Compounds > 5-(4-piperidyl)isoxazol-3-ol

Page last updated: 2024-09-03

5-(4-piperidyl)isoxazol-3-ol and isoxazoles

5-(4-piperidyl)isoxazol-3-ol has been researched along with isoxazoles in 15 studies

Compound Research Comparison

Studies (5-(4-piperidyl)isoxazol-3-ol)	Trials (5-(4-piperidyl)isoxazol-3-ol)	Recent Studies (post-2010) (5-(4-piperidyl)isoxazol-3-ol)	Studies (isoxazoles)	Trials (isoxazoles)	Recent Studies (post-2010) (isoxazoles)
21	0	4	8,633	900	3,337

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (26.67)	18.2507
2000's	8 (53.33)	29.6817
2010's	3 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Falch, E; Kristiansen, U; Krogsgaard-Larsen, P; Lambert, JD	1
Barker, JL; Kristiansen, U; Serafini, R	1
Kristiansen, U; Lambert, JD	1
Akaike, N; Murai, Y; Nielsen, M; Noguchi, K; Westh-Hansen, SE; Witt, MR	1
Hevers, W; Korpi, ER; Lüddens, H; Picard, R; Rabe, H; Uusi-Oukari, M	1
Maksay, G; McKernan, R	1
Engblom, C; Frølund, B; Kristiansen, U; Krogsgaard-Larsen, P; Liljefors, T; Stensbøl, TB; Tagmose, L	1
Ebert, B; Fjalland, B; Hansen, SL; Kristiansen, U	1
Ebert, B; Frølund, B; Kristiansen, U; Krogsgaard-Larsen, P; Liljefors, T	1
Ebert, B; Frølund, B; Jørgensen, AT; Krogsgaard-Larsen, P; Liljefors, T; Mortensen, M	1
Ebert, B; Frølund, B; Krogsgaard-Larsen, P; Liljefors, T	1
Akabas, MH; Dannhardt, G; Debus, F; Dieler, S; Jansen, M; Lüddens, H; Rabe, H; Strehle, A	1
Boström, J; Fjellström, O; Grant, JA; Gustafsson, D; Thelin, A	1
Boddum, K; Frølund, B; Kristiansen, U	1
Bright, DP; Frølund, B; Mortensen, M; Patel, B; Smart, TG	1

Reviews

1 review(s) available for 5-(4-piperidyl)isoxazol-3-ol and isoxazoles

Article	Year
GABA(A) receptor ligands and their therapeutic potentials. Current topics in medicinal chemistry, 2002, Volume: 2, Issue:8 Topics: Animals; Central Nervous System Diseases; GABA Agents; GABA Agonists; GABA Antagonists; Humans; Isonicotinic Acids; Isoxazoles; Ligands; Muscimol; Piperidines; Protein Subunits; Receptors, GABA-A	2002

Other Studies

14 other study(ies) available for 5-(4-piperidyl)isoxazol-3-ol and isoxazoles

Article	Year
Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones. British journal of pharmacology, 1991, Volume: 104, Issue:1 Topics: Animals; Bicuculline; Cells, Cultured; Female; Hippocampus; Isonicotinic Acids; Isoxazoles; Membrane Potentials; Neurons; Piperidines; Pregnancy; Rats; Receptors, GABA-A; Spinal Cord	1991
The low efficacy gamma-aminobutyric acid type A agonist 5-(4-piperidyl)isoxazol-3-ol opens brief Cl- channels in embryonic rat olfactory bulb neurons. Molecular pharmacology, 1995, Volume: 48, Issue:2 Topics: Animals; Chloride Channels; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Kinetics; Neurons; Olfactory Bulb; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley	1995
Benzodiazepine and barbiturate ligands modulate responses of cultured hippocampal neurones to the GABAA receptor partial agonist, 4-PIOL. Neuropharmacology, 1996, Volume: 35, Issue:9-10 Topics: Animals; Barbiturates; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Hippocampus; Hypnotics and Sedatives; Isonicotinic Acids; Isoxazoles; Membrane Potentials; Midazolam; Neurons; Patch-Clamp Techniques; Pentobarbital; Piperidines; Rats	1996
Effects of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, on recombinant human GABA(A) receptors. Neuroscience letters, 1997, Jul-11, Volume: 230, Issue:1 Topics: Animals; Cell Line; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Piperidines; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Transfection; Valine	1997
Coupling between agonist and chloride ionophore sites of the GABA(A) receptor: agonist/antagonist efficacy of 4-PIOL. European journal of pharmacology, 2000, Dec-15, Volume: 409, Issue:3 Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; GABA Agonists; Humans; Ionophores; Isoxazoles; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, GABA-A	2000
Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors. European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2 Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Entropy; GABA Agonists; GABA Antagonists; Humans; Isoxazoles; L Cells; Membranes; Mice; Muscimol; Piperidines; Pyridazines; Receptors, GABA-A; Recombinant Proteins; Temperature; Tritium	2001
A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology. Journal of medicinal chemistry, 2000, Dec-28, Volume: 43, Issue:26 Topics: Animals; Brain; Cells, Cultured; GABA Antagonists; Isoxazoles; Models, Molecular; Muscimol; Neurons; Patch-Clamp Techniques; Piperidines; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship; Synaptic Membranes	2000
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. British journal of pharmacology, 2001, Volume: 133, Issue:4 Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Piperidines; Pyridazines; Receptors, GABA-A; Xenopus laevis	2001
Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity. European journal of pharmacology, 2002, Sep-13, Volume: 451, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Female; GABA-A Receptor Agonists; Humans; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Piperidines; Receptors, GABA-A; Xenopus laevis	2002
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochemical pharmacology, 2004, Oct-15, Volume: 68, Issue:8 Topics: Analgesics, Non-Narcotic; Anxiety; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Hypnotics and Sedatives; Isoxazoles; Piperidines; Sleep Wake Disorders	2004
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Animals; Binding Sites; Brain; Cell Line; Electrophysiology; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis	2008
Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Antifibrinolytic Agents; Computational Biology; Drug Evaluation, Preclinical; Fibrinolysis; Humans; Isoxazoles; Models, Molecular; Piperidines; Plasminogen; Protein Binding; Static Electricity; Tranexamic Acid	2013
The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells. Neurochemical research, 2014, Volume: 39, Issue:11 Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Neurons; Piperidines; Receptors, GABA-A	2014
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-13, Volume: 36, Issue:2 Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	2016