5-(4-acetamidophenyl)pyrazin-2(1h)-one and zardaverine

5-(4-acetamidophenyl)pyrazin-2(1h)-one has been researched along with zardaverine in 1 studies

Compound Research Comparison

Studies (5-(4-acetamidophenyl)pyrazin-2(1h)-one)	Trials (5-(4-acetamidophenyl)pyrazin-2(1h)-one)	Recent Studies (post-2010) (5-(4-acetamidophenyl)pyrazin-2(1h)-one)	Studies (zardaverine)	Trials (zardaverine)	Recent Studies (post-2010) (zardaverine)
38	0	0	67	2	22

Protein Interaction Comparison

Protein	Taxonomy	zardaverine (IC50)
Chain A, Phosphodiesterase 4D	Homo sapiens (human)	0.16
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.39
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.764
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (human)	0.764
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.764
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Rattus norvegicus (Norway rat)	0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Rattus norvegicus (Norway rat)	0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Rattus norvegicus (Norway rat)	0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Rattus norvegicus (Norway rat)	0.21
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.8067
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (human)	0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.6691
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	0.6811
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	0.4912
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens (human)	0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	Homo sapiens (human)	0.94
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (human)	0.94

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H	1

Other Studies

1 other study(ies) available for 5-(4-acetamidophenyl)pyrazin-2(1h)-one and zardaverine

Article	Year
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity	1993

Article

Year

Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.

The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity

1993