4-phenylbutyric acid has been researched along with phenylacetic acid in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Armstrong, AJ; Collado, MS; Dillberger, JE; Figler, RA; Henke, BR; Hoang, SA; Johns, BA; Olson, MW; Pourtaheri, TD; Reardon, JE; Roper, TD; Taylor, JM; Wamhoff, BR | 1 |
| Smigel, K | 1 |
| Fibach, E; Prasanna, P; Rodgers, GP; Samid, D | 1 |
| Hommes, FA | 1 |
| Bowling, MK; Carducci, MA; Chen, TL; Donehower, RC; Eisenberger, MA; Gilbert, J; Grochow, LB; Noe, D; Sinibaldi, V; Zabelina, Y | 1 |
| Banik, NL; Dasgupta, S; Jana, M; Pahan, K; Zhou, Y | 1 |
| TESTA, E | 1 |
| MASTERS, R; STEINBERG, D | 1 |
| ZENI, G | 1 |
| Davies, JE; Eltis, LD; Mohn, WW; Navarro-Llorens, JM; Patrauchan, MA; Stewart, GR | 1 |
| Beliveau, M; Berry, SA; Diaz, GA; Dickinson, K; Gargosky, S; Lee, B; Marier, JF; Martinez, A; Mauney, J; Mian, A; Mokhtarani, M; Rhead, W; Scharschmidt, BF; Shchelochkov, O | 1 |
| Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M | 1 |
| Burrage, LC; Elsea, SH; Glinton, KE; Liu, N; Minard, CG; Nagamani, SCS; Sun, Q | 1 |
2 trial(s) available for 4-phenylbutyric acid and phenylacetic acid
| Article | Year |
|---|---|
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolence; Dose-Response Relationship, Drug; Fatigue; Female; Glutamine; Humans; Hypokalemia; Infusions, Intravenous; Male; Metabolic Clearance Rate; Nausea; Neoplasms; Neutropenia; Patient Dropouts; Phenylacetates; Phenylbutyrates; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Uric Acid | 2001 |
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control.
Topics: Adult; Aged; Ammonia; Cross-Over Studies; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2010 |
12 other study(ies) available for 4-phenylbutyric acid and phenylacetic acid
| Article | Year |
|---|---|
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Animals; Area Under Curve; Butyrates; Cells, Cultured; Dogs; Drug Evaluation, Preclinical; Half-Life; Hepatocytes; Humans; Mice; Models, Biological; Propionic Acidemia; Rats; ROC Curve; Structure-Activity Relationship | 2021 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplasms | 1992 |
Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia.
Topics: Anemia, Sickle Cell; Azacitidine; beta-Thalassemia; Blotting, Northern; Butyrates; Butyric Acid; Cell Division; Cells, Cultured; DNA Probes; Erythrocytes; Fetal Hemoglobin; Hematopoietic Stem Cells; Humans; Hydroxyurea; Kinetics; Phenylacetates; Phenylbutyrates; Reference Values | 1993 |
The assay of phenylacetic acid and 4-phenylbutyric acid in physiological fluids.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Phenylacetates; Phenylbutyrates; Reference Values; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.
Topics: Acute Disease; Administration, Oral; Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cell Movement; Chronic Disease; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Growth Inhibitors; Immunosuppressive Agents; Injections, Intraperitoneal; Lymphocyte Activation; Mice; Mice, Inbred Strains; Microglia; Myelin Basic Protein; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylacetates; Phenylbutyrates; Severity of Illness Index; Spinal Cord; T-Lymphocyte Subsets; Transcription Factor RelA; Tyrosine | 2003 |
[Substances active on the central nervous system. II. Derivatives of alpha-ethyl-alpha-phenyl-beta-hydroxypropionic acid & alpha-phenylbutyric acid].
Topics: Nervous System; Phenylacetates; Phenylbutyrates; Phenylpropionates; Propionates | 1957 |
Studies on mechanism of action of alpha-phenylbutyrate.
Topics: Phenylacetates; Phenylbutyrates | 1958 |
[Sodium phenylbutyrate in the treatment of arteriosclerotic disease].
Topics: Arteriosclerosis; Humans; Phenylacetates; Phenylbutyrates; Sodium | 1958 |
Phenylacetate catabolism in Rhodococcus sp. strain RHA1: a central pathway for degradation of aromatic compounds.
Topics: Acetaldehyde; Chromosomes, Bacterial; Electrophoresis, Gel, Two-Dimensional; Genes, Bacterial; GTP Cyclohydrolase; Multigene Family; Phenethylamines; Phenylacetates; Phenylalanine; Phenylbutyrates; Phenylethyl Alcohol; Phenylpyruvic Acids; Proteome; Rhodococcus | 2005 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; Epilepsy; Infusions, Intraventricular; Male; Mice; Pentylenetetrazole; Phenylacetates; Phenylbutyrates; Seizures; Shikimic Acid | 2017 |
Monitoring the treatment of urea cycle disorders using phenylbutyrate metabolite analyses: Still many lessons to learn.
Topics: Child; Humans; Phenylbutyrates; Retrospective Studies; Urea Cycle Disorders, Inborn | 2023 |