Page last updated: 2024-09-03

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and yohimbine

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with yohimbine in 4 studies

Compound Research Comparison

Studies
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Trials
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Recent Studies (post-2010)
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Studies
(yohimbine)
Trials
(yohimbine)
Recent Studies (post-2010) (yohimbine)
73085,893253532

Protein Interaction Comparison

ProteinTaxonomy5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50)yohimbine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.0353
Cytochrome P450 2D6Homo sapiens (human)1.02
D(2) dopamine receptorHomo sapiens (human)2.06
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-2B adrenergic receptorHomo sapiens (human)0.0428
Alpha-2C adrenergic receptorHomo sapiens (human)0.0466
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.126
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-1D adrenergic receptorHomo sapiens (human)1.013
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.126
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.074
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.3
5-hydroxytryptamine receptor 6Homo sapiens (human)1.689

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z1
Bhalla, S; Gulati, A; Rapolaviciute, V1
Andurkar, SV; Bhalla, S; Gulati, A2

Other Studies

4 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and yohimbine

ArticleYear
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
    Pharmacology, 2009, Volume: 83, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine

2009
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
    European journal of pharmacology, 2011, Jan-25, Volume: 651, Issue:1-3

    Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine

2011
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
    Pharmacology, 2011, Volume: 87, Issue:3-4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Body Temperature; Body Temperature Regulation; Brain; Clonidine; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Yohimbine

2011
Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Body Temperature Regulation; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Hypothermia; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Oxycodone; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Yohimbine

2013