Page last updated: 2024-09-05

4-tert-butyl-(3-(2-chloroethyl)ureido)benzene and paclitaxel

4-tert-butyl-(3-(2-chloroethyl)ureido)benzene has been researched along with paclitaxel in 4 studies

Compound Research Comparison

Studies
(4-tert-butyl-(3-(2-chloroethyl)ureido)benzene)
Trials
(4-tert-butyl-(3-(2-chloroethyl)ureido)benzene)
Recent Studies (post-2010)
(4-tert-butyl-(3-(2-chloroethyl)ureido)benzene)
Studies
(paclitaxel)
Trials
(paclitaxel)
Recent Studies (post-2010) (paclitaxel)
120031,8745,72915,395

Protein Interaction Comparison

ProteinTaxonomy4-tert-butyl-(3-(2-chloroethyl)ureido)benzene (IC50)paclitaxel (IC50)
Integrin beta-3Homo sapiens (human)0.034
Integrin alpha-V Homo sapiens (human)0.034
ATP-dependent translocase ABCB1Homo sapiens (human)2.598
Botulinum neurotoxin type A Clostridium botulinum5.2
UDP-glucuronosyltransferase 2B7Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1-6Homo sapiens (human)4.9
Substance-K receptorHomo sapiens (human)6.125
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1A4Homo sapiens (human)4.9
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)4.9
Delta-type opioid receptorHomo sapiens (human)4.202
Tyrosine-protein kinase MerHomo sapiens (human)4.9
Tubulin beta-3 chainHomo sapiens (human)0.0082
Beta-tubulin Leishmania donovani1
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)7.9433
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)0.26
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.28

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
C-Gaudreault, R; Desjardins, M; Fortin, JS; Lacroix, J; Patenaude, A; Petitclerc, E1
C-Gaudreault, R; Côté, MF; Fortin, JS; Lacroix, J; Patenaude, A; Petitclerc, E1
C-Gaudreault, R; Côté, MF; Fortin, JS; Lacroix, J; Petitclerc, E1
C-Gaudreault, R; Côté, MF; Desjardins, M; Fortin, JS; Lacroix, J; Petitclerc, E1

Other Studies

4 other study(ies) available for 4-tert-butyl-(3-(2-chloroethyl)ureido)benzene and paclitaxel

ArticleYear
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.
    Bioorganic & medicinal chemistry, 2007, Jul-01, Volume: 15, Issue:13

    Topics: Antineoplastic Agents, Alkylating; Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; HT29 Cells; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Protein Binding; Proteins; Structure-Activity Relationship; Substrate Specificity; Tubulin; Urea

2007
Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.
    Bioorganic & medicinal chemistry letters, 2008, Jun-15, Volume: 18, Issue:12

    Topics: Active Transport, Cell Nucleus; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Screening Assays, Antitumor; G1 Phase; Humans; Molecular Structure; Resting Phase, Cell Cycle; Signal Transduction; Stereoisomerism; Thioredoxins; Urea

2008
Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression.
    Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Humans; Molecular Structure; Structure-Activity Relationship; Thioredoxins; Urea

2008
Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.
    Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15

    Topics: Alkylation; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Humans; Microtubules; Molecular Structure; Oxidation-Reduction; Structure-Activity Relationship; Thioredoxins; Tubulin; Urea

2008