Compounds > 5-(4-acetamidophenyl)pyrazin-2(1h)-one
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5-(4-acetamidophenyl)pyrazin-2(1h)-one and cyclic gmp

5-(4-acetamidophenyl)pyrazin-2(1h)-one has been researched along with cyclic gmp in 8 studies

Compound Research Comparison

Studies
(5-(4-acetamidophenyl)pyrazin-2(1h)-one)		Trials
(5-(4-acetamidophenyl)pyrazin-2(1h)-one)		Recent Studies (post-2010)
(5-(4-acetamidophenyl)pyrazin-2(1h)-one)		Studies
(cyclic gmp)		Trials
(cyclic gmp)		Recent Studies (post-2010) (cyclic gmp)
380022,3463334,062

Protein Interaction Comparison

ProteinTaxonomy5-(4-acetamidophenyl)pyrazin-2(1h)-one (IC50)cyclic gmp (IC50)
Phosphodiesterase Bos taurus (cattle)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2.4

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burns, F; Pyne, NJ1
Lugnier, C; Muller, B; Stoclet, JC1
Barnette, MS; Barone, FC; Fowler, PJ; Grous, M; Ormsbee, HS; Price, WJ1
Barnes, PJ; Rhoden, KJ1
Diocee, BK; Martin, W; Moodie, SA; Souness, JE1
Bryson, SE; Rodger, IW1
Eckly, AE; Lugnier, C1
Eckly-Michel, A; Lugnier, C; Martin, V1

Other Studies

8 other study(ies) available for 5-(4-acetamidophenyl)pyrazin-2(1h)-one and cyclic gmp

ArticleYear
Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.
    Biochemical and biophysical research communications, 1992, Dec-30, Volume: 189, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaline Phosphatase; Animals; Cyclic GMP; Enzyme Activation; Guinea Pigs; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Protein Kinases; Purinones; Pyrazines; Pyrrolidinones; Rolipram

1992
Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Chloride; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Protoveratrines; Pyrazines; Pyridones; Sodium

1990
Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.
    Gut, 1991, Volume: 32, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Humans; In Vitro Techniques; Muscle Relaxation; Nitroprusside; Nucleotides, Cyclic; Purinones; Pyrazines; Tetrodotoxin

1991
Potentiation of nonadrenergic neural relaxation in guinea pig airways by a cyclic cAMP phosphodiesterase inhibitor.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Ethylmaleimide; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitroprusside; Potassium Chloride; Pyrazines; Tetrodotoxin; Trachea; Vasoactive Intestinal Peptide

1990
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
    The Biochemical journal, 1990, Feb-15, Volume: 266, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Cyclic GMP; Dipyridamole; Endothelium, Vascular; Isoquinolines; Kinetics; Purinones; Pyrazines; Pyrrolidinones; Rolipram; Swine; Tetrahydroisoquinolines

1990
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.
    British journal of pharmacology, 1987, Volume: 92, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines

1987
Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway.
    British journal of pharmacology, 1994, Volume: 113, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram

1994
Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.
    British journal of pharmacology, 1997, Volume: 122, Issue:1

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides

1997