4-phenylbutyric acid has been researched along with glycerol in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rubenstein, RC; Zeitlin, PL | 1 |
| Burrows, JA; Perlmutter, DH; Willis, LK | 1 |
| Csermely, P; Papp, E | 1 |
| Benos, DJ; Bubien, JK; Colby, G; Esimai, O; Fuller, CM; Gillespie, GY; Jovov, B; Kovacs, GG; Mapstone, TB; Markert, JM; Pahwa, AK; Vila-Carriles, WH; Zhou, ZH | 1 |
| Crilley, TK; Morrell, NW; Rudarakanchana, N; Sobolewski, A; Trembath, RC; Upton, PD; Yang, J | 1 |
| Leandro, J; Leandro, P; Nascimento, C; Tavares de Almeida, I | 1 |
| Beliveau, M; Berry, SA; Diaz, GA; Dickinson, K; Gargosky, S; Lee, B; Marier, JF; Martinez, A; Mauney, J; Mian, A; Mokhtarani, M; Rhead, W; Scharschmidt, BF; Shchelochkov, O | 1 |
| Beliveau, M; Diaz, GA; Dickinson, K; Feigenbaum, A; Jomphe, C; Lichter-Konecki, U; Marier, JF; Martinez, A; Mauney, J; Merritt, JL; Mokhtarani, M; Rhead, W; Scharschmidt, B | 1 |
| Aït-Slimane, T; Delaunay, JL; Delautier, D; Durand-Schneider, AM; Gabillet, J; Gautherot, J; Housset, C; Maurice, M; Rada, A | 1 |
| Bart, SA; Bartholomew, D; Bartley, J; Berquist, W; Berry, SA; C S Nagamani, S; Cederbaum, S; Coakley, DF; Diaz, GA; Dickinson, K; Feigenbaum, A; Gallagher, R; Harding, CO; Korson, MS; Krivitzky, LS; Kronn, D; Lee, B; Lemons, C; Lichter-Konecki, U; Longo, N; Mauney, J; McCandless, SE; Merritt, JL; Mokhtarani, M; Moors, TL; Rhead, W; Scharschmidt, BF; Smith, W; Vockley, G; Zori, R | 1 |
| Mistry, PK | 1 |
| Berry, SA; Coakley, DF; Diaz, GA; Dickinson, K; Harding, CO; Lee, B; LeMons, C; Lichter-Konecki, U; Mauney, J; McCandless, SE; Mokhtarani, M; Moors, T; Scharschmidt, BF; Smith, W | 1 |
| Guha, M | 1 |
| Agrawal, A; Chakraborty, K; Chakraborty, S; Ghosh, B; Krishnan, V; Mabalirajan, U; Maity, S; Makhija, L; Rehman, R | 1 |
| Chen, YL; Ding, XY; Hou, FF; Hu, LL; Li, C; Xu, GY; Zhou, QG; Zhu, Y | 1 |
| Bok, D; Hu, J; Izumi, T; Jacobson, SG; Jin, HH; Jin, M; Li, S; Siddiqui, AA | 1 |
| Carlisle, RE; Dickhout, JG; Upagupta, C | 1 |
4 trial(s) available for 4-phenylbutyric acid and glycerol
| Article | Year |
|---|---|
Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control.
Topics: Adult; Aged; Ammonia; Cross-Over Studies; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Phenylacetates; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2010 |
Ammonia control in children with urea cycle disorders (UCDs); phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate.
Topics: Adolescent; Ammonia; Child; Dose-Response Relationship, Drug; Glycerol; Humans; Male; Phenylbutyrates; Urea; Urea Cycle Disorders, Inborn | 2011 |
Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate.
Topics: Adolescent; Adult; Ammonia; Child; Cross-Over Studies; Double-Blind Method; Female; Glutamine; Glycerol; Humans; Male; Middle Aged; Neuropsychological Tests; Phenylbutyrates; Urea Cycle Disorders, Inborn; Young Adult | 2013 |
Ammonia control in children ages 2 months through 5 years with urea cycle disorders: comparison of sodium phenylbutyrate and glycerol phenylbutyrate.
Topics: Ammonia; Child; Child, Preschool; Drug Substitution; Female; Glutamine; Glycerol; Humans; Infant; Liver; Male; Phenylbutyrates; Surveys and Questionnaires; Urea Cycle Disorders, Inborn | 2013 |
13 other study(ies) available for 4-phenylbutyric acid and glycerol
| Article | Year |
|---|---|
Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR.
Topics: Animals; Antineoplastic Agents; Biological Transport; Butyrates; Calcium-Binding Proteins; Calnexin; Carrier Proteins; Cells, Cultured; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Down-Regulation; Gene Expression; Glycerol; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Multienzyme Complexes; Mutation; Phenylbutyrates; Proteasome Endopeptidase Complex; Rabbits; RNA, Messenger; Ubiquitins | 2000 |
Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency.
Topics: Administration, Oral; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Cell Line; Emphysema; Glycerol; Humans; Liver; Lung; Methylamines; Mice; Mice, Transgenic; Mutation; Phenylbutyrates; Protein Folding; Temperature | 2000 |
Chemical chaperones: mechanisms of action and potential use.
Topics: Animals; Enzyme Inhibitors; Glycerol; Humans; Methylamines; Molecular Chaperones; Phenylbutyrates; Protein Folding | 2006 |
Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells.
Topics: Acid Sensing Ion Channels; Amiloride; Antineoplastic Agents; Brain Neoplasms; Cell Membrane; Cell Movement; Cell Proliferation; Glioblastoma; Glioma; Glycerol; Humans; Membrane Proteins; Nerve Tissue Proteins; Phenylbutyrates; Sodium; Sodium Channel Blockers; Sodium Channels | 2006 |
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.
Topics: Amino Acid Substitution; Biological Transport, Active; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Cell Membrane; Endoplasmic Reticulum; Germ-Line Mutation; Glycerol; HeLa Cells; Humans; Hypertension, Pulmonary; Models, Biological; Phenylbutyrates; Recombinant Proteins; Signal Transduction; Smad Proteins, Receptor-Regulated; Thapsigargin; Transfection | 2008 |
Modulation of the activity of newly synthesized human phenylalanine hydroxylase mutant proteins by low-molecular-weight compounds.
Topics: Animals; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Enzymologic; Glycerol; Humans; Methylamines; Mutant Proteins; Phenylalanine Hydroxylase; Phenylbutyrates; Phenylketonurias; Recombinant Fusion Proteins; Temperature | 2008 |
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calnexin; Cholestasis; Cryoprotective Agents; Cyclosporine; Dogs; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Silencing; Glycerol; Hep G2 Cells; HSC70 Heat-Shock Proteins; Humans; Mutation, Missense; Phenylbutyrates; Protein Transport; Thapsigargin | 2012 |
Rare disease clinical research network's urea cycle consortium delivers a successful clinical trial to improve alternate pathway therapy.
Topics: Ammonia; Female; Glycerol; Humans; Male; Phenylbutyrates; Urea Cycle Disorders, Inborn | 2013 |
Urea cycle disorder drug approved.
Topics: Adult; Clinical Trials as Topic; Drug Approval; Drug Industry; Glycerol; Humans; Patient Compliance; Phenylbutyrates; Urea Cycle Disorders, Inborn | 2013 |
Chemical chaperones mitigate experimental asthma by attenuating endoplasmic reticulum stress.
Topics: Airway Remodeling; Animals; Asthma; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glycerol; Inflammation; Lung; Male; Methylamines; Mice; Mice, Inbred BALB C; Molecular Chaperones; Phenylbutyrates; Protein Folding; Trehalose; Unfolded Protein Response | 2014 |
The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease.
Topics: Acyltransferases; Adipocytes; Animals; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Glycerol; Intra-Abdominal Fat; Lipase; Lipolysis; Male; Membrane Proteins; Phenylbutyrates; Phosphorylation; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Sterol Esterase | 2014 |
Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.
Topics: Animals; Catalytic Domain; Cell Membrane; cis-trans-Isomerases; Disease; Gene Expression Regulation, Enzymologic; Glycerol; HEK293 Cells; Humans; Mice; Models, Molecular; Mutant Proteins; Mutation, Missense; Phenylbutyrates; Proteasome Endopeptidase Complex; Protein Folding; Proteolysis; Retinal Pigment Epithelium; Temperature; Ubiquitination | 2014 |
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Glycerol; Humans; Kidney Tubules, Proximal; Molecular Weight; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Staining and Labeling; Taurochenodeoxycholic Acid; Thapsigargin; Thiazoles; Trehalose; Unfolded Protein Response; Xenobiotics | 2017 |