Page last updated: 2024-09-05

4-trifluoromethylsalicylic acid and triflusal

4-trifluoromethylsalicylic acid has been researched along with triflusal in 24 studies

Compound Research Comparison

Studies
(4-trifluoromethylsalicylic acid)
Trials
(4-trifluoromethylsalicylic acid)
Recent Studies (post-2010)
(4-trifluoromethylsalicylic acid)
Studies
(triflusal)
Trials
(triflusal)
Recent Studies (post-2010) (triflusal)
465231643933

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.83)18.7374
1990's6 (25.00)18.2507
2000's9 (37.50)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hannah, J; Holtz, WJ; Houser, RA; Jones, H; Kelly, KW; Matzuk, AR; Ruyle, WV; Sarett, LH; Shen, TY; Witzel, BE1
Conte, L; Forn, J; Mis, R; Ramis, J2
Barbanoj, MJ; Conte, L; Forn, J; Jané, J; Mis, R; Ramis, J; Torrent, J1
Forn, J; García-Rafanell, J; Gomez, L; Ramis, J1
Albors, M; De Castellarnau, C; Rutllant, ML; Sancho, MJ; Vila, L1
Bellido, I; de la Cruz, JP; González, MC; Pavia, J; Sánchez de la Cuesta, F1
Forn, J; García Rafanell, J; Sánchez, MS1
De La Cruz, JP; García, PJ; Sánchez de la Cuesta, F; Smith-Agreda, JM; Villalobos, MA1
Alonso, A; Bayón, Y; Cavalcanti, F; Fernández de Arriba, A; Forn, J; García-Rafanell, J; Merlos, M; Miralles, A1
Alonso, A; Bayón, Y; Sánchez Crespo, M1
Boscá, F; Cuquerella, MC; Marín, ML; Miranda, MA1
Cho, HY; Jeong, TJ; Lee, YB1
Arrebola, MM; De La Cruz, JP; González-Correa, JA; Guerrero, A; Muñoz-Marín, J; Ruiz-Villafranca, D; Sánchez de la Cuesta, F; Ureña, IM1
Barbanoj, MJ; Brunner, M; Donner, A; Eichler, HG; Herranz, U; Izquierdo, I; Klein, N; Müller, M; Valle, M1
del Valle, C; Ferrit, M; Martínez, F1
Argemí, A; Domingo, C; López-Periago, A; Saurina, J1
Arnaiz, E; Bassols, J; Casamitjana, R; Fernández-Real, JM; Gomis, R; López-Bermejo, A; Nadal, A; Pérez, I; Piquer, S; Ricart, W; Ropero, AB1
Badimon, L; Duran, X; Sánchez, S; Vilahur, G1
Blanca, M; Jiménez, MC; Lhiaubet-Vallet, V; Miranda, MA; Montanaro, S1
Baek, IH; Kwon, KI; Lee, HW; Lee, J; Lim, MS; Park, J; Seo, JJ; Seong, SJ; Yoon, YR; Yun, HY1
Hua, W; Huang, M; Wang, M; Zhang, Q; Zhou, W; Zong, S1
Ding, LK; Ding, Y; Ge, J; Jia, YY; Lu, CT; Song, W; Song, Y; Wen, AD; Yang, J1
Choi, KJ; Kim, SW; Lee, JK; Park, JY; Yoon, SH1

Trials

5 trial(s) available for 4-trifluoromethylsalicylic acid and triflusal

ArticleYear
Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:2

    Topics: Adult; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Neuroprotective Agents; Salicylates

2005
Salicylates increase insulin secretion in healthy obese subjects.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:7

    Topics: Aged; C-Reactive Protein; Calcium; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Obesity; Salicylates

2008
A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.
    Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:12

    Topics: Administration, Oral; Adult; Arachidonic Acid; Asian People; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult

2011
Pharmacokinetics, safety and tolerability of triflusal and its main active metabolite HTB in healthy Chinese subjects.
    Drug research, 2014, Volume: 64, Issue:5

    Topics: Adult; Area Under Curve; Asian People; Female; Healthy Volunteers; Humans; Male; Salicylates; Young Adult

2014
Effect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Biotransformation; Capsules; China; Cross-Over Studies; Dietary Fats; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Platelet Aggregation Inhibitors; Postprandial Period; Salicylates; Therapeutic Equivalency; Young Adult

2015

Other Studies

19 other study(ies) available for 4-trifluoromethylsalicylic acid and triflusal

ArticleYear
Novel analgesic-antiinflammatory salicylates.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Dogs; Rats; Salicylates; Structure-Activity Relationship

1978
In-vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin

1992
Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:2

    Topics: Administration, Oral; Animals; Blood Proteins; Female; Humans; Orosomucoid; Platelet Aggregation Inhibitors; Protein Binding; Rats; Rats, Inbred Strains; Salicylates; Serum Albumin

1992
Pharmacokinetics of triflusal after single and repeated doses in man.
    International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:8

    Topics: Adult; Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Random Allocation; Salicylates

1990
Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 284, Issue:1

    Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Cyclic AMP; Dipyridamole; Drug Interactions; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

1986
Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 1988, Volume: 31, Issue:2

    Topics: Alprostadil; Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Drug Interactions; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Vasodilator Agents

1988
Platelet antiaggregatory effect of triflusal in human whole blood.
    Methods and findings in experimental and clinical pharmacology, 1988, Volume: 10, Issue:4

    Topics: Adenosine Diphosphate; Adult; Collagen; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2

1988
[Comparative study of the in vitro anti-aggregating action of various salicylic derivatives].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1

    Topics: Animals; Aspirin; Chemical Phenomena; Chemistry; Organophosphates; Platelet Aggregation; Rats; Salicylates

1981
Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers.
    European journal of clinical pharmacology, 1995, Volume: 47, Issue:6

    Topics: Adult; Animals; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; Male; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Salicylates

1995
Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
    Molecular pharmacology, 1999, Volume: 55, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Inflammation; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Membrane Proteins; NF-kappa B; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Salicylates

1999
4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Animals; Aspirin; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Macrophages, Peritoneal; NF-kappa B; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; RNA, Messenger; Salicylates; Thrombin; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1

1999
Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.
    Photochemistry and photobiology, 2001, Volume: 73, Issue:5

    Topics: Dermatitis, Photoallergic; Photochemistry; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin, Bovine; Spectrometry, Fluorescence

2001
Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Dec-25, Volume: 798, Issue:2

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Humans; Male; Rats; Reproducibility of Results; Salicylates; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2003
Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:1

    Topics: Animals; Aspirin; Brain Chemistry; Dinoprostone; Glutathione; Hypoxia, Brain; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Salicylates; Thiobarbituric Acid Reactive Substances

2005
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:3-4

    Topics: Algorithms; Alkalies; Aspirin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Platelet Aggregation Inhibitors; Polyethylene Glycols; Quaternary Ammonium Compounds; Salicylates; Salicylic Acid; Sodium Dodecyl Sulfate; Sodium Hydroxide; Spectrophotometry, Ultraviolet; Static Electricity; Surface-Active Agents; Water

2007
Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.
    Journal of pharmaceutical and biomedical analysis, 2008, Feb-13, Volume: 46, Issue:3

    Topics: Chromatography, Supercritical Fluid; Delayed-Action Preparations; Hydrogen-Ion Concentration; Salicylates; Solubility; Spectrophotometry; Technology, Pharmaceutical

2008
Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:8

    Topics: Animals; Aspirin; Base Sequence; Blood Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA Primers; Endothelium, Vascular; Fibrinolytic Agents; In Vitro Techniques; Male; Perfusion; Rabbits; Recurrence; RNA, Messenger; Salicylates; Thrombosis

2008
Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.
    ChemMedChem, 2009, Volume: 4, Issue:7

    Topics: Binding Sites; Dermatitis, Photoallergic; Humans; Lysine; Photolysis; Protein Binding; Salicylates; Serum Albumin; Spectrometry, Fluorescence

2009
Neuroprotective effect of triflusal and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the postischemic brain.
    Neuroscience letters, 2017, 03-16, Volume: 643

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Brain; Brain Ischemia; Cytokines; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Salicylates

2017