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5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and clonidine

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with clonidine in 2 studies

Compound Research Comparison

Studies
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Trials
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Recent Studies (post-2010)
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
Studies
(clonidine)
Trials
(clonidine)
Recent Studies (post-2010) (clonidine)
730813,6922,0441,394

Protein Interaction Comparison

ProteinTaxonomy5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50)clonidine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.101
Alpha-2B adrenergic receptorHomo sapiens (human)0.0353
Alpha-2C adrenergic receptorHomo sapiens (human)0.0115
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)5.365
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-1D adrenergic receptorHomo sapiens (human)1.21
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)5.365
Alpha-2A adrenergic receptorBos taurus (cattle)0.002
NischarinRattus norvegicus (Norway rat)0.3662

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z1
Andurkar, SV; Bhalla, S; Gulati, A1

Other Studies

2 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and clonidine

ArticleYear
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
    Pharmacology, 2009, Volume: 83, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine

2009
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
    Pharmacology, 2011, Volume: 87, Issue:3-4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Body Temperature; Body Temperature Regulation; Brain; Clonidine; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Yohimbine

2011