5-(3-methyl-1-triazeno)imidazole-4-carboxamide has been researched along with dacarbazine in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (33.33) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, AS; Deans, B; Denny, BJ; Hartley, JA; Stevens, MF; Tisdale, MJ; Wheelhouse, RT | 1 |
| Decker, RW; Mizuno, NS | 1 |
| Decker, RW; Mizuno, NS; Zakis, B | 1 |
| Gescher, A; Quarterman, CP; Slack, JA; Tsang, LL | 1 |
| Gore, JZ; Smith, RC | 1 |
| Cerny, T; Margison, GP; Maynard, K; Parsons, PG | 1 |
| Harris, AL; Lunn, JM | 1 |
| Lihou, MG; Parsons, PG; Smith, PJ | 1 |
| Little, JH; Maynard, KR; McLeod, GR; Parsons, PG | 1 |
| Maynard, K; Parsons, PG | 1 |
| Misra, NP | 1 |
| Hayward, IP; Parsons, PG | 1 |
| Babudri, N; Bartoli-Klugmann, F; Montibragadin, C; Pani, B; Tamaro, M; Venturini, S | 1 |
| Delben, F; Manzini, G; Nisi, C; Paoletti, S | 1 |
| Bonmassar, E; D'Atri, S; Gilberti, S; Graziani, G; Lacal, PM; Tentori, L | 1 |
| Denny, BJ; Slack, JA; Stevens, MF; Tsang, LL; Wheelhouse, RT | 1 |
| Ames, MM; Reid, JM; Rubin, J; Stevens, DC | 1 |
| Bowman, KJ; Curtin, NJ; Golding, BT; Griffin, RJ; White, A | 1 |
| Bowman, K; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Newell, DR; Pemberton, LC; Srinivasan, S | 1 |
| Alton, K; Baker, SD; Batra, V; Cutler, D; Donehower, RC; Dugan, M; Grochow, LB; Reidenberg, P; Rowinsky, EK; Sartorius, SE; Statkevich, P; Wirth, M | 1 |
| Ames, MM; Kuffel, MJ; Miller, JK; Reid, JM; Rios, R | 1 |
| Alton, KB; Blumenkrantz, N; Chowdhury, SK; Laudicina, D; Wirth, M | 1 |
| Brent, TP; Friedman, HS; Houghton, PJ; Kirstein, MN; Middlemas, DS; Poquette, C; Stewart, CF | 1 |
| Brent, TP; Cheshire, PJ; Friedman, HS; Houghton, PJ; Kirstein, MN; Poquette, CA; Richmond, LB; Stewart, CF; Tan, M | 1 |
| Ames, MM; Reid, JM; Rios, R; Safgren, SL | 1 |
| Chu, J; Gallo, JM; Li, S; Ma, J; Pulfer, S; Reed, K | 1 |
| Fouladi, M; Gajjar, A; Heideman, RL; Kirstein, MN; Nair, G; Panetta, JC; Stewart, CF; Wilkinson, M | 1 |
| Baker, SD; Batra, VK; Cutler, DL; Donehower, RC; Rudek, MA; Statkevich, P | 1 |
| Batra, VK; Patrick, J; Reyderman, L; Statkevich, P; Thonoor, CM; Wirth, M | 1 |
| Freeman, BB; Gajjar, A; Iacono, LC; Kirstein, MN; Nair, G; Panetta, JC; Stewart, CF | 1 |
| Adachi, J; Aoki, T; Matsutani, M; Mishima, K; Mizutani, T; Nishikawa, R; Nojima, K | 1 |
| Ames, MM; Easterling, TR; Hays, K; Hebert, MF; Kantrowitz-Gordon, I; Kaplan, HG; Kayode, O; Kumar, AR; Reid, JM; Safgren, SL | 1 |
| Andrade, S; Coelho, MÁN; Loureiro, JA; Pereira, MC; Ramalho, MJ | 1 |
5 trial(s) available for 5-(3-methyl-1-triazeno)imidazole-4-carboxamide and dacarbazine
| Article | Year |
|---|---|
Pharmacokinetics of 3-methyl-(triazen-1-yl)imidazole-4-carboximide following administration of temozolomide to patients with advanced cancer.
Topics: Adult; Alkylating Agents; Antineoplastic Agents, Alkylating; Chromatography, High Pressure Liquid; Dacarbazine; Half-Life; Humans; Metabolic Clearance Rate; Neoplasms; Regression Analysis; Temozolomide | 1997 |
Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer.
Topics: Absorption; Administration, Oral; Adult; Aged; Aminoimidazole Carboxamide; Antineoplastic Agents, Alkylating; Blood Proteins; Carbon Radioisotopes; Dacarbazine; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Temozolomide | 1999 |
Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Body Surface Area; Brain Neoplasms; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dacarbazine; Female; Humans; Infant; Linear Models; Male; Metabolic Clearance Rate; Reproducibility of Results; Temozolomide | 2003 |
Temozolomide in patients with advanced cancer: phase I and pharmacokinetic study.
Topics: Administration, Oral; Adult; Aged; Alkaline Phosphatase; Alkylating Agents; Area Under Curve; Bilirubin; Capsules; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Temozolomide; Thrombocytopenia; Tissue Distribution; Treatment Failure | 2004 |
Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC.
Topics: Antineoplastic Agents, Alkylating; Area Under Curve; Central Nervous System Neoplasms; Child; Dacarbazine; Humans; Infant; Metabolic Clearance Rate; Monte Carlo Method; Temozolomide | 2005 |
28 other study(ies) available for 5-(3-methyl-1-triazeno)imidazole-4-carboxamide and dacarbazine
| Article | Year |
|---|---|
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
Topics: Animals; Antineoplastic Agents; Base Sequence; Cell Survival; Dacarbazine; DNA; DNA Primers; Heterocyclic Compounds; Mice; Models, Molecular; Molecular Probes; Molecular Sequence Data; Temozolomide; Tumor Cells, Cultured | 1995 |
Alteration of DNA by 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (NSC-407347).
Topics: Alkylation; Antineoplastic Agents; Cells, Cultured; Dacarbazine; DNA; DNA Repair; DNA Replication; HeLa Cells; Humans; Time Factors; Triazenes | 1976 |
Effects of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (NSC-407347), an alkylating agent derived from 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388).
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cattle; Cell Division; Cells, Cultured; Dacarbazine; DNA; Fibroblasts; L Cells; Mice; Templates, Genetic; Time Factors; Triazenes | 1975 |
Comparison of the cytotoxicity in vitro of temozolomide and dacarbazine, prodrugs of 3-methyl-(triazen-1-yl)imidazole-4-carboxamide.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Dacarbazine; Lymphoma; Mice; Prodrugs; Temozolomide; Tumor Cells, Cultured | 1991 |
2-Imidazolethiones protect ascorbic acid from oxidation induced by copper.
Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Copper; Cysteine; Cystine; Dacarbazine; Imidazoles; Kinetics; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thiones | 1990 |
Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines.
Topics: Adenoviruses, Human; Alkylating Agents; Cell Survival; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Melanoma; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Simplexvirus; Tumor Cells, Cultured | 1989 |
Cytotoxicity of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) on Mer+, Mer+Rem- and Mer- cell lines: differential potentiation by 3-acetamidobenzamide.
Topics: Alkylating Agents; Benzamides; Cell Survival; Dacarbazine; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Humans; Mitosis; NAD; Nucleotidyltransferases; Tumor Cells, Cultured | 1988 |
Sensitivity of human neuroblastoma to activated dacarbazine: relationships between cell survival, methyltransferase activity and activation of adenovirus-5.
Topics: Adenoviridae; Alkylating Agents; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Humans; Methyltransferases; Mitosis; Neuroblastoma; Tumor Cells, Cultured; Virus Activation | 1988 |
Adenovirus replication as an in vitro probe for drug sensitivity in human tumors.
Topics: Adenoviridae; Antigens, Viral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Division; Cell Line; Dacarbazine; Humans; Immunoenzyme Techniques; Melanoma | 1986 |
Cross-sensitivity of methylating agents, hydroxyurea, and methotrexate in human tumor cells of the Mer- phenotype.
Topics: Adenoviridae; Alkylating Agents; Cell Line; Cell Survival; Dacarbazine; Drug Resistance; Humans; Hydroxyurea; Methotrexate; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Virus Replication | 1986 |
Bhopal tragedy--a year later.
Topics: Accidents, Occupational; Chemical Industry; Dacarbazine; Disasters; Humans; India | 1986 |
Epigenetic effects of the methylating agent 5-(3-methyl-1-triazeno) imidazole-4-carboxamide in human melanoma cells.
Topics: Alkylating Agents; Antineoplastic Agents; Cell Line; Dacarbazine; Deoxycytidine; Deoxyguanosine; Genes; Humans; Melanoma; Theophylline; Thymidine | 1984 |
In vitro mutagenic activity of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in eukaryotic and prokaryotic cells.
Topics: Animals; Cell Count; Cell Line; Cricetinae; Cricetulus; Dacarbazine; Dose-Response Relationship, Drug; Escherichia coli; Mutagenicity Tests; Mutation; Salmonella typhimurium | 1982 |
Influence of serum albumins on decomposition rates of para-substituted 1-phenyl-3-methyltriazenes and 5-(3-methyl-1-triazeno)imidazole-4-carboxamide in near physiological conditions.
Topics: Alkylating Agents; Dacarbazine; Drug Stability; Humans; Kinetics; Protein Binding; Serum Albumin; Thermodynamics; Triazenes | 1981 |
Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Dacarbazine; Gene Expression; Humans; Leukemia; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Temozolomide; Tumor Cells, Cultured | 1995 |
NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.
Topics: Antineoplastic Agents; Calorimetry; Dacarbazine; DNA; Drug Stability; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Nucleic Acid Conformation; Temozolomide | 1994 |
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzimidazoles; Bleomycin; Cell Death; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinazolines; Tumor Cells, Cultured | 1998 |
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Gamma Rays; Leukemia L1210; Mice; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
Topics: Antineoplastic Agents, Alkylating; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dacarbazine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microsomes, Liver | 1999 |
An LC/MS/MS method for the quantitation of MTIC (5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide), a bioconversion product of temozolomide, in rat and dog plasma.
Topics: Animals; Antineoplastic Agents, Alkylating; Calibration; Chromatography, High Pressure Liquid; Dacarbazine; Dogs; Female; Male; Mass Spectrometry; Quality Control; Rats; Reproducibility of Results; Temozolomide | 1999 |
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Brain Neoplasms; Carrier Proteins; Cell Division; Child; Dacarbazine; DNA Repair; DNA-Binding Proteins; Female; Humans; Mice; Mice, Inbred CBA; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Neuroblastoma; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Proto-Oncogene Proteins; Rhabdomyosarcoma; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
Topics: Administration, Oral; Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Base Pair Mismatch; Brain Neoplasms; Camptothecin; Dacarbazine; DNA Repair; Female; Glioblastoma; Irinotecan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rhabdomyosarcoma; Temozolomide; Time Factors | 2000 |
Validated high-performance liquid chromatographic assay for simultaneous determination of dacarbazine and the plasma metabolites 5-(3-hydroxymethyl-3-methyl-1-triazeno)imidazole-4-carboxamide and 5-(3-methyl-1-triazeno)imidazole-4-carboxamide.
Topics: Chromatography, High Pressure Liquid; Clinical Trials, Phase II as Topic; Dacarbazine; Drug Stability; Humans; Models, Chemical; Reproducibility of Results | 2001 |
Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Cyclohexanes; Dacarbazine; Dialysis Solutions; Drug Interactions; Humans; Male; Microdialysis; Neoplasms, Experimental; O-(Chloroacetylcarbamoyl)fumagillol; Rats; Rats, Nude; Sesquiterpenes; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Disposition and pharmacokinetics of temozolomide in rat.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Alkylating; Autoradiography; Brain; Carbon Radioisotopes; Dacarbazine; Female; Injections, Intravenous; Male; Radiopharmaceuticals; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Temozolomide; Tissue Distribution | 2004 |
Pharmacokinetic study of temozolomide on a daily-for-5-days schedule in Japanese patients with relapsed malignant gliomas: first study in Asians.
Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Asian People; Brain Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Temozolomide; White People | 2007 |
Pharmacokinetics of dacarbazine (DTIC) in pregnancy.
Topics: Administration, Intravenous; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bleomycin; Dacarbazine; Doxorubicin; Drug Monitoring; Female; Hodgkin Disease; Humans; Infant, Newborn; Neoplasm Staging; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Treatment Outcome; Vinblastine | 2018 |
Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy.
Topics: Antineoplastic Agents, Alkylating; Cholesterol; Dacarbazine; Dimyristoylphosphatidylcholine; Drug Interactions; Glioblastoma; Humans; Membranes, Artificial; Temozolomide | 2019 |