5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with bq 123 in 12 studies
| Studies (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Trials (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Recent Studies (post-2010) (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide) | Studies (bq 123) | Trials (bq 123) | Recent Studies (post-2010) (bq 123) |
|---|---|---|---|---|---|
| 73 | 0 | 8 | 1,391 | 63 | 152 |
| Protein | Taxonomy | 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50) | bq 123 (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.017 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 0.014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abboa-Offei, B; Bird, E; Bisaha, S; Giancarli, M; Girotra, R; Gu, Z; Hunt, JT; Kelly, YF; Lee, H; Lee, VG; Liu, EC; Lloyd, J; Mathers, P; Mathur, A; Misra, RN; Murugesan, N; Schmidt, J; Serafino, R; Seymour, AA; Spergel, S; Stein, PD; Stratton, L; Waldron, T; Webb, ML; Zhang, R | 1 |
| Bird, JE; Liu, EC; Moreland, S; Rose, PM; Serafino, R; Stein, PD; Webb, ML | 1 |
| Douglas, SA; Elliott, JD; Louden, C; Ohlstein, EH; Vickery-Clark, LM | 1 |
| Barthlow, HG; Bertelsen, DL; Bialecki, RA; Fisher, CS; Murdoch, WW | 1 |
| Gulati, A; Kumar, A; Morrison, S | 1 |
| D'Orléans-Juste, P; Piovezan, AP; Rae, GA; Tonussi, CR | 1 |
| Herzog, M; Scherer, EQ; Wangemann, P | 1 |
| Bhalla, S; Gulati, A; Matwyshyn, G | 3 |
| Hirata, Y; Sugiyama, T | 1 |
| Briyal, S; Gulati, A; Philip, T | 1 |
1 review(s) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and bq 123
| Article | Year |
|---|---|
[Endothelin-1 and arteriosclerosis].
Topics: Animals; Arteriosclerosis; Cell Division; Dansyl Compounds; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction | 2004 |
11 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and bq 123
| Article | Year |
|---|---|
Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-bip
Topics: Administration, Oral; Animals; Aorta, Thoracic; Blood Pressure; Carotid Arteries; Cerebellum; Endothelin Receptor Antagonists; Endothelin-1; Female; In Vitro Techniques; Injections, Intravenous; Isoxazoles; Macaca fascicularis; Male; Rabbits; Radioligand Assay; Rats; Receptor, Endothelin A; Structure-Activity Relationship; Sulfonamides; Vasoconstriction | 1998 |
BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.
Topics: Animals; Binding, Competitive; Blood Platelets; Calcium; Cerebellum; Dansyl Compounds; Dogs; Endothelin Receptor Antagonists; Endothelins; Glomerular Mesangium; Humans; Lung; Male; Muscle, Smooth, Vascular; Myocardium; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Swine | 1995 |
Endothelin receptor subtypes in the pathogenesis of angioplasty-induced neointima formation in the rat: a comparison of selective ETA receptor antagonism and dual ETA/ETB receptor antagonism using BQ-123 and SB 209670.
Topics: Angioplasty, Balloon; Animals; Dansyl Compounds; Endothelin Receptor Antagonists; Indans; Male; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 1995 |
Functional comparison of endothelin receptors in human and rat pulmonary artery smooth muscle.
Topics: Animals; Aorta; Dansyl Compounds; Endothelin Receptor Antagonists; Humans; Male; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Endothelin | 1997 |
Effect of ETA receptor antagonists on cardiovascular responses induced by centrally administered sarafotoxin 6b: role of sympathetic nervous system.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Injections, Intraventricular; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Regional Blood Flow; Reserpine; Sympathetic Nervous System; Vascular Resistance; Vasoconstrictor Agents; Viper Venoms | 1997 |
Effects of endothelin-1 on capsaicin-induced nociception in mice.
Topics: Analgesia; Animals; Bosentan; Capsaicin; Dansyl Compounds; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hindlimb; Hyperalgesia; Male; Mice; Oligopeptides; Peptide Fragments; Peptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Serotonin; Sulfonamides; Viper Venoms | 1998 |
Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide.
Topics: Amides; Animals; Antihypertensive Agents; Arteries; Calcitonin Gene-Related Peptide; Calcium; Dansyl Compounds; Ear, Inner; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Gerbillinae; Intracellular Signaling Peptides and Proteins; Myosin-Light-Chain Phosphatase; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; Receptor, Endothelin A; Regional Blood Flow; rho-Associated Kinases; Signal Transduction; Vascular Patency; Vasoconstriction; Vasospasm, Intracranial | 2002 |
Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats.
Topics: Animals; Antihypertensive Agents; Area Under Curve; Body Temperature; Dansyl Compounds; Endothelin Receptor Antagonists; Male; Morphine; Peptides, Cyclic; Placebos; Rats; Rats, Sprague-Dawley; Temperature; Time Factors | 2003 |
A novel combination of opiates and endothelin antagonists to manage pain without any tolerance development.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dansyl Compounds; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Endothelin A Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Opioid, mu; Sulfur Radioisotopes; Time Factors | 2004 |
Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists.
Topics: Analgesics, Opioid; Animals; Dansyl Compounds; Drug Interactions; Drug Tolerance; Endothelin A Receptor Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Pain Threshold; Peptides, Cyclic; Receptor, Endothelin A; Receptors, Opioid | 2005 |
Endothelin-A receptor antagonists prevent amyloid-β-induced increase in ETA receptor expression, oxidative stress, and cognitive impairment.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Dansyl Compounds; Endothelin A Receptor Antagonists; Gene Expression Regulation; Male; Oxidative Stress; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2011 |