Compounds > 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Page last updated: 2024-09-03

4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline and n-methylaspartate

4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline has been researched along with n-methylaspartate in 7 studies

Compound Research Comparison

Studies
(4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline)		Trials
(4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline)		Recent Studies (post-2010)
(4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline)		Studies
(n-methylaspartate)		Trials
(n-methylaspartate)		Recent Studies (post-2010) (n-methylaspartate)
320010,408591,902

Protein Interaction Comparison

ProteinTaxonomy4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline (IC50)n-methylaspartate (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)5.175
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)5.175

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bowen, DM; Foster, AC; Francis, PT; Middlemiss, DN; Pangalos, MN; Pearson, RC1
Baker, R; Carling, RW; Chan, T; Foster, AC; Grimwood, S; Leeson, PD; Moore, KW; Moseley, AM; Smith, JD; Stevenson, G1
Carter, C; Fage, D; Nicolas, C1
Baker, R; Carling, RW; Duncton, M; Foster, AC; Grimwood, S; Hudson, ML; Kemp, JA; Leeson, PD; Marshall, GR; Moore, KW; Moyes, CR; Saywell, KL; Tricklebank, MD1
Hashim, A; Javitt, DC; Lajtha, A; Sershen, H1
Bull, DJ; Carr, CL; Fray, MJ; Gautier, EC; Mowbray, CE; Stobie, A1
Baptista, V; Varanda, WA1

Other Studies

7 other study(ies) available for 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline and n-methylaspartate

ArticleYear
NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Aminoquinolines; Animals; Autoradiography; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neural Pathways; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium

1992
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.
    Journal of medicinal chemistry, 1992, May-29, Volume: 35, Issue:11

    Topics: Aminoquinolines; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Kynurenic Acid; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

1992
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
    Journal of neurochemistry, 1994, Volume: 62, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium

1994
4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.
    Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5

    Topics: Aminoquinolines; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Excitatory Amino Acid Antagonists; Glycine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred DBA; Molecular Structure; N-Methylaspartate; Quinolones; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

1997
Inhibition of striatal dopamine release by glycine and glycyldodecylamide.
    Brain research bulletin, 2000, Volume: 52, Issue:3

    Topics: Aminoquinolines; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Subcellular Fractions; Tritium

2000
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.
    Journal of medicinal chemistry, 2001, Jun-07, Volume: 44, Issue:12

    Topics: Aminoquinolines; Animals; Cell Membrane; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Indicators and Reagents; Mice; Models, Molecular; Motor Activity; N-Methylaspartate; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium

2001
Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons.
    Journal of neurophysiology, 2005, Volume: 94, Issue:1

    Topics: Aminoquinolines; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Solitary Nucleus; Strychnine; Synapses

2005