Compounds > 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
Page last updated: 2024-09-03

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and morphine

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with morphine in 11 studies

Compound Research Comparison

Studies
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Trials
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Recent Studies (post-2010)
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Studies
(morphine)		Trials
(morphine)		Recent Studies (post-2010) (morphine)
730844,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomy5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (72.73)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhalla, S; Gulati, A; Matwyshyn, G3
Bhalla, S; Gulati, A; Matwyshyn, G; Puppala, BL2
Bhalla, S; Ciaccio, N; Gulati, A; Wang, ZJ1
Bhalla, S; Gulati, A; Matwyshyn, GA1
Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z1
Bhalla, S; Gulati, A; Rapolaviciute, V1
Andurkar, SV; Bhalla, S; Gulati, A2

Other Studies

11 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and morphine

ArticleYear
Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats.
    Peptides, 2003, Volume: 24, Issue:4

    Topics: Animals; Antihypertensive Agents; Area Under Curve; Body Temperature; Dansyl Compounds; Endothelin Receptor Antagonists; Male; Morphine; Peptides, Cyclic; Placebos; Rats; Rats, Sprague-Dawley; Temperature; Time Factors

2003
Evidence that morphine tolerance may be regulated by endothelin in the neonatal rat.
    Biology of the neonate, 2004, Volume: 86, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Dansyl Compounds; Drug Tolerance; Endothelin A Receptor Antagonists; Endothelin-1; Endothelins; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Peptide Fragments; Placebos; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin

2004
A novel combination of opiates and endothelin antagonists to manage pain without any tolerance development.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dansyl Compounds; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Endothelin A Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors

2004
Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists.
    Brain research, 2005, Dec-07, Volume: 1064, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Dansyl Compounds; Drug Interactions; Drug Tolerance; Endothelin A Receptor Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Pain Threshold; Peptides, Cyclic; Receptor, Endothelin A; Receptors, Opioid

2005
Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Analgesics, Opioid; Cell Line, Tumor; Dansyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endothelin A Receptor Antagonists; Endothelin-1; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Neuroblastoma; Receptors, G-Protein-Coupled

2006
Involvement of central endothelin receptors in neonatal morphine withdrawal.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Central Nervous System; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelins; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Peptide Fragments; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Substance Withdrawal Syndrome

2006
Endothelin ETA receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in mice.
    European journal of pharmacology, 2006, Aug-14, Volume: 543, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Gastrointestinal Transit; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Morphine; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors

2006
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
    Pharmacology, 2009, Volume: 83, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine

2009
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
    European journal of pharmacology, 2011, Jan-25, Volume: 651, Issue:1-3

    Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine

2011
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
    Pharmacology, 2011, Volume: 87, Issue:3-4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Body Temperature; Body Temperature Regulation; Brain; Clonidine; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Yohimbine

2011
Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Body Temperature Regulation; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Hypothermia; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Oxycodone; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Yohimbine

2013