4-phenylcoumarin and efavirenz

4-phenylcoumarin has been researched along with efavirenz* in 1 studies

*efavirenz: HIV-1 reverse transcriptase inhibitor [MeSH]

Other Studies

1 other study(ies) available for 4-phenylcoumarin and efavirenz

Article	Year
4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies. Bioorganic chemistry, 2023, Volume: 141 A series of 4-phenylcoumarin derivatives was synthesized and evaluated for their cellular anti-HIV-1 and HIV-2 activities as well as their inhibitory effects against HIV-1 reverse transcriptase (RT). The hydrazone compound 8b and the ethylthiosemicarbazide derivative 4c showed the best inhibition activity against wild-type (WT) HIV-1. The promising compounds were further evaluated against HIV-1 RT and exhibited significant inhibitory activity with compound 8b showing comparable effect to the reference NNRTI Efavirenz (IC Topics: Anti-HIV Agents; Coumarins; Drug Design; HIV Reverse Transcriptase; HIV-1; Molecular Docking Simulation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2023

Article

Year

4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies.

Bioorganic chemistry, 2023, Volume: 141

A series of 4-phenylcoumarin derivatives was synthesized and evaluated for their cellular anti-HIV-1 and HIV-2 activities as well as their inhibitory effects against HIV-1 reverse transcriptase (RT). The hydrazone compound 8b and the ethylthiosemicarbazide derivative 4c showed the best inhibition activity against wild-type (WT) HIV-1. The promising compounds were further evaluated against HIV-1 RT and exhibited significant inhibitory activity with compound 8b showing comparable effect to the reference NNRTI Efavirenz (IC

Topics: Anti-HIV Agents; Coumarins; Drug Design; HIV Reverse Transcriptase; HIV-1; Molecular Docking Simulation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2023