5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin has been researched along with phenytoin in 4 studies
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
*Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [MeSH]
| Studies (5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin) | Trials (5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin) | Recent Studies (post-2010) (5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin) | Studies (phenytoin) | Trials (phenytoin) | Recent Studies (post-2010) (phenytoin) |
|---|---|---|---|---|---|
| 6 | 0 | 1 | 14,105 | 758 | 1,497 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maguire, JH; McClanahan, JS | 1 |
| Maguire, JH; Wilson, DC | 1 |
| Knoth, R; Meyer, RP; Schiltz, E; Volk, B | 1 |
| Aliwarga, T; Brundage, RC; Cloyd, JC; Goel, V; Leppik, IE; Marino, SE; Remmel, RP | 1 |
4 other study(ies) available for 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin and phenytoin
| Article | Year |
|---|---|
Evidence for stereoselective production of phenytoin (5,5-diphenylhydantoin) arene oxides in man.
Topics: Adolescent; Adult; Biotransformation; Child; Chromatography, High Pressure Liquid; Female; Humans; Male; Phenytoin; Stereoisomerism | 1986 |
Urinary dihydrodiol metabolites of phenytoin: high-performance liquid chromatographic assay of diastereomeric composition.
Topics: Animals; Child; Chromatography, High Pressure Liquid; Dogs; Humans; Phenytoin; Rats; Species Specificity; Stereoisomerism | 1985 |
Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary cultures.
Topics: Animals; Animals, Newborn; Antibodies; Antibody Specificity; Astrocytes; Brain; Cell Division; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Immunohistochemistry; Inactivation, Metabolic; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases; Phenytoin; Sequence Analysis, Protein | 2001 |
Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biological Availability; Chromatography, High Pressure Liquid; Drug Monitoring; Epilepsy; Female; Humans; Isotope Labeling; Male; Middle Aged; Phenytoin; Young Adult | 2011 |