4-thiopyridine and manganese-dioxide

For SERS analysis in living cells, the inevitable desorption of Raman molecule on the substrate surface is a key challenge. To ensure high stability, SERS systems with Raman molecules protected inside the core-Raman molecule-shell (C-M-S) structures have been designed, but at the expense of sacrificed sensing performances. Here a shell-switchable SERS blocking strategy is developed for the reliable SERS analysis in living cells, relying on the shell blockers to regulate the SERS sensing signal without affecting the internal Raman molecules. After several C-M-S structures were investigated, the SERS blocking mechanism confirmed that thick shells (Au, Ag, ZnO, and MnO

Topics: Drug Carriers; Glutathione; Gold; HeLa Cells; Humans; Limit of Detection; Manganese Compounds; Metal Nanoparticles; Oxides; Pyridines; Silver; Spectrum Analysis, Raman; Zinc Oxide