5--amino-5--deoxyadenosine and aniline

5--amino-5--deoxyadenosine has been researched along with aniline* in 1 studies

Other Studies

1 other study(ies) available for 5--amino-5--deoxyadenosine and aniline

Article	Year
Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing. Organic & biomolecular chemistry, 2013, Apr-28, Volume: 11, Issue:16 We recently reported the use of PSCl3 for the thiophosphorylation of alkylamines where the resulting N-thiophosphoramidate ions could be readily S-alkylated (Chem. Commun., 2011, 47, 6156-6158.). Herein we report the development of this methodology using amino acid, amino sugar, aminonucleoside and aniline substrates. The hydrolysis properties of N-thiophosphoramidate ions and their reactivities towards alkylating agents are also explored. In addition, we demonstrate the application of our approach to the preparation of a small library of compounds, including quinoline-based N,S-dialkylthiophosphoramidates which were tested for antileishmanial activity. Topics: Acetamides; Alkylating Agents; Alkylation; Amides; Aniline Compounds; Antiprotozoal Agents; Deoxyadenosines; Deoxyguanosine; Glucosamine; Humans; Hydrolysis; Leishmania mexicana; Leishmaniasis, Cutaneous; Phenylalanine; Phosphoric Acids; Phosphorylation; Sulfhydryl Compounds	2013

Article

Year

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

Organic & biomolecular chemistry, 2013, Apr-28, Volume: 11, Issue:16

We recently reported the use of PSCl3 for the thiophosphorylation of alkylamines where the resulting N-thiophosphoramidate ions could be readily S-alkylated (Chem. Commun., 2011, 47, 6156-6158.). Herein we report the development of this methodology using amino acid, amino sugar, aminonucleoside and aniline substrates. The hydrolysis properties of N-thiophosphoramidate ions and their reactivities towards alkylating agents are also explored. In addition, we demonstrate the application of our approach to the preparation of a small library of compounds, including quinoline-based N,S-dialkylthiophosphoramidates which were tested for antileishmanial activity.

Topics: Acetamides; Alkylating Agents; Alkylation; Amides; Aniline Compounds; Antiprotozoal Agents; Deoxyadenosines; Deoxyguanosine; Glucosamine; Humans; Hydrolysis; Leishmania mexicana; Leishmaniasis, Cutaneous; Phenylalanine; Phosphoric Acids; Phosphorylation; Sulfhydryl Compounds

2013