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5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol and benzofurans

5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol has been researched along with benzofurans in 12 studies

Compound Research Comparison

Studies
(5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol)
Trials
(5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol)
Recent Studies (post-2010)
(5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol)
Studies
(benzofurans)
Trials
(benzofurans)
Recent Studies (post-2010) (benzofurans)
135013,2934514,970

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (91.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Christensen, JV1
Andersen, PH; Nielsen, EB1
Andersen, PH; Braestrup, C; Grønvald, FC; Guddal, E; Hansen, LB; Hohlweg, R; Nielsen, EB1
Farde, L; Foged, C; Halldin, C; Hansen, KT; Karlsson, P; Sedvall, G; Skrumsager, B; Swahn, CG1
Farde, L; Foged, C; Grønvald, F; Hall, H; Halldin, C; Hansen, K; Karlsson, P; Sedvall, G; Swahn, CG1
Christensen, JV; Seiberling, M; Skrumsager, BK; Snel, S1
Andersen, J; Andersen, M; Clemmesen, L; Fensbo, C; Gerlach, J; Hansen, L; Karle, J; Lublin, H; Skrumsager, BK; Sloth-Nielsen, M1
Ahlenius, S; Salmi, P2
Andersen, M; Grodum, E; Hagen, C; Hangaard, J; Koldkjaer, O1
Ahlenius, S1
Eder, DN1

Reviews

2 review(s) available for 5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol and benzofurans

ArticleYear
Clozapine: dopamine D1 receptor agonism in the prefrontal cortex as the code to decipher a Rosetta stone of antipsychotic drugs.
    Pharmacology & toxicology, 1999, Volume: 84, Issue:5

    Topics: Animals; Antipsychotic Agents; Benzazepines; Benzofurans; Clozapine; Dopamine Antagonists; Humans; Prefrontal Cortex; Rats; Receptors, Dopamine D1

1999
CEE-03-310 CeNeS pharmaceuticals.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:2

    Topics: Alcoholism; Animals; Benzazepines; Benzofurans; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dopamine Antagonists; Drugs, Investigational; Humans; Lethal Dose 50; Randomized Controlled Trials as Topic; Receptors, Dopamine D1; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship; Treatment Outcome

2002

Trials

4 trial(s) available for 5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol and benzofurans

ArticleYear
PET examination of [11C]NNC 687 and [11C]NNC 756 as new radioligands for the D1-dopamine receptor.
    Psychopharmacology, 1993, Volume: 113, Issue:2

    Topics: Adult; Animals; Benzazepines; Benzofurans; Brain; Brain Chemistry; Carbon Isotopes; Chromatography, High Pressure Liquid; Dopamine Antagonists; Humans; Ligands; Macaca fascicularis; Male; Receptors, Dopamine D1; Species Specificity; Tomography, Emission-Computed; Tomography, X-Ray Computed

1993
Tolerability, safety and pharmacokinetics of single dose and multiple dosing of the selective D1 antagonist NNC 01-0687 in healthy subjects.
    Psychopharmacology, 1995, Volume: 121, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Benzazepines; Benzofurans; Dopamine Antagonists; Dosage Forms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Humans; Middle Aged; Safety; Time Factors

1995
NNC 01-0687, a selective dopamine D1 receptor antagonist, in the treatment of schizophrenia.
    Psychopharmacology, 1995, Volume: 121, Issue:3

    Topics: Adult; Benzazepines; Benzofurans; Dopamine Antagonists; Follow-Up Studies; Humans; Male; Placebo Effect; Receptors, Dopamine D1; Schizophrenia; Treatment Outcome

1995
Lack of effect of the dopamine D1 antagonist, NNC 01-0687, on unstimulated and stimulated release of anterior pituitary hormones in males.
    Journal of endocrinological investigation, 1998, Volume: 21, Issue:5

    Topics: Adult; Benzazepines; Benzofurans; Cross-Over Studies; Dopamine Antagonists; Double-Blind Method; Humans; Male; Pituitary Hormones, Anterior; Receptors, Dopamine D1

1998

Other Studies

6 other study(ies) available for 5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5-tetrahydro-1h-3-benzazepin-7-ol and benzofurans

ArticleYear
Determination of (+)-5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-8-nitro-2,3,4,5- tetrahydro-1H-3-benzazepin-7-ol (NNC 01-0687), a novel dopamine D-1 receptor antagonist, in plasma by solid-phase extraction and high-performance liquid chromatography.
    Journal of chromatography, 1992, Jun-10, Volume: 577, Issue:2

    Topics: Benzazepines; Benzofurans; Chromatography, High Pressure Liquid; Humans; Receptors, Dopamine D1; Reproducibility of Results; Spectrophotometry, Ultraviolet

1992
Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists.
    European journal of pharmacology, 1992, Aug-14, Volume: 219, Issue:1

    Topics: Amphetamine; Animals; Behavior, Animal; Benzazepines; Benzofurans; Catalepsy; Dopamine; Male; Mice; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior

1992
NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists.
    European journal of pharmacology, 1992, Aug-14, Volume: 219, Issue:1

    Topics: Animals; Benzazepines; Benzofurans; Dopamine; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Serotonin

1992
[11C]NNC 687 and [11C]NNC 756, dopamine D-1 receptor ligands. Preparation, autoradiography and PET investigation in monkey.
    Nuclear medicine and biology, 1993, Volume: 20, Issue:8

    Topics: Alkylation; Animals; Autoradiography; Benzazepines; Benzofurans; Brain; Carbon Radioisotopes; Cryoultramicrotomy; Humans; Macaca fascicularis; Male; Receptors, Dopamine D1; Tomography, Emission-Computed

1993
Further evidence for clozapine as a dopamine D1 receptor agonist.
    European journal of pharmacology, 1996, Jun-20, Volume: 307, Issue:1

    Topics: Animals; Benzazepines; Benzofurans; Body Temperature; Clozapine; Dopamine Agonists; Dopamine Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sensitivity and Specificity

1996
Dihydrexidine produces hypothermia in rats via activation of dopamine D1 receptors.
    Neuroscience letters, 1997, Oct-24, Volume: 236, Issue:1

    Topics: Animals; Benzazepines; Benzofurans; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Hypothermia, Induced; Male; Phenanthridines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1

1997