5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with morphine in 11 studies
Studies (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Trials (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Recent Studies (post-2010) (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
---|---|---|---|---|---|
73 | 0 | 8 | 44,270 | 5,200 | 8,695 |
Protein | Taxonomy | 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50) | morphine (IC50) |
---|---|---|---|
Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 8 (72.73) | 29.6817 |
2010's | 3 (27.27) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bhalla, S; Gulati, A; Matwyshyn, G | 3 |
Bhalla, S; Gulati, A; Matwyshyn, G; Puppala, BL | 2 |
Bhalla, S; Ciaccio, N; Gulati, A; Wang, ZJ | 1 |
Bhalla, S; Gulati, A; Matwyshyn, GA | 1 |
Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z | 1 |
Bhalla, S; Gulati, A; Rapolaviciute, V | 1 |
Andurkar, SV; Bhalla, S; Gulati, A | 2 |
11 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and morphine
Article | Year |
---|---|
Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats.
Topics: Animals; Antihypertensive Agents; Area Under Curve; Body Temperature; Dansyl Compounds; Endothelin Receptor Antagonists; Male; Morphine; Peptides, Cyclic; Placebos; Rats; Rats, Sprague-Dawley; Temperature; Time Factors | 2003 |
Evidence that morphine tolerance may be regulated by endothelin in the neonatal rat.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Dansyl Compounds; Drug Tolerance; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Peptide Fragments; Placebos; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 2004 |
A novel combination of opiates and endothelin antagonists to manage pain without any tolerance development.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dansyl Compounds; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Endothelin A Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors | 2004 |
Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists.
Topics: Analgesics, Opioid; Animals; Dansyl Compounds; Drug Interactions; Drug Tolerance; Endothelin A Receptor Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Pain Threshold; Peptides, Cyclic; Receptor, Endothelin A; Receptors, Opioid | 2005 |
Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells.
Topics: Analgesics, Opioid; Cell Line, Tumor; Dansyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endothelin A Receptor Antagonists; Endothelin-1; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Neuroblastoma; Receptors, G-Protein-Coupled | 2006 |
Involvement of central endothelin receptors in neonatal morphine withdrawal.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Central Nervous System; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelins; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Peptide Fragments; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Substance Withdrawal Syndrome | 2006 |
Endothelin ETA receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Gastrointestinal Transit; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Morphine; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors | 2006 |
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 2009 |
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine | 2011 |
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Body Temperature; Body Temperature Regulation; Brain; Clonidine; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Yohimbine | 2011 |
Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Body Temperature Regulation; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Hypothermia; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Oxycodone; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Yohimbine | 2013 |