Compounds > 4-phenylbutyric acid

4-phenylbutyric acid and ursodoxicoltaurine

4-phenylbutyric acid has been researched along with ursodoxicoltaurine in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (9.09)29.6817
2010's27 (61.36)24.3611
2020's13 (29.55)2.80

Authors

AuthorsStudies
Furuhashi, M; Görgün, CZ; Hotamisligil, GS; Ozcan, L; Ozcan, U; Smith, RO; Vaillancourt, E; Yilmaz, E1
Gregor, MF; Hotamisligil, GS1
Kador, PF; Madson, CJ; Mulhern, ML; Randazzo, J; Shinohara, T1
Chung, J; Ergin, AS; Lu, A; Myers, MG; Nie, D; Ozcan, L; Ozcan, U; Sarkar, S1
Arrojo e Drigo, R; Bianco, AC; Castillo, M; da-Silva, WS; Patti, ME; Ribich, S1
Alfany-Fernández, I; Ben Mosbah, I; Bintanel-Morcillo, M; Brenner, C; Martel, C; Peralta, C; Rimola, A; Rodés, J; Roselló-Catafau, J; Zaouali, MA1
Desai, T; Giacca, A; Ivovic, A; Koulajian, K; Minassian, B; Robson-Doucette, C; Schuiki, I; Tang, C; Volchuk, A; Wang, P; Wheeler, MB; Zhang, L1
Anderson, KA; Dewey, AM; Green, RM; Henkel, AS; Olivares, S1
Göke, B; Krüger, B; Kubisch, CH; Malo, A1
Dromparis, P; Haromy, A; Michelakis, ED; Paulin, R; Stenson, TH; Sutendra, G1
Liang, B; Viollet, B; Wang, Q; Wang, S; Zhang, W; Zhu, Y; Zou, MH1
Matsumoto, T; Spitler, KM; Webb, RC1
He, Z; Ma, M; Ma, W; Xi, H; Xu, H; Xu, W1
Cai, Z; Chen, C; Cianflone, K; Dong, N; Duan, Q; Gong, W; Li, F; Liu, W; Ni, L; Wang, DW; Xia, Y1
Daga, A; Debattisti, V; Pendin, D; Scorrano, L; Ziviani, E1
Jeong, JH; Kang, S; Lee, ES; Lee, HJ; Lee, YJ; Lim, YB1
Lappas, M; Liong, S1
Furuhashi, M; Fuseya, T; Hoshina, K; Inoue, K; Ishimura, S; Kokubu, N; Mita, T; Miura, T; Watanabe, Y; Yoshida, H1
Hao, BB; Lu, H; Lu, L; Lu, YJ; Xu, ZC; Zhang, F; Zhao, B; Zhuang, L1
Du, LD; Ke, Y; Li, AM; Shi, ZH; Wing, YK; Xie, H; Xu, LH; Yung, WH1
Chi, B; Wang, D; Xu, J; Zhou, Q1
Bassham, DC; Howell, SH; Srivastava, R; Yang, X1
Alnæs-Katjavivi, P; Burton, GJ; El-Bacha, T; Golic, M; Jones, CJ; Staff, AC; Yung, HW1
Cheang, WS; Chen, ZY; Huang, Y; Lau, CW; Ma, RC; Tian, XY; Wang, L; Wang, N; Wong, WT; Xu, A; Xu, J; Zhao, L1
Lombardi, A; Tomer, Y1
Carlisle, RE; Dickhout, JG; Upagupta, C1
Gani, AR; Ramaiah, KVA; Uppala, JK1
Kiaris, H; Mihailidou, C; Papavassiliou, AG1
Chen, C; Gu, Y; Hei, Z; Huang, F; Wang, Y; Wu, S; Yuan, D; Zhou, S1
Aerts-Kaya, F; Balta, G; Kuskonmaz, B; Sarikaya, A; Teker, HT; Uckan-Cetinkaya, D; Ulum, B1
Guo, W; Jia, Y; Xu, J; Zhou, Q1
Mariángelo, JIE; Mundiña-Weilenmann, C; Román, B; Said, M; Salas, M; Silvestri, MA; Vittone, L1
Liu, Y; Wang, M; Yang, J; Zheng, D; Zhou, S1
Bhatt, D; Cunningham-Rundles, C; de Camargo, MM; Machado, M; Maity, S; Pinhata, R; Stan, RC; Vogel, C1
Cao, F; Fang, Z; Jiang, M; Li, D; Li, S; Liu, C; Liu, J; Qiu, Y; Zhang, J; Zhang, R1
Andres, PL; Babu, S; Berry, JD; Caress, JB; Chan, J; Chase, M; Cohen, J; Cudkowicz, ME; Dagostino, D; Dickson, SP; Elliott, MA; Ellison, N; Fournier, CN; Gilbert, W; Glass, JD; Goutman, SA; Goyal, NA; Hall, M; Heiman-Patterson, T; Heitzman, D; Hendrix, K; Hendrix, S; Jackson, CE; Jenkins, L; Johnson, KM; Karam, C; Kasarskis, EJ; Katz, J; Kittle, G; Klee, J; Ladha, S; Leslie, K; Macklin, EA; Maiser, S; McGovern, M; Miller, TM; Ostrow, J; Owegi, MA; Paganoni, S; Pattee, GL; Pothier, L; Quick, A; Quinn, C; Randall, R; Rothstein, JD; Scelsa, SN; Schoenfeld, D; Shefner, JM; Sherman, AV; Swenson, A; Tanzi, RE; Tustison, E; Vigneswaran, P; Vu, TH; Walker, J; Wittes, J; Wymer, J; Yeramian, PD; Yu, H1
Andres, PL; Babu, S; Berry, JD; Caress, JB; Chan, J; Chase, M; Cohen, J; Cudkowicz, ME; Dagostino, D; Dickson, SP; Elliott, MA; Eydinov, M; Fournier, CN; Gilbert, W; Glass, JD; Goutman, SA; Goyal, NA; Hall, M; Heiman-Patterson, TD; Heitzman, D; Hendrix, S; Jackson, CE; Jenkins, L; Johnson, KM; Karam, C; Kasarskis, EJ; Katz, J; Kittle, G; Klee, J; Knowlton, N; Ladha, S; Leslie, K; Macklin, EA; Maiser, S; McGovern, M; Miller, TM; Ostrow, J; Owegi, MA; Paganoni, S; Pattee, GL; Pothier, L; Quick, A; Quinn, C; Randall, R; Rothstein, JD; Scelsa, SN; Schoenfeld, D; Shefner, JM; Sherman, AV; St Pierre, ME; Swenson, A; Tanzi, RE; Tustison, E; Vigneswaran, P; Vu, TH; Walker, J; Wittes, J; Wymer, J; Yeramian, PD; Yu, H; Yu, ZF1
Aoe, T; Jin, H; Kokubun, H; Okuyama, Y1
Hardiman, O1
Wang, Y; Xing, D; Xu, J; Zhou, Q1
Heo, YA1
Bedlack, R; Li, X; Sun, Y1
Albanese, A; Cocco, A; Lalli, S; Lo Giudice, M; Reggiardo, G1

Reviews

4 review(s) available for 4-phenylbutyric acid and ursodoxicoltaurine

ArticleYear
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
    Journal of lipid research, 2007, Volume: 48, Issue:9

    Topics: Adipocytes; Animals; Cholesterol; Endoplasmic Reticulum; Humans; Inflammation; Lipid Metabolism; Metabolic Diseases; Obesity; Phenylbutyrates; Protein Folding; Proteins; Stress, Physiological; Taurochenodeoxycholic Acid

2007
Sodium Phenylbutyrate and Ursodoxicoltaurine: First Approval.
    CNS drugs, 2022, Volume: 36, Issue:9

    Topics: Adult; Amyotrophic Lateral Sclerosis; Humans; Pharmaceutical Preparations; Phenylbutyrates; Taurochenodeoxycholic Acid

2022
An evaluation of the combination of sodium phenylbutyrate and taurursodiol for the treatment of amyotrophic lateral sclerosis.
    Expert review of neurotherapeutics, 2023, Volume: 23, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Edaravone; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic

2023
Tauro-Urso-Deoxycholic Acid Trials in Amyotrophic Lateral Sclerosis: What is Achieved and What to Expect.
    Clinical drug investigation, 2023, Volume: 43, Issue:12

    Topics: Amyotrophic Lateral Sclerosis; Humans; Phenylbutyrates; Taurochenodeoxycholic Acid

2023

Trials

2 trial(s) available for 4-phenylbutyric acid and ursodoxicoltaurine

ArticleYear
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
    The New England journal of medicine, 2020, 09-03, Volume: 383, Issue:10

    Topics: Aged; Amyotrophic Lateral Sclerosis; Disease Progression; Double-Blind Method; Drug Combinations; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Phenylbutyrates; Severity of Illness Index; Taurochenodeoxycholic Acid; Treatment Outcome

2020
Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.
    Muscle & nerve, 2021, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Phenylbutyrates; Taurochenodeoxycholic Acid; Time; Young Adult

2021

Other Studies

38 other study(ies) available for 4-phenylbutyric acid and ursodoxicoltaurine

ArticleYear
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
    Science (New York, N.Y.), 2006, Aug-25, Volume: 313, Issue:5790

    Topics: Adipose Tissue; Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Liver; Mice; Mice, Obese; Phenylbutyrates; Phosphorylation; Receptor, Insulin; Signal Transduction; Taurochenodeoxycholic Acid

2006
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.
    Molecular vision, 2007, Aug-10, Volume: 13

    Topics: Animals; Body Weight; Cataract; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum; Epithelial Cells; Galactose; Galactosemias; Humans; Lens, Crystalline; Methylamines; Phenylbutyrates; Protein Folding; Rats; Rats, Sprague-Dawley; Sodium Selenite; Taurochenodeoxycholic Acid; Tunicamycin; Up-Regulation

2007
Endoplasmic reticulum stress plays a central role in development of leptin resistance.
    Cell metabolism, 2009, Jan-07, Volume: 9, Issue:1

    Topics: Animals; Endoplasmic Reticulum; Hypothalamus; Leptin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Phenylbutyrates; Receptors, Leptin; Signal Transduction; Taurochenodeoxycholic Acid; Tunicamycin

2009
The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
    FEBS letters, 2011, Feb-04, Volume: 585, Issue:3

    Topics: Adipocytes, Brown; Animals; Cell Line; Cells, Cultured; Dietary Fats; Energy Metabolism; Gene Expression Regulation; Gene Knockout Techniques; Glucose Intolerance; Humans; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxygen Consumption; Phenylbutyrates; RNA, Messenger; Taurochenodeoxycholic Acid; Triiodothyronine

2011
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion.
    Cell death & disease, 2010, Jul-08, Volume: 1

    Topics: Activating Transcription Factor 6; Animals; Caspase 12; Cytochromes c; Endoplasmic Reticulum; Fatty Liver; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; Hepatectomy; JNK Mitogen-Activated Protein Kinases; Liver; Mitochondria; Phenylbutyrates; Rats; Rats, Zucker; Reperfusion Injury; Taurochenodeoxycholic Acid; Unfolded Protein Response; Voltage-Dependent Anion Channels

2010
Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress.
    Diabetologia, 2012, Volume: 55, Issue:5

    Topics: Animals; Antioxidants; Cyclic N-Oxides; Endoplasmic Reticulum Stress; Female; Glucose; Hyperglycemia; Insulin-Secreting Cells; Mitochondria; Oxidative Stress; Phenylbutyrates; Rats; Rats, Wistar; Spin Labels; Superoxides; Taurochenodeoxycholic Acid

2012
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Volume: 303, Issue:1

    Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endoplasmic Reticulum; Fatty Liver; Gene Expression; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Chaperones; Phenylbutyrates; Real-Time Polymerase Chain Reaction; Stress, Physiological; Taurochenodeoxycholic Acid

2012
4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini.
    Pancreas, 2013, Volume: 42, Issue:1

    Topics: Amylases; Animals; Apoptosis; Calcium; Cholecystokinin; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Male; Pancreas, Exocrine; Phenylbutyrates; Rats; Rats, Wistar; Signal Transduction; Taurochenodeoxycholic Acid; Time Factors; Trypsin; Unfolded Protein Response

2013
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.
    Circulation, 2013, Jan-01, Volume: 127, Issue:1

    Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cholagogues and Choleretics; Chronic Disease; Disease Models, Animal; Endoplasmic Reticulum Stress; Hypertension, Pulmonary; Hypoxia; Male; Mice; Mice, Inbred C57BL; Mitochondria; Models, Cardiovascular; Phenylbutyrates; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurochenodeoxycholic Acid

2013
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Activators; Humans; Hypertension; Leupeptins; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myosin Light Chains; Nitric Oxide Synthase Type III; Phenylbutyrates; Phenylephrine; Phosphorylation; Ribonucleotides; Taurochenodeoxycholic Acid; Time Factors; Tunicamycin; Vasoconstriction; Vasoconstrictor Agents

2013
Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat.
    American journal of physiology. Heart and circulatory physiology, 2013, Aug-01, Volume: 305, Issue:3

    Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Arachidonic Acid; bcl-2-Associated X Protein; Blood Pressure; Cells, Cultured; Cyclooxygenase 1; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Endothelium, Vascular; Epoprostenol; Hydrogen Peroxide; Hypertension; Male; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylbutyrates; Phospholipases A2, Cytosolic; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Taurochenodeoxycholic Acid; tert-Butylhydroperoxide; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2013
The ER luminal binding protein (BiP) alleviates Cd(2+)-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells.
    Journal of plant physiology, 2013, Nov-01, Volume: 170, Issue:16

    Topics: Apoptosis; Arabidopsis; Cadmium; Carrier Proteins; Endoplasmic Reticulum Stress; Nicotiana; Phenylbutyrates; Plant Cells; Plant Proteins; Plants, Genetically Modified; Signal Transduction; Taurochenodeoxycholic Acid

2013
Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:10

    Topics: Aged; Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Calcinosis; Calcium; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Male; Mice; Mice, Knockout; Middle Aged; Osteoblasts; Phenylbutyrates; Rabbits; RNA Interference; Signal Transduction; Swine; Taurochenodeoxycholic Acid; Transfection

2013
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion.
    The Journal of cell biology, 2014, Feb-03, Volume: 204, Issue:3

    Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Endoplasmic Reticulum Stress; Genetic Complementation Test; Humans; Locomotion; Membrane Proteins; Mice; Mitochondria; Phenylbutyrates; RNA Interference; Taurochenodeoxycholic Acid

2014
Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells.
    Biochemical and biophysical research communications, 2014, Jul-25, Volume: 450, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Cell Death; Cell Line; Endoplasmic Reticulum Stress; Enzyme Activation; Epithelial Cells; Intestinal Mucosa; Phenylbutyrates; Rats; Taurochenodeoxycholic Acid; Thapsigargin; Tunicamycin; Unfolded Protein Response

2014
Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.
    Biology of reproduction, 2014, Volume: 91, Issue:3

    Topics: Adult; Alternative Splicing; Biomarkers; Cesarean Section; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Extraembryonic Membranes; Female; Gene Expression Regulation, Developmental; Heat-Shock Proteins; Humans; Labor, Obstetric; Myometrium; Obstetric Labor, Premature; Phenylbutyrates; Pregnancy; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; Taurochenodeoxycholic Acid; Tissue Culture Techniques; Tocolytic Agents; Transcription Factors; Unfolded Protein Response; Up-Regulation; X-Box Binding Protein 1

2014
Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.
    Scientific reports, 2014, Nov-06, Volume: 4

    Topics: Animals; Becaplermin; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Vessels; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Endothelial Cells; Femoral Artery; Gene Expression Regulation; Heterozygote; Humans; Hyperplasia; Male; Mice; Myocytes, Smooth Muscle; Neointima; Phenylbutyrates; Proto-Oncogene Proteins c-sis; Regulatory Factor X Transcription Factors; Signal Transduction; Taurochenodeoxycholic Acid; Transcription Factors; Unfolded Protein Response; Vascular System Injuries; X-Box Binding Protein 1

2014
Tauroursodeoxycholic acid and 4-phenyl butyric acid alleviate endoplasmic reticulum stress and improve prognosis of donation after cardiac death liver transplantation in rats.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2014, Volume: 13, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cholagogues and Choleretics; Death; Delayed Graft Function; Endoplasmic Reticulum Stress; Liver Transplantation; Male; Models, Animal; Oxidative Stress; Phenylbutyrates; Prognosis; Rats, Sprague-Dawley; Reperfusion Injury; Survival Rate; Taurochenodeoxycholic Acid

2014
Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory.
    Antioxidants & redox signaling, 2015, Sep-20, Volume: 23, Issue:9

    Topics: Animals; Caspase 3; Endoplasmic Reticulum Stress; Hippocampus; Hypoxia; Male; Memory; Memory, Long-Term; Mice, Inbred C57BL; Mitochondria; Neuronal Plasticity; Neurons; Phenylbutyrates; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Spine; Taurochenodeoxycholic Acid

2015
Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model.
    Biological trace element research, 2016, Volume: 170, Issue:2

    Topics: Animals; Copper; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Liver; Mice; Phenylbutyrates; Taurochenodeoxycholic Acid; Zinc

2016
Activation of autophagy by unfolded proteins during endoplasmic reticulum stress.
    The Plant journal : for cell and molecular biology, 2016, Volume: 85, Issue:1

    Topics: Arabidopsis; Autophagy; Dithiothreitol; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Phenylbutyrates; Protein Unfolding; Taurochenodeoxycholic Acid; Tunicamycin; Vacuoles

2016
Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
    Diabetologia, 2016, Volume: 59, Issue:10

    Topics: Acidosis; Adult; Antioxidants; Ascorbic Acid; Blood Glucose; Blotting, Western; Cell Line; Diabetes, Gestational; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Female; Glucose; Humans; Phenylbutyrates; Phosphorylation; Placenta; Pregnancy; Taurochenodeoxycholic Acid; Unfolded Protein Response; Vitamin E

2016
PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice.
    Diabetes, 2017, Volume: 66, Issue:2

    Topics: Animals; Aorta; Blood Pressure; Diabetes Mellitus; Diabetic Angiopathies; Diet, High-Fat; Endoplasmic Reticulum Stress; Endothelium, Vascular; Male; Mesenteric Arteries; Mice; Mice, Knockout; Myography; Nitric Oxide; Obesity; Organ Culture Techniques; Oxidative Stress; Phenylbutyrates; Physical Conditioning, Animal; Receptors, Cytoplasmic and Nuclear; Taurochenodeoxycholic Acid; Vasodilation

2017
Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.
    Journal of autoimmunity, 2017, Volume: 80

    Topics: Apoptosis; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; Humans; Insulin; Insulin-Secreting Cells; Interferon-alpha; Phenylbutyrates; Proprotein Convertase 1; Proprotein Convertase 2; Taurochenodeoxycholic Acid; Transcription Factor CHOP; X-Box Binding Protein 1

2017
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
    Biochemical and biophysical research communications, 2017, 04-22, Volume: 486, Issue:1

    Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Glycerol; Humans; Kidney Tubules, Proximal; Molecular Weight; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Staining and Labeling; Taurochenodeoxycholic Acid; Thapsigargin; Thiazoles; Trehalose; Unfolded Protein Response; Xenobiotics

2017
Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death.
    Scientific reports, 2017, 06-19, Volume: 7, Issue:1

    Topics: Activating Transcription Factor 4; Apoptosis; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Hep G2 Cells; Humans; Molecular Chaperones; Molecular Sequence Annotation; Phenylbutyrates; Poly(ADP-ribose) Polymerases; Taurochenodeoxycholic Acid; Tunicamycin

2017
Cell-autonomous cytotoxicity of type I interferon response
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:12

    Topics: Animals; Azacitidine; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Ciclopirox; Endoplasmic Reticulum Stress; Enzyme-Linked Immunosorbent Assay; Interferon Type I; Mice; Mice, Inbred C57BL; Phenylbutyrates; Pyridones; Taurochenodeoxycholic Acid; Unfolded Protein Response

2017
Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.
    Journal of translational medicine, 2018, 05-04, Volume: 16, Issue:1

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Apoptosis; Connexins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Epithelial Cells; Gap Junction beta-1 Protein; Gene Deletion; Gene Knockout Techniques; Kidney; Male; Mice, Inbred C57BL; Phenylbutyrates; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Taurochenodeoxycholic Acid

2018
Bone marrow mesenchymal stem cell donors with a high body mass index display elevated endoplasmic reticulum stress and are functionally impaired.
    Journal of cellular physiology, 2018, Volume: 233, Issue:11

    Topics: Activating Transcription Factor 4; Adipogenesis; Adolescent; Adult; Alkaline Phosphatase; Body Mass Index; Cell Differentiation; Cell Proliferation; Cellular Senescence; Child; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Developmental; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Middle Aged; Obesity; Osteogenesis; Phenylbutyrates; Regenerative Medicine; Taurochenodeoxycholic Acid; Tissue Donors; Transcription Factor CHOP; Unfolded Protein Response; Young Adult

2018
Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
    Biological trace element research, 2019, Volume: 189, Issue:2

    Topics: Animals; Calcium; Diabetes Mellitus, Type 1; Heart; Kidney; Liver; Magnesium; Male; Mice; Myocardium; Phenylbutyrates; Spleen; Streptozocin; Taurochenodeoxycholic Acid

2019
Chemical chaperones improve the functional recovery of stunned myocardium by attenuating the endoplasmic reticulum stress.
    Acta physiologica (Oxford, England), 2020, Volume: 228, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cholagogues and Choleretics; Disease Models, Animal; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Male; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Phenylbutyrates; Rats; Rats, Wistar; Signal Transduction; Taurochenodeoxycholic Acid; Unfolded Protein Response

2020
Endoplasmic reticulum stress regulates epithelial‑mesenchymal transition in human lens epithelial cells.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Cataract; Cell Line; Endoplasmic Reticulum Stress; Epithelial Cells; Epithelial-Mesenchymal Transition; Eye Proteins; Humans; Lens, Crystalline; Phenylbutyrates; Taurochenodeoxycholic Acid; Thapsigargin; Tunicamycin

2020
Chemical chaperones reverse early suppression of regulatory circuits during unfolded protein response in B cells from common variable immunodeficiency patients.
    Clinical and experimental immunology, 2020, Volume: 200, Issue:1

    Topics: B-Lymphocytes; Cells, Cultured; Common Variable Immunodeficiency; Dimethyl Sulfoxide; Endoplasmic Reticulum Stress; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Immunoglobulins; Phenylbutyrates; Taurochenodeoxycholic Acid; Thapsigargin; Transcription Factors; Tunicamycin; Unfolded Protein Response

2020
Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2α-ATF4-CHOP pathway.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 08-01, Volume: 1866, Issue:8

    Topics: Activating Transcription Factor 4; Animals; Antioxidants; Cerebral Arteries; eIF-2 Kinase; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Heat-Shock Proteins; Hindlimb Suspension; Male; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphorus Compounds; Phenylbutyrates; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurochenodeoxycholic Acid; TOR Serine-Threonine Kinases; Transcription Factor CHOP

2020
Pharmacological Chaperones Attenuate the Development of Opioid Tolerance.
    International journal of molecular sciences, 2020, Oct-13, Volume: 21, Issue:20

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Phenylbutyrates; Taurochenodeoxycholic Acid

2020
Major advances in amyotrophic lateral sclerosis in 2020.
    The Lancet. Neurology, 2021, Volume: 20, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Drug Combinations; Humans; Oligonucleotides; Phenylbutyrates; Superoxide Dismutase-1; Taurochenodeoxycholic Acid

2021
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
    Biological trace element research, 2023, Volume: 201, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endoplasmic Reticulum Stress; Mice; Pharmaceutical Preparations; Selenium; Taurochenodeoxycholic Acid

2023
Sodium Phenylbutyrate and Taurursodiol.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2023, 03-07, Volume: 80, Issue:6

    Topics: Humans; Phenylbutyrates; Taurochenodeoxycholic Acid

2023