5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate has been researched along with lamotrigine in 8 studies
| Studies (5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate) | Trials (5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate) | Recent Studies (post-2010) (5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate) | Studies (lamotrigine) | Trials (lamotrigine) | Recent Studies (post-2010) (lamotrigine) |
|---|---|---|---|---|---|
| 19 | 0 | 0 | 3,550 | 501 | 1,351 |
| Protein | Taxonomy | 5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate (IC50) | lamotrigine (IC50) |
|---|---|---|---|
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arvin, B; Meldrum, BS; Moncada, CR | 1 |
| Meldrum, BS; Smith, SE | 1 |
| Meldrum, BS | 1 |
| al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Beal, MF; Henshaw, DR; Matthews, RT; Schulz, JB | 1 |
| Obrenovitch, TP | 1 |
| Batchelor, AM; Brown, G; Garthwaite, G; Garthwaite, J; Goodwin, DA | 1 |
| Garman, R; Garman, RH; Kofke, WA; Rose, M | 1 |
2 review(s) available for 5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate and lamotrigine
| Article | Year |
|---|---|
The role of glutamate in epilepsy and other CNS disorders.
Topics: Animals; Central Nervous System Diseases; Epilepsy; Glutamic Acid; Humans; Lamotrigine; Mice; N-Methylaspartate; Parkinson Disease; Piperazines; Pyrimidines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Triazines | 1994 |
Sodium and potassium channel modulators: their role in neuroprotection.
Topics: Animals; Benzeneacetamides; Cell Survival; Disease Models, Animal; Lamotrigine; Neurons; Neuroprotective Agents; Piperazines; Piperidines; Potassium Channels; Pyrimidines; Riluzole; Sodium Channels; Thiazoles; Triazines | 1997 |
6 other study(ies) available for 5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine ethane sulfonate and lamotrigine
| Article | Year |
|---|---|
The pyrimidine derivative BW 1003C87 protects against excitotoxic lesions induced by kainate in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Hippocampus; Kainic Acid; Lamotrigine; Male; Neostriatum; Nervous System Diseases; Neural Pathways; Pyrimidines; Rats; Rats, Wistar; Triazines | 1994 |
Cerebroprotective effect of lamotrigine after focal ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Lamotrigine; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred F344; Sodium Channels; Triazines | 1995 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Epilepsy; Female; Lamotrigine; Male; Motor Activity; Phenytoin; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Triazines | 1993 |
Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Anticonvulsants; Coenzymes; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Free Radicals; Lamotrigine; Male; Malonates; Memantine; Mitochondria; Nervous System Diseases; Neuroprotective Agents; Neurotoxins; Niacinamide; Nitro Compounds; Nitrogen Oxides; Propionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Spin Labels; Thallium; Triazines; Ubiquinone | 1996 |
Mechanisms of ischaemic damage to central white matter axons: a quantitative histological analysis using rat optic nerve.
Topics: Animals; Axons; Glucose; Hypoxia; In Vitro Techniques; Ischemia; Lamotrigine; Microscopy, Electron; Neuroprotective Agents; Optic Nerve; Piperazines; Pyrimidines; Rats; Rats, Wistar; Sodium Channel Blockers; Triazines | 1999 |
Opioid neurotoxicity: role of neurotransmitter systems.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Opioid; Animals; Blood Pressure; Body Temperature; Brain; Excitatory Amino Acid Antagonists; Fentanyl; Lamotrigine; Male; Neuromuscular Depolarizing Agents; Neuroprotective Agents; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Reserpine; Triazines | 2000 |