4-phenylbutyric acid has been researched along with chlorine in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Egan, ME; Rubenstein, RC; Zeitlin, PL | 1 |
| Rubenstein, RC; Zeitlin, PL | 1 |
| Loffing, J; Moyer, BD; Reynolds, D; Stanton, BA | 1 |
| Boyle, MP; Brass-Ernst, L; Diener-West, M; Lee, CK; Rubenstein, RC; Zeitlin, PL | 1 |
| Andersson, C; Roomans, GM; Servetnyk, Z | 1 |
| Floyd, AD; Kwon, E; Lim, M; McKenzie, K; Zeitlin, PL | 1 |
| Deng, Y; Liu, C; Liu, W; Ma, Z; Tan, X; Wang, C; Xu, B; Xu, ZF; Yan, DY; Yang, TY | 1 |
2 trial(s) available for 4-phenylbutyric acid and chlorine
| Article | Year |
|---|---|
A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function.
Topics: Administration, Oral; Adolescent; Adult; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Female; Homozygote; Humans; Male; Mutation; Nasal Cavity; Phenylbutyrates; Pilot Projects; Sweat | 1998 |
Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate.
Topics: Adult; Biological Transport, Active; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Male; Nasal Mucosa; Phenylbutyrates | 2002 |
5 other study(ies) available for 4-phenylbutyric acid and chlorine
| Article | Year |
|---|---|
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.
Topics: Biological Transport; Cells, Cultured; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Immunohistochemistry; Kinetics; Membrane Potentials; Nasal Mucosa; Nasal Polyps; Patch-Clamp Techniques; Phenylbutyrates; Point Mutation | 1997 |
PBA increases CFTR expression but at high doses inhibits Cl(-) secretion in Calu-3 airway epithelial cells.
Topics: Butyrates; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Electric Conductivity; Epithelial Cells; Humans; Phenylbutyrates; Respiratory System; Sodium-Potassium-Exchanging ATPase; Valproic Acid | 1999 |
Activation of CFTR by genistein in human airway epithelial cell lines.
Topics: Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Genistein; Humans; Ion Transport; Phenylbutyrates; Respiratory Mucosa | 2003 |
Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids.
Topics: Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Drug Therapy, Combination; Flavonoids; Humans; Molecular Chaperones; Phenylbutyrates; Protein Folding; Protein Transport; Respiratory Mucosa; Up-Regulation | 2004 |
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.
Topics: Adenine; alpha-Synuclein; Animals; Apoptosis; Autophagy; Brain; Butylamines; Chlorides; Endoplasmic Reticulum Stress; Environmental Pollutants; Manganese; Manganese Compounds; Mice, Inbred C57BL; Neurons; Phenylbutyrates; Polymerization; Signal Transduction; Sirolimus | 2018 |