5-(4-piperidyl)isoxazol-3-ol has been researched along with gamma-aminobutyric acid in 6 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Studies (5-(4-piperidyl)isoxazol-3-ol) | Trials (5-(4-piperidyl)isoxazol-3-ol) | Recent Studies (post-2010) (5-(4-piperidyl)isoxazol-3-ol) | Studies (gamma-aminobutyric acid) | Trials (gamma-aminobutyric acid) | Recent Studies (post-2010) (gamma-aminobutyric acid) |
|---|---|---|---|---|---|
| 21 | 0 | 4 | 40,215 | 1,423 | 9,631 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brehm, L; Falch, E; Frølund, B; Hansen, AB; Kristiansen, U; Krogsgaard-Larsen, P | 1 |
| Barker, JL; Kristiansen, U; Serafini, R | 1 |
| Akaike, N; Murai, Y; Nielsen, M; Noguchi, K; Westh-Hansen, SE; Witt, MR | 1 |
| Akabas, MH; Dannhardt, G; Debus, F; Dieler, S; Jansen, M; Lüddens, H; Rabe, H; Strehle, A | 1 |
| Boddum, K; Frølund, B; Kristiansen, U | 1 |
| Bright, DP; Frølund, B; Mortensen, M; Patel, B; Smart, TG | 1 |
6 other study(ies) available for 5-(4-piperidyl)isoxazol-3-ol and gamma-aminobutyric acid
| Article | Year |
|---|---|
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
Topics: Animals; Cells, Cultured; Cerebral Cortex; GABA-A Receptor Agonists; Isoxazoles; Magnetic Resonance Spectroscopy; Mice; Neurons; Rats; Rats, Sprague-Dawley | 1995 |
The low efficacy gamma-aminobutyric acid type A agonist 5-(4-piperidyl)isoxazol-3-ol opens brief Cl- channels in embryonic rat olfactory bulb neurons.
Topics: Animals; Chloride Channels; Female; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoxazoles; Kinetics; Neurons; Olfactory Bulb; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Effects of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, on recombinant human GABA(A) receptors.
Topics: Animals; Cell Line; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Macromolecular Substances; Membrane Potentials; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Piperidines; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Transfection; Valine | 1997 |
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
Topics: Animals; Binding Sites; Brain; Cell Line; Electrophysiology; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Mutation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Mice; Neurons; Piperidines; Receptors, GABA-A | 2014 |
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2016 |