4-trifluoromethylsalicylic acid has been researched along with salicylates in 31 studies
| Studies (4-trifluoromethylsalicylic acid) | Trials (4-trifluoromethylsalicylic acid) | Recent Studies (post-2010) (4-trifluoromethylsalicylic acid) | Studies (salicylates) | Trials (salicylates) | Recent Studies (post-2010) (salicylates) |
|---|---|---|---|---|---|
| 46 | 5 | 23 | 13,317 | 853 | 1,678 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 6 (19.35) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Conte, L; Forn, J; Mis, R; Ramis, J | 2 |
| Barbanoj, MJ; Conte, L; Forn, J; Jané, J; Mis, R; Ramis, J; Torrent, J | 1 |
| Forn, J; García-Rafanell, J; Gomez, L; Ramis, J | 1 |
| Albors, M; De Castellarnau, C; Rutllant, ML; Sancho, MJ; Vila, L | 1 |
| Bellido, I; de la Cruz, JP; González, MC; Pavia, J; Sánchez de la Cuesta, F | 1 |
| Forn, J; García Rafanell, J; Sánchez, MS | 1 |
| De La Cruz, JP; García, PJ; Sánchez de la Cuesta, F; Smith-Agreda, JM; Villalobos, MA | 1 |
| Alonso, A; Bayón, Y; Cavalcanti, F; Fernández de Arriba, A; Forn, J; García-Rafanell, J; Merlos, M; Miralles, A | 1 |
| Alonso, A; Bayón, Y; Sánchez Crespo, M | 1 |
| Boscá, F; Cuquerella, MC; Marín, ML; Miranda, MA | 1 |
| Angelico, P; Clarke, DE; Guarneri, L; Leonardi, A; Testa, R; Velasco, C | 1 |
| Fernández, N; García-Rodríguez, C; Renedo, M; Sánchez Crespo, M | 1 |
| Cho, HY; Jeong, TJ; Lee, YB | 1 |
| Arrebola, MM; De La Cruz, JP; González-Correa, JA; Guerrero, A; Muñoz-Marín, J; Ruiz-Villafranca, D; Sánchez de la Cuesta, F; Ureña, IM | 1 |
| Barbanoj, MJ; Brunner, M; Donner, A; Eichler, HG; Herranz, U; Izquierdo, I; Klein, N; Müller, M; Valle, M | 1 |
| del Valle, C; Ferrit, M; Martínez, F | 1 |
| Argemí, A; Domingo, C; López-Periago, A; Saurina, J | 1 |
| Arnaiz, E; Bassols, J; Casamitjana, R; Fernández-Real, JM; Gomis, R; López-Bermejo, A; Nadal, A; Pérez, I; Piquer, S; Ricart, W; Ropero, AB | 1 |
| Badimon, L; Duran, X; Sánchez, S; Vilahur, G | 1 |
| Blanca, M; Jiménez, MC; Lhiaubet-Vallet, V; Miranda, MA; Montanaro, S | 1 |
| Baek, IH; Kwon, KI; Lee, HW; Lee, J; Lim, MS; Park, J; Seo, JJ; Seong, SJ; Yoon, YR; Yun, HY | 1 |
| Hua, W; Huang, M; Wang, M; Zhang, Q; Zhou, W; Zong, S | 1 |
| Choi, DK; In, PJ; Kang, SM; Kim, BW; More, SV; Park, JY; Yoon, SH | 1 |
| Ding, LK; Ding, Y; Ge, J; Jia, YY; Lu, CT; Song, W; Song, Y; Wen, AD; Yang, J | 1 |
| Kim, ID; Kim, SW; Lee, H; Lee, HK; Lee, JK; Luo, L; Park, JY; Yoon, SH | 1 |
| Choi, KJ; Kim, SW; Lee, JK; Park, JY; Yoon, SH | 1 |
| Choi, DK; Kim, BW; Kim, IS; Koppula, S; Park, JY; Song, SY; Yoon, SH | 1 |
| Balcı, KG; Çakmak Karaaslan, Ö; Kanal, Y; Könte, HC; Maden, O; Selçuk, H; Selçuk, MT; Yakut, İ; Yaman, NM | 1 |
| Chen, S; Chen, Z; Gao, C; Hao, W; Wang, S; Wang, Y; Wu, X; Yuan, Q; Zhou, H | 1 |
| Asanprakit, W; Bennett, AJ; Eremin, O; Lobo, DN | 1 |
5 trial(s) available for 4-trifluoromethylsalicylic acid and salicylates
| Article | Year |
|---|---|
Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.
Topics: Adult; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Neuroprotective Agents; Salicylates | 2005 |
Salicylates increase insulin secretion in healthy obese subjects.
Topics: Aged; C-Reactive Protein; Calcium; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Obesity; Salicylates | 2008 |
A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.
Topics: Administration, Oral; Adult; Arachidonic Acid; Asian People; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult | 2011 |
Pharmacokinetics, safety and tolerability of triflusal and its main active metabolite HTB in healthy Chinese subjects.
Topics: Adult; Area Under Curve; Asian People; Female; Healthy Volunteers; Humans; Male; Salicylates; Young Adult | 2014 |
Effect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Biotransformation; Capsules; China; Cross-Over Studies; Dietary Fats; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Platelet Aggregation Inhibitors; Postprandial Period; Salicylates; Therapeutic Equivalency; Young Adult | 2015 |
26 other study(ies) available for 4-trifluoromethylsalicylic acid and salicylates
| Article | Year |
|---|---|
In-vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin | 1992 |
Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man.
Topics: Administration, Oral; Animals; Blood Proteins; Female; Humans; Orosomucoid; Platelet Aggregation Inhibitors; Protein Binding; Rats; Rats, Inbred Strains; Salicylates; Serum Albumin | 1992 |
Pharmacokinetics of triflusal after single and repeated doses in man.
Topics: Adult; Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Random Allocation; Salicylates | 1990 |
Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets.
Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Cyclic AMP; Dipyridamole; Drug Interactions; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1986 |
Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.
Topics: Alprostadil; Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Drug Interactions; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Vasodilator Agents | 1988 |
Platelet antiaggregatory effect of triflusal in human whole blood.
Topics: Adenosine Diphosphate; Adult; Collagen; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2 | 1988 |
[Comparative study of the in vitro anti-aggregating action of various salicylic derivatives].
Topics: Animals; Aspirin; Chemical Phenomena; Chemistry; Organophosphates; Platelet Aggregation; Rats; Salicylates | 1981 |
Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers.
Topics: Adult; Animals; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; Male; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Salicylates | 1995 |
Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Inflammation; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Membrane Proteins; NF-kappa B; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Salicylates | 1999 |
4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation.
Topics: Animals; Aspirin; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Macrophages, Peritoneal; NF-kappa B; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; RNA, Messenger; Salicylates; Thrombin; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1999 |
Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.
Topics: Dermatitis, Photoallergic; Photochemistry; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin, Bovine; Spectrometry, Fluorescence | 2001 |
Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Cystitis; Female; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Salicylates; Urination; Urodynamics | 2001 |
Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES.
Topics: Antigen-Antibody Complex; Base Sequence; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Cross-Linking Reagents; Gene Expression Regulation; Humans; Interleukin-8; Leupeptins; Macrophage Activation; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monocytes; NF-kappa B; Receptors, IgG; RNA, Messenger; Salicylates; Tumor Cells, Cultured | 2002 |
Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Humans; Male; Rats; Reproducibility of Results; Salicylates; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2003 |
Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.
Topics: Animals; Aspirin; Brain Chemistry; Dinoprostone; Glutathione; Hypoxia, Brain; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Salicylates; Thiobarbituric Acid Reactive Substances | 2005 |
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
Topics: Algorithms; Alkalies; Aspirin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Platelet Aggregation Inhibitors; Polyethylene Glycols; Quaternary Ammonium Compounds; Salicylates; Salicylic Acid; Sodium Dodecyl Sulfate; Sodium Hydroxide; Spectrophotometry, Ultraviolet; Static Electricity; Surface-Active Agents; Water | 2007 |
Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.
Topics: Chromatography, Supercritical Fluid; Delayed-Action Preparations; Hydrogen-Ion Concentration; Salicylates; Solubility; Spectrophotometry; Technology, Pharmaceutical | 2008 |
Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.
Topics: Animals; Aspirin; Base Sequence; Blood Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA Primers; Endothelium, Vascular; Fibrinolytic Agents; In Vitro Techniques; Male; Perfusion; Rabbits; Recurrence; RNA, Messenger; Salicylates; Thrombosis | 2008 |
Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.
Topics: Binding Sites; Dermatitis, Photoallergic; Humans; Lysine; Photolysis; Protein Binding; Salicylates; Serum Albumin; Spectrometry, Fluorescence | 2009 |
A novel synthetic HTB derivative, BECT inhibits lipopolysaccharide-mediated inflammatory response by suppressing the p38 MAPK/JNK and NF-κB activation pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Salicylates; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Robust neuroprotective effects of 2-((2-oxopropanoyl)oxy)-4-(trifluoromethyl)benzoic acid (OPTBA), a HTB/pyruvate ester, in the postischemic rat brain.
Topics: Animals; Benzoates; Blood-Brain Barrier; Brain Ischemia; Cytokines; Disease Models, Animal; Hydrolysis; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Salicylates; Stroke | 2016 |
Neuroprotective effect of triflusal and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the postischemic brain.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Brain; Brain Ischemia; Cytokines; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Salicylates | 2017 |
2-Hydroxy-4-Methylbenzoic Anhydride Inhibits Neuroinflammation in Cellular and Experimental Animal Models of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Benzoates; Cell Survival; Cyclooxygenase 2; Disease Models, Animal; Drug Design; In Vitro Techniques; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Models, Theoretical; Neuroglia; Neurons; Nitric Oxide; Parkinson Disease; Peptides; Phosphorylation; Salicylates; Signal Transduction | 2020 |
Association of CHA
Topics: Aged; Atrial Fibrillation; Humans; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Salicylates; Thrombosis | 2022 |
Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Berberine; China; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Mice; Salicylates; Tannins; Tight Junction Proteins; Tissue Distribution | 2022 |
M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.
Topics: Breast Neoplasms; Culture Media, Conditioned; Cytokines; Female; Humans; Interferon-gamma; Interleukin-1beta; Macrophages; Receptors, Interleukin-1; Receptors, Polymeric Immunoglobulin; RNA, Messenger; Salicylates; Secretory Component | 2022 |