5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with sulfisoxazole in 4 studies
| Studies (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Trials (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Recent Studies (post-2010) (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Studies (sulfisoxazole) | Trials (sulfisoxazole) | Recent Studies (post-2010) (sulfisoxazole) |
|---|---|---|---|---|---|
| 73 | 0 | 8 | 1,000 | 81 | 58 |
| Protein | Taxonomy | 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50) | sulfisoxazole (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.78 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 4.89 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bisaha, S; Dickey, J; Floyd, DM; Girotra, RN; Gougoutas, JZ; Kozlowski, M; Lee, VG; Liu, EC; Malley, MF; Stein, PD | 1 |
| Hunt, JT; Krystek, SR; Stein, PD; Stouch, TR | 1 |
| Dickey, J; Dickinson, KE; Floyd, DM; Hunt, JT; Liu, EC; Mitchell, C; Moreland, S; Murugesan, N; Stein, PD; Webb, ML | 1 |
| Wermuth, CG | 1 |
1 review(s) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and sulfisoxazole
| Article | Year |
|---|---|
Selective optimization of side activities: another way for drug discovery.
Topics: Animals; Biological Availability; Combinatorial Chemistry Techniques; Databases, Factual; Drug Design; Humans; Patents as Topic; Pharmaceutical Preparations; Structure-Activity Relationship | 2004 |
3 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and sulfisoxazole
| Article | Year |
|---|---|
Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.
Topics: Animals; Benzenesulfonamides; Carotid Arteries; Cell Line; Endothelin Receptor Antagonists; In Vitro Techniques; Muscle, Smooth, Vascular; Rabbits; Radioligand Assay; Rats; Receptor, Endothelin A; Structure-Activity Relationship; Sulfonamides | 1995 |
Three-dimensional quantitative structure-activity relationships of sulfonamide endothelin inhibitors.
Topics: Animals; Endothelins; In Vitro Techniques; Molecular Conformation; Muscle, Smooth, Vascular; Rats; Structure-Activity Relationship; Sulfonamides | 1995 |
The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
Topics: Animals; Antihypertensive Agents; Cell Line; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Hypertension; Molecular Structure; Muscle, Smooth, Vascular; Rabbits; Rats; Structure-Activity Relationship | 1994 |