5-(4-acetamidophenyl)pyrazin-2(1h)-one has been researched along with zaprinast in 10 studies
| Studies (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Trials (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Recent Studies (post-2010) (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Studies (zaprinast) | Trials (zaprinast) | Recent Studies (post-2010) (zaprinast) |
|---|---|---|---|---|---|
| 38 | 0 | 0 | 576 | 2 | 87 |
| Protein | Taxonomy | 5-(4-acetamidophenyl)pyrazin-2(1h)-one (IC50) | zaprinast (IC50) |
|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | 1.9442 | |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Canis lupus familiaris (dog) | 0.76 | |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Bos taurus (cattle) | 2.6 | |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | 3.55 | |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Bos taurus (cattle) | 2.6 | |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | 3.55 | |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | 3.55 | |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Bos taurus (cattle) | 0.4 | |
| G-protein coupled receptor 35 | Homo sapiens (human) | 0.8294 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burns, F; Pyne, NJ | 2 |
| Barnette, MS; Barone, FC; Fowler, PJ; Grous, M; Ormsbee, HS; Price, WJ | 1 |
| Diocee, BK; Martin, W; Moodie, SA; Souness, JE | 1 |
| Barnette, MS; Grous, M; Ormsbee, HS; Torphy, TJ | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| Barnette, M; Grous, M | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
10 other study(ies) available for 5-(4-acetamidophenyl)pyrazin-2(1h)-one and zaprinast
| Article | Year |
|---|---|
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1992 |
Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Humans; In Vitro Techniques; Muscle Relaxation; Nitroprusside; Nucleotides, Cyclic; Purinones; Pyrazines; Tetrodotoxin | 1991 |
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines | 1990 |
Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Electric Stimulation; Enzyme Activation; Esophagogastric Junction; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Protein Kinases; Purinones; Pyrazines | 1990 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
Topics: Animals; Calmodulin; Cardiotonic Agents; Dermatitis; Edema; Eosinophils; Female; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Isoenzymes; Male; Neutrophils; Passive Cutaneous Anaphylaxis; Phosphodiesterase Inhibitors; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Skin | 1994 |
Lung phosphodiesterase isoenzymes.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Catalysis; Enzyme Activation; Guinea Pigs; Isoenzymes; Lung; Muscle, Smooth; Perfusion; Phosphoric Diester Hydrolases; Purinones; Pyrazines | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |