Compounds > 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide
Page last updated: 2024-09-03

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and aldosterone

5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide has been researched along with aldosterone in 4 studies

Compound Research Comparison

Studies
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Trials
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Recent Studies (post-2010)
(5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)		Studies
(aldosterone)		Trials
(aldosterone)		Recent Studies (post-2010) (aldosterone)
730825,3331,5174,169

Protein Interaction Comparison

ProteinTaxonomy5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50)aldosterone (IC50)
Mineralocorticoid receptor Homo sapiens (human)0.0048
Mineralocorticoid receptorRattus norvegicus (Norway rat)0.043

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Park, JB; Schiffrin, EL2
Chen, X; He, G; Schiffrin, EL; Tostes, RC; Touyz, RM1
Neves, MF; Pu, Q; Schiffrin, EL; Touyz, RM; Virdis, A1

Other Studies

4 other study(ies) available for 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide and aldosterone

ArticleYear
ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:6

    Topics: Aldosterone; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension; Hypertrophy; Infusions, Parenteral; Male; Mesenteric Arteries; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Vasoconstriction; Vasodilation

2001
Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1.
    American journal of hypertension, 2002, Volume: 15, Issue:2 Pt 1

    Topics: Aldosterone; Animals; Antihypertensive Agents; Aorta; Aortic Diseases; Blood Pressure; Body Weight; Cardiomyopathies; Collagen; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Heart; Hypertrophy; Male; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A

2002
Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Aldosterone; Analysis of Variance; Animals; Dansyl Compounds; DNA; Electrophoretic Mobility Shift Assay; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Immunohistochemistry; Kidney; Macrophages; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Transcription Factor AP-1

2002
Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:1

    Topics: Aldosterone; Animals; Blood Pressure; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Matrix; Heart; Hydralazine; Intercellular Adhesion Molecule-1; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Spironolactone; Thiobarbituric Acid Reactive Substances; Vasodilator Agents

2003