Compounds > 4-phenylbutyric acid

4-phenylbutyric acid and sirolimus

4-phenylbutyric acid has been researched along with sirolimus in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Düvel, K; Hotamisligil, GS; Manning, BD; Ozcan, L; Ozcan, U; Sahin, M; Yilmaz, E1
Dai, H; Fujita, E; Miyakawa, T; Momoi, MY; Momoi, T; Tanabe, Y; Tanokura, M; Yamagata, T; Zhiling, Y1
Huang, H; Kang, R; Luo, G; Wang, J; Yang, W; Zhao, Z1
Deng, Y; Liu, C; Liu, W; Ma, Z; Tan, X; Wang, C; Xu, B; Xu, ZF; Yan, DY; Yang, TY1
Abdel-Ghaffar, A; Ahmed, EK; Gadallah, SH; Ghanem, HM; Hanafy, LK; Metwaly, FG1
Bai, J; Jia, H; Li, J; Si, X; Wu, Z1

Reviews

1 review(s) available for 4-phenylbutyric acid and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

6 other study(ies) available for 4-phenylbutyric acid and sirolimus

ArticleYear
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
    Molecular cell, 2008, Mar-14, Volume: 29, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Child, Preschool; eIF-2 Kinase; Endoplasmic Reticulum; Genes, Tumor Suppressor; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiprotein Complexes; Neoplasms; Neurons; Oxidative Stress; Phenylbutyrates; Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

2008
Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1.
    Cell death & disease, 2010, Jun-03, Volume: 1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Bacterial Agents; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Child; Child Development Disorders, Pervasive; Child, Preschool; Endoplasmic Reticulum; Humans; Immunoglobulins; Membrane Proteins; Mice; Mutation, Missense; Nerve Tissue Proteins; Neurons; Phenylbutyrates; Protein Structure, Tertiary; Sirolimus; Transcription Factor CHOP; Up-Regulation

2010
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
    Autophagy, 2013, Feb-01, Volume: 9, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Knockdown Techniques; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Metformin; Models, Biological; Multiprotein Complexes; Phenylbutyrates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Virus Replication

2013
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.
    Environmental toxicology, 2018, Volume: 33, Issue:3

    Topics: Adenine; alpha-Synuclein; Animals; Apoptosis; Autophagy; Brain; Butylamines; Chlorides; Endoplasmic Reticulum Stress; Environmental Pollutants; Manganese; Manganese Compounds; Mice, Inbred C57BL; Neurons; Phenylbutyrates; Polymerization; Signal Transduction; Sirolimus

2018
4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.
    Archives of physiology and biochemistry, 2021, Volume: 127, Issue:3

    Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Endoplasmic Reticulum Stress; Phenylbutyrates; Sirolimus

2021
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
    Chemico-biological interactions, 2023, Apr-01, Volume: 374

    Topics: Animals; Apoptosis; Autophagy; Benzo(a)pyrene; Epithelial Cells; Intestinal Mucosa; Sirolimus; Swine; Tight Junctions

2023