5-(4-acetamidophenyl)pyrazin-2(1h)-one has been researched along with isoproterenol in 12 studies
| Studies (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Trials (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Recent Studies (post-2010) (5-(4-acetamidophenyl)pyrazin-2(1h)-one) | Studies (isoproterenol) | Trials (isoproterenol) | Recent Studies (post-2010) (isoproterenol) |
|---|---|---|---|---|---|
| 38 | 0 | 0 | 30,780 | 803 | 2,640 |
| Protein | Taxonomy | 5-(4-acetamidophenyl)pyrazin-2(1h)-one (IC50) | isoproterenol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 0.246 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.333 | |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | 0.2125 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 1.77 | |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | 0.2125 | |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | 0.2125 | |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | 0.6667 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, AM; Harris, DA | 2 |
| Beleta, J; Berga, P; Bou, J; Cardelús, I; Fernández, AG; Gristwood, RW; Llenas, J | 1 |
| Lugnier, C; Muller, B; Stoclet, JC | 1 |
| Bailey, IA; Kemp, PR; Radda, GK; Seymour, AM | 1 |
| Barnette, MS; Grous, M; Ormsbee, HS; Torphy, TJ | 1 |
| English, TA; Gristwood, RW; Owen, DA; Sampford, KA; Wallwork, J | 1 |
| Eden, RJ; Gristwood, RW; Owen, DA; Taylor, EM | 1 |
| Barrett, RJ; Harleman, JH; Joseph, EC | 1 |
| Harding, SE; Poole-Wilson, PA; Wynne, DG | 1 |
| Eckly-Michel, AE; Le Bec, A; Lugnier, C | 1 |
| Eckly-Michel, A; Lugnier, C; Martin, V | 1 |
12 other study(ies) available for 5-(4-acetamidophenyl)pyrazin-2(1h)-one and isoproterenol
| Article | Year |
|---|---|
Mitochondrial ATP synthase regulation in heart: defects in hypertension are restored after treatment with captopril.
Topics: Animals; Captopril; Cardiotonic Agents; Cells, Cultured; Electric Stimulation; Hypertension; Isoproterenol; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardium; NADH, NADPH Oxidoreductases; Proton-Translocating ATPases; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ruthenium Red; Verapamil | 1992 |
Studies on the cardiac actions of flosequinan in vitro.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Action Potentials; Animals; Carbachol; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pyrazines; Pyrrolidinones; Quinolines; Rolipram; Vasodilator Agents | 1992 |
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium | 1990 |
Control of mitochondrial ATP synthase in heart cells: inactive to active transitions caused by beating or positive inotropic agents.
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Enzyme Activation; Isoproterenol; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardial Contraction; NADH, NADPH Oxidoreductases; Propranolol; Proton-Translocating ATPases; Pyrazines; Rats; Rats, Inbred Strains; Ruthenium Red | 1990 |
Metabolic consequences of positive inotropy in rat and guinea-pig hearts.
Topics: Acidosis; Animals; Chemical Phenomena; Chemistry; Cyclic AMP; Guinea Pigs; Heart; Heart Rate; Isoproterenol; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardium; Perfusion; Phosphates; Pyrazines; Rats | 1990 |
Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Electric Stimulation; Enzyme Activation; Esophagogastric Junction; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Protein Kinases; Purinones; Pyrazines | 1990 |
Analysis of responses to a selective phosphodiesterase III inhibitor, SK&F 94120, on isolated myocardium, including human ventricular myocardium from "end-stage" failure patients.
Topics: Animals; Carbachol; Cats; Female; Guinea Pigs; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyrazines; Swine | 1987 |
Pharmacological studies with SK&F 94120, a novel positive inotropic agent with vasodilator activity.
Topics: Animals; Cardiotonic Agents; Cats; Female; Guinea Pigs; Hemodynamics; In Vitro Techniques; Isoproterenol; Male; Microspheres; Pyrazines; Rats; Rats, Inbred Strains; Species Specificity; Time Factors; Vascular Resistance; Vasodilator Agents | 1986 |
The evaluation of HBDH and LDH isoenzymes in cardiac cell necrosis of the rat.
Topics: Animals; Female; Heart; Humans; Hydroxybutyrate Dehydrogenase; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardium; Necrosis; Pyrazines; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Guanidines; Guinea Pigs; Heart; Heart Failure; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Norepinephrine; Pyrazines; Pyridazines | 1993 |
Chelerythrine, a protein kinase C inhibitor, interacts with cyclic nucleotide phosphodiesterases.
Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Aorta; Benzophenanthridines; Cardiotonic Agents; Cattle; Drug Interactions; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Glycoproteins; Hydrolysis; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Pyrazines; Rats; Rats, Wistar | 1997 |
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides | 1997 |