubin-3'-monoxime in 4 studies

*indirubin-3'-monoxime: has antiangiogenic activity [MeSH]

*indirubin-3'-monoxime: has antiangiogenic activity [MeSH]

Compound Research Comparison

Studies
(5'-iodoindirubin)		Trials
(5'-iodoindirubin)		Recent Studies (post-2010)
(5'-iodoindirubin)		Studies
(indirubin-3'-monoxime)		Trials
(indirubin-3'-monoxime)		Recent Studies (post-2010) (indirubin-3'-monoxime)
601139082

Protein Interaction Comparison

ProteinTaxonomy5'-iodoindirubin (IC50)indirubin-3'-monoxime (IC50)
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Chain B, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.022
Glycogen synthase kinase-3 beta Sus scrofa (pig)0.022
[Tau protein] kinase Sus scrofa (pig)0.022
Serine/threonine-protein kinase Sgk1Homo sapiens (human)0.38
Aurora kinase AHomo sapiens (human)4
Cyclin-T1Homo sapiens (human)2.4
Serine/threonine-protein kinase 17BHomo sapiens (human)0.71
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.099
Tyrosine-protein kinase LckHomo sapiens (human)0.3
Cyclin-dependent kinase 1Homo sapiens (human)0.126
Insulin-like growth factor 1 receptorHomo sapiens (human)5.3
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)8.2
Fibroblast growth factor receptor 1Homo sapiens (human)2.5
Cyclin-dependent kinase 4Homo sapiens (human)3.33
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.099
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)0.1
Cyclin-A2Homo sapiens (human)0.515
G1/S-specific cyclin-D1Homo sapiens (human)3.33
G1/S-specific cyclin-E1Homo sapiens (human)0.7
Cyclin-dependent kinase 2Homo sapiens (human)0.5767
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0785
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.022
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0599
Cyclin-dependent kinase 9Homo sapiens (human)2.4
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.1
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.1
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.099
Aurora kinase BHomo sapiens (human)2.3
Aurora kinase CHomo sapiens (human)0.3

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Greengard, P; Leost, M; Magiatis, P; Meijer, L; Mikros, E; Musacchio, A; Myrianthopoulos, V; Pearl, L; Polychronopoulos, P; Roe, SM; Skaltsounis, AL; Tarricone, A1
Grundt, P; Jones-Brando, L; Krivogorsky, B; Yolken, R1
Choi, SJ; Choi, SU; Han, SY; Kim, YC; Lee, SD; Moon, MJ1
Byun, BJ; Choi, G; Choi, SU; Jung, ME; Kim, HM; Kim, SJ; Kim, YC; Lee, JY; Lee, K; Lee, N; Park, JH; Son, YH; Yang, KM1

Other Studies

4 other study(ies) available for 5'-iodoindirubin and indirubin-3'-monoxime

ArticleYear
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Indoles; Models, Molecular; Oximes; Structure-Activity Relationship

2004
Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Animals; Antiprotozoal Agents; Drugs, Chinese Herbal; Indoles; Isatis; Parasitic Sensitivity Tests; Quinazolines; Toxoplasma

2008
Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
    Bioorganic & medicinal chemistry letters, 2010, Mar-15, Volume: 20, Issue:6

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Leukemia, Myeloid, Acute

2010
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
    Bioorganic & medicinal chemistry letters, 2016, 06-01, Volume: 26, Issue:11

    Topics: Apoptosis Regulatory Proteins; Dose-Response Relationship, Drug; Drug Discovery; High-Throughput Screening Assays; Humans; Indoles; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship

2016