4-phenylbutyric acid has been researched along with thapsigargin in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 24 (82.76) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Crilley, TK; Morrell, NW; Rudarakanchana, N; Sobolewski, A; Trembath, RC; Upton, PD; Yang, J | 1 |
| Hashimoto, C; Hosoi, T; Matsuo, S; Miyahara, T; Ozawa, K; Sasaki, M; Yoshii, M | 1 |
| Friedman, JE; Janssen, RC; Qadri, I; Rahman, SM | 1 |
| Bothwell, M; Frankowski, H; Ladiges, WC; Meabon, JS; Schecterson, LC; Smith, EA; Wiley, JC | 1 |
| Joe, MK; Jung, MH; Kim, WH; Koh, IU; Lim, JH; Song, J; Yoon, JB | 1 |
| Akasaka, Y; Ishiyama, J; Ito, M; Murakami, K; Nagasawa, M; Shibata, S; Taguchi, R | 1 |
| Bartley, C; Biden, TJ; Boslem, E; Busch, AK; Fuller, M; Laybutt, DR; MacIntosh, G; Meikle, PJ; Preston, AM | 1 |
| Almanza, G; Mahadevan, NR; Pérez, AF; Rodvold, J; Wheeler, MC; Zanetti, M | 1 |
| Hunziker, W; Kausalya, PJ | 1 |
| Aït-Slimane, T; Delaunay, JL; Delautier, D; Durand-Schneider, AM; Gabillet, J; Gautherot, J; Housset, C; Maurice, M; Rada, A | 1 |
| Chae, HJ; Kim, DS; Kim, HR; Lee, W; Li, B; Lim, HD; Oh, HW; Rhew, KY | 1 |
| Biden, TJ; Chan, JY; Laybutt, DR | 1 |
| Baker, M; Beri, R; Chandel, NS; Cheresh, P; Kamp, DW; Kim, SJ; Lam, AP; Liu, G; Mueller, A; Ridge, K; Trejo, H; Tulasiram, S; Williams, D | 1 |
| Arora, DK; Kowluru, A; Mohammed, AM; Syeda, K | 1 |
| Chang, H; Liang, X; Mi, M; Peng, X; Shi, L; Shu, F; Zhou, Y; Zhu, J | 1 |
| Chae, HJ; Kim, HR; Lee, EG; Sung, MS; Yoo, HG; Yoo, WH | 1 |
| Jeong, JH; Kang, S; Lee, ES; Lee, HJ; Lee, YJ; Lim, YB | 1 |
| Ayala, P; Baeza, P; Catalán, M; Díaz-Araya, G; García, L; Humeres, C; Lavandero, S; Letelier, A; Montenegro, J; Muñoz, C; Olmedo, I; Rivas, C; Varela, M; Vivar, R | 1 |
| Garg, SK; Ghosh, AK; Liu, J; Mau, T; O'Brien, M; Yung, R | 1 |
| Jiang, Y; Li, M; Liu, S; Wang, B; Wang, J; Yang, L; Yin, Y | 1 |
| Gong, J; Han, P; He, J; Li, M; Liu, J; Tian, D; Wang, Y; Yan, W | 1 |
| Beguinot, F; D'Esposito, V; Di Jeso, B; Fiory, F; Formisano, P; Longo, M; Miele, C; Nigro, C; Raciti, GA; Spinelli, R; Zatterale, F | 1 |
| Brüne, B; Huang, S; Hwang, DH; Jandali, O; Namgaladze, D; Sama, S; Shao, T; Snodgrass, RG | 1 |
| Lv, J; Nie, H; Wu, Q; Yang, J | 1 |
| Beriault, DR; Dang, VT; McAlpine, CS; Petlura, CI; Shi, Y; Werstuck, GH; Zhong, LH | 1 |
| Carlisle, RE; Dickhout, JG; Upagupta, C | 1 |
| Liu, Y; Wang, M; Yang, J; Zheng, D; Zhou, S | 1 |
| Bhatt, D; Cunningham-Rundles, C; de Camargo, MM; Machado, M; Maity, S; Pinhata, R; Stan, RC; Vogel, C | 1 |
| Jeung, EB; Jung, EM; Yoo, YM | 1 |
29 other study(ies) available for 4-phenylbutyric acid and thapsigargin
| Article | Year |
|---|---|
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.
Topics: Amino Acid Substitution; Biological Transport, Active; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Cell Membrane; Endoplasmic Reticulum; Germ-Line Mutation; Glycerol; HeLa Cells; Humans; Hypertension, Pulmonary; Models, Biological; Phenylbutyrates; Recombinant Proteins; Signal Transduction; Smad Proteins, Receptor-Regulated; Thapsigargin; Transfection | 2008 |
Endoplasmic reticulum stress induces leptin resistance.
Topics: Animals; Brefeldin A; Cell Line; Endoplasmic Reticulum; Homocysteine; Humans; Leptin; Mice; Mice, Inbred C57BL; Phenylbutyrates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptors, Leptin; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thapsigargin; Transfection; Tunicamycin | 2008 |
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Topics: AMP-Activated Protein Kinases; Blotting, Western; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Endoplasmic Reticulum; Enzyme Activation; Fatty Acids; Fatty Liver; Fenofibrate; Hepacivirus; Humans; Hypolipidemic Agents; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phenylbutyrates; Phosphorylation; Receptors, Adiponectin; Thapsigargin; Triglycerides; Tunicamycin | 2009 |
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Blotting, Western; Brefeldin A; Cell Line, Tumor; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Green Fluorescent Proteins; Immunohistochemistry; Neurons; Phenylbutyrates; Protein Transport; Recombinant Fusion Proteins; Thapsigargin; Transfection; Tunicamycin | 2010 |
AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells.
Topics: Activating Transcription Factor 3; Animals; Chromatin Immunoprecipitation; DNA; Electrophoretic Mobility Shift Assay; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gene Deletion; Gene Expression; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Hep G2 Cells; Humans; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Phenylbutyrates; Promoter Regions, Genetic; Protein Binding; Receptors, Adiponectin; Regulatory Elements, Transcriptional; RNA, Small Interfering; Stress, Physiological; Thapsigargin; Transfection | 2010 |
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages.
Topics: Animals; Cell Line; Endoplasmic Reticulum; Fatty Acids, Unsaturated; Humans; Palmitic Acid; Phenylbutyrates; Receptors, Oxidized LDL; RNA, Small Interfering; Stress, Physiological; Thapsigargin; Up-Regulation | 2011 |
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
Topics: Animals; Apoptosis; Biomarkers; Cell Line; Endoplasmic Reticulum; Enzyme Inhibitors; Glucosylceramides; Glucosyltransferases; Insulin-Secreting Cells; Lipid Metabolism; Metabolomics; Mice; Palmitic Acid; Phenylbutyrates; Protein Biosynthesis; Protein Transport; Serine C-Palmitoyltransferase; Sphingolipids; Stress, Physiological; Thapsigargin; Transcription Factor CHOP; Tunicamycin | 2011 |
ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner.
Topics: Acute-Phase Proteins; Adenocarcinoma; Animals; Cell Line, Tumor; Endoplasmic Reticulum; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lipocalin-2; Lipocalins; Male; Mice; Neoplasm Proteins; NF-kappa B; Nitriles; Oncogene Proteins; Phenylbutyrates; Prostatic Neoplasms; Protein Biosynthesis; Proto-Oncogene Proteins; Sulfones; Thapsigargin; Transcription, Genetic; Tunicamycin; Unfolded Protein Response; Up-Regulation | 2011 |
Methods to analyze subcellular localization and intracellular trafficking of Claudin-16.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Claudins; Dogs; Electrophoresis, Polyacrylamide Gel; Endocytosis; Humans; Loop of Henle; Magnesium Deficiency; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Multiprotein Complexes; Mutation; Nephrocalcinosis; Phenylbutyrates; Plasmids; Protein Transport; Sodium Channels; Thapsigargin; Tight Junctions | 2011 |
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calnexin; Cholestasis; Cryoprotective Agents; Cyclosporine; Dogs; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Silencing; Glycerol; Hep G2 Cells; HSC70 Heat-Shock Proteins; Humans; Mutation, Missense; Phenylbutyrates; Protein Transport; Thapsigargin | 2012 |
The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts.
Topics: Autophagy; Biomarkers; Cell Proliferation; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fibroblasts; Gingiva; Heat-Shock Proteins; Humans; Phenylbutyrates; Protective Agents; RNA Interference; Signal Transduction; Thapsigargin; Time Factors; Transfection; Unfolded Protein Response | 2012 |
Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Cytokines; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Mice; Mice, Inbred C57BL; NF-kappa B; Pancreatic Neoplasms; Phenylbutyrates; RNA, Small Interfering; Signal Transduction; Thapsigargin; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Tunicamycin; Unfolded Protein Response | 2012 |
Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response.
Topics: Alveolar Epithelial Cells; Animals; Antioxidants; Apoptosis; Asbestos, Amosite; bcl-X Protein; Calcium Signaling; Cell Line; Cells, Cultured; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Heat-Shock Proteins; Humans; Membrane Proteins; Organometallic Compounds; Phenylbutyrates; Protein Serine-Threonine Kinases; Rats; Regulatory Factor X Transcription Factors; RNA, Messenger; Salicylates; Thapsigargin; Transcription Factor CHOP; Transcription Factors | 2013 |
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine.
Topics: Animals; Calcium Channel Blockers; Caspase 3; Cells, Cultured; Cytosol; Endoplasmic Reticulum Stress; Glucose; Humans; Insulin-Secreting Cells; Lamin Type B; Male; Nifedipine; Phenylbutyrates; Rats; Rats, Sprague-Dawley; Thapsigargin; Transcription Factor CHOP | 2013 |
Ampelopsin induces cell growth inhibition and apoptosis in breast cancer cells through ROS generation and endoplasmic reticulum stress pathway.
Topics: Acetylcysteine; Activating Transcription Factor 6; Ampelopsis; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Phenylbutyrates; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Thapsigargin; Transcription Factor CHOP; Transcription Factors | 2014 |
Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Interleukin-1beta; Macrophages; Male; Mice; Mice, Inbred ICR; Models, Animal; Osteoclasts; Phenylbutyrates; RANK Ligand; Signal Transduction; Thapsigargin | 2014 |
Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Death; Cell Line; Endoplasmic Reticulum Stress; Enzyme Activation; Epithelial Cells; Intestinal Mucosa; Phenylbutyrates; Rats; Taurochenodeoxycholic Acid; Thapsigargin; Tunicamycin; Unfolded Protein Response | 2014 |
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Endoplasmic Reticulum Stress; Fibroblasts; Myocytes, Cardiac; Phenylbutyrates; Procollagen; Rats; Rats, Sprague-Dawley; Thapsigargin; Unfolded Protein Response | 2014 |
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging.
Topics: Activating Transcription Factor 6; Adipose Tissue; Age Factors; Animals; Cell Culture Techniques; Cytokines; DNA-Binding Proteins; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Enzyme Inhibitors; Heat-Shock Proteins; Inflammation; Macrophages; Male; Mice; Phenylbutyrates; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Stromal Cells; Thapsigargin; Transcription Factor CHOP; Transcription Factors; X-Box Binding Protein 1 | 2015 |
FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis.
Topics: Anthraquinones; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspases; Cell Line; Endoplasmic Reticulum Chaperone BiP; Epithelial Cells; Eukaryotic Initiation Factor-2; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Hep G2 Cells; Humans; Mammary Glands, Human; MCF-7 Cells; Membrane Proteins; Phenylbutyrates; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Thapsigargin; Transcription Factor CHOP | 2015 |
Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Calcium-Binding Proteins; Carcinoma, Hepatocellular; Caspase 3; Cell Proliferation; eIF-2 Kinase; Endoplasmic Reticulum Stress; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phenylbutyrates; RNA Interference; RNA, Small Interfering; Thapsigargin; Transcription Factor CHOP; Transplantation, Heterologous | 2015 |
Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.
Topics: 3T3-L1 Cells; Adipocytes; Adult; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cells, Cultured; Cytokines; Endoplasmic Reticulum Stress; Gene Expression; Glucosamine; Humans; Inflammation Mediators; Mice; Middle Aged; NF-kappa B; Phenotype; Phenylbutyrates; Phenylenediamines; Reverse Transcriptase Polymerase Chain Reaction; Thapsigargin; Unfolded Protein Response | 2016 |
Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Immunomodulation; Inflammasomes; Interleukin-1beta; Ligands; Lipopeptides; Lipopolysaccharides; Monocytes; Palmitic Acid; Phenylbutyrates; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Thapsigargin; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2016 |
4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Butylamines; Caspase 3; Cell Line; Dexamethasone; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucocorticoids; Humans; Mice; Mitochondria; Osteoblasts; Phenylbutyrates; Thapsigargin | 2017 |
Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation.
Topics: Animals; Cell Line; Dithiothreitol; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Fibroblasts; Glucosamine; Glycosylation; Lipopolysaccharides; Mice; Phenylbutyrates; Thapsigargin; Unfolded Protein Response | 2017 |
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Glycerol; Humans; Kidney Tubules, Proximal; Molecular Weight; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Staining and Labeling; Taurochenodeoxycholic Acid; Thapsigargin; Thiazoles; Trehalose; Unfolded Protein Response; Xenobiotics | 2017 |
Endoplasmic reticulum stress regulates epithelial‑mesenchymal transition in human lens epithelial cells.
Topics: Cataract; Cell Line; Endoplasmic Reticulum Stress; Epithelial Cells; Epithelial-Mesenchymal Transition; Eye Proteins; Humans; Lens, Crystalline; Phenylbutyrates; Taurochenodeoxycholic Acid; Thapsigargin; Tunicamycin | 2020 |
Chemical chaperones reverse early suppression of regulatory circuits during unfolded protein response in B cells from common variable immunodeficiency patients.
Topics: B-Lymphocytes; Cells, Cultured; Common Variable Immunodeficiency; Dimethyl Sulfoxide; Endoplasmic Reticulum Stress; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Immunoglobulins; Phenylbutyrates; Taurochenodeoxycholic Acid; Thapsigargin; Transcription Factors; Tunicamycin; Unfolded Protein Response | 2020 |
Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endoplasmic Reticulum Stress; Insulin; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Melatonin; Phenylbutyrates; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Thapsigargin; Tunicamycin | 2019 |