5--amino-5--deoxyadenosine and clitocine

5--amino-5--deoxyadenosine has been researched along with clitocine* in 1 studies

Other Studies

1 other study(ies) available for 5--amino-5--deoxyadenosine and clitocine

Article	Year
Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors. Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18 Adenosine kinase (AK) is the primary enzyme responsible for adenosine metabolism. Inhibition of AK effectively increases extracellular adenosine concentrations and represents an alternative approach to enhance the beneficial actions of adenosine as compared to direct-acting receptor agonists. Clitocine (3), isolated from the mushroom Clitocybe inversa, has been found to be a weak inhibitor of AK. We have prepared a number of analogues of clitocine in order to improve its potency and demonstrated that 5'-deoxy-5'-amino-clitocine (7) improved AK inhibitory potency by 50-fold. Topics: Adenosine Kinase; Animals; Biochemistry; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inhibitory Concentration 50; Pyrimidine Nucleosides; Rats; Structure-Activity Relationship	2001

Article

Year

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.

Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18

Adenosine kinase (AK) is the primary enzyme responsible for adenosine metabolism. Inhibition of AK effectively increases extracellular adenosine concentrations and represents an alternative approach to enhance the beneficial actions of adenosine as compared to direct-acting receptor agonists. Clitocine (3), isolated from the mushroom Clitocybe inversa, has been found to be a weak inhibitor of AK. We have prepared a number of analogues of clitocine in order to improve its potency and demonstrated that 5'-deoxy-5'-amino-clitocine (7) improved AK inhibitory potency by 50-fold.

Topics: Adenosine Kinase; Animals; Biochemistry; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inhibitory Concentration 50; Pyrimidine Nucleosides; Rats; Structure-Activity Relationship

2001